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Volumn 139, Issue 19-20, 2009, Pages 274-277

Severe asthma: How can we differentiate phenotypes?

Author keywords

Asthma; Diagnosis; Phenotypes

Indexed keywords

ANTIINFLAMMATORY AGENT; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; IMMUNOGLOBULIN E ANTIBODY; LEUKOTRIENE RECEPTOR BLOCKING AGENT; THEOPHYLLINE; TOBACCO SMOKE;

EID: 67650069357     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (13)

References (30)
  • 1
    • 3543134378 scopus 로고    scopus 로고
    • Worldwide severity and control of asthma in children and adults: The global asthma insights and reality surveys
    • DOI 10.1016/j.jaci.2004.04.042, PII S0091674904014137
    • Rabe K.F. Adachi M. Lai C.K.W. Soriano J.B. Vermeire P.A. Weiss K.B. Weiss S.T. Worldwide severity and control of asthma in children and adults: The global asthma insights and reality surveys Journal of Allergy and Clinical Immunology 2004 114 1 40-47 DOI 10.1016/j.jaci.2004.04.042, PII S0091674904014137 1 Rabe KF, Adachi M, Lai CK, Soriano JB, Vermeire PA, Weiss KB, Weiss ST. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol. 2004;114:40-47 (Pubitemid 39022491)
    • (2004) Journal of Allergy and Clinical Immunology , vol.114 , Issue.1 , pp. 40-47
    • Rabe, K.F.1    Adachi, M.2    Lai, C.K.W.3    Soriano, J.B.4    Vermeire, P.A.5    Weiss, K.B.6    Weiss, S.T.7
  • 2
    • 0032409133 scopus 로고    scopus 로고
    • Costs of asthma according to the degree of severity
    • DOI 10.1183/09031936.98.12061322
    • Serra-Batlles J. Plaza V. Morejon E. Comella A. Brugues J. Costs of asthma according to the degree of severity European Respiratory Journal 1998 12 6 1322-1326 DOI 10.1183/09031936.98.12061322 2 Serra-Batlles J, Plaza V, Morejon E, Comella A, Brugues J. Costs of asthma according to the degree of severity. Eur Respir J. 1998;12:1322-1326 (Pubitemid 29011423)
    • (1998) European Respiratory Journal , vol.12 , Issue.6 , pp. 1322-1326
    • Serra-Batlles, J.1    Plaza, V.2    Morejon, E.3    Comella, A.4    Brugues, J.5
  • 3
    • 15844363866 scopus 로고    scopus 로고
    • Severe asthma treatment: Need for characterising patients
    • DOI 10.1016/S0140-6736(05)71087-4, PII S0140673605710874
    • Heaney L.G. Robinson D.S. Severe asthma treatment: Need for characterising patients Lancet 2005 365 9463 974-976 DOI 10.1016/S0140-6736(05) 71087-4, PII S0140673605710874 3 Heaney LG, Robinson DS. Severe asthma treatment: need for characterising patients. Lancet 2005;365:974-976 (Pubitemid 41071432)
    • (2005) Lancet , vol.365 , Issue.9463 , pp. 974-976
    • Heaney, L.G.1    Robinson, D.S.2
  • 6
    • 67650048481 scopus 로고    scopus 로고
    • National Heart and Lung Institute, National Institutes of Health USA, and the World Health Organization. Updated november 2006. Available at
    • Global Initiative for Asthma. National Heart and Lung Institute, National Institutes of Health USA, and the World Health Organization. Updated november 2006. Available at: http://www.ginasthma.org. Ref Type: Generic
  • 8
    • 10744231300 scopus 로고    scopus 로고
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
    • European Network for Understanding Mechanisms of Severe Asthma.
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J. 2003;22:470-477
    • (2003) Eur Respir J. , vol.22 , pp. 470-477
  • 10
    • 43549117048 scopus 로고    scopus 로고
    • Overcoming steroid insensitivity in smoking asthmatics
    • Ahmad T. Barnes P.J. Adcock I.M. Overcoming steroid insensitivity in smoking asthmatics Current Opinion in Investigational Drugs 2008 9 5 470-477 10 Ahmad T, Barnes PJ, Adcock IM. Overcoming steroid insensitivity in smoking asthmatics. Curr Opin Investig Drugs 2008; 9:470-477 (Pubitemid 351677900)
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.5 , pp. 470-477
    • Ahmad, T.1    Barnes, P.J.2    Adcock, I.M.3
  • 12
    • 0346041503 scopus 로고    scopus 로고
    • Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
    • DOI 10.1016/j.jaci.2003.10.041
    • Miranda C. Busacker A. Balzar S. Trudeau J. Wenzel S.E. Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation Journal of Allergy and Clinical Immunology 2004 113 1 101-108 DOI 10.1016/j.jaci.2003.10.041 12 Miranda C, Busacker A, Balzar S, Trudeau J, Wenzel SE. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J.Allergy Clin.Immunol. 2004;113: 101-108 (Pubitemid 38096168)
    • (2004) Journal of Allergy and Clinical Immunology , vol.113 , Issue.1 , pp. 101-108
    • Miranda, C.1    Busacker, A.2    Balzar, S.3    Trudeau, J.4    Wenzel, S.E.5
  • 14
    • 33747756534 scopus 로고    scopus 로고
    • Asthma: Defining of the persistent adult phenotypes
    • DOI 10.1016/S0140-6736(06)69290-8, PII S0140673606692908
    • Wenzel S.E. Asthma: defining of the persistent adult phenotypes Lancet 2006 368 9537 804-813 DOI 10.1016/S0140-6736(06)69290-8, PII S0140673606692908 14 Wenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet. 2006;368:804-813 (Pubitemid 44279058)
    • (2006) Lancet , vol.368 , Issue.9537 , pp. 804-813
    • Wenzel, S.E.1
  • 15
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
    • DOI 10.1016/S0140-6736(02)11679-5
    • Green R.H. Brightling C.E. McKenna S. Hargadon B. Parker D. Bradding P. Wardlaw A.J. Pavord I.D. Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial Lancet 2002 360 9347 1715-1721 DOI 10.1016/S0140-6736(02)11679-5 15 Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002; 360:1715-1721 (Pubitemid 35447900)
    • (2002) Lancet , vol.360 , Issue.9347 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Parker, D.5    Bradding, P.6    Wardlaw, A.J.7    Pavord, I.D.8
  • 17
    • 0037090945 scopus 로고    scopus 로고
    • Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma
    • DOI 10.1016/S0002-9343(02)01047-1, PII S0002934302010471
    • Little S.A. MacLeod K.J. Chalmers G.W. Love J.G. McSharry C. Thomson N.C. Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma American Journal of Medicine 2002 112 6 446-452 DOI 10.1016/S0002-9343(02)01047-1, PII S0002934302010471 17 Little SA, MacLeod KJ, Chalmers GW, Love JG, McSharry C, Thomson NC. Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma. Am J Med. 2002;112:446-452 (Pubitemid 34450704)
    • (2002) American Journal of Medicine , vol.112 , Issue.6 , pp. 446-452
    • Little, S.A.1    MacLeod, K.J.2    Chalmers, G.W.3    Love, J.G.4    McSharry, C.5    Thomson, N.C.6
  • 18
    • 4444221246 scopus 로고    scopus 로고
    • Refractory eosinophilic airway inflammation in severe asthma: Effect of parenteral corticosteroids
    • ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. "Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids. Am J Respir Crit Care Med. 2004;170:601-605
    • (2004) Am J Respir Crit Care Med. , vol.170 , pp. 601-605
    • Ten Brinke, A.1    Zwinderman, A.H.2    Sterk, P.J.3    Rabe, K.F.4    Bel, E.H.5
  • 19
    • 33646267939 scopus 로고    scopus 로고
    • Is the neutrophil a worthy target in severe asthma and chronic obstructive pulmonary disease?
    • Louis R, Djukanovic R. Is the neutrophil a worthy target in severe asthma and chronic obstructive pulmonary disease? Clin Exp Allergy. 2006;36:563-567
    • (2006) Clin Exp Allergy. , vol.36 , pp. 563-567
    • Louis, R.1    Djukanovic, R.2
  • 20
    • 33845478528 scopus 로고    scopus 로고
    • Multiple inflammatory hits and the pathogenesis of severe airway disease
    • DOI 10.1183/09031936.06.00128105
    • Pavord I.D. Birring S.S. Berry M. Green R.H. Brightling C.E. Wardlaw A.J. Multiple inflammatory hits and the pathogenesis of severe airway disease European Respiratory Journal 2006 27 5 884-888 DOI 10.1183/09031936.06.00128105 20 Pavord ID, Birring SS, Berry M, Green RH, Brightling CE, Wardlaw AJ. Multiple inflammatory hits and the pathogenesis of severe airway disease. Eur Respir J. 2006;27:884-888 (Pubitemid 44911098)
    • (2006) European Respiratory Journal , vol.27 , Issue.5 , pp. 884-888
    • Pavord, I.D.1    Birring, S.S.2    Berry, M.3    Green, R.H.4    Brightling, C.E.5    Wardlaw, A.J.6
  • 22
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • DOI 10.1016/S0140-6736(06)69288-X, PII S014067360669288X
    • Holgate S.T. Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults Lancet 2006 368 9537 780-793 DOI 10.1016/S0140-6736(06) 69288-X, PII S014067360669288X 22 Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet. 2006;368:780-793 (Pubitemid 44279056)
    • (2006) Lancet , vol.368 , Issue.9537 , pp. 780-793
    • Holgate, S.T.1    Polosa, R.2
  • 23
    • 0037952701 scopus 로고    scopus 로고
    • Airway structural alterations selectively associated with severe asthma
    • DOI 10.1164/rccm.200209-1030OC
    • Benayoun L. Druilhe A. Dombret M.-C. Aubier M. Pretolani M. Airway structural alterations selectively associated with severe asthma American Journal of Respiratory and Critical Care Medicine 2003 167 10 1360-1368 DOI 10.1164/rccm.200209-1030OC 23 Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med. 2003;167:1360-1368 (Pubitemid 36609720)
    • (2003) American Journal of Respiratory and Critical Care Medicine , vol.167 , Issue.10 , pp. 1360-1368
    • Benayoun, L.1    Druilhe, A.2    Dombret, M.-C.3    Aubier, M.4    Pretolani, M.5
  • 24
    • 34249779227 scopus 로고    scopus 로고
    • Specificity of basement membrane thickening in severe asthma
    • DOI 10.1016/j.jaci.2007.01.055, PII S0091674907004502
    • Bourdin A. Neveu D. Vachier I. Paganin F. Godard P. Chanez P. Specificity of basement membrane thickening in severe asthma Journal of Allergy and Clinical Immunology 2007 119 6 1367-1374 DOI 10.1016/j.jaci.2007.01.055, PII S0091674907004502 24 Bourdin A, Neveu D, Vachier I, Paganin F, Godard P, Chanez P. Specificity of basement membrane thickening in severe asthma. J Allergy Clin Immunol. 2007;119:1367-1374 (Pubitemid 46855858)
    • (2007) Journal of Allergy and Clinical Immunology , vol.119 , Issue.6 , pp. 1367-1374
    • Bourdin, A.1    Neveu, D.2    Vachier, I.3    Paganin, F.4    Godard, P.5    Chanez, P.6
  • 25
    • 0027404742 scopus 로고
    • The structure of large and small airways in nonfatal and fatal asthma
    • Carroll N. Elliot J. Morton A. James A. The structure of large and small airways in nonfatal and fatal asthma American Review of Respiratory Disease 1993 147 2 405-410 25 Carroll N, Elliot J, Morton A, James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis. 1993;147:405-410 (Pubitemid 23044915)
    • (1993) American Review of Respiratory Disease , vol.147 , Issue.2 , pp. 405-410
    • Carroll, N.1    Elliot, J.2    Morton, A.3    James, A.4
  • 26
    • 20444506757 scopus 로고    scopus 로고
    • Alveolar nitric oxide in adults with asthma: Evidence of distal lung inflammation in refractory asthma
    • DOI 10.1183/09031936.05.00132404
    • Berry M. Hargadon B. Morgan A. Shelley M. Richter J. Shaw D. Green R.H. Brightling C. Wardlaw A.J. Pavord I.D. Alveolar nitric oxide in adults with asthma: Evidence of distal lung inflammation in refractory asthma European Respiratory Journal 2005 25 6 986-991 DOI 10.1183/09031936.05.00132404 26 Berry M, Hargadon B, Morgan A, Shelley M, Richter J, Shaw D, et al. Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma. Eur Respir J. 2005;25:98-191 (Pubitemid 40823772)
    • (2005) European Respiratory Journal , vol.25 , Issue.6 , pp. 986-991
    • Berry, M.1    Hargadon, B.2    Morgan, A.3    Shelley, M.4    Richter, J.5    Shaw, D.6    Green, R.H.7    Brightling, C.8    Wardlaw, A.J.9    Pavord, I.D.10
  • 27
    • 0034131479 scopus 로고    scopus 로고
    • Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes
    • in 'tVeen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med. 2000;161:1902-1906.
    • (2000) Am J Respir Crit Care Med. , vol.161 , pp. 1902-1906
    • In 'tVeen, J.C.1    Beekman, A.J.2    Bel, E.H.3    Sterk, P.J.4
  • 28
    • 33644902403 scopus 로고    scopus 로고
    • Nitrogen washout slope in poorly controlled asthma
    • DOI 10.1111/j.1398-9995.2006.00970.x
    • Bourdin A. Paganin F. Prefaut C. Kieseler D. Godard P. Chanez P. Nitrogen washout slope in poorly controlled asthma Allergy: European Journal of Allergy and Clinical Immunology 2006 61 1 85-89 DOI 10.1111/j.1398-9995.2006.00970.x 28 Bourdin A, Paganin F, Prefaut C, Kieseler D, Godard P, Chanez P. Nitrogen washout slope in poorly controlled asthma. Allergy. 2006;61:85-89 (Pubitemid 43381196)
    • (2006) Allergy: European Journal of Allergy and Clinical Immunology , vol.61 , Issue.1 , pp. 85-89
    • Bourdin, A.1    Paganin, F.2    Prefaut, C.3    Kieseler, D.4    Godard, P.5    Chanez, P.6
  • 30
    • 38949165471 scopus 로고    scopus 로고
    • Lung function in adults with stable but severe asthma: Air trapping and incomplete reversal of obstruction with bronchodilation
    • DOI 10.1152/japplphysiol.00329.2007
    • Sorkness R.L. Bleecker E.R. Busse W.W. Calhoun W.J. Castro M. Chung K.F. Curran-Everett D. Erzurum S.C. Gaston B.M. Israel E. Jarjour N.N. Moore W.C. Peters S.P. Teague W.G. Wenzel S.E. Lung function in adults with stable but severe asthma: Air trapping and incomplete reversal of obstruction with bronchodilation Journal of Applied Physiology 2008 104 2 394-403 http://jap.physiology.org/cgi/reprint/104/2/394 DOI 10.1152/japplphysiol.00329. 2007 30 Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol. 2008;104:394-403. (Pubitemid 351231486)
    • (2008) Journal of Applied Physiology , vol.104 , Issue.2 , pp. 394-403
    • Sorkness, R.L.1    Bleecker, E.R.2    Busse, W.W.3    Calhoun, W.J.4    Castro, M.5    Chung, K.F.6    Curran-Everett, D.7    Erzurum, S.C.8    Gaston, B.M.9    Israel, E.10    Jarjour, N.N.11    Moore, W.C.12    Peters, S.P.13    Teague, W.G.14    Wenzel, S.E.15


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.