Actions of fibroblast growth factor-8 in bone cells in vitro

American Journal of Physiology - Endocrinology and Metabolism

Volumn 297, Issue 1, 2009, Pages

  Lin, Jian Ming ^a   Callon, Karen E ^a   Lin, Jun Sheng ^b   Watson, Maureen ^a   Empson, Victoria ^a   Tong, Pak C ^a   Grey, Andrew ^a   Naot, Dorit ^a   Green, Colin R ^a   Reid, Ian R ^a   Cornish, Jillian ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b INVERMAY AGRICULTURAL CENTRE   (New Zealand)

Author keywords

Anabolic; Osteoblasts; Osteoclasts; Osteoprotegerin; Receptor activator of nuclear factor B ligand

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; BONE SIALOPROTEIN; CELL MARKER; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 18; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR 8A; FIBROBLAST GROWTH FACTOR 8B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BONE CELL; BONE MINERALIZATION; CALVARIA; CELL PROLIFERATION; CONTROLLED STUDY; FETUS; IN VITRO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT;

ANIMALS; AUTOCRINE COMMUNICATION; BONE AND BONES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CONNEXIN 43; FIBROBLAST GROWTH FACTOR 8; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; RATS; SIGNAL TRANSDUCTION;

EID: 67650065286     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90743.2008     Document Type: Article

References (55)

1. Albertson RC, Yelick PC. Fgf8 haploinsufficiency results in distinct craniofacial defects in adult zebrafish. Dev Biol 306: 505-515, 2007.
2. Burgess TL, Qian YX, Kaufman S, Ring BD, Van G, Capparelli C, Kelley M, Hsu HL, Boyle WJ, Dunstan CR, Hu S, Lacey DL. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol 145: 527-538, 1999.
3. Chikazu D, Hakeda Y, Ogata N, Nemoto K, Itabashi A, Takato T, Kumegawa M, Nakamura K, Kawaguchi H. Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42/p44 MAP kinase. J Biol Chem 275: 31444-31450, 2000.
4. Chikazu D, Katagiri M, Ogasawara T, Ogata N, Shimoaka T, Takato T, Nakamura K, Kawaguchi H. Regulation of osteoclast differentiation by fibroblast growth factor 2: stimulation of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor expression in osteoblasts and inhibition of macrophage colony-stimulating factor function in osteoclast precursors. J Bone Miner Res 16: 2074-2081, 2001.
5. Civitelli R, Ziambaras K, Warlow PM, Lecanda F, Nelson T, Harley J, Atal N, Beyer EC, Steinberg TH. Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells. J Cell Biochem 68: 8-21, 1998.
6. Cornish J, Callon KE, Bava U, Kamona SA, Cooper GJ, Reid IR. Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. Bone 29: 162-168, 2001.
7. Cornish J, Callon KE, Bava U, Watson M, Xu X, Lin JM, Chan VA, Grey AB, Naot D, Buchanan CM, Cooper GJ, Reid IR. Preptin, another peptide product of the pancreatic β-cell, is osteogenic in vitro and in vivo. Am J Physiol Endocrinol Metab 292: E117-E122, 2007.
8. Cornish J, Callon KE, Lin CQ, Xiao CL, Mulvey TB, Coy DH, Cooper GJ, Reid IR. Dissociation of the effects of amylin on osteoblast proliferation and bone resorption. Am J Physiol Endocrinol Metab 274: E827-E833, 1998.
9. Cornish J, Callon KE, Naot D, Palmano KP, Banovic T, Bava U, Watson M, Lin JM, Tong PC, Chen Q, Chan VA, Reid HE, Fazzalari N, Baker HM, Baker EN, Haggarty NW, Grey AB, Reid IR. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145: 4366-4374, 2004.
10. Crossley PH, Minowada G, MacArthur CA, Martin GR. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84: 127-136, 1996.
11. Debiais F, Hott M, Graulet AM, Marie PJ. The effects of fibroblast growth factor-2 on human neonatal calvaria osteoblastic cells are differentiation stage specific. J Bone Miner Res 13: 645-654, 1998.
12. Fischer S, Draper BW, Neumann CJ. The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation. Development 130: 3515-3524, 2003.
13. Ghosh AK, Shankar DB, Shackleford GM, Wu K, T'Ang A, Miller GJ, Zheng J, Roy-Burman P. Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ 7: 1425-1434, 1996.
14. Gramsch B, Gabriel HD, Wiemann M, Grummer R, Winterhager E, Bingmann D, Schirrmacher K. Enhancement of connexin 43 expression increases proliferation and differentiation of an osteoblast-like cell line. Exp Cell Res 264: 397-407, 2001.
15. Grey A, Banovic T, Naot D, Hill B, Callon K, Reid I, Cornish J. Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G(i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases. Endocrinology 142: 1098-1106, 2001.
16. Heikinheimo M, Lawshé A, Shackleford GM, Wilson DB, MacArthur CA. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev 48: 129-138, 1994.
17. Hotokezaka H, Sakai E, Ohara N, Hotokezaka Y, Gonzales C, Matsuo K, Fujimura Y, Yoshida N, Nakayama K. Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan. J Cell Biochem 101: 122-134, 2007.
18. Hurley MM, Lee SK, Raisz LG, Bernecker P, Lorenzo J. Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures. Bone 22: 309-316, 1998.
19. Ilvesaro J, Vaananen K, Tuukkanen J. Bone-resorbing osteoclasts contain gap-junctional connexin-43. J Bone Miner Res 15: 919-926, 2000.
20. Jackson RA, Kumarasuriyar A, Nurcombe V, Cool SM. Long-term loading inhibits ERK1/2 phosphorylation and increases FGFR3 expression in MC3T3-E1 osteoblast cells. J Cell Physiol 209: 894-904, 2006.
21. Jones SJ, Gray C, Sakamaki H, Arora M, Boyde A, Gourdie R, Green C. The incidence and size of gap junctions between the bone cells in rat calvaria. Anat Embryol (Berl) 187: 343-352, 1993.
22. Kawaguchi H, Chikazu D, Nakamura K, Kumegawa M, Hakeda Y. Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures. J Bone Miner Res 15: 466-473, 2000.
23. Kobayashi Y, Takahashi N. [Regulatory mechanism of bone resorption: roles of bone remodeling-regulatory cytokines "osteokines" in osteoclast differentiation and function]. Nippon Rinsho 61: 200-206, 2003.
24. Lecanda F, Warlow PM, Sheikh S, Furlan F, Steinberg TH, Civitelli R. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151: 931-943, 2000.
25. Lewandoski M, Sun X, Martin GR. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26: 460-463, 2000.
26. Lin JM, Callon KE, Lin CQ, Bava U, Zheng MH, Reid IR, Cornish J. Alteration of bone cell function by RANKL and OPG in different in vitro models. Eur J Clin Invest 37: 407-415, 2007.
27. Lin JS, Zhang V, Law LY, Stott S, Green RC. Upregulation of connexin 43 by recombinant fibroblast growth factor-8a and its functional implications (Abstract). Mol Biol Cell 11: 225A, 2000.
28. MacArthur CA, Lawshé A, Shankar DB, Heikinheimo M, Shackleford GM. FGF-8 isoforms differ in NIH3T3 cell transforming potential. Cell Growth Differ 6: 817-825, 1995.
29. Makarenkova H, Becker DL, Tickle C, Warner AE. Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb Bud. J Cell Biol 138: 1125-1137, 1997.
30. Maruoka Y, Ohbayashi N, Hoshikawa M, Itoh N, Hogan BL, Furuta Y. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mech Dev 74: 175-177, 1998.
31. Murakami T, Yamamoto M, Ono K, Nishikawa M, Nagata N, Motoyoshi K, Akatsu T. Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem Biophys Res Commun 252: 747-752, 1998.
32. Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun 253: 395-400, 1998.
33. Nakagawa N, Yasuda H, Yano K, Mochizuki S, Kobayashi N, Fujimoto H, Shima N, Morinaga T, Chikazu D, Kawaguchi H, Higashio K. Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells. Biochem Biophys Res Commun 265: 158-163, 1999.
34. Nakagawa N, Yasuda H, Yano K, Mochizuki S, Kobayashi N, Fujimoto H, Yamaguchi K, Shima N, Morinaga T, Higashio K. Basic fibroblast growth factor inhibits osteoclast formation induced by 1alpha, 25-dihydroxyvitamin D(3) through suppressing the production of osteoclast differentiation factor. Biochem Biophys Res Commun 265: 45-50, 1999.
35. Ohuchi H, Nakagawa T, Yamamoto A, Araga A, Ohata T, Ishimaru Y, Yoshioka H, Kuwana T, Nohno T, Yamasaki M, Itoh N, Noji S. The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124: 2235-2244, 1997.
36. Powers CJ, McLeskey SW, Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 7: 165-197, 2000.
37. Reardon W, Winter RM, Rutland P, Pulleyn LJ, Jones BM, Malcolm S. Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nat Genet 8: 98-103, 1994.
38. Reid IR, Lowe C, Cornish J, Skinner SJ, Hilton DJ, Willson TA, Gearing DP, Martin TJ. Leukemia inhibitory factor: a novel bone-active cytokine. Endocrinology 126: 1416-1420, 1990.
39. Rodan SB, Wesolowski G, Thomas KA, Yoon K, Rodan GA. Effects of acidic and basic fibroblast growth factors on osteoblastic cells. Connect Tissue Res 20: 283-288, 1989.
40. Rousseau F, Bonaventure J, Legeai-Mallet L, Pelet A, Rozet JM, Maroteaux P, Le Merrer M, Munnich A. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 371: 252-254, 1994.
41. Schiller PC, Mehta PP, Roos BA, Howard GA. Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells. Mol Endocrinol 6: 1433-1440, 1992.
42. Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, Itoh N, Kawaguchi H. Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. J Biol Chem 277: 7493-7500, 2002.
43. Shiokawa-Sawada M, Mano H, Hanada K, Kakudo S, Kameda T, Miyazawa K, Nakamaru Y, Yuasa T, Mori Y, Kumegawa M, Hakeda Y. Down-regulation of gap junctional intercellular communication between osteoblastic MC3T3-E1 cells by basic fibroblast growth factor and a phorbol ester (12-O-tetradecanoylphorbol- 13-acetate). J Bone Miner Res 12: 1165-1173, 1997.
44. Suda T, Kobayashi K, Jimi E, Udagawa N, Takahashi N. The molecular basis of osteoclast differentiation and activation. Novartis Found Symp 232: 235-247; discussion 247-250, 2001.
45. Sun X, Meyers EN, Lewandoski M, Martin GR. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 13: 1834-1846, 1999.
46. Szebenyi G, Fallon JF. Fibroblast growth factors as multifunctional signaling factors. Int Rev Cytol 185: 45-106, 1999.
47. Tanaka A, Furuya A, Yamasaki M, Hanai N, Kuriki K, Kamiakito T, Kobayashi Y, Yoshida H, Koike M, Fukayama M. High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8. Cancer Res 58: 2053-2056, 1998.
48. Tanaka A, Miyamoto K, Minamino N, Takeda M, Sato B, Matsuo H, Matsumoto K. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci USA 89: 8928-8932, 1992.
49. Valta MP, Hentunen T, Qu Q, Valve EM, Harjula A, Seppänen JA, Väänänen HK, Härkönen PL. Regulation of osteoblast differentiation: a novel function for fibroblast growth factor 8. Endocrinology 147: 2171-2182, 2006.
50. Valta MP, Tuomela J, Bjartell A, Valve E, Väänänen HK, Härkönen P. FGF-8 is involved in bone metastasis of prostate cancer. Int J Cancer 123: 22-31, 2008.
51. Valve E, Penttilä TL, Paranko J, Härkönen P. FGF-8 is expressed during specific phases of rodent oocyte and spermatogonium development. Biochem Biophys Res Commun 232: 173-177, 1997.
52. Vogel A, Rodriguez C, Izpisua-Belmonte JC. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122: 1737-1750, 1996.
53. Xu J, Lawshe A, MacArthur CA, Ornitz DM. Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev 83: 165-178, 1999.
54. Xu Y, Malladi P, Zhou D, Longaker MT. Molecular and cellular characterization of mouse calvarial osteoblasts derived from neural crest and paraxial mesoderm. Plast Reconstr Surg 120: 1783-1795, 2007.
55. Zhou YX, Xu XL, Chen L, Li CL, Brodie SG, Deng CX. A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 9: 2001-2008, 2000.