Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb bud

Journal of Cell Biology

Volumn 138, Issue 5, 1997, Pages 1125-1137

  Makarenkova, H ^a   Becker, D L ^a   Tickle, C ^a   Warner, A E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; GAP JUNCTION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMMUNICATION; CELL INTERACTION; CELL JUNCTION; CHICKEN; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; LIMB DEVELOPMENT; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VERTEBRATE;

ANIMALS; CARTILAGE, ARTICULAR; CELL POLARITY; CELLS, CULTURED; CHICK EMBRYO; CONNEXIN 43; CONNEXINS; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; GAP JUNCTIONS; LIMB BUD; MESODERM; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA; GALLUS GALLUS; VERTEBRATA;

EID: 0030924020     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.5.1125     Document Type: Article

References (23)

1. Allen, F.L.G. 1988. Gap junctional communication during patterning of the limb and neuromuscular junction formation. PhD thesis. University of London, London, UK.
2. Allen, F.L.G., C. Tickle, and A. Warner. 1990. The role of gap junctions in patterning of the chick limb bud. Development (Comb.). 108:623-634.
3. Anderson, R., M. Landry, and K. Muneoka. 1993. Maintenance of ZPA signalling in cultured mouse limb bud cells. Development (Camb.). 117:1421-1433.
4. Becker, D.L., W.H. Evans, C.R. Green, and A.E. Warner. 1995. Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions. J. Cell Sci. 108:1455-1467.
5. Bueno, D., J. Skinner, H. Abud, and J.K. Heath. 1996. Spatial and temporal relationships between shh, Fgf-4 and Fgf-8 gene expression at diverse signalling centers during mouse development. Dev. Dyn. 207:291-299.
6. Coelho, C.N., and R.A. Kosher. 1991. A gradient of gap junctional communication along the anterior-posterior axis of the developing chick limb bud. Dev. Biol. 148:529-535.
7. Dealy, C.N., E.C. Beyer, and R.A. Kosher. 1994. Expression patterns of mRNAs for gap junction proteins, eonnexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature. Dev. Dyn. 199:156-167.
8. Fallon, J.F., A. López, M.A. Roz, M.P. Savage. B.B. Olwin, and B.K. Simandl. 1994. FGF2: apical ectodermal ridge growth signal for chick limb development. Science (Wash. DC). 264:104-107.
9. Green, C.R., N.S. Peters, R.G. Gourdie, S. Rothery, and N.J. Severs. 1993. Validation of immunohistochemical quantification in confocal laser scanning microscopy: a comparative assessment of gap junction size with confocal and ultrastructural techniques. J. Histochem. Cytochem. 41:1339-1349.
10. Green, C.R., L. Bowles, A. Crawley, and C. Tickle. 1994. Expression of the connexin43 gap junctional protein in tissues at the tip of the chick limb bud is related to the epithelial-mesenchymal interactions that mediate morphogenesis. Dev. Biol. 161:12-21.
11. Laird, D.W., S.B. Yancey, L. Bugga, and J.-P. Revel. 1992. Connexin expression and gap junction communication compartments in the developing mouse limb. Dev. Dyn. 195:153-161.
12. Laufer, E., C.E. Nelson, R.L. Johnson, B.A. Morgan, and C. Tabin. 1994. Sonic hedgehog and FgF-4 act through a signalling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell. 79:993-1003.
13. Nelles, E., C. Butzler, D. Jung, A. Temme, H.D. Gabriel, U. Dahl, O. Traub, F. Stumpel, K. Jungermann, J. Zielasek, et al. 1996. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc. Natl. Acad. Sci. USA. 93:9565-9570.
14. Niswander, L., C. Tickle, A. Vogel, I. Booth, and G.R. Martin. 1993. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell. 75:579-587.
15. Niswander, L., S. Jeffrey, G.R. Martin, and C. Tickle. 1994. A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature (Lond.). 371:609-612.
16. Reaume, A.G., P.A. de Sousa., S. Kulkarni, B.L. Langille, D. Zhu, T.C. Davies, S.C. Juneja, G.M. Kidder, and J. Rossant. 1995. Cardiac malformation in neonatal mice lacking connexin43. Science (Wash. DC). 267:1831-1834.
17. Riddle, R.D., R.L. Johnson, E. Laufer, and C. Tabin. 1993. Sonic hedgehog mediates the polarising activity of the ZPA. Cell. 75:1402-1416.
18. Saunders, J.W. 1948. The proximo-distal sequence of origin of limb parts of the chick wing and the role of the ectoderm. J. Exp. Zool. 108:363-404.
19. Saunders, J.W., and M.T. Gasseling. 1968. Ectodermal-mesodermal interactions in the origin of limb symmetry. In Epithelial-Mesenchymal Interactions. R. Fleischmajer and R.E. Billingham, editors. Williams and Wilkins, Baltimore. 78-97.
20. Summerbell, D. 1974. A quantitative analysis of the effect of excision of the AER from the chick limb bud. J. Embryol. Exp. Morphol. 35:241-260.
21. Tickle, C. 1981. The number of polarising region cells required to specify additional digits in the developing chick wing. Nature (Lond.). 289:295-298.
22. Tickle, C., G. Shellswell, A. Crawley, and L. Wolpert. 1976. Positional signalling by mouse limb polarising region in the chick limb bud. Nature (Lond.). 259:396-397.
23. Vogel, A., and C. Tickle. 1993. FGF-4 maintains polarising activity of posterior limb bud cells in vivo and in vitro. Development (Camb.). 119:199-206.