Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins

Journal of Nutrition

Volumn 139, Issue 7, 2009, Pages 1303-1307

  Lessard, Martin ^a,b   Boudry, Gaëlle ^a   Sève, Bernard ^a   Oswald, Isabelle P ^a   Lallès, Jean Paul ^a  

^a CEMAGREF   (France)

^b AGRICULTURE AND AGRI FOOD CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FUMONISIN B1; HORSERADISH PEROXIDASE; MICROSOMAL AMINOPEPTIDASE; PEPTIDASE; SODIUM; THEOPHYLLINE; FUMONISIN; GLUCOSE; PEPTIDE HYDROLASE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOAR (MALE PIG); CONTROLLED STUDY; CORN; DIETARY INTAKE; ENZYME ACTIVITY; GLUCOSE ABSORPTION; ILEUM; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; JEJUNUM MUCOSA; LIVER WEIGHT; MALE; NONHUMAN; ANIMAL; ANIMAL FOOD; CELL MEMBRANE PERMEABILITY; DRUG EFFECT; INTESTINE MUCOSA; MAIZE; METABOLISM; MICROVILLUS; MOUSE; ORCHIECTOMY; ORGAN SIZE; PHYSIOLOGY; SMOOTH MUSCLE; SWINE; WEANING;

ARMORACIA RUSTICANA; SUIDAE; ZEA MAYS;

ANIMAL FEED; ANIMALS; CELL MEMBRANE PERMEABILITY; FUMONISINS; GLUCOSE; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; MICE; MICROVILLI; MUSCLE, SMOOTH; ORCHIECTOMY; ORGAN SIZE; PEPTIDE HYDROLASES; PLANT EXTRACTS; SODIUM; SWINE; THEOPHYLLINE; WEANING; ZEA MAYS;

EID: 67649998932     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.109.105023     Document Type: Article

References (30)

1. Council for Agricultural Science and Technology. Mycotoxins: risks in plants, animals and human systems. Ames (IA): Council for Agricultural Science and Technology; 2003.
2. WHO. Fumonisin B1. Environmental health criteria 219. Geneva: WHO; 2000. p 153.
3. Taranu I, Marin DE, Bouhet S, Pascale F, Bailly JD, Miller JD, Pinton P, Oswald IP. Mycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol Sci. 2005;84:301-7.
4. Oswald IP, Desautels C, Laffitte J, Fournout S, Peres SY, Odin M, Le Bars P, Le Bars J, Fairbrother JM. Mycotoxin fumonisin B1 increases intestinal colonization by pathogenic Escherichia coli in pigs. Appl Environ Microbiol. 2003;69:5870-4.
5. Soriano JM, Gonzá lez L, Catalá AI. Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. Prog Lipid Res. 2005;44:345-56.
6. Voss KA, Smith GW, Haschek WM. Fumonisins: toxicokinetics, mechanism of action and toxicity. Anim. Feed Sci. Technol. 2007;137:299-325.
7. Loiseau N, Debrauwer L, Sambou T, Bouhet S, Miller JD, Martin PG, Viadère JL, Pinton P, Puel O, et al. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. Biochem Pharmacol. 2007;74:144-52.
8. Piva A, Casadei G, Pagliuca G, Cabassi E, Galvano F, Solfrizzo M, Riley RT, Diaz DE. Activated carbon does not prevent the toxicity of culture material containing fumonisin B1 when fed to weanling piglets. J Anim Sci. 2005;83:1939-47.
9. Bouhet S, Oswald IP. The intestine as a possible target for fumonisin toxicity. Mol Nutr Food Res. 2007;51:925-31.
10. Schmelz EM, Dombrink-Kurtzman MA, Roberts PC, Kozutsumi Y, Kawasaki T, Merrill AH, Jr. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol Appl Pharmacol. 1998;148:252-60.
11. Bouhet S, Hourcade E, Loiseau N, Fikry A, Martinez S, Roselli M, Galtier P, Mengheri E, Oswald IP. The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicol Sci. 2004;77:165-71.
12. Bouhet S, Le Dorze E, Peres S, Fairbrother JM, Oswald IP. Mycotoxin fumonisin B1 selectively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitro studies. Food Chem Toxicol. 2006;44:1768-73.
13. Marin DE, Taranu I, Pascale F, Lionide A, Burlacu R, Bailly JD, Oswald IP. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. Br J Nutr. 2006;95:1185-92.
14. Rotter BA, Thompson BK, Prelusky DB, Trenholm HL, Stewart B, Miller JD, Savard ME. Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. Nat Toxins. 1996;4:42-50.
15. Institut National de la Recherche Agronomique. 2007. InraPorc [Database to predict pig performance; cited 20 May 2009.]. Available from: http://w3.rennes.inra.fr/inraporc/.
16. Dersjant-Li Y, Verstegen MWA, Gerrits WJJ. The impact of low concentrations of aflatoxin, deoxinivalenol or fumonisin in diets of growing pigs and poultry. Nutr Res Rev. 2003;16:223-39.
17. Boudry G, Lallès JP, Malbert CH, Bobillier E, Sève B. Diet-related adaptation of the small intestine at weaning in pigs is functional rather than structural. J Pediatr Gastroenterol Nutr. 2002;34:180-7.
18. Boudry G, Péron V, Luron I, Lallès JP, Sève B.Weaning induces transient and long-lasting modifications of absorptive and secretory properties and epithelial barrier function of piglet intestine. J Nutr. 2004;134:2256-62.
19. Piel C, Montagne L, Sève B, Lallès JP. Increasing digesta viscosity using carboxymethylcellulose in weaned piglets stimulates ileal goblet cell numbers and maturation. J Nutr. 2005;135:86-91.
20. Salgado P, Lallès JP, Toullec R, Mourato M, Cabral FM, Freire JPB. Nutrient digestibility of chickpea (Cicer arietinum L.) seeds and effects on the small intestine of weaned piglets. Anim. Feed Sci. Technol. 2001;91:197-212.
21. Li H, Sheppard DN, Hug MJ. Transepithelial electrical measurements with Ussing chamber. J Cyst Fibros. 2004;3:123-6.
22. Thorbøll JE, Bindslev N, Tindholdt TT, Schmidt P, Christensen P, Skadhauge E. Tachykinins mediate changes in ion transport in porcine jejunum through release of prostaglandins and neurotransmitters. Regul Pept. 1998;77:105-11.
23. Pinelli E, Poux N, Garren L, Pipy B, Castegnaro M, Miller DJ, Pfohl-Leszkowicz A. Activation of mitogen-activated protein kinase by fumonisin B(1) stimulates cPLA(2) phosphorylation, the arachidonic acid cascade and cAMP production. Carcinogenesis. 1999;20:1683-8.
24. Carey HV, Hayden UL, Tucker KE. Fasting alters basal and stimulated ion transport in piglet jejunum. Am J Physiol. 1994;267:R156-63.
25. Hardin J, Kroeker K, Chung B, Gall DG. Effect of proinflammatory interleukins on jejunal nutrient transport. Gut. 2000;47:184-91.
26. De Angelis I, Friggè G, Raimondi F, Stammati A, Zucco F, Caloni F. Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein. Toxicon. 2005;45:285-91.
27. Kramer W, Girbig F, Corsiero D, Pfenninger A, Frick W, Jähne G, Rhein M, Wendler W, Lottspeich F, et al. Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane. J Biol Chem. 2005;280:1306-20.
28. Motelin GK, Haschek WM, Ness DK, Hall WF, Harlin KS, Schaeffer DJ, Beasley VR. Temporal and dose-response features in swine fed corn screenings contaminated with fumonisin mycotoxins. Mycopathologia. 1994;126:27-40.
29. Dilkin P, Zorzete P, Mallmann CA, Gomes JD, Utiyama CE, Oetting LL, Corrêa B. Toxicological effects of chronic low doses of aflatoxin B(1) and fumonisin B(1)-containing Fusarium moniliforme culture material in weaned piglets. Food Chem Toxicol. 2003;41:1345-53.
30. Gelderblom WC, Abel S, Smuts CM, Marnewick J, Marasas WF, Lemmer ER, Ramljak D. Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion. Environ Health Perspect. 2001;109 Suppl 2:291-300.