Role of dopamine transporters in the behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in nonhuman primates

Psychopharmacology

Volumn 205, Issue 2, 2009, Pages 337-347

  Fantegrossi, William E ^a,b   Bauzo, Rayna M ^b   Manvich, Daniel M ^b   Morales, Jose C ^b   Votaw, John R ^c   Goodman, Mark M ^c   Howell, Leonard L ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b EMORY UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dopamine; MDMA; Microdialysis; Nonhuman primates; Operant behavior; PET neuroimaging; Serotonin

Indexed keywords

2BETA CARBOMETHOXY 3BETA (4 CHLOROPHENYL) 8 (2 FLUOROETHYL)NORTROPANE F 18; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; DOPAMINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; FLUORINE 18; FLUOXETINE; NORTROPANE DERIVATIVE; RTI 177; UNCLASSIFIED DRUG; VOLINANSERIN;

ANIMAL EXPERIMENT; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DRUG SELECTIVITY; FEMALE; IN VIVO STUDY; INSTRUMENTAL CONDITIONING; MALE; MICRODIALYSIS; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIMATE; PRIORITY JOURNAL; REINFORCEMENT; RHESUS MONKEY; SQUIRREL MONKEY; STIMULUS RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; CONDITIONING, OPERANT; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROCHEMICAL TECHNIQUES; FEMALE; FLUORINE RADIOISOTOPES; FLUOROBENZENES; HALLUCINOGENS; MACACA MULATTA; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METHAMPHETAMINE; MICRODIALYSIS; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NORTROPANES; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; REINFORCEMENT SCHEDULE; SAIMIRI; SEROTONIN ANTAGONISTS; TROPANES;

EID: 67649986050     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1545-0     Document Type: Article

References (47)

1. E Acquas A Pisanu S Spiga A Plumitallo G Zernig G Di Chiara 2007 Differential effects of intravenous R,S-(+/-)-3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its S(+)- and R(-)-enantiomers on dopamine transmission and extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus accumbens shell and core J Neurochem 102 1 121 132 (Pubitemid 46906254)
2. ML Banks JE Sprague PW Czoty MA Nader 2008 Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys Psychopharmacology 196 1 63 70
3. MG Bankson KA Cunningham 2001 3, 4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interaction J Pharmacol Exp Ther 297 846 852 (Pubitemid 32472478)
4. MG Bankson KA Cunningham 2002 Pharmacological studies of the acute effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-HT1b/1d and 5-HT2 receptors Neuropsychopharmacology 26 40 52 (Pubitemid 34075275)
5. MH Baumann RD Clark AG Budzynskix JS Partilla BE Blough RB Rothman 2008 Effects of "Legal X" piperazine analogs on dopamine and serotonin release in rat brain Ann N Y Acad Sci 1025 189 197
6. MH Baumann RD Clark RB Rothman 2008 Locomotor stimulation produced by 3, 4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain Pharmacol Biochem Behav 90 2 208 217
7. PM Beardsley RL Balster LS Harris 1986 Self-administration of methylenedioxymethamphetamine (MDMA) by rhesus monkeys Drug Alcohol Depend 18 2 149 157 (Pubitemid 16002930)
8. MJ Bubar KM Pack PS Frankel KA Cunningham 2004 Effects of dopamine D1- or D2-like receptor antagonists on the hypermotive and discriminative stimulus effects of (+)-MDMA Psychopharmacology 173 3-4 326 336 (Pubitemid 38703806)
9. RD Crean SA Davis SN Von Huben CC Lay SN Katner MA Taffe 2006 Effects of (+/-) 3, 4-methylenedioxymethamphetamine, (+/-) 3, 4-methylenedioxyamphetamine and methamphetamine on temperature and activity in rhesus macaques Neuroscience 142 2 515 525 (Pubitemid 44430041)
10. PW Czoty JB Justice Jr LL Howell 2000 Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys Psychopharmacology 148 3 299 306 (Pubitemid 30136737)
11. PW Czoty BC Ginsburg LL Howell 2002 Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys J Pharmacol Exp Ther 300 3 831 837 (Pubitemid 34164986)
12. PW Czoty A Makriyannis J Bergman 2004 Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys Psychopharmacology 175 2 170 178 (Pubitemid 39222347)
13. E Daniela K Brennan D Gittings L Hely S Schenk 2004 Effect of SCH 23390 on (+/-)-3, 4-methylenedioxymethamphetamine hyperactivity and self-administration in rats Pharmacol Biochem Behav 77 4 745 750 (Pubitemid 38510285)
14. WE Fantegrossi T Ullrich KC Rice JH Woods G Winger 2002 3, 4-Methylenedioxy-methamphetamine (MDMA, "Ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement Psychopharmacology 161 356 364 (Pubitemid 34595786)
15. WE Fantegrossi WL Woolverton M Kilbourn P Sherman J Yuan G Hatzidimitriou GA Ricaurte JH Woods G Winger 2004 Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys Neuropsychopharmacology 29 7 1270 1281 (Pubitemid 38780650)
16. C Fischer G Hatzidimitriou J Wlos J Katz G Ricaurte 1995 Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-) 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") J Neurosci 15 8 5476 5485
17. DL Frederick SF Ali W Slikker Jr MP Gillam RR Allen MG Paule 1995 Behavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys Neurotoxicol Teratol 17 5 531 543
18. BC Ginsburg HL Kimmel FI Carroll MM Goodman LL Howell 2005 Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys Pharmacol Biochem Behav 80 3 481 491 (Pubitemid 40299350)
19. MM Goodman CD Kilts R Keil B Shi L Martarello D Xing J Votaw TD Ely P Lambert MJ Owens VM Camp E Malveaux JM Hoffman 2000 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters Nucl Med Biol 27 1 1 12 (Pubitemid 30099609)
20. GA Gudelsky BK Yamamoto 2008 Actions of 3, 4- methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons Pharmacol Biochem Behav 90 2 198 207 (Pubitemid 351787346)
21. LL Howell LD Byrd 1995 Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey J Pharmacol Exp Ther 275 3 1551 1559 (Pubitemid 26129947)
22. LL Howell PW Czoty LD Byrd 1997 Pharmacological interactions between serotonin and dopamine on behavior in the squirrel monkey Psychopharmacology 131 1 40 48 (Pubitemid 27242853)
23. MM Iravani D Asari J Patel WJ Wieczorek ZL Kruk 2000 Direct effects of 3, 4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphe nucleus slices Synapse 36 275 285 (Pubitemid 30257312)
24. CE Johanson M Kilbey K Gatchalian M Tancer 2006 Discriminative stimulus effects of 3, 4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo Drug Alcohol Depend 81 1 27 36 (Pubitemid 41682476)
25. JB Kamien CE Johanson CR Schuster WL Woolverton 1986 The effects of (+/-)-methylenedioxymethamphetamine and (+/-)-methylenedioxyamphetamine in monkeys trained to discriminate (+)-amphetamine from saline Drug Alcohol Depend 18 2 139 147 (Pubitemid 16002929)
26. JL Katz K Alling E Shores JM Witkin 1995 Effects of D1 dopamine agonists on schedule-controlled behavior in the squirrel monkey Behav Pharmacol 6 2 143 148
27. HL Kimmel JA O'Connor FI Carroll LL Howell 2007 Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys Pharmacol Biochem Behav 86 1 45 54 (Pubitemid 46274968)
28. RJ Lamb RR Griffiths 1987 Self-injection of d, 1-3, 4- methylenedioxymethamphetamine (MDMA) in the baboon Psychopharmacology 91 3 268 272 (Pubitemid 17018090)
29. JA Lile JT Ross MA Nader 2005 A comparison of the reinforcing efficacy of 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeys Drug Alcohol Depend 78 2 135 140 (Pubitemid 40544600)
30. KP Lindsey KM Wilcox JR Votaw MM Goodman C Plisson FI Carroll KC Rice LL Howell 2004 Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging J Pharmacol Exp Ther 309 3 959 969 (Pubitemid 38669681)
31. JF Nash J Brodkin 1991 Microdialysis studies on 3, 4- methylenedioxymehtamphetmine-induced dopamine release: effect of dopamine uptake inhibitors J Pharmacol Exp Ther 259 820 825
32. SJ Peroutka H Newman H Harris 1988 Subjective effects of 3,4-methylenedioxymethamphetamine in recreational users Neuropsychopharmacology 1 4 273 277 (Pubitemid 19126146)
33. VB Risbrough VL Masten S Caldwell MP Paulus MJ Low MA Geyer 2006 Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice Neuropsychopharmacology 31 11 2349 2358
34. MC Ritz MJ Kuhar 1989 Relationship between self-administration of amphetamine and monoamine receptors in brain: comparison with cocaine J Pharmacol Exp Ther 248 3 1010 1017 (Pubitemid 19100749)
35. V Setola SJ Hufeisen KJ Grande-Allen I Vesely RA Glennon B Blough RB Rothman BL Roth 2003 3, 4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro Mol Pharmacol 63 6 1223 1229 (Pubitemid 36627216)
36. W Slikker Jr SF Ali AC Scallet CH Frith GD Newport JR Bailey 1988 Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA) Toxicol Appl Pharmacol 94 3 448 457 (Pubitemid 18210462)
37. W Slikker Jr RR Holson SF Ali MG Kolta MG Paule AC Scallet DE McMillan JR Bailey JS Hong FM Scalzo 1989 Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate Neurotoxicology 10 529 542 (Pubitemid 20084638)
38. MA Taffe CC Lay SN Von Huben SA Davis RD Crean SN Katner 2006 Hyperthermia induced by 3, 4-methylenedioxymethamphetamine in unrestrained rhesus monkeys Drug Alcohol Depend 82 3 276 281
39. M Tancer CE Johanson 2001 The subjective effects of MDMA and mCPP in moderate users Drug Alcohol Depend 65 1 97 101 (Pubitemid 33063665)
40. M Tancer CE Johanson 2003 Reinforcing, subjective, and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP Drug Alcohol Depend 72 1 33 44 (Pubitemid 37255328)
41. M Tancer CE Johanson 2007 The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans Psychopharmacology 189 4 565 573 (Pubitemid 44791225)
42. FX Vollenweider S Remensberger D Hell MA Geyer 1999 Opposite effects of 3, 4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans Psychopharmacology 143 4 365 372 (Pubitemid 29222481)
43. JR Votaw LL Howell L Martarello JM Hoffman CD Kilts KP Lindsey MM Goodman 2002 Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT Synapse 44 4 203 210 (Pubitemid 34496645)
44. Z Wang WL Woolverton 2007 Estimating the relative reinforcing strength of (±)-3, 4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine Psychopharmacology 189 483 488 (Pubitemid 44791218)
45. SR White T Obradovic KM Imel MJ Wheaton 1996 The effects of methylenedioxymethamphetamine (MDMA, 'ecstasy') on monoaminergic neurotransmission in the central nervous system Prog Neurobiol 49 455 479 (Pubitemid 26312773)
46. KM Wilcox KP Lindsey JR Votaw MM Goodman L Martarello FI Carroll LL Howell 2002 Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys Synapse 43 1 78 85 (Pubitemid 33115670)
47. BK Yamamoto LJ Spanos 1988 The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat Eur J Pharmacol 148 195 203 (Pubitemid 18087136)