Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans

Psychopharmacology

Volumn 143, Issue 4, 1999, Pages 365-372

  Vollenweider, F X ^a   Remensberger, S ^a   Hell, D ^a   Geyer, M A ^b  

^a UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Habituation; Human; MDMA (3,4 methylenedioxymethamphetamine); Prepulse inhibition; Psychopathology; Rat; Schizophrenia; Serotonin

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; SEROTONIN; SEROTONIN AGONIST;

ADULT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY STIMULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MOOD; NONHUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; RATING SCALE; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; SEROTONIN RELEASE; SPECIES DIFFERENCE; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

ACOUSTIC STIMULATION; ADULT; AFFECT; ANALYSIS OF VARIANCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HABITUATION, PSYCHOPHYSIOLOGIC; HUMANS; MIDDLE AGED; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PSYCHOMETRICS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGENTS; STARTLE REACTION;

EID: 0032924820     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050960     Document Type: Article

References (42)

1. Bolino F, Manna V, Di Cicco L, Di Michele V, Daneluzzo E, Rossi A, Casacchia M (1992) Startle reflex habituation in functional psychoses: a controlled study. Neurosci Lett 145:126-128
2. Bolino F, Di Michele V, Di Cicco L, Manna V, Daneluzzo E, Casacchia M (1994) Sensorimotor gating and habituation evoked by electrocutaneous stimulation in schizophrenia. Biol Psychiatry 36:670-679
3. Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia: human and animal model studies. Arch Gen Psychiatry 47:181-188
4. Braff DL, Stone C, Callaway E, Geyer MA, Glick I, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343
5. Braff DL, Grillon C, Geyer MA (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215
6. Cadenhead KS, Geyer MA, Braff DL (1993) Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am J Psychiatry 150:1862-1869
7. Dittrich A (1994) Psychological aspects of altered states of consciousness of the LSD type: measurements of their basic dimensions and prediction of individual differences. In: Pletscher A, Ladewig D (eds) 50 years of LSD. Current status and perspectives of hallucinogens, 1st edition. Parthenon, New York, pp 101-118
8. Dittrich A (1996) Ätiologie-unabhängige Strukturen veränderter Wachbewusstseinszustände, 2nd edn. VWB-Verlag für Wissenschaft und Bildung, Stuttgart
9. Dittrich A, von Arx S, Staub S (1981) International study on altered states of consciousness (ISASC). Schweiz Z Psychol Anw 40: 189-200
10. Dixon WJ (1990) BMDP Biomedical computer programs. University of California Press, Los Angeles
11. Dulawa SC, Geyer MA (1996) Psychopharmacology of prepulse inhibition in mice. Chin J Physiol 39:139-146
12. Dulawa SC, Hen R, Scearce-Levie K, Geyer MA (1997) Serotonin 1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin 1B receptor knockout mice. Psychopharmacology 132:125-134
13. Geyer MA, Braff DL (1982) Habituation of the blink reflex in normals and schizophrenic patients. Psychophysiolgy 19:1-6
14. Geyer MA, Callaway CW (1994) Behavioral pharmacology of ring-substituted amphetamine analogs. In: Cho AK, Segal DS (eds) Amphetamine and its analogs: psychopharmacology, toxicology, and abuse. Academic Press, San Diego, pp 177-208
15. Geyer MA, Markou A (1995) Animal models of psychiatric disorders. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 787-798
16. Geyer MA, Tapson GS (1988) Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors. Neuropsychopharmacology 1:135-147
17. Geyer MA, Petersen LR, Rose GJ, Horwitt DD, Light RK, Adams LM, Zook JA, Hawkins RL, Mandell AJ (1978) The effects of LSD and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. J Pharmacol Exp Ther 207: 837-847
18. Geyer MA, Swerdlow NR, Mansbach RS, Braff DL (1990) Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull 25:485-498
19. Gouzoulis E, von Bardeleben U, Rupp A, Kovar KA, Hermle L (1993) Neuroendocrine and cardiovascular effects of MDE in healthy volunteers. Neuropsychopharmacology 8:187-193
20. Gouzoulis-Mayfrank E, Heekeren K, Thelen B, Lindenblatt H, Kovar KA, Sass H, Geyer MA (1998) The hallucinogen psilocybin increases prepulse inhibition of the startle reflex in humans. Behav Pharmacol (in press)
21. Greer G, Tolbert P (1986) Subjective reports on the effects of MDMA in a clinical setting. J Psychoact Drugs 18:319-327
22. Grillon C, Ameli R, Charney DS, Krystal J, Braff DL (1992) Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol Psychiatry 32:939-943
23. Helmlin HJ, Bracher K, Bourquin D, Vonlanthen D, Brenneisen R (1996) Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS. J Anal Toxicol 20:432-440
24. Ison JR (1984) Reflex modification as an objective test for sensory processing following toxicant exposure. Neurobehav Toxicol Teratol 6:437-445
25. Janke W, Debus G (1978) Die Eigenschaftswörterliste (AM-K) -Ein Verfahren zur Erfassung der Befindlichkeit, 1st edn. Hogrefe, Göttingen
26. Kehne JH, Timothy C, McCloskey TC, Taylor VL, Black CK, Fadayel GM, Schmidt CJ (1992) Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats. J Pharmacol Exp Ther 260:78-89
27. Mansbach RS, Geyer MA, Braff DL (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94:507-514
28. Mansbach RS, Braff DL, Geyer MA (1989) Prepulse inhibition of the acoustic startle response is disrupted by N-ethyl-3,4-methylenedioxyamphetamine (MDEA) in the rat. Eur J Pharmacol 167:49-55
29. Martinez DL, Geyer MA (1997) Characterization of the disruptions of prepulse inhibition and habituation of startle induced by ethyltryptamine. Neuropsychopharmacology 16:246-255
30. Nichols DE (1994) Medicinal chemistry and stucture-activity relationships. In: Cho AK, Segal DS (eds) Amphetamine and its analogs: psychopharmacology, toxicology, and abuse, 1st edn. Academic Press, San Diego, pp 3-41
31. 2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats. Psychopharmacology 124:107-116
32. Rigdon C, Weatherspoon J (1992) 5-HT1 A agonists block prepulse inhibition of the acoustic startle reflex. J Pharmacol Exp Ther 263:486-493
33. Sipes TA, Geyer MA (1994) Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology 33:441-448
34. Sipes TA, Geyer MA (1995) 8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action. Psychopharmacology 117:41-48
35. Sipes TA, Geyer MA (1996) Functional behavioral homology between rat 5-HT1B and guinea pig 5-HT1D receptors in the modulation of prepulse inhibition of startle. Psychopharmacology 125:231-237
36. 2A receptors in the ventral pallidum. Brain Res 761:97-104
37. StatSoft (1995) STATISTICA for Windows, 5.1 edn. StatSoft, Inc., Tulsa
38. Swerdlow NR, Caine SB, Braff DL, Geyer MA (1992) The neural substrates of sensorimotor gating of the starle reflex: a review of the recent findings and their implications. J Psychopharmacol 6:176-190
39. Swerdlow NR, Benbow CH, Zisook S, Geyer MA, Braff DL (1993) A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder (OCD). Biol Psychiatry 33:298-301
40. Swerdlow NR, Filion D, Geyer MA, Braff DL (1995a) "Normal" personality correlates of sensorimotor cognitive, and visuospatial gating. Biol Psychiatry 37:286-299
41. Swerdlow NR, Paulsen J, Braff DL, Butters N, Geyer MA, Swenson MR (1995b) Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease. J Neurol Neurosurg Psychiatry 58:192-200
42. Vollenweider FX, Liechti M, Gamma A, Huber Th, Gamma AG, Huber T (1998) Psychological and cardiovascular effects and short-term sequelae of MDMA ("Ecstasy") on MDMA-naive healthy volunteers. Neuropsychopharmacology 19:241-251