Effect of p27 on motility of MDA-MB-231 breast cancer cells

Oncology Reports

Volumn 21, Issue 6, 2009, Pages 1621-1625

  Lee, Eun Young ^a   Jeon, Min Jeong ^a   Yang, Wonseok ^a   Shin, Incheol ^a  

^a Hanyang University   (South Korea)

Author keywords

Breast cancer; Cell motility; p27

Indexed keywords

COMPLEMENTARY DNA; CYCLOHEXIMIDE; PROTEIN P27; SHORT HAIRPIN RNA; CDKN1B PROTEIN, HUMAN; SIGNAL PEPTIDE; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL FRACTIONATION; CELL MOTILITY; CELL NUCLEUS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA INTERFERENCE; BREAST TUMOR; CELL MOTION; CYTOPLASM; FEMALE; GENETICS; METABOLISM; PATHOLOGY; TIME;

BREAST NEOPLASMS; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; CYTOPLASM; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 67649975277     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000396     Document Type: Article

References (28)

1. Sherr CJ: Cancer cell cycles. Science 274: 1672-1677, 1996.
2. Reed SI: Keeping p27(Kip1) in the cytoplasm: a second front in cancer's war on p27. Cell Cycle 1: 389-390, 2002.
3. Reynisdottir I and Massague J: The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev 11: 492-503, 1997.
4. Shin I, Rotty J, Wu FY and Arteaga CL: Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry. J Biol Chem 280: 6055-6063, 2005.
5. Orend G, Hunter T and Ruoslahti E: Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells. Oncogene 16: 2575-2583, 1998.
6. Ciaparrone M, Yamamoto H, Yao Y, Sgambato A, Cattoretti G, Tomita N, et al: Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Cancer Res 58: 114-122, 1998.
7. Singh SP, Lipman J, Goldman H, Ellis FH Jr, Aizenman L, Cangi MG, et al: Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res 58: 1730-1735, 1998.
8. Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, et al: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J 21: 3390-3401, 2002.
9. Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, et al: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8: 1145-1152, 2002.
10. Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, et al: Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4: 1449-1452, 1998.
11. Itoh Y, Masuyama N, Nakayama K, Nakayama KI and Gotoh Y: The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex. J Biol Chem 282: 390-396, 2007.
12. Wu FY, Wang SE, Sanders ME, Shin I, Rojo F, Baselga J, et al: Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res 66: 2162-2172, 2006.
13. Wang XQ, Lui EL, Cai Q, Ching WY, Liu KS, Poon RT, et al: p27Kip1 promotes migration of metastatic hepatocellular carcinoma cells. Tumour Biol 29: 217-223 2008.
14. Baliga BS, Pronczuk AW and Munro HN: Mechanism of cyclo-heximide inhibition of protein synthesis in a cell-free system prepared from rat liver. J Biol Chem 244: 4480-4489, 1969.
15. Muraoka RS, Lenferink AE, Law B, Hamilton E, Brantley DM, Roebuck LR, et al: ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol 22: 2204-2219, 2002.
16. Gao H, Ouyang X, Banach-Petrosky W, Borowsky AD, Lin Y, Kim M, et al: A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci USA 101: 17204-17209, 2004.
17. Philipp-Staheli J, Payne SR and Kemp CJ: p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res 264: 148-168, 2001.
18. Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, et al: p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 20: 6672-6682, 2001.
19. Schiappacassi M, Lovat F, Canzonieri V, Belletti B, Berton S, Di Stefano D, et al: p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis. Mol Cancer Ther 7: 1164-1175, 2008.
20. Yuan Y, Qin L, Liu D, Wu RC, Mussi P, Zhou S, et al: Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression. Cancer Res 67: 8032-8042, 2007.
21. Sicinski P, Zacharek S and Kim C: Duality of p27Kip1 function in tumorigenesis. Genes Dev 21: 1703-1706, 2007.
22. Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, et al: Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 21: 1731-1746, 2007.
23. Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, et al: Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. Oncogene 9: 3127-3138, 1994.
24. Fujita N, Sato S, Katayama K and Tsuruo T: Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem 277: 28706-28713, 2002.
25. McAllister SS, Becker-Hapak M, Pintucci G, Pagano M and Dowdy SF: Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 23: 216-228, 2003.
26. Besson A, Gurian-West M, Schmidt A, Hall A and Roberts JM: p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18: 862-876, 2004.
27. Hall A: Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
28. Tao Y, Chen YC, Li YY, Yang SQ and Xu WR: Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901. World J Gastroenterol 14: 1175-1181, 2008.