Expression, localisation and functional implications of the transporter protein PEPT2 in the upper respiratory tract

Respiration

Volumn 77, Issue 4, 2009, Pages 440-446

  Quarcoo, David ^a   Fischer, Tanja C ^a   Heppt, Werner ^b   Lauenstein, Hans Dieter ^c,d   Pilzner, Carolin ^c   Welte, Tobias ^c   Groneberg, David A ^c,e  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d FRAUNHOFER GESELLSCHAFT   (Germany)

^e Institute of Occupational Medicine   (Germany)

Author keywords

Airway; Drug uptake; Mucosa; Oligopeptide transporters; Rhinitis

Indexed keywords

AMINOLEVULINIC ACID; BETA LACTAM; MESSENGER RNA; PEPTIDE TRANSPORTER 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPPER RESPIRATORY TRACT;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; COUMARINS; GENE EXPRESSION; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; RESPIRATORY TRACT INFECTIONS; RNA, MESSENGER; SYMPORTERS;

EID: 67649965607     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000179901     Document Type: Article

References (45)

1. Welte T, Groneberg DA: Asthma and COPD. Exp Toxicol Pathol 2006; 57(suppl 2):35-40.
2. Balter MS, La Forge J, Low DE, Mandell L, Grossman RF: Canadian guidelines for the management of acute exacerbations of chronic bronchitis. Can Respir J 2003; 10 (suppl B):3B -32B.
3. Groneberg DA, Nowak D, Wussow A, Fischer A: Chronic cough due to occupational factors. J Occup Med Toxicol 2006; 1:3.
4. Boschetto P, Quintavalle S, Miotto D, Lo Cascio N, Zeni E, Mapp CE: Chronic obstructive pulmonary disease (COPD) and occupational exposures. J Occup Med Toxicol 2006; 1:11.
5. Charavaryamath C, Singh B: Pulmonary effects of exposure to pig barnair. J Occup Med Toxicol 2006; 1:10.
6. Groneberg-Kloft B, Kraus T, van Mark A, Wagner U, Fischer A: Analysing the causes of chronic cough: relation to diesel exhaust, ozone, nitrogen oxides, sulphur oxides and other environmental factors. J Occup Med Toxicol 2006;1:6.
7. Yelin E, Katz P, Balmes J, Trupin L, Earnest G, Eisner M, Blanc P: Work life of persons with asthma, rhinitis, and COPD: a study using a national, population-based sample. J Occup Med Toxicol 2006; 1:2.
8. Sin DD, McAlister FA, Man SF, Anthonisen NR: Contemporary management of chronic obstructive pulmonary disease: scientific review. JAMA 2003; 290: 2301-2312.
9. Gonda I: The ascent of pulmonary drug delivery. J Pharm Sci 2000; 89:940-945.
10. Honeybourne D, Baldwin DR: The site concentrations of antimicrobial agents in the lung. J A ntimicrob Chemother 1992;30:249- 260.
11. Daniel H, Rubio-Aliaga I: An update on renal peptide transporters. Am J Physiol Renal Physiol 2003; 284:F885-F892.
12. Groneberg DA, Doring F, Theis S, Nickolaus M, Fischer A, Daniel H: Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein. Am J Physiol Endocrinol Metab 2002; 282:E1172- E1179.
13. Groneberg DA, Eynott PR, Doring F, Thai Dinh Q, Oates T, Barnes PJ, Chung KF, Daniel H, Fischer A: Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax 2002; 57:55-60.
14. Doring F, Schmitt R, Bernhardt WM, Klapper M, Bachmann S, Daniel H, Groneberg DA: Hypothyroidism induces expression of the peptide transporter PEPT2. Biol Chem 2005; 386: 785-790.
15. Groneberg DA, Doring F, Nickolaus M, Daniel H, Fischer A: Renal assimilation of short chain peptides: visualization of tubular peptide uptake. Pharm Res 2002; 19:1209-1214.
16. Groneberg DA, Nickolaus M, Springer J, Doring F, Daniel H, Fischer A: Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake. Am J Pathol 2001;158: 707-714.
17. Groneberg DA, Rubio-Aliaga I, Nickolaus M, Doring F, Fischer A, Daniel H: Direct visualization of peptide uptake activity in the central nervous system of the rat. Neurosci Lett 2004; 364:32-36.
18. Dieck ST, Heuer H, Ehrchen J, Otto C, Bauer K: The peptide transporter PepT2 is expressed in rat brain and mediates the accumulation of the fluorescent dipeptide derivative beta-Ala-Lys-Nepsilon-AMCA in astrocytes. Glia 1999; 25:10-20.
19. Groneberg DA, Doring F, Nickolaus M, Daniel H, Fischer A: Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia. Neurosci Lett 2001; 304:181-184.
20. Groneberg DA, Doring F, Eynott PR, Fischer A, Daniel H: Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol 2001; 281:G697-G704.
21. Terada T, Saito H, Inui K: Interaction of β-lactam antibiotics with histidine residue of rat H+/peptide cotransporters, PEPT1 and PEPT2. J Biol Chem 1998; 273: 5582-5585.
22. Groneberg DA, Witt C, Wagner U, Chung KF, Fischer A: Fundamentals of pulmonary drug delivery. Respir Med 2003; 97:382-387.
23. Groneberg DA, Paul H, Welte T: Novel strategies of aerosolic pharmacotherapy. Exp Toxicol Pathol 2006; 57(suppl 2):49-53.
24. Groneberg DA, Fischer A, Chung KF, Daniel H: Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport. Am J Respir Cell Mol Biol 2004; 30: 251-260.
25. Groneberg DA, Poutanen SM, Low DE, Lode H, Welte T, Zabel P: Treatment and vaccines for severe acute respiratory syndrome. Lancet Infect Dis 2005; 5: 147-155.
26. Bahadduri PM, D'Souza VM, Pinsonneault JK, Sadee W, Bao S, Knoell DL, Swaan PW: Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium. Am J Respir Cell Mol Biol 2005; 32:319-325.
27. Groneberg DA, Nickolaus M, Springer J, Doring F, Daniel H, Fischer A: Pulmonary uptake of oligopeptides: expression and functional aspects of PEPT2 in airway tissue. Am J Respir Crit Care Med 1999; 159:A38.
28. Groneberg DA, Doring F, Daniel H, Fischer A: Distribution of the oligopeptide transporter PEPT2 in normal human lung. Am J Respir Crit Care Med 2000; 161:A150.
29. Fink J, Dhand R: Bronchodilator resuscitation in the emergency department. Part 2 of 2: dosing strategies. Respir Care 2000; 45: 497-512.
30. Hasegawa T, Suzuki E, Fujimori K, Sakagami T, Toyabe S, Akazawa K, Kawano K, Haraguchi M, Toyama J, Arakawa M, et al: Comparison between compliance of fluticasone propionate diskhaler and of fluticasone propionate diskus in adult bronchial asthma patients. Respiration 2006; 73: 680-684.
31. O'Riordan TG: Optimizing delivery of inhaled corticosteroids: matching drugs with devices. J Aerosol Med 2002; 15: 245-250.
32. Rodrigo GJ, Rodrigo C: Aerosol and inhaled therapy in treatment of acute adult airway obstruction in the emergency department. Respir Care Clin N Am 2001; 7:215-231, v.
33. Rau JL Jr: Recent developments in respiratory care pharmacology. J Perianesth Nurs 1998; 13: 359-369.
34. Gessler T, Schmehl T, Olschewski H, Grimminger F, Seeger W: Aerosolized vasodilators in pulmonary hypertension. J Aerosol Med 2002; 15: 117-122.
35. O'Riordan T, Faris M: Inhaled antimicrobial t herapy. Respir Care Clin N Am 1999; 5: 617- 631.
36. Newhouse MT, Corkery KJ: Aerosols for systemic delivery of macromolecules. Respir Care Clin N Am 2001; 7:261-275, vi.
37. Smaldone GC, Palmer LB: Aerosolized antibiotics: current and future. Respir Care 2000; 45:667-675.
38. Groneberg DA, Heppt W, Cryer A, Wussow A, Peiser C, Zweng M, Dinh QT, Witt C, Fischer A: Toxic rhinitis-induced changes of human nasal mucosa innervation. Toxicol Pathol 2003; 31:326-331.
39. Heppt W, Thai Dinh Q, Cryer A, Zweng M, Noga O, Peiser C, Melva n M, Witt C, Fischer A, Groneberg DA: Phenotypic alteration of neuropeptide-containing nerve fibres in seasonal intermittent allergic rhinitis. Clin Exp Allergy 2004; 34:1105-1110.
40. Fischer A, Wussow A, Cryer A, Schmeck B, Noga O, Zweng M, Peiser C, Dinh QT, Heppt W, Groneberg DA: Neuronal plasticity in persistent perennial allergic rhinitis. J Occup Environ Med 2005; 47: 20-25.
41. Groneberg DA, Heppt W, Welker P, Peiser C, Dinh QT, Cryer A, Zweng M, Witt C, Fischer A: Aspirin-sensitive rhinitis-associated changes in upper airway innervation. Eur Respir J 2003; 22: 986-991.
42. Heppt W, Peiser C, Cryer A, Dinh QT, Zweng M, Witt C, Fischer A, Groneberg DA: Innervation of human nasal mucosa in environmentally triggered hyperreflectoric rhinitis. J Occup Environ Med 2002; 44:924-929.
43. Dinh QT, Groneberg DA, Peiser C, Springer J, Joachim RA, Arck PC, Klapp BF, Fischer A: Nerve growth factor-induced substance P in capsaicin-insensitive vagal neurons innervating the lower mouse airway. Clin Exp Allergy 2004; 34:1474 -1479.
44. Dinh QT, Mingomataj E, Quarcoo D, Groneberg DA, Witt C, Klapp BF, Braun A, Fischer A: Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways. Clin Exp Allergy 2005; 35: 820-825.
45. Dinh QT, Groneberg DA, Witt C, Peiser C, Cifuentes LB, Frossard N, Klapp BF, Fischer A: Expression of tyrosine hydroxylase and neuropeptide tyrosine in mouse sympathetic airway-specific neurons under normal situation and allergic airway inflammation. Clin Exp Allergy 2004; 34:1934-1941.