Novel strategies of aerosolic pharmacotherapy

Experimental and Toxicologic Pathology

Volumn 57, Issue SUPPL. 2, 2006, Pages 49-53

  Groneberg, David A ^a,b   Paul, Hanna ^b   Welte, Tobias ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Aerosol; Airways; Asthma; COPD; Drug; Inhalation; Transport

Indexed keywords

CALCITONIN; ERGOTAMINE; HEPARIN; INSULIN; MESSENGER RNA; PENICILLIN G; PENTAMIDINE; PROSTAGLANDIN; PROTON; RIBAVIRIN; STEROID; TRYPSIN; VACCINE;

ARTICLE; BLOOD CLOTTING DISORDER; BRONCHIECTASIS; CYSTIC FIBROSIS; DIABETES MELLITUS; EPITHELIUM CELL; HEADACHE; HUMAN; INFECTION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS PROTEINOSIS; OSTEOPOROSIS; PULMONARY HYPERTENSION; RESPIRATORY TRACT DISEASE; SYSTEMIC DISEASE;

EID: 33646779218     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2006.02.007     Document Type: Article

References (54)

1. Ariyananda P.L., Agnew J.E., and Clarke S.W. Aerosol delivery systems for bronchial asthma. Postgrad Med J 72 (1996) 151-156
2. Beringer P.M. New approaches to optimizing antimicrobial therapy in patients with cystic fibrosis. Curr Opin Pulm Med 5 (1999) 371-377
3. Chung K.F., Caramori G., and Groneberg D.A. Airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 351 (2004) 1459-1461
4. Daniel H., and Rubio-Aliaga I. An update on renal peptide transporters. Am J Physiol Renal Physiol 284 (2003) F885-F892
5. Dinh Q.T., Groneberg D.A., Peiser C., et al. Nerve growth factor-induced substance P in capsaicin-insensitive vagal neurons innervating the lower mouse airway. Clin Exp Allergy 34 (2004) 1474-1479
6. Doring F., Michel T., Rosel A., et al. Expression of the mammalian renal peptide transporter PEPT2 in the yeast Pichia pastoris and applications of the yeast system for functional analysis. Mol Membr Biol 15 (1998) 79-88
7. Fischer A., Wussow A., Cryer A., et al. Neuronal plasticity in persistent perennial allergic rhinitis. J Occup Environ Med 47 (2005) 20-25
8. Flume P., and Klepser M.E. The rationale for aerosolized antibiotics. Pharmacotherapy 22 (2002) 71S-79S
9. Groneberg D.A., Nickolaus M., Springer J., et al. Pulmonary uptake of oligopeptides: expression and functional aspects of PEPT2 in airway tissue. Am J Respir Crit Care Med 159 (1999) A38
10. Groneberg D.A., Doring F., Daniel H., et al. Distribution of the oligopeptide transporter PEPT2 in normal human lung. Am J Respir Crit Care Med 161 (2000) A150
11. Groneberg D.A., Dinh Q.T., Eynott F., et al. Peptide transport mechanisms in cystic fibrosis and normal human lung. Allergy 56 (2001) A19
12. Groneberg D.A., Doring F., Eynott P.R., et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol 281 (2001) G697-G704
13. Groneberg D.A., Doring F., Nickolaus M., et al. Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia. Neurosci Lett 304 (2001) 181-184
14. Groneberg D.A., Nickolaus M., Springer J., et al. Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake. Am J Pathol 158 (2001) 707-714
15. Groneberg D.A., Doring F., Nickolaus M., et al. Renal assimilation of short chain peptides: visualization of tubular peptide uptake. Pharm Res 19 (2002) 1209-1214
16. Groneberg D.A., Doring F., Theis S., et al. Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein. Am J Physiol Endocrinol Metab 282 (2002) E1172-E1179
17. Groneberg D.A., Eynott P.R., Doring F., et al. Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax 57 (2002) 55-60
18. Groneberg D.A., Eynott P.R., Oates T., et al. Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med 96 (2002) 81-86
19. Groneberg D.A., Peiser C., Dinh Q.T., et al. Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope 113 (2003) 520-524
20. Groneberg D.A., Welker P., Fischer T.C., et al. Down-regulation of vasoactive intestinal polypeptide receptor expression in atopic dermatitis. J Allergy Clin Immunol 111 (2003) 1099-1105
21. Groneberg D.A., Witt C., Wagner U., et al. Fundamentals of pulmonary drug delivery. Respir Med 97 (2003) 382-387
22. Groneberg D.A., Zhang L., Welte T., et al. Severe acute respiratory syndrome: global initiatives for disease diagnosis. Q J Math 96 (2003) 845-852
23. Groneberg D.A., Fischer A., Chung K.F., et al. Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport. Am J Respir Cell Mol Biol 30 (2004) 251-260
24. Groneberg D.A., Rubio-Aliaga I., Nickolaus M., et al. Direct visualization of peptide uptake activity in the central nervous system of the rat. Neurosci Lett 364 (2004) 32-36
25. Groneberg D.A., Bester C., Grutzkau A., et al. Mast cells and vasculature in atopic dermatitis - potential stimulus of neoangiogenesis. Allergy 60 (2005) 90-97
26. Groneberg D.A., Hilgenfeld R., and Zabel P. Molecular mechanisms of severe acute respiratory syndrome (SARS). Respir Res 6 (2005) 8
27. Groneberg D.A., Poutanen S., Low D.E., et al. Treatment and vaccines for severe acute respiratory syndrome (SARS). Lancet Infect Dis 5 (2005) 147-155
28. Heppt W., Thai Dinh Q., Cryer A., et al. Phenotypic alteration of neuropeptide-containing nerve fibres in seasonal intermittent allergic rhinitis. Clin Exp Allergy 34 (2004) 1105-1110
29. Hirai K., and Ogawa K. Cytochemical quantitation of cytochrome oxidase activity in rat pulmonary alveolar epithelial cells and possible defect in type I cells. J Electron Microsc (Tokyo) 35 (1986) 19-28
30. Inoue S., Michel R.P., and Hogg J.C. Zonulae occludentes in alveolar epithelium and capillary endothelium of dog lungs studies with the freeze-fracture technique. J Ultrastruct Res 56 (1976) 215-225
31. Kerzel S., Path G., Nockher W.A., et al. Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma. Am J Respir Cell Mol Biol 28 (2003) 170-178
32. Lippmann M., and Albert R.E. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J 30 (1969) 257-275
33. Lippmann M., Yeates D.B., and Albert R.E. Deposition, retention, and clearance of inhaled particles. Br J Ind Med 37 (1980) 337-362
34. Low F. Electron microscopy of the rat lung. Anat Rec 113 (1952) 437-443
35. Mason R.J., and Crystal R.G. Pulmonary cell biology. Am J Respir Crit Care Med 157 (1998) S72-S81
36. Newhouse M.T., and Corkery K.J. Aerosols for systemic delivery of macromolecules. Respir Care Clin N Am 7 (2001) 261-275
37. Newman S.P. Aerosol generators and delivery systems. Respir Care 36 (1991) 939-951
38. Newman S.P., Wilding I.R., and Hirst P.H. Human lung deposition data: the bridge between in vitro and clinical evaluations for inhaled drug products?. Int J Pharm 208 (2000) 49-60
39. Ogihara H., Saito H., Shin B.C., et al. Immuno-localization of H+/peptide cotransporter in rat digestive tract. Biochem Biophys Res Commun 220 (1996) 848-852
40. O'Riordan T., and Faris M. Inhaled antimicrobial therapy. Respir Care Clin N Am 5 (1999) 617-631
41. Quarcoo D., Weixler S., Groneberg D., et al. Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity. J Allergy Clin Immunol 114 (2004) 288-295
42. Rubin B.K., and Fink J.B. Aerosol therapy for children. Respir Care Clin N Am 7 (2001) 175-213
43. Rubio-Aliaga I., Frey I., Boll M., et al. Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol Cell Biol 23 (2003) 3247-3252
44. Sorokin S.P. Properties of alveolar cells and tissues that strengthen alveolar defenses. Arch Intern Med 126 (1970) 450-463
45. Springer J., Amadesi S., Trevisani M., et al. Effects of alpha calcitonin gene-related peptide in human bronchial smooth muscle and pulmonary artery. Regul Pept 118 (2004) 127-134
46. Springer J., Scholz F.R., Peiser C., et al. SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem 385 (2004) 649-653
47. Springer J., Wagner S., Subramamiam A., et al. BDNF-overexpression regulates the reactivity of small pulmonary arteries to neurokinin A. Regul Pept 118 (2004) 19-23
48. Springer J., Groneberg D.A., Pregla R., et al. Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis. Regul Pept 124 (2005) 195-201
49. Taylor A.E., and Gaar Jr. K.A. Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes. Am J Physiol 218 (1970) 1133-1140
50. Thompson P.J. Drug delivery to the small airways. Am J Respir Crit Care Med 157 (1998) S199-S202
51. Trevisani M., Gazzieri D., Benvenuti F., et al. Ethanol causes inflammation in the airways by a neurogenic and TRPV1-dependent mechanism. J Pharmacol Exp Ther 309 (2004) 1167-1173
52. Wangensteen O.D., Wittmers Jr. L.E., and Johnson J.A. Permeability of the mammalian blood-gas barrier and its components. Am J Physiol 216 (1969) 719-727
53. Weibel E.R. Morphometry of the human lung: the state of the art after two decades. Bull Physiopathol Respir (Nancy) 15 (1979) 999-1013
54. Wood G.C., and Boucher B.A. Aerosolized antimicrobial therapy in acutely ill patients. Pharmacotherapy 20 (2000) 166-181