Aerosolized antibiotics: Current and future

Respiratory Care

Volumn 45, Issue 6, 2000, Pages 667-675

  Smaldone, Gerald C ^a   Palmer, Lucy B ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Aerosol; Antibiotic; Pulmonary deposition; Ventilator associated pneumonia

Indexed keywords

ANTIBIOTIC AGENT;

AEROSOL; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; CONFERENCE PAPER; CYSTIC FIBROSIS; DRUG DELIVERY SYSTEM; HUMAN; INTUBATION; LUNG INFECTION; OUTPATIENT CARE;

AEROSOLS; AMBULATORY CARE; ANTI-BACTERIAL AGENTS; CYSTIC FIBROSIS; HUMANS; INTUBATION, INTRATRACHEAL; NEBULIZERS AND VAPORIZERS; RESPIRATORY TRACT INFECTIONS;

EID: 0033932274     PISSN: 00201324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (37)

1. Baran D, Dachy A, Klastersky J Concentration of gentamicin in bronchial secretions of children with cystic fibrosis or tracheostomy. Int J Clin Pharmacol Biochem 1975;12(3):336-341
2. Nolan G, Melvor P, Levison H, Fleming PC, Corey M, Gold R. Antibiotic prophylaxis in cystic fibrosis inhaled cephaloridine as an adjunct to oral clovacillin J Pediatr 1982;101(4):626-630.
3. Hodson ME, Penketh ARL, Batten JC Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis Lancet 1981;2(8256):1137-1139.
4. Stephens D, Garey N, Isles A, Levison H, Gold R. Efficacy of inhaled tobramycin in the treatment of pulmonary exacerbations in children with cystic fibrosis Pediatr Infect Dis 1983;2(3):209-211.
5. Ramsey BW, Pepe MS, Quan JM, Otto KL, Montgomery AB, Williams-Warren J. et al Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group N Engl J Med 1999;340(1):23-30.
6. Brown RB, Kruse JA, Courts GW, Russell JA, Christou NV, Sands ML. Double-blind study of endotracheal tobramycin in the treatment of Gram-negative bacterial pneumona The Endotracheal Tobramycin Study Group Antimicrob Agents Chemother 1990;34(2):269-272
7. Smaldone GC, O'Riordan TG Aerosol deposition and clearance. In: Wagner HN Jr Principles of nuclear medicine, 2nd ed. Philadelphia. WB Saunders, 1995
8. Determinants of dose and response to inhaled therapeutic agents in asthma. In: Schleimer R, Busse W, O'Byrne P, editors. Inhaled glucocorticoids in asthma mechanisms and clinical actions. New York Marcel Dekker, 1997
9. O'Riordan TG, Smaldone GC Aerosols In: Adkinson NF Jr, Busse WW, Ellis EF, Middleton F, Jr, Reed C, Yunginger JW Jr, editors. Allergy, principles and practices, 5th ed. St Louis' Mosby, 1998.
10. Smaldone GC Drug delivery via aerosol systems: concept of "aerosol inhaled". J Aerosol Med 1991:4(3) 229-235.
11. Ilowite JS Gorvoy JD, Smaldone GC. Quantitative deposition of aerosolized gentamicin in cystic fibrosis Am Rev Respir Dis 1987; 136(6)1445-1449
12. Smaldone GC, Perry RJ, Bennett WD, Messina MS, Zwang J, Ilowite J. Interpretation of '24 hour lung retention' in studies of mucociliary clearance. J Aerosol Med 1988,1 11-20
13. Johanson WG Jr, Pierce AK, Sanford JP, Thomas GD Nosocomial respiratory infections with Gram-negative bacilli the significance of colonization of the respiratory tract Ann Intern Med 1972;77(5): 701-706.
14. Palmer LB. Bacterial colonization, pathogenesis and clinical significance. In: Niederman MS, editor Clinics in chest medicine Philadelphia: WB Saunders; 1987.
15. Guidelines for prevention of nosocomial pneumonia Centers for Disease Control and Prevention MMWR Morb Mortal Wkly Rep 1997 Jan 3;46(RR-1):1-79.
16. Langer M, Mosconi PM, Cigada M, Mandella M Long-term respiratory support and risk of pneumonia in critically ill patients Intensive Care Unit Group of Infection Control. Am Rev Respir Dis 1989;140(2):302-305
17. Fagon JY, Chastre J, Domart Y, Trouillet JL, Pierre J, Darne C, Gibert C. Nosocomial pneumonia in patients receiving continuous mechanical ventilation: prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques Am Rev Respir Dis 1989;139(4):877-884.
18. Bassin AS, Niederman MS Prevention of ventilator-associated pneumonia: an attainable goal? (review) Clin Chest Med 1995;16(1):195-208.
19. Unertl K, Ruckdeschel G, Selbmann HK, Jensen U, Forst H, Lenhart FP, Peter K. Prevention of colonization and respiratory infection in long-term ventilated patients by local antimicrobial prophylaxis. Intensive Cure Med 1987;13(2):106-113.
20. Stoutenbeek CP, van Saene HFK, Miranda DR, Zandstra DF, Langrehr D The effect of oropharyngeal decontamination using topical nonabsorbable antibiotics on the incidence of nosocomial respiratory tract infections in multiple trauma patients. J Trauma 1987;27(4). 357-364
21. Pugin J, Aukenthaler R, Lew DP, Suter PM. Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia, a randomized, placebo controlled, double-blind clinical mal. JAMA 1991;265(20):2704-2710.
22. Gastinne H, Wolff M, Delatour F, Faurisson F, Chevret S. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. The French Study Group on Selective Decontamination of the Digestive Tract. N Engl J Med 1992;326(9):594-599.
23. Ferrer M, Torres A, Gonzalez J, Puig de la Bellacasa J, el-Ebiary M, Roca M, et al. Utility of selective digestive decontamination in mechanically ventilated patients. Ann Intern Med 1994;120(5):389-395.
24. Quinio B, Albanèse J, Bues-Charbit M, Viviand X, Martin C. Selective decontamination of the digestive tract in multiple trauma patients a prospective double-blind, randomized, placebo-controlled study. Chest 1996;109(3):765-772.
25. Klick JM, du Moulin GC, Hedley-Whyte J, Teres D, Bushnell LS, Feingold DS Prevention of Gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia m senously ill patients. J Clin invest 1975;55(3):514-519.
26. Feeley TW, du Moulin GC, Hedley-Whyte J, Bushnell LS, Gilbert JP, Feingold DS Aerosol polymyxin and pneumonia in seriously ill patients. N Engl J Med 1975;293(10):471-475.
27. Kollef MH The prevention of ventilator-associated pneumonia (review). N Engl J Med 1999;340(8):627-634.
28. Fuller HD, Dolovich MB, Posmituck G, Puck WW, Newhouse MT, Pressurized aerosol versus jet aerosol delivery to mechanically ventilated patients: comparison of dose to the lungs. Am Rev Respir Dis 1990;141(2):440-444.
29. MacIntyre N, Silver RM, Miller CW, Schuler F, Coleman RE. Aerosol delivery to intubated, mechanically ventilated patients. Crit Care Med 1985;13(2):81-84.
30. O'Riordan TG, Greco MJ, Smaldone GC. Nebulizer function during mechanical ventilation. Am Rev Respir Dis 1992;145(5):1117-1122.
31. O'Riordan TG, Palmer LB, Smaldone GC. Aerosol deposition In mechanically ventilated patients: optimizing nebulizer delivery. Am J Respir Crit Care Med 1994;149(1):214-219.
32. Diot P, Morra L, Smaldone GC, Albuterol delivery in a model of mechanical ventilation, comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 1995;152(4 Pt 1): 1391-1394
33. Cabahug CJ, McPeck M, Palmer LB, Cuccia A, Atkins HL, Smaldone GC Utility of technetium-99m-DTPA in determining regional ventilation. J Nucl Med 1996;37(2):239-244.
34. Palmer LB, Smaldone GC, Simon SR, O'Riordan TG, Cuccia A. Aerosolized antibiotics in mechanically ventilated patients delivery and response. Crit Care Med 1998;26(1):31-39.
35. Palmer LB, Smaldone GC, Simon S, O'Riordan T, Morra L Tracheal aspirates in long-term mechanically ventilated patients: a human model of Gram-negative infection and airway inflammation. Chest 1995;108(5):1326-1332.
36. Diot P, Morra L, Smaldone GC. Albuterol delivery in a model of mechanical ventilation: comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 1995;152(4 Pt 1): 1391-1394.
37. Palmer L, Smaldone GC. Targeting pneumonia in the ICU: secretion volume (abstract). Am J Respir Crit Care Med 2000:161(3)A92.