Direct visualization of peptide uptake activity in the central nervous system of the rat

Neuroscience Letters

Volumn 364, Issue 1, 2004, Pages 32-36

  Groneberg, David A ^a   Rubio Aliaga, Isabel ^b   Nickolaus, Monika ^b   Döring, Frank ^b   Fischer, Axel ^a   Daniel, Hannelore ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Drug; Peptide; Plexus choroideus; Transport; Uptake

Indexed keywords

CEFADROXIL; DIPEPTIDE DERIVATIVE; GLYCYLGLUTAMIC ACID; PEPTIDE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GLIA CELL; IMAGING SYSTEM; LABELING INDEX; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; CENTRAL NERVOUS SYSTEM; DIPEPTIDES; EPITHELIAL CELLS; MEMBRANE TRANSPORT PROTEINS; NEUROGLIA; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYMPORTERS;

EID: 2942544305     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.04.013     Document Type: Article

References (24)

1. Berger U.V., Hediger M.A. Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat. Embryol. (Berl.). 199:1999;439-449
2. Dieck S.T., Heuer H., Ehrchen J., Otto C., Bauer K. The peptide transporter PepT2 is expressed in rat brain and mediates the accumulation of the fluorescent dipeptide derivative beta-Ala-Lys-Nepsilon-AMCA in astrocytes. Glia. 25:1999;10-20
3. Doring F., Walter J., Will J., Focking M., Boll M., Amasheh S., Clauss W., Daniel H. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J. Clin. Invest. 101:1998;2761-2767
4. Dringen R., Hamprecht B., Broer S. The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures. J. Neurochem. 71:1998;388-393
5. Fujita T., Kishida T., Wada M., Okada N., Yamamoto A., Leibach F.H., Ganapathy V. Functional characterization of brain peptide transporter in rat cerebral cortex: identification of the high-affinity type H(+)/peptide transporter PEPT2. Brain Res. 997:2004;52-61
6. Groneberg D.A., Doring F., Eynott P.R., Fischer A., Daniel H. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am. J. Physiol. Gastrointest. Liver Physiol. 281:2001;G697-G704
7. Groneberg D.A., Doring F., Nickolaus M., Daniel H., Fischer A. Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia. Neurosci. Lett. 304:2001;181-184
8. Groneberg D.A., Doring F., Nickolaus M., Daniel H., Fischer A. Renal assimilation of short chain peptides: visualization of tubular peptide uptake. Pharm Res. 19:2002;1209-1214
9. Groneberg D.A., Doring F., Theis S., Nickolaus M., Fischer A., Daniel H. Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein. Am. J. Physiol. Endocrinol. Metab. 282:2002;E1172-E1179
10. Groneberg D.A., Eynott P.R., Doring F., Thai Dinh Q., Oates T., Barnes P.J., Chung K.F., Daniel H., Fischer A. Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax. 57:2002;55-60
11. Groneberg D.A., Hartmann P., Dinh Q.T., Fischer A. Expression and distribution of vasoactive intestinal polypeptide receptor VPAC(2) mRNA in human airways. Lab. Invest. 81:2001;749-755
12. Groneberg D.A., Nickolaus M., Springer J., Doring F., Daniel H., Fischer A. Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake. Am. J. Pathol. 158:2001;707-714
13. Novotny A., Xiang J., Stummer W., Teuscher N.S., Smith D.E., Keep R.F. Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J. Neurochem. 75:2000;321-328
14. Ocheltree S.M., Shen H., Hu Y., Xiang J., Keep R.F., Smith D. Mechanisms of Cefadroxil uptake in the choroid plexus: studies in wild type and PEPT2 knockout mice. J. Pharmacol. Exp. Ther. 4:2003;4
15. Otto C., Tom Dieck S., Bauer K. Dipeptide uptake by adenohypophysial folliculostellate cells. Am. J. Physiol. 271:1996;C210-C217
16. Rubio-Aliaga I., Daniel H. Mammalian peptide transporters as targets for drug delivery. Trends Pharmacol. Sci. 23:2002;434-440
17. Rubio-Aliaga I., Frey I., Boll M., Groneberg D.A., Eichinger H.M., Balling R., Daniel H. Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol. Cell. Biol. 23:2003;3247-3252
18. Shen H., Smith D.E., Keep R.F., Xiang J., Brosius F.C. III Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J. Biol. Chem. 278:2003;4786-4791
19. Shu C., Shen H., Teuscher N.S., Lorenzi P.J., Keep R.F., Smith D.E. Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture. J. Pharmacol. Exp. Ther. 301:2002;820-829
20. Teuscher N.S., Keep R.F., Smith D.E. PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm. Res. 18:2001;807-813
21. Teuscher N.S., Novotny A., Keep R.F., Smith D.E. Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine. J. Pharmacol. Exp. Ther. 294:2000;494-499
22. Theis S., Hartrodt B., Kottra G., Neubert K., Daniel H. Defining minimal structural features in substrates of the H(+)/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives. Mol. Pharmacol. 61:2002;214-221
23. Wang H., Fei Y.J., Ganapathy V., Leibach F.H. Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain. Am. J. Physiol. 275:1998;C967-C975
24. +-peptide cotransporter in LLC-PK1 cells. Am. J. Physiol. 275:1998;C1573-C1579