Stereoselective synthesis and biological evaluations of novel 3′-deoxy-4′-azaribonucleosides as inhibitors of hepatitis C virus RNA replication

Journal of Medicinal Chemistry

Volumn 52, Issue 13, 2009, Pages 4054-4057

  Chiacchio, Ugo ^a   Borrello, Luisa ^a   Crispino, Lia ^a   Rescifina, Antonio ^a   Merino, Pedro ^b   Macchi, Beatrice ^c   Balestrieri, Emanuela ^c   Mastino, Antonio ^d   Piperno, Anna ^d   Romeo, Giovanni ^d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ETHYL 2 [5 FLUORO 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL] 3 HYDROXY 5 (HYDROXYMETHYL)PYRROLIDINE 1 CARBOXYLATE; INTERFERON; TERT BUTYL 2 [2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL] 3 HYDROXY 5 (HYDROXYMETHYL)PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 2 [4 AMINO 2 OXOPYRIMIDIN 1(2H) YL] 3 HYDROXY 5 (HYDROXYMETHYL)PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 2 [5 FLUORO 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL] 3 HYDROXY 5 (HYDROXYMETHYL)PYRROLIDINE 1 CARBOXYLATE; TERT BUTYL 3 HYDROXY 5 (HYDROXYMETHYL) 2 [5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL]PYRROLIDINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; REPLICON; RNA REPLICATION; STEREOCHEMISTRY;

ANTIVIRAL AGENTS; DEOXYRIBONUCLEOSIDES; HEPACIVIRUS; HUMANS; PROLINE; PYRROLIDINES; RNA, VIRAL; STEREOISOMERISM; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 67649964788     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900197j     Document Type: Article

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