메뉴 건너뛰기




Volumn 28, Issue 25, 2009, Pages 2365-2369

The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt

Author keywords

Extracellular signal regulated MAP kinases; Neoplastic cell transformation; P21 activated kinases; Protein kinase B

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; P21 ACTIVATED KINASE; PROTEIN KINASE B;

EID: 67649958065     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.114     Document Type: Article
Times cited : (53)

References (28)
  • 1
    • 2642606981 scopus 로고    scopus 로고
    • Bereiter-Hahn J, Munnich A, Woiteneck P. (1998). Dependence of energy metabolism on the density of cells in culture. Cell Struct Funct 23: 85-93. Chaudhary A, King WG,MattalianoMD, Frost JA, Diaz B, Morrison
    • Bereiter-Hahn J, Munnich A, Woiteneck P. (1998). Dependence of energy metabolism on the density of cells in culture. Cell Struct Funct 23: 85-93. Chaudhary A, King WG,MattalianoMD, Frost JA, Diaz B, Morrison
  • 2
    • 0034193426 scopus 로고    scopus 로고
    • DK et al. (2000). Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol 10: 551-554.
    • DK et al. (2000). Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol 10: 551-554.
  • 3
    • 0022649091 scopus 로고
    • Tumor measurement in the nude mouse
    • Galang CK, Garcia-Ramirez JJ, Solski PA, Westwick JK, Der CJ
    • Euhus DM, Hudd C, LaRegina MC, Johnson FE. (1986). Tumor measurement in the nude mouse. J Surg Oncol 31: 229-234. Galang CK, Garcia-Ramirez JJ, Solski PA, Westwick JK, Der CJ,
    • (1986) J Surg Oncol , vol.31 , pp. 229-234
    • Euhus, D.M.1    Hudd, C.2    LaRegina, M.C.3    Johnson, F.E.4
  • 4
    • 0029932755 scopus 로고    scopus 로고
    • Oncogenic Neu/ErbB-2 increases Ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting Ets activation blocks neu-mediated cellular transformation
    • Neznanov NN et al. (1996). Oncogenic Neu/ErbB-2 increases Ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting Ets activation blocks neu-mediated cellular transformation. J Biol Chem 271: 7992-7998.
    • (1996) J Biol Chem , vol.271 , pp. 7992-7998
    • Neznanov, N.N.1
  • 5
    • 0037799232 scopus 로고    scopus 로고
    • Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription
    • Galetic I, Maira SM, Andjelkovic M, Hemmings BA. (2003). Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription. J Biol Chem 278: 4416-4423.
    • (2003) J Biol Chem , vol.278 , pp. 4416-4423
    • Galetic, I.1    Maira, S.M.2    Andjelkovic, M.3    Hemmings, B.A.4
  • 6
    • 32644452086 scopus 로고    scopus 로고
    • RNA interference in cancer
    • Gartel AL, Kandel ES. (2006). RNA interference in cancer. Biomol Eng 23: 17-34.
    • (2006) Biomol Eng , vol.23 , pp. 17-34
    • Gartel, A.L.1    Kandel, E.S.2
  • 7
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel ES, Hay N. (1999). The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253: 210-229.
    • (1999) Exp Cell Res , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 9
    • 0032808154 scopus 로고    scopus 로고
    • Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
    • Kennedy SG, Kandel ES, Cross TK, Hay N. (1999). Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 19: 5800-5810.
    • (1999) Mol Cell Biol , vol.19 , pp. 5800-5810
    • Kennedy, S.G.1    Kandel, E.S.2    Cross, T.K.3    Hay, N.4
  • 10
    • 0032511882 scopus 로고    scopus 로고
    • The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
    • King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S et al. (1998). The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396: 180-183.
    • (1998) Nature , vol.396 , pp. 180-183
    • King, A.J.1    Sun, H.2    Diaz, B.3    Barnard, D.4    Miao, W.5    Bagrodia, S.6
  • 11
    • 0028272507 scopus 로고
    • Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
    • Leevers SJ, Paterson HF, Marshall CJ. (1994). Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369: 411-414.
    • (1994) Nature , vol.369 , pp. 411-414
    • Leevers, S.J.1    Paterson, H.F.2    Marshall, C.J.3
  • 12
    • 0035224494 scopus 로고    scopus 로고
    • Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells
    • McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand
    • McCubrey JA, Lee JT, Steelman LS, Blalock WL,Moye PW, Chang F et al. (2001). Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells. Cancer Detect Prev 25: 375-393. McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand
    • (2001) Cancer Detect Prev , vol.25 , pp. 375-393
    • McCubrey, J.A.1    Lee, J.T.2    Steelman, L.S.3    Blalock, W.L.4    Moye, P.W.5    Chang, F.6
  • 13
    • 33748063941 scopus 로고    scopus 로고
    • FE et al. (2006). Roles of the RAF/MEK/ERK and PI3K/PTEN/ AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul 46: 249-279. Mirza AM, Gysin S, Malek N, Nakayama K-I, Roberts JM,
    • FE et al. (2006). Roles of the RAF/MEK/ERK and PI3K/PTEN/ AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul 46: 249-279. Mirza AM, Gysin S, Malek N, Nakayama K-I, Roberts JM,
  • 14
    • 10044274332 scopus 로고    scopus 로고
    • Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT
    • McMahon M. (2004). Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol 24: 10868-10881.
    • (2004) Mol Cell Biol , vol.24 , pp. 10868-10881
    • McMahon, M.1
  • 15
    • 0033919237 scopus 로고    scopus 로고
    • Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB
    • Mirza AM, Kohn AD, Roth RA, McMahon M. (2000). Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB. Cell Growth Differ 11: 279-292.
    • (2000) Cell Growth Differ , vol.11 , pp. 279-292
    • Mirza, A.M.1    Kohn, A.D.2    Roth, R.A.3    McMahon, M.4
  • 17
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
    • Morgenstern JP, Land H. (1990). Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res18: 3587-3596.
    • (1990) Nucleic Acids Res , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 18
    • 2942675416 scopus 로고    scopus 로고
    • PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition
    • Nheu T, He H, Hirokawa Y, Walker F, Wood J, Maruta H. (2004). PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle 3: 71-74.
    • (2004) Cell Cycle , vol.3 , pp. 71-74
    • Nheu, T.1    He, H.2    Hirokawa, Y.3    Walker, F.4    Wood, J.5    Maruta, H.6
  • 19
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer
    • Roberts PJ, Der CJ. (2007). Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291-3310.
    • (2007) Oncogene , vol.26 , pp. 3291-3310
    • Roberts, P.J.1    CJ, D.2
  • 20
    • 4644283083 scopus 로고    scopus 로고
    • Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells
    • Shelton JG, Blalock WL, White ER, Steelman LS, McCubrey JA. (2004). Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells. Cell Cycle 3: 503-512.
    • (2004) Cell Cycle , vol.3 , pp. 503-512
    • Shelton, J.G.1    Blalock, W.L.2    White, E.R.3    Steelman, L.S.4    McCubrey, J.A.5
  • 21
    • 0035958062 scopus 로고    scopus 로고
    • Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells
    • Sheng H, Shao J, DuBois RN. (2001). Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells. J Biol Chem 276: 14498-14504.
    • (2001) J Biol Chem , vol.276 , pp. 14498-14504
    • Sheng, H.1    Shao, J.2    DuBois, R.N.3
  • 22
    • 58149217066 scopus 로고    scopus 로고
    • 14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly
    • Somanath PR, Byzova TV. (2009). 14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly. J Cell Physiol 218: 394-404.
    • (2009) J Cell Physiol , vol.218 , pp. 394-404
    • Somanath, P.R.1    Byzova, T.V.2
  • 24
    • 0034624783 scopus 로고    scopus 로고
    • Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
    • Sun H, King AJ, Diaz HB, Marshall MS. (2000). Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak. Current Biology 10: 281-284.
    • (2000) Current Biology , vol.10 , pp. 281-284
    • Sun, H.1    King, A.J.2    Diaz, H.B.3    Marshall, M.S.4
  • 25
    • 0030811528 scopus 로고    scopus 로고
    • Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts
    • Tang Y, Chen Z, Ambrose D, Liu J, Gibbs JB, Chernoff J et al. (1997). Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol 17: 4454-4464.
    • (1997) Mol Cell Biol , vol.17 , pp. 4454-4464
    • Tang, Y.1    Chen, Z.2    Ambrose, D.3    Liu, J.4    Gibbs, J.B.5    Chernoff, J.6
  • 27
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC. (2008). PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 28
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • Zimmermann S, Moelling K. (1999). Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286: 1741-1744.
    • (1999) Science , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.