-
1
-
-
0001889919
-
Pro-drugs: an overview and definition
-
American Chemical Society, Washington, DC, T. Higuchi, V. Stella (Eds.)
-
Stella V. Pro-drugs: an overview and definition. Pro-drugs as a Novel Drug Delivery System 1975, Vol. 14:1-115. American Chemical Society, Washington, DC. T. Higuchi, V. Stella (Eds.).
-
(1975)
Pro-drugs as a Novel Drug Delivery System
, vol.14
, pp. 1-115
-
-
Stella, V.1
-
2
-
-
84882469049
-
Prodrugs, protective groups and the medicinal chemist
-
Elsevier, Amsterdam, J. Mathieu (Ed.)
-
Sinkula A.A. Prodrugs, protective groups and the medicinal chemist. Medicinal Chemistry 1977, Vol. 5:125-133. Elsevier, Amsterdam. J. Mathieu (Ed.).
-
(1977)
Medicinal Chemistry
, vol.5
, pp. 125-133
-
-
Sinkula, A.A.1
-
3
-
-
84942868247
-
Designing prodrugs and bioprecursors
-
Academic press, London, C.G. Wermuth (Ed.)
-
Wermuth C.G. Designing prodrugs and bioprecursors. The Practice of Medicinal Chemistry 2003, 561-585. Academic press, London. C.G. Wermuth (Ed.).
-
(2003)
The Practice of Medicinal Chemistry
, pp. 561-585
-
-
Wermuth, C.G.1
-
4
-
-
2342481809
-
Lessons learned from marketed and investigational prodrugs
-
Ettmayer P., Amidon G.L., Clement B., Testa B. Lessons learned from marketed and investigational prodrugs. J. Med. Chem. 2004, 47:2393-2403.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2393-2403
-
-
Ettmayer, P.1
Amidon, G.L.2
Clement, B.3
Testa, B.4
-
5
-
-
84906476318
-
Prodrug objectives and design
-
Elsevier, Amsterdam, J.B. Taylor, D.J. Triggle (Eds.)
-
Testa B. Prodrug objectives and design. Comprehensive Medicinal Chemistry II 2007, Vol. 5:1009-1041. Elsevier, Amsterdam. J.B. Taylor, D.J. Triggle (Eds.).
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.5
, pp. 1009-1041
-
-
Testa, B.1
-
6
-
-
0001199533
-
Chemical aspects of selective toxicity
-
Albert A. Chemical aspects of selective toxicity. Nature (London) 1958, 182:421-423.
-
(1958)
Nature (London)
, vol.182
, pp. 421-423
-
-
Albert, A.1
-
8
-
-
84882480281
-
Biopre acute;curseurs contre prodrogues
-
Sanofi-Clin-Midy, Montpellier, M. Briot, W. Cautreels, R. Roncucci (Eds.)
-
Wermuth C.G. Bioprécurseurs contre prodrogues. Drug Metabolism and Drug Design: Quo Vadis? 1983, 253-271. Sanofi-Clin-Midy, Montpellier. M. Briot, W. Cautreels, R. Roncucci (Eds.).
-
(1983)
Drug Metabolism and Drug Design: Quo Vadis?
, pp. 253-271
-
-
Wermuth, C.G.1
-
9
-
-
0004579318
-
Designing prodrugs and bioprecursors
-
Academic Press, London, G. Jollès, K.R.H. Wooldrige (Eds.)
-
Wermuth C.G. Designing prodrugs and bioprecursors. Drug Design: Fact or Fantasy? 1984, 47-72. Academic Press, London. G. Jollès, K.R.H. Wooldrige (Eds.).
-
(1984)
Drug Design: Fact or Fantasy?
, pp. 47-72
-
-
Wermuth, C.G.1
-
10
-
-
84882534429
-
Les prodrogues, des me acute;dicaments plus su circ;rs et plus maniables
-
Wermuth C.G. Les prodrogues, des médicaments plus sûrs et plus maniables. Bull. Soc. Pharm. Bordeaux. 1980, 119:107-129.
-
(1980)
Bull. Soc. Pharm. Bordeaux.
, vol.119
, pp. 107-129
-
-
Wermuth, C.G.1
-
11
-
-
84882559016
-
Modulation of natural substances in order to improve their pharmacokinetic properties
-
Hippokrates Verlag, Stuttgart, J.L. Beal, E. Reinhard (Eds.)
-
Wermuth C.G. Modulation of natural substances in order to improve their pharmacokinetic properties. Natural Products as Medicinal Agents 1981, 185-216. Hippokrates Verlag, Stuttgart. J.L. Beal, E. Reinhard (Eds.).
-
(1981)
Natural Products as Medicinal Agents
, pp. 185-216
-
-
Wermuth, C.G.1
-
12
-
-
0014824052
-
Acyloxymethyl esters of ampicillin
-
Daehne W.V., Frederiksen E., Gundersen E., Lund F., March P., Petersen H.J., Roholt K., Tybring L., Godtfredsen W.O. Acyloxymethyl esters of ampicillin. J. Med. Chem. 1970, 13:607-612.
-
(1970)
J. Med. Chem.
, vol.13
, pp. 607-612
-
-
Daehne, W.V.1
Frederiksen, E.2
Gundersen, E.3
Lund, F.4
March, P.5
Petersen, H.J.6
Roholt, K.7
Tybring, L.8
Godtfredsen, W.O.9
-
13
-
-
0016679986
-
Bacampicillin: a new orally well-absorbed derivative of ampicillin
-
Bodin N.O., Ekström B., Forsgren U., Jalar L.P., Magni L., Ramsey C.H., Sjöberg B. Bacampicillin: a new orally well-absorbed derivative of ampicillin. Antimicrob. Agents Chemother. 1975, 8:518-525.
-
(1975)
Antimicrob. Agents Chemother.
, vol.8
, pp. 518-525
-
-
Bodin, N.O.1
Ekström, B.2
Forsgren, U.3
Jalar, L.P.4
Magni, L.5
Ramsey, C.H.6
Sjöberg, B.7
-
14
-
-
0017132164
-
Preparation, hydrolysis, and oral absorption of lactonyl esters of penicillins
-
Clayton J.P., Cole M., Elson S.W., Ferres H., Hanson J.C., Mizen L.W., Sutherland R. Preparation, hydrolysis, and oral absorption of lactonyl esters of penicillins. J. Med. Chem. 1976, 19(12):1385-1391.
-
(1976)
J. Med. Chem.
, vol.19
, Issue.12
, pp. 1385-1391
-
-
Clayton, J.P.1
Cole, M.2
Elson, S.W.3
Ferres, H.4
Hanson, J.C.5
Mizen, L.W.6
Sutherland, R.7
-
16
-
-
0004632628
-
Synthesis of a new antiinflammatory agent, cis -5-fluoro-2-methyl-1-[ p -(methylsulfinyl) benzylidenyl]-indene-3-acetic acid
-
Shen T.I., Witzel B.E., Jones H., Linn B.O., McPherson J., Greenwald R., Fordice M., Jacobs A. Synthesis of a new antiinflammatory agent, cis -5-fluoro-2-methyl-1-[ p -(methylsulfinyl) benzylidenyl]-indene-3-acetic acid. Fed. Proc. 1972, 31:577.
-
(1972)
Fed. Proc.
, vol.31
, pp. 577
-
-
Shen, T.I.1
Witzel, B.E.2
Jones, H.3
Linn, B.O.4
McPherson, J.5
Greenwald, R.6
Fordice, M.7
Jacobs, A.8
-
17
-
-
0015773336
-
Physiological disposition and metabolic fate of a new anti-inflamatory agent, cis -5-fluoro-2-methyl-1-[ p -(methylsulfinyl) benzylidenyl]-indene-3-acetic acid in the rat, dog, rhesus monkey, and man
-
Hucker H.B., Stauffer S.C., White S.D., Rhodes R.A., Arrison B.H., Umbenhauer E.R., Bower R.J., McMahon F.G. Physiological disposition and metabolic fate of a new anti-inflamatory agent, cis -5-fluoro-2-methyl-1-[ p -(methylsulfinyl) benzylidenyl]-indene-3-acetic acid in the rat, dog, rhesus monkey, and man. Drug Metab. Dispos. 1973, 1:721-736.
-
(1973)
Drug Metab. Dispos.
, vol.1
, pp. 721-736
-
-
Hucker, H.B.1
Stauffer, S.C.2
White, S.D.3
Rhodes, R.A.4
Arrison, B.H.5
Umbenhauer, E.R.6
Bower, R.J.7
McMahon, F.G.8
-
18
-
-
0017356867
-
The disposition of sulindac
-
Duggan D.E., Hare L.E., Ditzler C.A., Lei B.W., Kwan K.C. The disposition of sulindac. C lin. Pharmacol. Ther. 1977, 21:326-335.
-
(1977)
C lin. Pharmacol. Ther.
, vol.21
, pp. 326-335
-
-
Duggan, D.E.1
Hare, L.E.2
Ditzler, C.A.3
Lei, B.W.4
Kwan, K.C.5
-
19
-
-
0018130406
-
Comparative biodisposition of sulindac and metabolites in five species
-
Duggan D.E., Hooke K.F., Noll R.M., Hucker H.B., Van Arman C.G. Comparative biodisposition of sulindac and metabolites in five species. Biochem. Pharmacol. 1978, 27:2311-2320.
-
(1978)
Biochem. Pharmacol.
, vol.27
, pp. 2311-2320
-
-
Duggan, D.E.1
Hooke, K.F.2
Noll, R.M.3
Hucker, H.B.4
Van Arman, C.G.5
-
20
-
-
0017603154
-
Identification of the biologically active form of sulindac
-
Duggan D.E., Hooke K.F., Risley E.A., Shen T.Y., Van Arman C.G. Identification of the biologically active form of sulindac. J. Pharmacol. Exp. Ther. 1977, 201(1):8-13.
-
(1977)
J. Pharmacol. Exp. Ther.
, vol.201
, Issue.1
, pp. 8-13
-
-
Duggan, D.E.1
Hooke, K.F.2
Risley, E.A.3
Shen, T.Y.4
Van Arman, C.G.5
-
21
-
-
0142027423
-
Proinsecticides
-
John Wiley & Sons, Ltd., Chichester, D.H. Hutson, T.R. Roberts (Eds.)
-
Drabek J., Neumann R. Proinsecticides. Progress in Pesticide Biochemistry and Toxicology 1985, Vol. 5:35-86. John Wiley & Sons, Ltd., Chichester. D.H. Hutson, T.R. Roberts (Eds.).
-
(1985)
Progress in Pesticide Biochemistry and Toxicology
, vol.5
, pp. 35-86
-
-
Drabek, J.1
Neumann, R.2
-
23
-
-
0001033723
-
Design and application of prodrugs
-
Harwood Academic Publishers, Chur, P. Krogsgaard-Larsen, H. Bundgaard (Eds.)
-
Bundgaard H. Design and application of prodrugs. A Textbook of Drug Design and Development 1991, 113-191. Harwood Academic Publishers, Chur. 1st Edition. P. Krogsgaard-Larsen, H. Bundgaard (Eds.).
-
(1991)
A Textbook of Drug Design and Development
, pp. 113-191
-
-
Bundgaard, H.1
-
24
-
-
0342444799
-
The effect of a pro-drug of epinephrine (dipivaloylepinephrine) in glaucoma-general pharmacology, toxicology and clinical experience
-
American Chemical Society, Washington, DC, T. Higuchi, V. Stella (Eds.)
-
McClure D. The effect of a pro-drug of epinephrine (dipivaloylepinephrine) in glaucoma-general pharmacology, toxicology and clinical experience. Pro-Drugs as a Novel Drug Delivery Systems 1975, Vol. 14:224-235. American Chemical Society, Washington, DC. T. Higuchi, V. Stella (Eds.).
-
(1975)
Pro-Drugs as a Novel Drug Delivery Systems
, vol.14
, pp. 224-235
-
-
McClure, D.1
-
25
-
-
0018901643
-
Pro-drugs of dopaminergic agonists
-
Horn A.S. Pro-drugs of dopaminergic agonists. C hemistry and Industry 1980, 12:441-444.
-
(1980)
C hemistry and Industry
, vol.12
, pp. 441-444
-
-
Horn, A.S.1
-
26
-
-
0018898101
-
Dopaminergic prodrugs: brain concentration and neurochemical effects of 5,6- and 6,7-ADTN after administration as dibenzoyl esters
-
Westerink B.H.C., Dijkstra D., Feenstra M.G.P., Grol C.J., Horn A.S., Rollema H., Wirix E. Dopaminergic prodrugs: brain concentration and neurochemical effects of 5,6- and 6,7-ADTN after administration as dibenzoyl esters. Eur. J. Pharmacol. 1980, 61:7-15.
-
(1980)
Eur. J. Pharmacol.
, vol.61
, pp. 7-15
-
-
Westerink, B.H.C.1
Dijkstra, D.2
Feenstra, M.G.P.3
Grol, C.J.4
Horn, A.S.5
Rollema, H.6
Wirix, E.7
-
27
-
-
0017182455
-
Esters of N-tert-butylarterenol. Long-acting new bronchodilators with reduced cardiac effects
-
Tullar B.F., Minatoya H., Lorenz R.R. Esters of N-tert-butylarterenol. Long-acting new bronchodilators with reduced cardiac effects. J. Med. Chem. 1976, 19:834-838.
-
(1976)
J. Med. Chem.
, vol.19
, pp. 834-838
-
-
Tullar, B.F.1
Minatoya, H.2
Lorenz, R.R.3
-
28
-
-
0021720852
-
Synthesis and in vitro antiviral activity of 3 prime;-O-acyl derivatives of 5 prime;-amino-2 prime;-deoxy thymidine: potential prodrugs for topical application
-
Lin T.S. Synthesis and in vitro antiviral activity of 3'-O-acyl derivatives of 5'-amino-2'-deoxy thymidine: potential prodrugs for topical application. J. Pharm. Sci. 1984, 73:1568-1571.
-
(1984)
J. Pharm. Sci.
, vol.73
, pp. 1568-1571
-
-
Lin, T.S.1
-
29
-
-
0024354624
-
Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties
-
Harnden M.R., Jarvest R.L., Boyd M.R., Sutton D., Verehodge R.A. Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties. J. Med. Chem. 1989, 32:1738-1743.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 1738-1743
-
-
Harnden, M.R.1
Jarvest, R.L.2
Boyd, M.R.3
Sutton, D.4
Verehodge, R.A.5
-
30
-
-
0026499933
-
Di- and triester prodrugs of the varicella-zoster antiviral agent 6-methoxypurine arabinoside
-
Jones L.A., Moorman A.R., Chamberlain S.D., Miranda P.d., Reynolds D.J., Burns C.L., Krenitsky T.A. Di- and triester prodrugs of the varicella-zoster antiviral agent 6-methoxypurine arabinoside. J. Med. Chem. 1992, 35:56-63.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 56-63
-
-
Jones, L.A.1
Moorman, A.R.2
Chamberlain, S.D.3
Miranda, P.4
Reynolds, D.J.5
Burns, C.L.6
Krenitsky, T.A.7
-
31
-
-
0019990671
-
Soft drugs 4. 3-Spirothiazolidines of hydrocortisone and its derivatives
-
Bodor N., Sloan K.B., Little R.J., Selk S.H., Caldwell L. Soft drugs 4. 3-Spirothiazolidines of hydrocortisone and its derivatives. Int. J. Pharm. 1982, 10:307-321.
-
(1982)
Int. J. Pharm.
, vol.10
, pp. 307-321
-
-
Bodor, N.1
Sloan, K.B.2
Little, R.J.3
Selk, S.H.4
Caldwell, L.5
-
33
-
-
0344537543
-
Effects of tyrosine hydroxylase inhibition on the amine levels of central monoamine neurons
-
Anden N.E., Corrodi H., Dahlström A., Fuxe K., Högfelt T. Effects of tyrosine hydroxylase inhibition on the amine levels of central monoamine neurons. Life Sci. 1966, 5:561-568.
-
(1966)
Life Sci.
, vol.5
, pp. 561-568
-
-
Anden, N.E.1
Corrodi, H.2
Dahlström, A.3
Fuxe, K.4
Högfelt, T.5
-
34
-
-
0034981540
-
Etilevodopa
-
Anonymous
-
Anonymous. Etilevodopa. Drugs Fut. 26 (2001) 219-223.
-
(2001)
Drugs Fut.
, vol.26
, pp. 219-223
-
-
-
35
-
-
0018386217
-
Influence of inhibitors of the high affinity GABA uptake on seizure threshold in mice
-
Frey H.H., Popp C., Löscher W. Influence of inhibitors of the high affinity GABA uptake on seizure threshold in mice. Neuropharmacology 1979, 18:581-590.
-
(1979)
Neuropharmacology
, vol.18
, pp. 581-590
-
-
Frey, H.H.1
Popp, C.2
Löscher, W.3
-
36
-
-
0020403483
-
Enalapril maleate and a lysine analogue (MK-521): disposition in man
-
Ulm E.H., Hichens M., Gomez H.J., Till A.E., Hand E., Vassil T.C., Biollaz J., Brunner H.R., Schelling J.L. Enalapril maleate and a lysine analogue (MK-521): disposition in man. Br. J. Pharmacol. 1982, 14:357-362.
-
(1982)
Br. J. Pharmacol.
, vol.14
, pp. 357-362
-
-
Ulm, E.H.1
Hichens, M.2
Gomez, H.J.3
Till, A.E.4
Hand, E.5
Vassil, T.C.6
Biollaz, J.7
Brunner, H.R.8
Schelling, J.L.9
-
37
-
-
0021747275
-
Influence of food on the bioavailability of enalapril
-
Swanson B.L., Vlasses P.H., Ferguson R.K., Berquist P.A., Till A.E., Irvin J.D., Harris K. Influence of food on the bioavailability of enalapril. J. Pharm. Sci. 1984, 73:1655-1657.
-
(1984)
J. Pharm. Sci.
, vol.73
, pp. 1655-1657
-
-
Swanson, B.L.1
Vlasses, P.H.2
Ferguson, R.K.3
Berquist, P.A.4
Till, A.E.5
Irvin, J.D.6
Harris, K.7
-
38
-
-
0027742889
-
Trandolapril: how does it differ from other angiotensin converting enzyme inhibitors?
-
Zannad F. Trandolapril: how does it differ from other angiotensin converting enzyme inhibitors?. Drugs 1993, 46:172-183.
-
(1993)
Drugs
, vol.46
, pp. 172-183
-
-
Zannad, F.1
-
39
-
-
84882561122
-
Synthesis and pharmacological activity of gamma-aminobutyric acid derivatives
-
Tsybina N., Ostrovskaya R.U., Protopova T.V., Parin V.V., Selezneva N.I., Skolainov A.P. Synthesis and pharmacological activity of gamma-aminobutyric acid derivatives. Khim. Pharm. Zh. 1974, 17:10-13.
-
(1974)
Khim. Pharm. Zh.
, vol.17
, pp. 10-13
-
-
Tsybina, N.1
Ostrovskaya, R.U.2
Protopova, T.V.3
Parin, V.V.4
Selezneva, N.I.5
Skolainov, A.P.6
-
40
-
-
0015252995
-
The comparative neurotropic potency of gamma-aminobutyric acid and its cetyl ester
-
Ostrovskaya R.U., Parin V.V., Tsybina N.M. The comparative neurotropic potency of gamma-aminobutyric acid and its cetyl ester. Byul. Eksp. Biol. Med. 1972, 73:51-55.
-
(1972)
Byul. Eksp. Biol. Med.
, vol.73
, pp. 51-55
-
-
Ostrovskaya, R.U.1
Parin, V.V.2
Tsybina, N.M.3
-
41
-
-
84882553561
-
Effect of methotrexate γ-monohexadecylester (γ-MHxMTX) on nucleoside uptake by human leukemic cells
-
71 Meeting
-
Beardsley, G. P., Rosowsky, A. Effect of methotrexate γ-monohexadecylester (γ-MHxMTX) on nucleoside uptake by human leukemic cells. In Proc. Am. Assoc. Cancer Res. 21, 71 Meeting, 1980, p. 264.
-
(1980)
Proc. Am. Assoc. Cancer Res.
, vol.21
, pp. 264
-
-
Beardsley, G.P.1
Rosowsky, A.2
-
42
-
-
0002323166
-
Designing prodrugs and bioprecursors I: carrier prodrugs
-
Academic Press, London, C.G. Wermuth (Ed.)
-
Wermuth C.G., Gaignault J.-C., Marchandeau C. Designing prodrugs and bioprecursors I: carrier prodrugs. The Practice of Medicinal Chemistry 1996, 671-696. Academic Press, London. C.G. Wermuth (Ed.).
-
(1996)
The Practice of Medicinal Chemistry
, pp. 671-696
-
-
Wermuth, C.G.1
Gaignault, J.-C.2
Marchandeau, C.3
-
43
-
-
0018858802
-
Lipoidal pro-drug analogues of various anti-inflammatory agents
-
Jones G. Lipoidal pro-drug analogues of various anti-inflammatory agents. Chem. Ind. (London), 1980, 452-456.
-
(1980)
Chem. Ind. (London)
, pp. 452-456
-
-
Jones, G.1
-
44
-
-
37049060814
-
Some novel penicillin derivatives
-
Jansen A.B.A., Russel T.J. Some novel penicillin derivatives. J. Chem. Soc. 1965, 2127-2132.
-
(1965)
J. Chem. Soc.
, pp. 2127-2132
-
-
Jansen, A.B.A.1
Russel, T.J.2
-
46
-
-
0021251618
-
3-Hydroxy- alpha;-methyltyrosine progenitors: synthesis and evaluation of some (2-oxo-1,3-dioxol-4-yl)methyl esters
-
Saari W.S., Halczenko W., Cochran D.W., Dobrinska M.R., Vincek W.C., Titus D.C., Gaul S.L., Sweet C.S. 3-Hydroxy-α-methyltyrosine progenitors: synthesis and evaluation of some (2-oxo-1,3-dioxol-4-yl)methyl esters. J. Med. Chem. 1984, 27:713-717.
-
(1984)
J. Med. Chem.
, vol.27
, pp. 713-717
-
-
Saari, W.S.1
Halczenko, W.2
Cochran, D.W.3
Dobrinska, M.R.4
Vincek, W.C.5
Titus, D.C.6
Gaul, S.L.7
Sweet, C.S.8
-
48
-
-
0022543002
-
Tranexamic acid derivatives with enhanced absorption
-
Svahn C.M., Merenyi F., Karlson L., Widlund L., Grälls M. Tranexamic acid derivatives with enhanced absorption. J. Med. Chem. 1986, 29:448-453.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 448-453
-
-
Svahn, C.M.1
Merenyi, F.2
Karlson, L.3
Widlund, L.4
Grälls, M.5
-
49
-
-
0018363322
-
Talniflumate
-
Torriani H. Talniflumate. Drugs Fut 1979, 4:448-450.
-
(1979)
Drugs Fut
, vol.4
, pp. 448-450
-
-
Torriani, H.1
-
50
-
-
0020394737
-
Talmetacin
-
Torriani H. Talmetacin. Drugs Fut 1982, 7:823-824.
-
(1982)
Drugs Fut
, vol.7
, pp. 823-824
-
-
Torriani, H.1
-
51
-
-
0026092702
-
(Acyloxy)alkyl carbamate prodrugs of norfloxacin
-
Alexander J., Fromtling R.A., Bland J.A., Pelak B.A., Gilfillan E.C. (Acyloxy)alkyl carbamate prodrugs of norfloxacin. J. Med. Chem. 1991, 34:78-81.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 78-81
-
-
Alexander, J.1
Fromtling, R.A.2
Bland, J.A.3
Pelak, B.A.4
Gilfillan, E.C.5
-
52
-
-
0344731435
-
Bisphophonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate
-
Ahlmark M., Vepsaelaeinen J., Taipale H., Niemi R., Jaervinen T. Bisphophonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate. J. Med. Chem. 1999, 42:1473-1476.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 1473-1476
-
-
Ahlmark, M.1
Vepsaelaeinen, J.2
Taipale, H.3
Niemi, R.4
Jaervinen, T.5
-
53
-
-
0033552861
-
Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid
-
Aicher T.D., Bebernitz G.R., Bell P.A., Brand L.J., Dain J.G., Deems R., Fillers W.S., Foley J.E., Knorr D.C., Nadelson J., Otero D.A., Simpson R., Strohschein R.J., Young D.A. Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid. J. Med. Chem. 1999, 42:153-163.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 153-163
-
-
Aicher, T.D.1
Bebernitz, G.R.2
Bell, P.A.3
Brand, L.J.4
Dain, J.G.5
Deems, R.6
Fillers, W.S.7
Foley, J.E.8
Knorr, D.C.9
Nadelson, J.10
Otero, D.A.11
Simpson, R.12
Strohschein, R.J.13
Young, D.A.14
-
54
-
-
0025018013
-
Inhibition of hepatic glucose production by SDZ 51641
-
Young D.A., Ho R.S., Bell P.A., Cohen D.K., McIntosh R.H., Nadelson J., Foley J.E. Inhibition of hepatic glucose production by SDZ 51641. Diabetes 1990, 39:1408-1413.
-
(1990)
Diabetes
, vol.39
, pp. 1408-1413
-
-
Young, D.A.1
Ho, R.S.2
Bell, P.A.3
Cohen, D.K.4
McIntosh, R.H.5
Nadelson, J.6
Foley, J.E.7
-
55
-
-
0025367096
-
Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzene eacetic acid,
-
Walsh D.A., Moran H.W., Shamblee D.A., Welstead W.J., Nolan J.C., Sancilio L.F., Graff G. Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzene eacetic acid,. J. Med. Chem. 1990, 33:2296-2304.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 2296-2304
-
-
Walsh, D.A.1
Moran, H.W.2
Shamblee, D.A.3
Welstead, W.J.4
Nolan, J.C.5
Sancilio, L.F.6
Graff, G.7
-
56
-
-
0018218096
-
Properties of two derivatives of gamma;-aminobutyric acid (GABA) capable of abolishing cardiazol- and bicuculline-induced convulsions in the rat
-
Galzinga L., Garbin L., Bianchi M., Marzotto A. Properties of two derivatives of γ-aminobutyric acid (GABA) capable of abolishing cardiazol- and bicuculline-induced convulsions in the rat. Arch. Int. Pharmacodyn. 1978, 235:73-85.
-
(1978)
Arch. Int. Pharmacodyn.
, vol.235
, pp. 73-85
-
-
Galzinga, L.1
Garbin, L.2
Bianchi, M.3
Marzotto, A.4
-
57
-
-
0018416603
-
Comparison of the central nervous system actions of taurine and N -pivaloyltaurine
-
480 pages
-
Ahtee L., Halmekoski J., Heinonen H., Koskimies A. Comparison of the central nervous system actions of taurine and N -pivaloyltaurine. Br. J. Pharmacol. 1979, 66(3). 480 pages.
-
(1979)
Br. J. Pharmacol.
, vol.66
, Issue.3
-
-
Ahtee, L.1
Halmekoski, J.2
Heinonen, H.3
Koskimies, A.4
-
58
-
-
0018823887
-
New anticonvulsants: Schiff bases of gamma;-aminobutyric acid and gamma;-aminobutyramide
-
Kaplan J.P., Raizon B., Desarmenien M., Feltz P., Headley P.M., Worms P., Lloyd K.G., Bartholini G. New anticonvulsants: Schiff bases of γ-aminobutyric acid and γ-aminobutyramide. J. Med. Chem. 1980, 23:702-704.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 702-704
-
-
Kaplan, J.P.1
Raizon, B.2
Desarmenien, M.3
Feltz, P.4
Headley, P.M.5
Worms, P.6
Lloyd, K.G.7
Bartholini, G.8
-
59
-
-
0018844243
-
Use of acetylacetone to prepare a prodrug of cycloserine
-
Jensen N.P., Friedman J.J., Kropp H., Kahan F.M. Use of acetylacetone to prepare a prodrug of cycloserine. J. Med. Chem. 1980, 23:6-8.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 6-8
-
-
Jensen, N.P.1
Friedman, J.J.2
Kropp, H.3
Kahan, F.M.4
-
60
-
-
84882561738
-
Novel transient pro-drug forms of L -DOPA
-
(June 24, 1975; Inter'X Res. Corpn.)
-
Bodor, N. S., Sloan, K. B., Hussain, A. A., Novel transient pro-drug forms of L -DOPA, US Patent 3,891,696 (June 24, 1975; Inter'X Res. Corpn.) 1975.
-
(1975)
US Patent
, vol.3
-
-
Bodor, N.S.1
Sloan, K.B.2
Hussain, A.A.3
-
61
-
-
0019505851
-
ST-1059
-
Koch H. ST-1059. Drugs Fut 1981, 6:244-246.
-
(1981)
Drugs Fut
, vol.6
, pp. 244-246
-
-
Koch, H.1
-
62
-
-
0020807950
-
Hypoglycemic compounds. Sulfonylurea derivatives containing amino acids and dipeptides,
-
Vicentini C.B., Guarneri M., Sarto G. Hypoglycemic compounds. Sulfonylurea derivatives containing amino acids and dipeptides,. Farmaco, Ed. Sci. 1983, 38:595-608.
-
(1983)
Farmaco, Ed. Sci.
, vol.38
, pp. 595-608
-
-
Vicentini, C.B.1
Guarneri, M.2
Sarto, G.3
-
63
-
-
0035950186
-
Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier
-
Rubenstein S.M., Baichwal V., Beckmann H., Clark D.L., Frankmoelle W., Roche D., Santha E., Schwender S., Thoolen M., Ye Q., Jaen J.C. Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier. J. Med. Chem. 2001, 44:3599-3605.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3599-3605
-
-
Rubenstein, S.M.1
Baichwal, V.2
Beckmann, H.3
Clark, D.L.4
Frankmoelle, W.5
Roche, D.6
Santha, E.7
Schwender, S.8
Thoolen, M.9
Ye, Q.10
Jaen, J.C.11
-
64
-
-
84882465694
-
-
Boehringer, Dérivés de la L-(3,4-dihydroxy-phényl)-2-méthyl alanine et leur préparation, (March 9, 1976 to Boehringer Mannheim GMBH)
-
Boehringer, Dérivés de la L-(3,4-dihydroxy-phényl)-2-méthyl alanine et leur préparation, Belg. Pat. 839,362 (March 9, 1976 to Boehringer Mannheim GMBH), 1976.
-
(1976)
Belg. Pat.
-
-
-
65
-
-
0021049799
-
Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m -fluorophenylalanine peptide conjugates
-
Kingsbury W.D., Boehm J.C., Mehta R.J., Grappel S.F. Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m -fluorophenylalanine peptide conjugates. J. Med. Chem. 1983, 26:1725-1729.
-
(1983)
J. Med. Chem.
, vol.26
, pp. 1725-1729
-
-
Kingsbury, W.D.1
Boehm, J.C.2
Mehta, R.J.3
Grappel, S.F.4
-
66
-
-
0024505073
-
Use of the peptide carrier system to improve the intestinal absorption of l- alpha;-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of l- alpha;-methyldopa
-
Hu M., Subramanian P., Mosberg H.I., Amidon G.L. Use of the peptide carrier system to improve the intestinal absorption of l-α-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of l-α-methyldopa. Pharm. Res. 1989, 6:66-70.
-
(1989)
Pharm. Res.
, vol.6
, pp. 66-70
-
-
Hu, M.1
Subramanian, P.2
Mosberg, H.I.3
Amidon, G.L.4
-
67
-
-
0033598329
-
Prodrugs for amidines: synthesis and anti- pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan
-
Rahmathullah S.M., Hall J.E., Bender B.C., McCurdy D.R., Tidwell R.R., Boykin D.W. Prodrugs for amidines: synthesis and anti- pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan. J. Med. Chem. 1999, 42:3994-4000.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3994-4000
-
-
Rahmathullah, S.M.1
Hall, J.E.2
Bender, B.C.3
McCurdy, D.R.4
Tidwell, R.R.5
Boykin, D.W.6
-
68
-
-
0023033065
-
Prodrugs of 5-fluorouracil. VII. Hydrolysis kinetics and physicochemical properties of N -ethoxy- and N -phenoxycarbonylmethyl derivatives of 5-fluorouracil,
-
Buur A., Bundgaard H., Falch E. Prodrugs of 5-fluorouracil. VII. Hydrolysis kinetics and physicochemical properties of N -ethoxy- and N -phenoxycarbonylmethyl derivatives of 5-fluorouracil,. Acta Pharm. Suec. 1986, 23:205-216.
-
(1986)
Acta Pharm. Suec.
, vol.23
, pp. 205-216
-
-
Buur, A.1
Bundgaard, H.2
Falch, E.3
-
69
-
-
0023227249
-
Prodrug forms for the sulfonamide group. I. Evaluation of N -acyl derivatives, N -sulfonylamidines, N -sulfonyl- sulfilimines and sulfonylureas as possible prodrug derivatives,
-
Larsen J.D., Bundgaard H. Prodrug forms for the sulfonamide group. I. Evaluation of N -acyl derivatives, N -sulfonylamidines, N -sulfonyl- sulfilimines and sulfonylureas as possible prodrug derivatives,. Int. J. Pharm. 1987, 37:87-95.
-
(1987)
Int. J. Pharm.
, vol.37
, pp. 87-95
-
-
Larsen, J.D.1
Bundgaard, H.2
-
70
-
-
0023942776
-
Prodrugs as drug delivery systems. 77. Phthalidyl derivatives as prodrug forms for amides, sulfonamides, carbamates and other NH-acidic compounds,
-
Bundgaard H., Buur A., Hansen K.T., Larsen J.D., Moss J., Olsen L. Prodrugs as drug delivery systems. 77. Phthalidyl derivatives as prodrug forms for amides, sulfonamides, carbamates and other NH-acidic compounds,. Int. J. Pharm. 1988, 45:47-57.
-
(1988)
Int. J. Pharm.
, vol.45
, pp. 47-57
-
-
Bundgaard, H.1
Buur, A.2
Hansen, K.T.3
Larsen, J.D.4
Moss, J.5
Olsen, L.6
-
71
-
-
0013890753
-
The preparation and structure of hetacillin
-
Hardcastle G.A., Johnson D.A., Panetta C.A., Scott A.I., Sutherland S.A. The preparation and structure of hetacillin. J. Org. Chem. 1966, 31:897-899.
-
(1966)
J. Org. Chem.
, vol.31
, pp. 897-899
-
-
Hardcastle, G.A.1
Johnson, D.A.2
Panetta, C.A.3
Scott, A.I.4
Sutherland, S.A.5
-
72
-
-
0002327694
-
Design of prodrugs: bioreversible derivatives for various functional groups and chemical entities
-
Elsevier, Amsterdam, H. Bundgaard (Ed.)
-
Bundgaard H. Design of prodrugs: bioreversible derivatives for various functional groups and chemical entities. Design of Prodrugs 1985, 1-92. Elsevier, Amsterdam. H. Bundgaard (Ed.).
-
(1985)
Design of Prodrugs
, pp. 1-92
-
-
Bundgaard, H.1
-
73
-
-
0022992546
-
Droxicam
-
Anonymous
-
Anonymous. Droxicam. Drugs Fut. 11 (1986) 835-836.
-
(1986)
Drugs Fut.
, vol.11
, pp. 835-836
-
-
-
74
-
-
70449300652
-
Amino acid and fatty acid hydrazides: chemistry and action on monoamine oxidase
-
Zeller P., Pletscher A., Gey K.F., Gutmann H., Hegedus B., Staub O. Amino acid and fatty acid hydrazides: chemistry and action on monoamine oxidase. Ann. NY Acad. Sci. 1959, 80:555-567.
-
(1959)
Ann. NY Acad. Sci.
, vol.80
, pp. 555-567
-
-
Zeller, P.1
Pletscher, A.2
Gey, K.F.3
Gutmann, H.4
Hegedus, B.5
Staub, O.6
-
75
-
-
0020603227
-
New myocardial imaging agents: stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids
-
Knapp F.F.J., Goodman M.M., Callahan A.P., Ferren L.A., Kabalka G.W., Sastry K.A.R. New myocardial imaging agents: stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids. J. Med. Chem. 1983, 26:1293-1300.
-
(1983)
J. Med. Chem.
, vol.26
, pp. 1293-1300
-
-
Knapp, F.F.J.1
Goodman, M.M.2
Callahan, A.P.3
Ferren, L.A.4
Kabalka, G.W.5
Sastry, K.A.R.6
-
76
-
-
84942898758
-
Coupling of drugs to modified bile acids for liver specific targeting
-
205th Meeting of the American Chemical Society, MEDI 152
-
Wess, G., Kramer, W., Schubert, G., Bickel, M., Hoffmann, A.,Baringhaus, K. H. Coupling of drugs to modified bile acids for liver specific targeting. Abst. Pap.205th Meeting of the American Chemical Society. 1993, 16. Pt. 1, MEDI 152.
-
(1993)
Abst. Pap.
, vol.16 PART. 1
-
-
Wess, G.1
Kramer, W.2
Schubert, G.3
Bickel, M.4
Hoffmann, A.5
Baringhaus, K.H.6
-
77
-
-
0034986641
-
Targeted cytotoxic somatostatin analogs: a modern approach to the therapy of various cancers
-
Nagy A., Schally A.V. Targeted cytotoxic somatostatin analogs: a modern approach to the therapy of various cancers. Drugs Fut 2001, 26:261-270.
-
(2001)
Drugs Fut
, vol.26
, pp. 261-270
-
-
Nagy, A.1
Schally, A.V.2
-
78
-
-
84882539706
-
Organic synthesis as a source of new drugs
-
American Chemical Society, Washington, DC, A.C. Society (Ed.)
-
Biel J.H., Martin Y.C. Organic synthesis as a source of new drugs. Drug Discovery-Science and Development in a Changing Society 1971, Vol. 108:81-111. American Chemical Society, Washington, DC. A.C. Society (Ed.).
-
(1971)
Drug Discovery-Science and Development in a Changing Society
, vol.108
, pp. 81-111
-
-
Biel, J.H.1
Martin, Y.C.2
-
79
-
-
0015240319
-
Biosynthesis of a thiouracil pheomelanin in embryonic pigment cells exposed to thiouracil
-
Whittaker J.R. Biosynthesis of a thiouracil pheomelanin in embryonic pigment cells exposed to thiouracil. J. Biol. Chem. 1971, 246:6217-6226.
-
(1971)
J. Biol. Chem.
, vol.246
, pp. 6217-6226
-
-
Whittaker, J.R.1
-
80
-
-
0018772929
-
False precursors of melanin as selective melanoma seekers
-
Dencker L., Larsson B., Olander K., Ullberg S., Yokota M. False precursors of melanin as selective melanoma seekers. Br. J. Cancer 1979, 39:449-452.
-
(1979)
Br. J. Cancer
, vol.39
, pp. 449-452
-
-
Dencker, L.1
Larsson, B.2
Olander, K.3
Ullberg, S.4
Yokota, M.5
-
81
-
-
0020336174
-
Affinity therapeutics. 1. Selective incorporation of 2-thiouracil derivatives in murine melanomas. Cytostatic activity of 2-thiouracil arotinoids, 2-thiouracil retinoids, arotinoids and retinoids,
-
Wätjen F., Buchardt O., Langvad E. Affinity therapeutics. 1. Selective incorporation of 2-thiouracil derivatives in murine melanomas. Cytostatic activity of 2-thiouracil arotinoids, 2-thiouracil retinoids, arotinoids and retinoids,. J. Med. Chem. 1982, 25:956-960.
-
(1982)
J. Med. Chem.
, vol.25
, pp. 956-960
-
-
Wätjen, F.1
Buchardt, O.2
Langvad, E.3
-
82
-
-
0002693050
-
Modulation of pharmacokinetics by molecular manipulation
-
Academic Press, New York, E.J. Ariëns (Ed.)
-
Ariëns E.J. Modulation of pharmacokinetics by molecular manipulation. Drug Des 1971, Vol. II:1-127. Academic Press, New York. E.J. Ariëns (Ed.).
-
(1971)
Drug Des
, vol.2
, pp. 1-127
-
-
Ariëns, E.J.1
-
83
-
-
84882459768
-
-
Twenty- Seventh Annual Symposium on Fundamental Cancer Research. The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, 1974; The Williams and Wilkins Company, Baltimore, MD
-
Ariëns, E. J. Pharmacological basis of cancer therapy, In Twenty- Seventh Annual Symposium on Fundamental Cancer Research. The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, 1974; The Williams and Wilkins Company, Baltimore, MD, 1975.
-
(1975)
Pharmacological basis of cancer therapy
-
-
Ariëns, E.J.1
-
84
-
-
0020595398
-
Sitedirected chemotherapy with a drug bound to anti-idiotypic antibody to a lymphoma cell-surface IgM
-
Hurwitx E., Kashi R., Burowsky D., Arnon R., Haimovitch J. Sitedirected chemotherapy with a drug bound to anti-idiotypic antibody to a lymphoma cell-surface IgM. Int. J. Cancer 1983, 31:745-748.
-
(1983)
Int. J. Cancer
, vol.31
, pp. 745-748
-
-
Hurwitx, E.1
Kashi, R.2
Burowsky, D.3
Arnon, R.4
Haimovitch, J.5
-
86
-
-
0018117844
-
Gamma-glutamyl-DOPA: a kidney specific dopamine precursor
-
Wilk S., Mizoguchi H., Orlowski M. Gamma-glutamyl-DOPA: a kidney specific dopamine precursor. J. Pharmacol. Exp. Ther. 1978, 206:227-232.
-
(1978)
J. Pharmacol. Exp. Ther.
, vol.206
, pp. 227-232
-
-
Wilk, S.1
Mizoguchi, H.2
Orlowski, M.3
-
87
-
-
84882474816
-
Peripheral dopamine receptors
-
Pergamon Press, Oxford, J.L. Imbs, J. Schwartz (Eds.)
-
Kyncl J.J., Minard F.N., Jones P.H. Peripheral dopamine receptors. Symposium on Peripheral Dopaminergic Receptors-Strasbourg, July 1978 1979, 369-380. Pergamon Press, Oxford. J.L. Imbs, J. Schwartz (Eds.).
-
(1979)
Symposium on Peripheral Dopaminergic Receptors-Strasbourg, July 1978
, pp. 369-380
-
-
Kyncl, J.J.1
Minard, F.N.2
Jones, P.H.3
-
88
-
-
84882529409
-
Esters of γ-glutamylamide of dopamine
-
(12 April 1977, to Abott Laboratories)
-
Jones, P. H., Kyncl, J., Ours, C. W., Somani, P. Esters of γ-glutamylamide of dopamine. US Patent. 4,017,636 (12 April 1977, to Abott Laboratories) 1977.
-
(1977)
US Patent
, vol.4
-
-
Jones, P.H.1
Kyncl, J.2
Ours, C.W.3
Somani, P.4
-
89
-
-
0018833881
-
N-acyl- gamma;-glutamyl derivatives of sulfamethoxazole as models of kidney-selective prodrugs
-
Orlowski M., Mizoguchi H., Wilk S. N-acyl-γ-glutamyl derivatives of sulfamethoxazole as models of kidney-selective prodrugs. J. Pharmacol. Exp. Ther. 1979, 212:167-172.
-
(1979)
J. Pharmacol. Exp. Ther.
, vol.212
, pp. 167-172
-
-
Orlowski, M.1
Mizoguchi, H.2
Wilk, S.3
-
90
-
-
0021992017
-
Drug glycosides: potential prodrugs for colon-specific drug delivery
-
Friend D.R., Chang G.W. Drug glycosides: potential prodrugs for colon-specific drug delivery. J. Med. Chem. 1985, 28:51-57.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 51-57
-
-
Friend, D.R.1
Chang, G.W.2
-
91
-
-
0021354414
-
A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria
-
Friend D.R., Chang G.W. A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria. J. Med. Chem. 1984, 27:261-266.
-
(1984)
J. Med. Chem.
, vol.27
, pp. 261-266
-
-
Friend, D.R.1
Chang, G.W.2
-
92
-
-
0018576207
-
Florinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5 prime;-deoxy-5fluoropyrimidine nucleosides,
-
Cook A.F., Holman M.J., Kramer M.J., Trown P.W. Florinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5fluoropyrimidine nucleosides,. J. Med. Chem. 1979, 22:1330-1335.
-
(1979)
J. Med. Chem.
, vol.22
, pp. 1330-1335
-
-
Cook, A.F.1
Holman, M.J.2
Kramer, M.J.3
Trown, P.W.4
-
93
-
-
0021068589
-
Y. Pharmacokinetic studies of 5-fluorouracil and 5 prime;-deoxy-5-fluorouridine in rats
-
Au J., -S.Walker L., Rustum J.S. Y. Pharmacokinetic studies of 5-fluorouracil and 5'-deoxy-5-fluorouridine in rats. J. Pharmacol. Exp. Ther. 1983, 227:174-180.
-
(1983)
J. Pharmacol. Exp. Ther.
, vol.227
, pp. 174-180
-
-
Au, J.-S.1
Walker, L.2
Rustum, J.S.3
-
94
-
-
0034632849
-
Synthesis and biological evaluation of 2 prime;-carbamate-linked and 3 prime;-carbonate-linked prodrugs of paclitaxel: selective activation by the tumor-associated protease plasmin
-
de Groot F.M.H., van Berkom L.W.A., Scheeren H.W. Synthesis and biological evaluation of 2'-carbamate-linked and 3'-carbonate-linked prodrugs of paclitaxel: selective activation by the tumor-associated protease plasmin. J. Med. Chem. 2000, 43:3093-3102.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3093-3102
-
-
de Groot, F.M.H.1
van Berkom, L.W.A.2
Scheeren, H.W.3
-
95
-
-
0021800252
-
Prodrugs do they have advantages in clinical practice?
-
Stella V.J., Charman W.N.A., Naringrekar V.H. Prodrugs do they have advantages in clinical practice?. Drugs 1985, 29:455-473.
-
(1985)
Drugs
, vol.29
, pp. 455-473
-
-
Stella, V.J.1
Charman, W.N.A.2
Naringrekar, V.H.3
-
96
-
-
0009520507
-
Sustained drug action accomplished by the prodrug approach
-
Elsevier, Amsterdam, H. Bundgaard (Ed.)
-
Sinkula A.A. Sustained drug action accomplished by the prodrug approach. Design of Prodrugs 1985, 157-176. Elsevier, Amsterdam. H. Bundgaard (Ed.).
-
(1985)
Design of Prodrugs
, pp. 157-176
-
-
Sinkula, A.A.1
-
98
-
-
0015421390
-
Oral long-lasting estrogenic activity of estradiol 3-benzoate 17-cyclooctenyl ether
-
Falconi G., Galetti F., Celasco G., Gardi R. Oral long-lasting estrogenic activity of estradiol 3-benzoate 17-cyclooctenyl ether. Steroids 1972, 20:627-632.
-
(1972)
Steroids
, vol.20
, pp. 627-632
-
-
Falconi, G.1
Galetti, F.2
Celasco, G.3
Gardi, R.4
-
99
-
-
0041824340
-
D4-3-keto steroidal ethers. Paradoxical dependency of their effectiveness on the administration route,
-
Ercoli A., Gardi R. D4-3-keto steroidal ethers. Paradoxical dependency of their effectiveness on the administration route,. J. Am. Chem. Soc. 1960, 82:746-748.
-
(1960)
J. Am. Chem. Soc.
, vol.82
, pp. 746-748
-
-
Ercoli, A.1
Gardi, R.2
-
100
-
-
0016531320
-
The role of structure-activity studies in the design of antitumor agents
-
Cain B.F. The role of structure-activity studies in the design of antitumor agents. Cancer Chemother. Rep. 1975, 59(4):679-683.
-
(1975)
Cancer Chemother. Rep.
, vol.59
, Issue.4
, pp. 679-683
-
-
Cain, B.F.1
-
101
-
-
0000341931
-
2-Acyloxymethylbenzoic acids. Novel amine protective functions providing amides with the lability of esters,
-
Cain B.F. 2-Acyloxymethylbenzoic acids. Novel amine protective functions providing amides with the lability of esters,. J. Org. Chem. 1976, 41(11):2029-2031.
-
(1976)
J. Org. Chem.
, vol.41
, Issue.11
, pp. 2029-2031
-
-
Cain, B.F.1
-
102
-
-
0021256508
-
Studies on prodrugs. II. Preparation and characterization of (5-substituted 2-oxo-1,3-dioxolen-4-yl)methyl esters of ampicillin,
-
Sakamoto F., Ikeda S., Tsukamoto G. Studies on prodrugs. II. Preparation and characterization of (5-substituted 2-oxo-1,3-dioxolen-4-yl)methyl esters of ampicillin,. Chem. Pharm. Bull. 1984, 32:2241-2248.
-
(1984)
Chem. Pharm. Bull.
, vol.32
, pp. 2241-2248
-
-
Sakamoto, F.1
Ikeda, S.2
Tsukamoto, G.3
-
103
-
-
0025778632
-
Novel chemical approaches in prodrug design
-
Bundgaard H. Novel chemical approaches in prodrug design. Drugs Fut 1991, 16:443-458.
-
(1991)
Drugs Fut
, vol.16
, pp. 443-458
-
-
Bundgaard, H.1
-
104
-
-
0016796832
-
The acetylation of apomorphine. An improved method for the selective preparation of diacetylapomorphine utilizing trifluoroacetic acid/acetyl bromide,
-
Borgman R.J., Smith R.V., Keiser J.E. The acetylation of apomorphine. An improved method for the selective preparation of diacetylapomorphine utilizing trifluoroacetic acid/acetyl bromide,. Synthesis 1975, 249-250.
-
(1975)
Synthesis
, pp. 249-250
-
-
Borgman, R.J.1
Smith, R.V.2
Keiser, J.E.3
-
105
-
-
0027258227
-
Wrasidlo
-
Nicolaou K.C., Riemer C., Kerr M.A., Rideout D. Wrasidlo. W. Design, synthesis and biological activity of protaxols, Nature (London) 1993, 364:464-466.
-
(1993)
W. Design, synthesis and biological activity of protaxols, Nature (London)
, vol.364
, pp. 464-466
-
-
Nicolaou, K.C.1
Riemer, C.2
Kerr, M.A.3
Rideout, D.4
-
107
-
-
0024593762
-
A novel prodrug of an impermeant inhibitor of 3-deoxy- d -manno-2-octulosonate cytidylyl-transferase has antibacterial activity
-
Norbeck D.W., Rosenbrook W., Kramer J.B., Grampovnik D.J., Lartey P.A. A novel prodrug of an impermeant inhibitor of 3-deoxy- d -manno-2-octulosonate cytidylyl-transferase has antibacterial activity. J. Med. Chem. 1989, 32:625-629.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 625-629
-
-
Norbeck, D.W.1
Rosenbrook, W.2
Kramer, J.B.3
Grampovnik, D.J.4
Lartey, P.A.5
-
108
-
-
0022572105
-
Pilocarpine prodrugs Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters
-
Bundgaard H., Falch E., Larsen C., Mikkelson T.J. Pilocarpine prodrugs Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters. J. Pharm. Sci. 1986, 75:36-44.
-
(1986)
J. Pharm. Sci.
, vol.75
, pp. 36-44
-
-
Bundgaard, H.1
Falch, E.2
Larsen, C.3
Mikkelson, T.J.4
-
109
-
-
0022543135
-
Pilocarpine prodrugs II. Synthesis, stability, bioconversion and physicochemical properties of sequentially labile pilocarpine acid diesters,
-
Bundgaard H., Falch E., Larsen C., Mosher G.L., Mikkelson T.J. Pilocarpine prodrugs II. Synthesis, stability, bioconversion and physicochemical properties of sequentially labile pilocarpine acid diesters,. J. Pharm. Sci. 1986, 75:775-783.
-
(1986)
J. Pharm. Sci.
, vol.75
, pp. 775-783
-
-
Bundgaard, H.1
Falch, E.2
Larsen, C.3
Mosher, G.L.4
Mikkelson, T.J.5
-
110
-
-
0025869654
-
Amine prodrugs which utilize hydroxy-amide lactonization. I. A potential redox-sensitive amide prodrug,
-
Amsberry K.L., Borchardt R.T. Amine prodrugs which utilize hydroxy-amide lactonization. I. A potential redox-sensitive amide prodrug,. Pharm. Res. 1991, 8:323-330.
-
(1991)
Pharm. Res.
, vol.8
, pp. 323-330
-
-
Amsberry, K.L.1
Borchardt, R.T.2
-
111
-
-
0025907182
-
Amine prodrugs which utilize hydroxy-amide lactonization. II. A potential esterase-sensitive prodrug,
-
Amsberry K.L., Gerstenberger A.E., Borchardt R.T. Amine prodrugs which utilize hydroxy-amide lactonization. II. A potential esterase-sensitive prodrug,. Pharm. Res. 1991, 8:455-461.
-
(1991)
Pharm. Res.
, vol.8
, pp. 455-461
-
-
Amsberry, K.L.1
Gerstenberger, A.E.2
Borchardt, R.T.3
-
112
-
-
0037075836
-
Design and synthesis of a novel L -dopa-entacapone codrug
-
Leppänen J., Huuskonen J., Nevalainen T., Gynther J., Taipale H., Järvinen T. Design and synthesis of a novel L -dopa-entacapone codrug. J. Med. Chem 2002, 45:1379-1382.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1379-1382
-
-
Leppänen, J.1
Huuskonen, J.2
Nevalainen, T.3
Gynther, J.4
Taipale, H.5
Järvinen, T.6
-
113
-
-
0001803257
-
Novel approaches for the design of membrane transport properties of drugs
-
American Pharmaceutical Association, Washington, DC, E.B. Roche (Ed.)
-
Bodor N.S. Novel approaches for the design of membrane transport properties of drugs. Design of biopharmaceutical properties through prodrugs and analogs 1977, 98-135. American Pharmaceutical Association, Washington, DC. E.B. Roche (Ed.).
-
(1977)
Design of biopharmaceutical properties through prodrugs and analogs
, pp. 98-135
-
-
Bodor, N.S.1
-
114
-
-
33745609384
-
Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials,
-
Bodor N.S., Kaminski J.J., Selk S. Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials,. J. Med. Chem. 1980, 23:469-474.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 469-474
-
-
Bodor, N.S.1
Kaminski, J.J.2
Selk, S.3
-
115
-
-
0018908788
-
Soft drugs. 2. Soft alkylating compounds as potential antitumor agents,
-
Bodor N.S., Kaminski J.J. Soft drugs. 2. Soft alkylating compounds as potential antitumor agents,. J. Med. Chem. 1980, 232:566-569.
-
(1980)
J. Med. Chem.
, vol.232
, pp. 566-569
-
-
Bodor, N.S.1
Kaminski, J.J.2
-
116
-
-
0019014701
-
Soft drugs. 3. A new class of anticholinergic agents,
-
Bodor N.S., Woods R., Raper C., Kearney P., Kaminski J.J. Soft drugs. 3. A new class of anticholinergic agents,. J. Med. Chem. 1980, 23:474-480.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 474-480
-
-
Bodor, N.S.1
Woods, R.2
Raper, C.3
Kearney, P.4
Kaminski, J.J.5
-
117
-
-
0006645882
-
Prodrugs versus soft drugs
-
Elsevier, Amsterdam, H. Bundgaard (Ed.)
-
Bodor N. Prodrugs versus soft drugs. Design of Prodrugs 1985, 333-354. Elsevier, Amsterdam. H. Bundgaard (Ed.).
-
(1985)
Design of Prodrugs
, pp. 333-354
-
-
Bodor, N.1
-
118
-
-
0030682098
-
Remifentanyl pharmacokinetics and metabolism
-
Peacock J.E., Francis G. Remifentanyl pharmacokinetics and metabolism. Drugs Today 1997, 33:611-618.
-
(1997)
Drugs Today
, vol.33
, pp. 611-618
-
-
Peacock, J.E.1
Francis, G.2
-
119
-
-
0023277876
-
Esmolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy,
-
Benfield P., Sorkin E.M. Esmolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy,. Drugs 1987, 392-412.
-
(1987)
Drugs
, pp. 392-412
-
-
Benfield, P.1
Sorkin, E.M.2
-
120
-
-
0019723346
-
Pro-drugs of amides, imides, and amines
-
John Wiley & Sons, New York, G. deStevens (Ed.)
-
Pitman I.H. Pro-drugs of amides, imides, and amines. Med. Res. Rev. 1981, Vol. 1:189-214. John Wiley & Sons, New York. G. deStevens (Ed.).
-
(1981)
Med. Res. Rev.
, vol.1
, pp. 189-214
-
-
Pitman, I.H.1
-
121
-
-
0026050837
-
Non-peptide angiotensin II antagonists: the discovery of a series of N -(biphenylmethyl) imidazoles as potent, orally active antihypertensives
-
Carini D.J., Duncia J.V., Aldrich P.E., Chiu A.T., Johnson A.U., Piera M.E., Price W.A., Santellar J.B.r., Wells G.J., Wexler R.R., Wong P.C., Yoo S.-E., Timmerman P.B. Non-peptide angiotensin II antagonists: the discovery of a series of N -(biphenylmethyl) imidazoles as potent, orally active antihypertensives. J. Med. Chem. 1991, 34:2525-2547.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2525-2547
-
-
Carini, D.J.1
Duncia, J.V.2
Aldrich, P.E.3
Chiu, A.T.4
Johnson, A.U.5
Piera, M.E.6
Price, W.A.7
Santellar, J.8
Wells, G.J.9
Wexler, R.R.10
Wong, P.C.11
Yoo, S.-E.12
Timmerman, P.B.13
-
122
-
-
0025086862
-
Non-peptide angiotensin II receptor antagonists. XI. Pharmacology of Exp 3174: an active metabolite of DuP 753, an orally activeantihypertensive agent,
-
Wong P.C., Price W.A.J., Chiu A.T., Duncia J.V., Carini D.J., Wexler R.R., Johnson A.L., Timmerman P.B. Non-peptide angiotensin II receptor antagonists. XI. Pharmacology of Exp 3174: an active metabolite of DuP 753, an orally activeantihypertensive agent,. J. Pharmacol. Exp. Ther. 1990, 255:211-217.
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.255
, pp. 211-217
-
-
Wong, P.C.1
Price, W.A.J.2
Chiu, A.T.3
Duncia, J.V.4
Carini, D.J.5
Wexler, R.R.6
Johnson, A.L.7
Timmerman, P.B.8
-
123
-
-
0020058804
-
An orally effective, longacting dopaminergic prodrug: (-)-10,11-methylenedioxy- N - propylnorapomorphine
-
Baldessarini R.J., Neumeyer J.L., Campbell A., Sperk G., Ram V.J., Arana G.W., Kula N.S. An orally effective, longacting dopaminergic prodrug: (-)-10,11-methylenedioxy- N - propylnorapomorphine. Eur. J. Pharmacol. 1982, 77:87-88.
-
(1982)
Eur. J. Pharmacol.
, vol.77
, pp. 87-88
-
-
Baldessarini, R.J.1
Neumeyer, J.L.2
Campbell, A.3
Sperk, G.4
Ram, V.J.5
Arana, G.W.6
Kula, N.S.7
-
124
-
-
0037030601
-
A new type of prodrug of catecholamines: an opportunity to improve the treatment of Parkinson's disease
-
Venhuis B.J., Wikström H.V., Rodenhuis N., Sundell S., Dijkstra D. A new type of prodrug of catecholamines: an opportunity to improve the treatment of Parkinson's disease. J. Med. Chem. 2002, 45:2349-2351.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2349-2351
-
-
Venhuis, B.J.1
Wikström, H.V.2
Rodenhuis, N.3
Sundell, S.4
Dijkstra, D.5
-
125
-
-
0033678468
-
Identification and biological activity of the active metabolite of clopidogrel
-
Savi P., Pereillo J.M., Uzabiaga M.F., Combalbert J., Picard C., Maffrand J.P., Pascal M., Herbert J.M. Identification and biological activity of the active metabolite of clopidogrel. Thromb. Haemostasis 2000, 84:891-896.
-
(2000)
Thromb. Haemostasis
, vol.84
, pp. 891-896
-
-
Savi, P.1
Pereillo, J.M.2
Uzabiaga, M.F.3
Combalbert, J.4
Picard, C.5
Maffrand, J.P.6
Pascal, M.7
Herbert, J.M.8
-
126
-
-
0038508970
-
The mechanism of clopidogrel is catalyzed by human cytochrome P450 3Aand is inhibited by atorvastatin
-
Clarke T.A., Waskell L.A. The mechanism of clopidogrel is catalyzed by human cytochrome P450 3Aand is inhibited by atorvastatin. Drug Metab. Dispos. 2003, 31:53-59.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 53-59
-
-
Clarke, T.A.1
Waskell, L.A.2
-
127
-
-
0016907546
-
Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N -methylpyridinium-2-carbaldoxime chloride,
-
Bodor N., Shek E., Higuchi T. Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N -methylpyridinium-2-carbaldoxime chloride,. J. Med. Chem. 1976, 19:102-107.
-
(1976)
J. Med. Chem.
, vol.19
, pp. 102-107
-
-
Bodor, N.1
Shek, E.2
Higuchi, T.3
-
128
-
-
0016907487
-
Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N -methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N -methylpyridinium-2-carbaldoxime chloride,
-
Shek E., Higuchi T., Bodor N. Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N -methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N -methylpyridinium-2-carbaldoxime chloride,. J. Med. Chem. 1976, 19:108-112.
-
(1976)
J. Med. Chem.
, vol.19
, pp. 108-112
-
-
Shek, E.1
Higuchi, T.2
Bodor, N.3
-
129
-
-
0016915152
-
Improved delivery through biological membranes. 3. Delivery of N -methylpyridinium-2-carbaldoxime chloride through the blood-brain-barrier in its dihydropyridine prodrug form,
-
Shek E., Higuchi T., Bodor N. Improved delivery through biological membranes. 3. Delivery of N -methylpyridinium-2-carbaldoxime chloride through the blood-brain-barrier in its dihydropyridine prodrug form,. J. Med. Chem. 1976, 19:113-117.
-
(1976)
J. Med. Chem.
, vol.19
, pp. 113-117
-
-
Shek, E.1
Higuchi, T.2
Bodor, N.3
-
130
-
-
0343258430
-
Deoxyacyclovir: a xanthine oxidase-acitvated prodrug of acyclovir
-
Krenitsky T.A., Hall W.W., de Miranda P., Beauchamp L.M., Schaeffer H.J., Whiteman P.D. Deoxyacyclovir: a xanthine oxidase-acitvated prodrug of acyclovir. Proc. Natl. Acad. Sci. USA 1984, 31:3209-3213.
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.31
, pp. 3209-3213
-
-
Krenitsky, T.A.1
Hall, W.W.2
de Miranda, P.3
Beauchamp, L.M.4
Schaeffer, H.J.5
Whiteman, P.D.6
-
131
-
-
0021709894
-
Tolerance and pharmacokinetics of A515U, an acyclovir analogue in healthy volunteers
-
Whiteman P.D., Bye A., Fowle A.S.E., Jeal S., Land G., Posner J. Tolerance and pharmacokinetics of A515U, an acyclovir analogue in healthy volunteers. Eur. J. Clin. Pharmacol. 1984, 27:471-475.
-
(1984)
Eur. J. Clin. Pharmacol.
, vol.27
, pp. 471-475
-
-
Whiteman, P.D.1
Bye, A.2
Fowle, A.S.E.3
Jeal, S.4
Land, G.5
Posner, J.6
-
134
-
-
0020437503
-
Cyclophosphamide analogues
-
Elsevier, Amsterdam, G.P. Ellis, G.B. West (Eds.)
-
Zon G. Cyclophosphamide analogues. Progress in Medicinal Chemistry 1982, 205-246. Elsevier, Amsterdam. G.P. Ellis, G.B. West (Eds.).
-
(1982)
Progress in Medicinal Chemistry
, pp. 205-246
-
-
Zon, G.1
-
135
-
-
0010401337
-
NeuartigeKrebs-Chemotherapeutika aus der Gruppe der zyklischen N -Lostphosphamidester
-
Arnold H., Bourseaux F., Brock N. NeuartigeKrebs-Chemotherapeutika aus der Gruppe der zyklischen N -Lostphosphamidester. Naturwissenschaften 1958, 45:64-66.
-
(1958)
Naturwissenschaften
, vol.45
, pp. 64-66
-
-
Arnold, H.1
Bourseaux, F.2
Brock, N.3
-
136
-
-
0000957859
-
Chemotherapeutic action of a cyclic nitrogen mustard phosphamide ester (B518-ASTA) in experimental tumors of the rat
-
Arnold H., Bourseaux F., Brock N. Chemotherapeutic action of a cyclic nitrogen mustard phosphamide ester (B518-ASTA) in experimental tumors of the rat. Nature 1958, 181:931.
-
(1958)
Nature
, vol.181
, pp. 931
-
-
Arnold, H.1
Bourseaux, F.2
Brock, N.3
-
137
-
-
84985841260
-
Ueber die Chemie neuer zytostatisch wirksamer N - Chloroaethyl-phosphorsa die;ureesterdiamide
-
Verlag der Wiener Medizinischen Akademie, Wien, K. Spitzy, H. Haschek (Eds.)
-
Arnold H. Ueber die Chemie neuer zytostatisch wirksamer N - Chloroaethyl-phosphorsäureesterdiamide. Proceedings of the Fifth International Congress on Chemotherapy 1967, 751-754. Verlag der Wiener Medizinischen Akademie, Wien. K. Spitzy, H. Haschek (Eds.).
-
(1967)
Proceedings of the Fifth International Congress on Chemotherapy
, pp. 751-754
-
-
Arnold, H.1
-
138
-
-
0018914018
-
The hypoxic tumor cell: a target for selective cancer chemotherapy
-
Kennedy K.A., Teicher B.A., Rockwell S., Sartorelli A.C. The hypoxic tumor cell: a target for selective cancer chemotherapy. Biochem. Pharmacol. 1980, 29:1-8.
-
(1980)
Biochem. Pharmacol.
, vol.29
, pp. 1-8
-
-
Kennedy, K.A.1
Teicher, B.A.2
Rockwell, S.3
Sartorelli, A.C.4
-
139
-
-
0022349983
-
Sulindac oxidation/reduction by microbial cultures; microbial models for mammalian metabolism
-
Davis P.J., Guenthner L.E. Sulindac oxidation/reduction by microbial cultures; microbial models for mammalian metabolism. Xenobiotica 1985, 15:845-857.
-
(1985)
Xenobiotica
, vol.15
, pp. 845-857
-
-
Davis, P.J.1
Guenthner, L.E.2
-
140
-
-
0026721021
-
P -(Methylsulfinyl)phenyl nitrogen mustard as a novel bioreductive prodrug selective against hypoxic tumors
-
Kwon C.-H., Blanco D.R., Baturay N. p -(Methylsulfinyl)phenyl nitrogen mustard as a novel bioreductive prodrug selective against hypoxic tumors. J. Med. Chem. 1992, 35:2137-2139.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2137-2139
-
-
Kwon, C.-H.1
Blanco, D.R.2
Baturay, N.3
-
141
-
-
0037448395
-
Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase
-
Cole C., Reigan P., Gbaj A., Edwards P.N., Douglas K.T., Stratford I.J., Freeman S., Jaffar M. Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J. Med. Chem. 2003, 46:207-209.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 207-209
-
-
Cole, C.1
Reigan, P.2
Gbaj, A.3
Edwards, P.N.4
Douglas, K.T.5
Stratford, I.J.6
Freeman, S.7
Jaffar, M.8
-
143
-
-
0021356993
-
Omeprazole in Zollinger-Ellison Syndrome
-
Lamers C.B.H.W., Lind T., Moberg S., Jansen J.B.M., OIbe L. Omeprazole in Zollinger-Ellison Syndrome. New Engl. J. Med. 1984, 310:758-761.
-
(1984)
New Engl. J. Med.
, vol.310
, pp. 758-761
-
-
Lamers, C.B.H.W.1
Lind, T.2
Moberg, S.3
Jansen, J.B.M.4
OIbe, L.5
-
145
-
-
0022523138
-
The mechanism of action of the gastric acid secretion inhibitoromeprazole
-
Lindberg P., Nordberg P., Alminger T., Brändström A., Wallmark B. The mechanism of action of the gastric acid secretion inhibitoromeprazole. J. Med. Chem. 1986, 33:1329-1685.
-
(1986)
J. Med. Chem.
, vol.33
, pp. 1329-1685
-
-
Lindberg, P.1
Nordberg, P.2
Alminger, T.3
Brändström, A.4
Wallmark, B.5
-
146
-
-
0016266032
-
Anti-inflammatoires non ste acute;roidiques: De acute;rive acute;s de l'acide phe acute;nyl-4-butyrique et phe acute;nyl-4, oxo-4, butyrique
-
Krausz F., Demarne H., Vaillant J., Brunaud M., Navarro J. Anti-inflammatoires non stéroidiques: Dérivés de l'acide phényl-4-butyrique et phényl-4, oxo-4, butyrique. Arzneim.-Forsch. (Drug Res.) 1974, 24(9a):1360-1364.
-
(1974)
Arzneim.-Forsch. (Drug Res.)
, vol.24
, Issue.9 A
, pp. 1360-1364
-
-
Krausz, F.1
Demarne, H.2
Vaillant, J.3
Brunaud, M.4
Navarro, J.5
-
147
-
-
0016266030
-
Metabolic and pharmacokinetic study of bucloxic acid
-
Gros P.M., Davi H.J., Chasseaud L.F., Hawkins D.R. Metabolic and pharmacokinetic study of bucloxic acid. Arzneim.-Forsch. (Drug Res.) 1974, 24(9a):1385-1390.
-
(1974)
Arzneim.-Forsch. (Drug Res.)
, vol.24
, Issue.9 A
, pp. 1385-1390
-
-
Gros, P.M.1
Davi, H.J.2
Chasseaud, L.F.3
Hawkins, D.R.4
-
148
-
-
0018902378
-
A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function
-
Kohler C., Tolman E., Wooding W., Ellenbogen L. A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function. Arzneim.-Forsch. (Drug Res.), 1980, 30:702-707.
-
(1980)
Arzneim.-Forsch. (Drug Res.),
, vol.30
, pp. 702-707
-
-
Kohler, C.1
Tolman, E.2
Wooding, W.3
Ellenbogen, L.4
-
149
-
-
0018850911
-
Disposition and metabolism of fenbufen in several laboratory animals
-
Chicarelli F.S., Eisner H.J., Van Lear G.E. Disposition and metabolism of fenbufen in several laboratory animals. Arzneim.-Forsch. (Drug Res.), 1980, 30:707-715.
-
(1980)
Arzneim.-Forsch. (Drug Res.),
, vol.30
, pp. 707-715
-
-
Chicarelli, F.S.1
Eisner, H.J.2
Van Lear, G.E.3
-
150
-
-
0016209639
-
Antiinflammatory properties of furobufen
-
Martel R.R., Rochefort J.G., Klicius J., Dobson T.A. Antiinflammatory properties of furobufen. Can. J. Physiol. Pharmacol. 1974, 52:669-673.
-
(1974)
Can. J. Physiol. Pharmacol.
, vol.52
, pp. 669-673
-
-
Martel, R.R.1
Rochefort, J.G.2
Klicius, J.3
Dobson, T.A.4
-
151
-
-
0023576062
-
Metabolic synthesis of arylacetic acid antiinflammatory drugs from arylhexenoic acids. 2. Indomethacin,
-
Gilard J.W., Belanger P. Metabolic synthesis of arylacetic acid antiinflammatory drugs from arylhexenoic acids. 2. Indomethacin,. J. Med. Chem. 1987, 30:2051-2058.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 2051-2058
-
-
Gilard, J.W.1
Belanger, P.2
-
152
-
-
2842598462
-
Stimulation of hepatic glutathione formation by administration of l -2-oxothiazolidine-4-carboxylate, a 5-oxo- l -prolinase substrate
-
Williamson J.M., Meister A. Stimulation of hepatic glutathione formation by administration of l -2-oxothiazolidine-4-carboxylate, a 5-oxo- l -prolinase substrate. Proc. Natl. Acad. Sci. USA 1981, 78(2):936-939.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, Issue.2
, pp. 936-939
-
-
Williamson, J.M.1
Meister, A.2
-
153
-
-
38149040881
-
The synthesis of S -acylthiamine derivatives and their stability
-
Matsukawa T., Yuruki S., Oka Y. The synthesis of S -acylthiamine derivatives and their stability. Ann. NY Acad Sci. 1962, 98:430-444.
-
(1962)
Ann. NY Acad Sci.
, vol.98
, pp. 430-444
-
-
Matsukawa, T.1
Yuruki, S.2
Oka, Y.3
-
154
-
-
0015040694
-
Thiamine propyl disulphide: absorption and utilization
-
Thomson A.D., Frank O., Baker H., Leevy C.M. Thiamine propyl disulphide: absorption and utilization. Ann. Int. Med. 1971, 74:529-534.
-
(1971)
Ann. Int. Med.
, vol.74
, pp. 529-534
-
-
Thomson, A.D.1
Frank, O.2
Baker, H.3
Leevy, C.M.4
-
155
-
-
0019843193
-
Site-specific, sustained release of drugs to the brain
-
Bodor N., Farag H.H., Brewster.M.E. Site-specific, sustained release of drugs to the brain. Science 1981, 214:1370-1372.
-
(1981)
Science
, vol.214
, pp. 1370-1372
-
-
Bodor, N.1
Farag, H.H.2
Brewster, M.E.3
-
156
-
-
0017887445
-
L'hydroxy e acute;thyl nicotinamide vecteur d'acides the acute;rapeutiquement actifs
-
Cousse H., Casadio S., Mouzin G. L'hydroxy éthyl nicotinamide vecteur d'acides thérapeutiquement actifs. Trav. Soc. Pharm. Montpellier 1978, 38:71-76.
-
(1978)
Trav. Soc. Pharm. Montpellier
, vol.38
, pp. 71-76
-
-
Cousse, H.1
Casadio, S.2
Mouzin, G.3
-
157
-
-
84882528724
-
Nouvelles formes modulées de médicaments utilisant les N -hydroxy alcoyl pyridine carboxamides comme vecteur
-
(May 2, 1977, to P. Fabre S.A.)
-
Casadio, S., Cousse, H., Mouzin, G. Nouvelles formes modulées de médicaments utilisant les N -hydroxy alcoyl pyridine carboxamides comme vecteur. Fr. Pat.NO. 77.13478 (May 2, 1977, to P. Fabre S.A.) 1977.
-
(1977)
Fr. Pat.NO. 77.13478
-
-
Casadio, S.1
Cousse, H.2
Mouzin, G.3
-
158
-
-
0018665270
-
Nicafenine, a new analgesic
-
Vezin J.C., Mouzin G., Cousse H., Casadio S. Nicafenine, a new analgesic. Arzneim.-Forsch. 1979, 29:1659-1661.
-
(1979)
Arzneim.-Forsch.
, vol.29
, pp. 1659-1661
-
-
Vezin, J.C.1
Mouzin, G.2
Cousse, H.3
Casadio, S.4
-
159
-
-
0018854303
-
Potential hazards of the pro-drug approach
-
Gorrod J.W. Potential hazards of the pro-drug approach. Chem. Ind. 1980, 457-461.
-
(1980)
Chem. Ind.
, pp. 457-461
-
-
Gorrod, J.W.1
-
160
-
-
0000616228
-
Prodrugs of l -cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids,
-
Roberts J.C., Nagasawa H.T., Zera R.T., Fricke R.F., Goon D.J.W. Prodrugs of l -cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids,. J. Med. Chem. 1987, 30:1891-1896.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 1891-1896
-
-
Roberts, J.C.1
Nagasawa, H.T.2
Zera, R.T.3
Fricke, R.F.4
Goon, D.J.W.5
-
161
-
-
0018194551
-
Synthesis and antihypertensive activity of some ester progenitors of methyldopa
-
Saari W.S., Freedman M.B., Hartman R.D., King S.W., Raab A.W., Randall W.C., Engelhart E.L., Hirschmann R., Rosegay A., Ludden C.T., Scriabine A. Synthesis and antihypertensive activity of some ester progenitors of methyldopa. J. Med. Chem. 1978, 21:746-753.
-
(1978)
J. Med. Chem.
, vol.21
, pp. 746-753
-
-
Saari, W.S.1
Freedman, M.B.2
Hartman, R.D.3
King, S.W.4
Raab, A.W.5
Randall, W.C.6
Engelhart, E.L.7
Hirschmann, R.8
Rosegay, A.9
Ludden, C.T.10
Scriabine, A.11
-
162
-
-
0018240526
-
Evaluation of succinimidoethyl and pivaloyloxyethyl esters as progenitors of methyldopa in man, rhesus monkey, dog, and rat
-
Vickers S., Duncan C.A., White S.D., Breault G.O., Boyds R.B., Shepper d.P.J., Tempero K.F. Evaluation of succinimidoethyl and pivaloyloxyethyl esters as progenitors of methyldopa in man, rhesus monkey, dog, and rat. Drug Metab. Dispos. 1978, 6:640-646.
-
(1978)
Drug Metab. Dispos.
, vol.6
, pp. 640-646
-
-
Vickers, S.1
Duncan, C.A.2
White, S.D.3
Breault, G.O.4
Boyds, R.B.5
Shepper, D.6
Tempero, K.F.7
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