메뉴 건너뛰기




Volumn 23, Issue 4, 2009, Pages 507-523

The search for lupus biomarkers

Author keywords

biomarkers; diagnosis; disease activity; genetics; lupus; SLE

Indexed keywords

BIOLOGICAL MARKER; CD27 ANTIGEN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q ANTIBODY; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C4D; DOUBLE STRANDED DNA ANTIBODY; FC RECEPTOR; HLA ANTIGEN; INTERFERON; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 21; INTERLEUKIN 6; LA ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; MANNOSE BINDING LECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; N METHYL DEXTRO ASPARTIC ACID; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; OSTEOPONTIN; RO ANTIBODY; STAT4 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

EID: 67649811064     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.berh.2009.01.008     Document Type: Review
Times cited : (68)

References (129)
  • 1
    • 14244250736 scopus 로고    scopus 로고
    • Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients
    • Sherer Y., Gorstein A., Fritzler M.J., et al. Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Semin Arthritis Rheum 34 2 (2004) 501-537
    • (2004) Semin Arthritis Rheum , vol.34 , Issue.2 , pp. 501-537
    • Sherer, Y.1    Gorstein, A.2    Fritzler, M.J.3
  • 2
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Rahman A., and Isenberg D.A. Systemic lupus erythematosus. N Engl J Med 358 9 (2008) 929-939
    • (2008) N Engl J Med , vol.358 , Issue.9 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 3
    • 33744945033 scopus 로고    scopus 로고
    • Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus
    • Cook H.T., and Botto M. Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus. Nat Clin Pract Rheumatol 2 6 (2006) 330-337
    • (2006) Nat Clin Pract Rheumatol , vol.2 , Issue.6 , pp. 330-337
    • Cook, H.T.1    Botto, M.2
  • 4
    • 2642552411 scopus 로고    scopus 로고
    • Biomarkers in systemic lupus erythematosus. I. General overview of biomarkers and their applicability
    • Illei G.G., Tackey E., Lapteva L., et al. Biomarkers in systemic lupus erythematosus. I. General overview of biomarkers and their applicability. Arthritis Rheum 50 (2004) 1709-1720
    • (2004) Arthritis Rheum , vol.50 , pp. 1709-1720
    • Illei, G.G.1    Tackey, E.2    Lapteva, L.3
  • 5
    • 3142729924 scopus 로고    scopus 로고
    • Biomarkers in systemic lupus erythematosus. II. Markers of disease activity
    • Illei G.G., Tackey E., Lapteva L., et al. Biomarkers in systemic lupus erythematosus. II. Markers of disease activity. Arthritis Rheum 50 (2004) 2048-2065
    • (2004) Arthritis Rheum , vol.50 , pp. 2048-2065
    • Illei, G.G.1    Tackey, E.2    Lapteva, L.3
  • 6
    • 34249110312 scopus 로고    scopus 로고
    • Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus
    • Jonsen A., Gullstrand B., Guner N., et al. Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus. Lupus 16 4 (2007) 245-253
    • (2007) Lupus , vol.16 , Issue.4 , pp. 245-253
    • Jonsen, A.1    Gullstrand, B.2    Guner, N.3
  • 8
    • 0034816964 scopus 로고    scopus 로고
    • Delineating the genetic basis of systemic lupus erythematosus
    • Wakeland E.K., Liu K., Graham R.R., et al. Delineating the genetic basis of systemic lupus erythematosus. Immunity 15 (2001) 397-408
    • (2001) Immunity , vol.15 , pp. 397-408
    • Wakeland, E.K.1    Liu, K.2    Graham, R.R.3
  • 9
    • 7044223152 scopus 로고    scopus 로고
    • Genetics of human systemic lupus erythematosus: the emerging picture
    • Nath S.K., Kilpatrick J., and Harley J.B. Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol 16 6 (2004) 794-800
    • (2004) Curr Opin Immunol , vol.16 , Issue.6 , pp. 794-800
    • Nath, S.K.1    Kilpatrick, J.2    Harley, J.B.3
  • 10
    • 34247485974 scopus 로고    scopus 로고
    • Significance of MHC class II haplotypes and IgG Fc receptors in SLE
    • Hirose S., Jiang Y., Nishimura H., et al. Significance of MHC class II haplotypes and IgG Fc receptors in SLE. Springer Semin Immunopathol 28 2 (2006) 163-174
    • (2006) Springer Semin Immunopathol , vol.28 , Issue.2 , pp. 163-174
    • Hirose, S.1    Jiang, Y.2    Nishimura, H.3
  • 11
    • 27344457455 scopus 로고    scopus 로고
    • Genetics of susceptibility and severity in systemic lupus erythematosus
    • [see comment]
    • Croker J.A., and Kimberly R.P. Genetics of susceptibility and severity in systemic lupus erythematosus. [see comment]. Curr Opin Rheumatol 17 5 (2005) 529-537
    • (2005) Curr Opin Rheumatol , vol.17 , Issue.5 , pp. 529-537
    • Croker, J.A.1    Kimberly, R.P.2
  • 12
    • 34447099218 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease
    • Fairhurst A.M., Wandstrat A.E., and Wakeland E.K. Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv Immunol 92 (2006) 1-69
    • (2006) Adv Immunol , vol.92 , pp. 1-69
    • Fairhurst, A.M.1    Wandstrat, A.E.2    Wakeland, E.K.3
  • 13
    • 37349076340 scopus 로고    scopus 로고
    • General aspects of the genetics of SLE
    • Rhodes B., and Vyse T.J. General aspects of the genetics of SLE. Autoimmunity 40 8 (2007) 550-559
    • (2007) Autoimmunity , vol.40 , Issue.8 , pp. 550-559
    • Rhodes, B.1    Vyse, T.J.2
  • 14
    • 0033752720 scopus 로고    scopus 로고
    • Systemic lupus erythematosus, complement deficiency, and apoptosis
    • Pickering M.C., Botto M., Taylor P.R., et al. Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol 76 (2000) 227-324
    • (2000) Adv Immunol , vol.76 , pp. 227-324
    • Pickering, M.C.1    Botto, M.2    Taylor, P.R.3
  • 15
    • 1442288762 scopus 로고    scopus 로고
    • The intricate role of complement component C4 in human systemic lupus erythematosus
    • Yang Y., Chung E.K., Zhou B., et al. The intricate role of complement component C4 in human systemic lupus erythematosus. Curr Dir Autoimmun 7 (2004) 98-132
    • (2004) Curr Dir Autoimmun , vol.7 , pp. 98-132
    • Yang, Y.1    Chung, E.K.2    Zhou, B.3
  • 16
    • 0021472477 scopus 로고
    • A comparison of the properties of two classes, C4A and C4B, of the human complement component C4
    • Law S.K.A., Dodds A.W., and Porter R.R. A comparison of the properties of two classes, C4A and C4B, of the human complement component C4. EMBO J 3 (1984) 1819-1823
    • (1984) EMBO J , vol.3 , pp. 1819-1823
    • Law, S.K.A.1    Dodds, A.W.2    Porter, R.R.3
  • 17
    • 0036782903 scopus 로고    scopus 로고
    • Determining the one, two, three, or four long and short loci of human complement C4 in a major histocompatibility complex haplotype encoding C4A or C4B proteins
    • Chung E.K., Yang Y., Rupert K.L., et al. Determining the one, two, three, or four long and short loci of human complement C4 in a major histocompatibility complex haplotype encoding C4A or C4B proteins. Am J Hum Genet 71 4 (2002) 810-822
    • (2002) Am J Hum Genet , vol.71 , Issue.4 , pp. 810-822
    • Chung, E.K.1    Yang, Y.2    Rupert, K.L.3
  • 18
    • 34250841166 scopus 로고    scopus 로고
    • Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans
    • Yang Y., Chung E.K., Wu Y.L., et al. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Am J Hum Genet 80 6 (2007) 1037-1054
    • (2007) Am J Hum Genet , vol.80 , Issue.6 , pp. 1037-1054
    • Yang, Y.1    Chung, E.K.2    Wu, Y.L.3
  • 19
    • 34249815834 scopus 로고    scopus 로고
    • FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    • Fanciulli M., Norsworthy P.J., Petretto E., et al. FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet 39 6 (2007) 721-723
    • (2007) Nat Genet , vol.39 , Issue.6 , pp. 721-723
    • Fanciulli, M.1    Norsworthy, P.J.2    Petretto, E.3
  • 20
    • 4143105691 scopus 로고    scopus 로고
    • Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE
    • Kyogoku C., Langefeld C.D., Ortmann W.A., et al. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet 75 3 (2004) 504-507
    • (2004) Am J Hum Genet , vol.75 , Issue.3 , pp. 504-507
    • Kyogoku, C.1    Langefeld, C.D.2    Ortmann, W.A.3
  • 21
    • 33845578510 scopus 로고    scopus 로고
    • The PTPN22 C1858T functional polymorphism and autoimmune diseases-a meta-analysis
    • Lee Y.H., Rho Y.H., Choi S.J., et al. The PTPN22 C1858T functional polymorphism and autoimmune diseases-a meta-analysis. Rheumatology 46 1 (2007) 49-56
    • (2007) Rheumatology , vol.46 , Issue.1 , pp. 49-56
    • Lee, Y.H.1    Rho, Y.H.2    Choi, S.J.3
  • 22
    • 23644432242 scopus 로고    scopus 로고
    • Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
    • Wu H., Cantor R.M., Graham D.S., et al. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis Rheum 52 8 (2005) 2396-2402
    • (2005) Arthritis Rheum , vol.52 , Issue.8 , pp. 2396-2402
    • Wu, H.1    Cantor, R.M.2    Graham, D.S.3
  • 23
    • 20144387851 scopus 로고    scopus 로고
    • Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes
    • Criswell L.A., Pfeiffer K.A., Lum R.F., et al. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet 76 4 (2005) 561-571
    • (2005) Am J Hum Genet , vol.76 , Issue.4 , pp. 561-571
    • Criswell, L.A.1    Pfeiffer, K.A.2    Lum, R.F.3
  • 24
    • 37449023760 scopus 로고    scopus 로고
    • PTPN22: its role in SLE and autoimmunity
    • Chung S.A., and Criswell L.A. PTPN22: its role in SLE and autoimmunity. Autoimmunity 40 8 (2007) 582-590
    • (2007) Autoimmunity , vol.40 , Issue.8 , pp. 582-590
    • Chung, S.A.1    Criswell, L.A.2
  • 25
    • 0018775078 scopus 로고
    • Immune interferon in the circulation of patients with autoimmune disease
    • Hooks J.J., Moutsopoulos H.M., Geis S.A., et al. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med 301 1 (1979) 5-8
    • (1979) N Engl J Med , vol.301 , Issue.1 , pp. 5-8
    • Hooks, J.J.1    Moutsopoulos, H.M.2    Geis, S.A.3
  • 26
    • 37349039478 scopus 로고    scopus 로고
    • The genetics and biology of Irf5-mediated signaling in lupus
    • Kozyrev S.V., and Alarcon-Riquelme M.E. The genetics and biology of Irf5-mediated signaling in lupus. Autoimmunity 40 8 (2007) 591-601
    • (2007) Autoimmunity , vol.40 , Issue.8 , pp. 591-601
    • Kozyrev, S.V.1    Alarcon-Riquelme, M.E.2
  • 27
    • 13844292408 scopus 로고    scopus 로고
    • Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
    • Sigurdsson S., Nordmark G., Goring H.H., et al. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 76 3 (2005) 528-537
    • (2005) Am J Hum Genet , vol.76 , Issue.3 , pp. 528-537
    • Sigurdsson, S.1    Nordmark, G.2    Goring, H.H.3
  • 28
    • 33646368404 scopus 로고    scopus 로고
    • A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
    • Graham R.R., Kozyrev S.V., Baechler E.C., et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 38 5 (2006) 550-555
    • (2006) Nat Genet , vol.38 , Issue.5 , pp. 550-555
    • Graham, R.R.1    Kozyrev, S.V.2    Baechler, E.C.3
  • 29
    • 42549152933 scopus 로고    scopus 로고
    • Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans
    • Kelly J.A., Kelley J.M., Kaufman K.M., et al. Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans. Genes Immun 9 3 (2008) 187-194
    • (2008) Genes Immun , vol.9 , Issue.3 , pp. 187-194
    • Kelly, J.A.1    Kelley, J.M.2    Kaufman, K.M.3
  • 30
    • 40549100665 scopus 로고    scopus 로고
    • Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms
    • Kawasaki A., Kyogoku C., Ohashi J., et al. Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms. Arthritis Rheum 58 3 (2008) 826-834
    • (2008) Arthritis Rheum , vol.58 , Issue.3 , pp. 826-834
    • Kawasaki, A.1    Kyogoku, C.2    Ohashi, J.3
  • 31
    • 34249860408 scopus 로고    scopus 로고
    • Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
    • Graham R.R., Kyogoku C., Sigurdsson S., et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A 104 16 (2007) 6758-6763
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.16 , pp. 6758-6763
    • Graham, R.R.1    Kyogoku, C.2    Sigurdsson, S.3
  • 32
    • 40649121122 scopus 로고    scopus 로고
    • Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
    • Sigurdsson S., Goring H.H., Kristjansdottir G., et al. Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum Mol Genet 17 6 (2008) 872-881
    • (2008) Hum Mol Genet , vol.17 , Issue.6 , pp. 872-881
    • Sigurdsson, S.1    Goring, H.H.2    Kristjansdottir, G.3
  • 33
    • 43949086215 scopus 로고    scopus 로고
    • Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis
    • Dieguez-Gonzalez R., Calaza M., Perez-Pampin E., et al. Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis. Arthritis Rheum 58 5 (2008) 1264-1274
    • (2008) Arthritis Rheum , vol.58 , Issue.5 , pp. 1264-1274
    • Dieguez-Gonzalez, R.1    Calaza, M.2    Perez-Pampin, E.3
  • 34
    • 55249101270 scopus 로고    scopus 로고
    • STAT4: genetics, mechanisms, and implications for autoimmunity
    • Korman B.D., Kastner D.L., Gregersen P.K., et al. STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep 8 5 (2008) 398-403
    • (2008) Curr Allergy Asthma Rep , vol.8 , Issue.5 , pp. 398-403
    • Korman, B.D.1    Kastner, D.L.2    Gregersen, P.K.3
  • 35
    • 34548427925 scopus 로고    scopus 로고
    • STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    • Remmers E.F., Plenge R.M., Lee A.T., et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 357 10 (2007) 977-986
    • (2007) N Engl J Med , vol.357 , Issue.10 , pp. 977-986
    • Remmers, E.F.1    Plenge, R.M.2    Lee, A.T.3
  • 36
    • 47249119222 scopus 로고    scopus 로고
    • Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population
    • Kobayashi S., Ikari K., Kaneko H., et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum 58 7 (2008) 1940-1946
    • (2008) Arthritis Rheum , vol.58 , Issue.7 , pp. 1940-1946
    • Kobayashi, S.1    Ikari, K.2    Kaneko, H.3
  • 37
    • 44849140782 scopus 로고    scopus 로고
    • STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians
    • Palomino-Morales R.J., Rojas-Villarraga A., Gonzalez C.I., et al. STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun 9 4 (2008) 379-382
    • (2008) Genes Immun , vol.9 , Issue.4 , pp. 379-382
    • Palomino-Morales, R.J.1    Rojas-Villarraga, A.2    Gonzalez, C.I.3
  • 38
    • 51849120731 scopus 로고    scopus 로고
    • Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases
    • Martinez A., Varade J., Marquez A., et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 58 9 (2008) 2598-2602
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2598-2602
    • Martinez, A.1    Varade, J.2    Marquez, A.3
  • 39
    • 0347917232 scopus 로고    scopus 로고
    • Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus
    • Russell A.I., Cunninghame Graham D.S., Shepherd C., et al. Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet 13 1 (2004) 137-147
    • (2004) Hum Mol Genet , vol.13 , Issue.1 , pp. 137-147
    • Russell, A.I.1    Cunninghame Graham, D.S.2    Shepherd, C.3
  • 40
    • 0033560931 scopus 로고    scopus 로고
    • PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus
    • Tsao B.P., Cantor R.M., Grossman J.M., et al. PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. J Clin Invest 103 8 (1999) 1135-1140
    • (1999) J Clin Invest , vol.103 , Issue.8 , pp. 1135-1140
    • Tsao, B.P.1    Cantor, R.M.2    Grossman, J.M.3
  • 41
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • International Consortium for Systemic Lupus Erythematosus G, Harley J.B., Alarcon-Riquelme M.E., et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40 2 (2008) 204-210
    • (2008) Nat Genet , vol.40 , Issue.2 , pp. 204-210
    • International Consortium for Systemic Lupus Erythematosus G1    Harley, J.B.2    Alarcon-Riquelme, M.E.3
  • 42
    • 40049108936 scopus 로고    scopus 로고
    • Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    • Hom G., Graham R.R., Modrek B., et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358 9 (2008) 900-909
    • (2008) N Engl J Med , vol.358 , Issue.9 , pp. 900-909
    • Hom, G.1    Graham, R.R.2    Modrek, B.3
  • 43
    • 2942726299 scopus 로고    scopus 로고
    • Predictive value of autoantibodies for activity of systemic lupus erythematosus
    • Reveille J.D. Predictive value of autoantibodies for activity of systemic lupus erythematosus. Lupus 13 5 (2004) 290-297
    • (2004) Lupus , vol.13 , Issue.5 , pp. 290-297
    • Reveille, J.D.1
  • 44
    • 8444228924 scopus 로고    scopus 로고
    • Measurement of erythrocyte C4d and complement receptor 1 in the diagnosis of systemic lupus erythematosus
    • Manzi S., Navratil J.S., Ruffing M.J., et al. Measurement of erythrocyte C4d and complement receptor 1 in the diagnosis of systemic lupus erythematosus. Arthritis Rheum 50 (2004) 3596-3604
    • (2004) Arthritis Rheum , vol.50 , pp. 3596-3604
    • Manzi, S.1    Navratil, J.S.2    Ruffing, M.J.3
  • 45
    • 32444432716 scopus 로고    scopus 로고
    • Platelet C4d is highly specific for systemic lupus erythematosus
    • Navratil J.S., Manzi S., Kao A.H., et al. Platelet C4d is highly specific for systemic lupus erythematosus. Arthritis Rheum 54 2 (2006) 670-674
    • (2006) Arthritis Rheum , vol.54 , Issue.2 , pp. 670-674
    • Navratil, J.S.1    Manzi, S.2    Kao, A.H.3
  • 46
    • 0024419180 scopus 로고
    • Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus
    • Liang M.H., Socher S.A., Larson M.G., et al. Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum 32 (1989) 1107-1118
    • (1989) Arthritis Rheum , vol.32 , pp. 1107-1118
    • Liang, M.H.1    Socher, S.A.2    Larson, M.G.3
  • 47
    • 0026777352 scopus 로고
    • Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE
    • Bombardier C., Gladman D.D., Urowitz M.B., et al. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35 (1992) 630-640
    • (1992) Arthritis Rheum , vol.35 , pp. 630-640
    • Bombardier, C.1    Gladman, D.D.2    Urowitz, M.B.3
  • 48
    • 0027325557 scopus 로고
    • The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus
    • Hay E.M., Bacon P.A., Gordon C., et al. The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus. Q J Med 86 7 (1993) 447-458
    • (1993) Q J Med , vol.86 , Issue.7 , pp. 447-458
    • Hay, E.M.1    Bacon, P.A.2    Gordon, C.3
  • 49
    • 2942547330 scopus 로고    scopus 로고
    • Complement as a source of biomarkers in systemic lupus erythematosus: past, present, and future
    • Liu C.-C., Ahearn J.M., and Manzi S. Complement as a source of biomarkers in systemic lupus erythematosus: past, present, and future. Curr Rheumatol Rep 6 (2004) 85-88
    • (2004) Curr Rheumatol Rep , vol.6 , pp. 85-88
    • Liu, C.-C.1    Ahearn, J.M.2    Manzi, S.3
  • 50
    • 34447320202 scopus 로고    scopus 로고
    • Fifty years of anti-ds DNA antibodies: are we approaching journey's end?
    • Isenberg D.A., Manson J.J., Ehrenstein M.R., et al. Fifty years of anti-ds DNA antibodies: are we approaching journey's end?. Rheumatology 46 7 (2007) 1052-1056
    • (2007) Rheumatology , vol.46 , Issue.7 , pp. 1052-1056
    • Isenberg, D.A.1    Manson, J.J.2    Ehrenstein, M.R.3
  • 51
    • 0035555161 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity
    • Lipsky P.E. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol 2 9 (2001) 764-766
    • (2001) Nat Immunol , vol.2 , Issue.9 , pp. 764-766
    • Lipsky, P.E.1
  • 52
    • 0034669990 scopus 로고    scopus 로고
    • Disturbed peripheral B lymphocyte homeostasis in systmic lupus erythematosus
    • Odendahl M., Jocobi A., Hansen A., et al. Disturbed peripheral B lymphocyte homeostasis in systmic lupus erythematosus. J Immunol 165 (2000) 5970-5979
    • (2000) J Immunol , vol.165 , pp. 5970-5979
    • Odendahl, M.1    Jocobi, A.2    Hansen, A.3
  • 53
    • 0035881627 scopus 로고    scopus 로고
    • Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
    • Arce E., Jackson D.G., Gill M.A., et al. Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. J Immunol 167 4 (2001) 2361-2369
    • (2001) J Immunol , vol.167 , Issue.4 , pp. 2361-2369
    • Arce, E.1    Jackson, D.G.2    Gill, M.A.3
  • 54
    • 0037991063 scopus 로고    scopus 로고
    • Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    • Jacobi A.M., Odendahl M., Reiter K., et al. Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 48 5 (2003) 1332-1342
    • (2003) Arthritis Rheum , vol.48 , Issue.5 , pp. 1332-1342
    • Jacobi, A.M.1    Odendahl, M.2    Reiter, K.3
  • 55
    • 26844559344 scopus 로고    scopus 로고
    • Reticulocytes bearing C4d as biomarkers of disease activity for systemic lupus eryhematosus
    • Liu C.C., Manzi S., Kao A.H., et al. Reticulocytes bearing C4d as biomarkers of disease activity for systemic lupus eryhematosus. Arthritis Rheum 52 (2005) 3087-3099
    • (2005) Arthritis Rheum , vol.52 , pp. 3087-3099
    • Liu, C.C.1    Manzi, S.2    Kao, A.H.3
  • 56
    • 0344492212 scopus 로고    scopus 로고
    • Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    • Baechler E.C., Batliwalla F.M., Karypis G., et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A 100 (2003) 2610-2615
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2610-2615
    • Baechler, E.C.1    Batliwalla, F.M.2    Karypis, G.3
  • 57
    • 4344617762 scopus 로고    scopus 로고
    • Interferon-alpha in systemic lupus erythematosus
    • Crow M.K., and Kirou K.A. Interferon-alpha in systemic lupus erythematosus. Curr Opin Rheumatol 16 (2004) 541-547
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 541-547
    • Crow, M.K.1    Kirou, K.A.2
  • 58
    • 32444451688 scopus 로고    scopus 로고
    • The type I interferon system in systemic lupus erythematosus
    • Ronnblom L., Eloranta M.L., and Alm G.V. The type I interferon system in systemic lupus erythematosus. Arthritis Rheum 54 2 (2006) 408-420
    • (2006) Arthritis Rheum , vol.54 , Issue.2 , pp. 408-420
    • Ronnblom, L.1    Eloranta, M.L.2    Alm, G.V.3
  • 59
    • 33750378268 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: all roads lead to type I interferons
    • Pascual V., Farkas L., and Banchereau J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Rheumatol 18 6 (2006) 676-682
    • (2006) Curr Opin Rheumatol , vol.18 , Issue.6 , pp. 676-682
    • Pascual, V.1    Farkas, L.2    Banchereau, J.3
  • 60
    • 0141986842 scopus 로고    scopus 로고
    • Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray
    • Han G.M., Chen S.L., Shen N., et al. Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray. Genes Immun 4 3 (2003) 177-186
    • (2003) Genes Immun , vol.4 , Issue.3 , pp. 177-186
    • Han, G.M.1    Chen, S.L.2    Shen, N.3
  • 61
    • 0037451167 scopus 로고    scopus 로고
    • Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    • Bennett L., Palucka K.A., Arce E., et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 197 (2003) 711-723
    • (2003) J Exp Med , vol.197 , pp. 711-723
    • Bennett, L.1    Palucka, K.A.2    Arce, E.3
  • 62
    • 18644384042 scopus 로고    scopus 로고
    • Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
    • Kirou K.A., Lee C., George S., et al. Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis Rheum 52 5 (2005) 1491-1503
    • (2005) Arthritis Rheum , vol.52 , Issue.5 , pp. 1491-1503
    • Kirou, K.A.1    Lee, C.2    George, S.3
  • 63
    • 33845877145 scopus 로고    scopus 로고
    • Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus
    • Bauer J.W., Baechler E.C., Petri M., et al. Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Med 3 12 (2006) e491
    • (2006) PLoS Med , vol.3 , Issue.12
    • Bauer, J.W.1    Baechler, E.C.2    Petri, M.3
  • 64
    • 33749331301 scopus 로고    scopus 로고
    • Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
    • Feng X., Wu H., Grossman J.M., et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 54 9 (2006) 2951-2962
    • (2006) Arthritis Rheum , vol.54 , Issue.9 , pp. 2951-2962
    • Feng, X.1    Wu, H.2    Grossman, J.M.3
  • 65
    • 34147161266 scopus 로고    scopus 로고
    • Association of serum MIP-1alpha, MIP-1beta, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus
    • Vila L.M., Molina M.J., Mayor A.M., et al. Association of serum MIP-1alpha, MIP-1beta, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus. Clin Rheumatol 26 5 (2007) 718-722
    • (2007) Clin Rheumatol , vol.26 , Issue.5 , pp. 718-722
    • Vila, L.M.1    Molina, M.J.2    Mayor, A.M.3
  • 66
    • 47949089923 scopus 로고    scopus 로고
    • Association of a gene expression profile from whole blood with disease activity in systemic lupus erythaematosus
    • Nikpour M., Dempsey A.A., Urowitz M.B., et al. Association of a gene expression profile from whole blood with disease activity in systemic lupus erythaematosus. Ann Rheum Dis 67 8 (2008) 1069-1075
    • (2008) Ann Rheum Dis , vol.67 , Issue.8 , pp. 1069-1075
    • Nikpour, M.1    Dempsey, A.A.2    Urowitz, M.B.3
  • 67
    • 10444248118 scopus 로고    scopus 로고
    • Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus
    • Kirou K.A., Lee C., George S., et al. Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus. Arthritis Rheum 50 12 (2004) 3958-3967
    • (2004) Arthritis Rheum , vol.50 , Issue.12 , pp. 3958-3967
    • Kirou, K.A.1    Lee, C.2    George, S.3
  • 68
    • 67649800767 scopus 로고    scopus 로고
    • Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus
    • (online publication; Sept. 4)
    • Landolt-Marticorena C., Bonventi G., Lubovich A., et al. Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus. Ann Rheum Dis (2008) (online publication; Sept. 4)
    • (2008) Ann Rheum Dis
    • Landolt-Marticorena, C.1    Bonventi, G.2    Lubovich, A.3
  • 69
    • 33749346381 scopus 로고    scopus 로고
    • The systemic lupus erythematosus interferon signature is associated with current activity and is also predictive of hematologic and mucocutaneous disease activity at the next visit
    • Petri M., Tesfasyone H., Singh S., et al. The systemic lupus erythematosus interferon signature is associated with current activity and is also predictive of hematologic and mucocutaneous disease activity at the next visit. Arthritis Rheum 52 9 Suppl (2005) S464
    • (2005) Arthritis Rheum , vol.52 , Issue.9 SUPPL
    • Petri, M.1    Tesfasyone, H.2    Singh, S.3
  • 70
    • 33749341804 scopus 로고    scopus 로고
    • Gene signatures in peripheral blood predict future disease activity in patients with systemic lupus erythematosus
    • Baechler E.C., Batliwalla F., Ortmann W.A., et al. Gene signatures in peripheral blood predict future disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 52 9 Suppl. (2005) S700
    • (2005) Arthritis Rheum , vol.52 , Issue.9 SUPPL
    • Baechler, E.C.1    Batliwalla, F.2    Ortmann, W.A.3
  • 71
    • 51849117301 scopus 로고    scopus 로고
    • The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus
    • Kariuki S.N., Crow M.K., and Niewold T.B. The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus. Arthritis Rheum 58 9 (2008) 2813-2823
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2813-2823
    • Kariuki, S.N.1    Crow, M.K.2    Niewold, T.B.3
  • 72
    • 49449104525 scopus 로고    scopus 로고
    • Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients
    • Niewold T.B., Kelly J.A., Flesch M.H., et al. Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients. Arthritis Rheum 58 8 (2008) 2481-2487
    • (2008) Arthritis Rheum , vol.58 , Issue.8 , pp. 2481-2487
    • Niewold, T.B.1    Kelly, J.A.2    Flesch, M.H.3
  • 73
    • 44849085476 scopus 로고    scopus 로고
    • The innate immune system in SLE: type I interferons and dendritic cells
    • Ronnblom L., and Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 17 5 (2008) 394-399
    • (2008) Lupus , vol.17 , Issue.5 , pp. 394-399
    • Ronnblom, L.1    Pascual, V.2
  • 74
    • 40549128298 scopus 로고    scopus 로고
    • Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells
    • Yan B., Ye S., Chen G., et al. Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells. Arthritis Rheum 58 3 (2008) 801-812
    • (2008) Arthritis Rheum , vol.58 , Issue.3 , pp. 801-812
    • Yan, B.1    Ye, S.2    Chen, G.3
  • 75
    • 36049038869 scopus 로고    scopus 로고
    • Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus
    • Lee P.Y., Li Y., Richards H.B., et al. Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis Rheum 56 11 (2007) 3759-3769
    • (2007) Arthritis Rheum , vol.56 , Issue.11 , pp. 3759-3769
    • Lee, P.Y.1    Li, Y.2    Richards, H.B.3
  • 76
    • 35548948085 scopus 로고    scopus 로고
    • Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis
    • Denny M.F., Thacker S., Mehta H., et al. Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood 110 8 (2007) 2907-2915
    • (2007) Blood , vol.110 , Issue.8 , pp. 2907-2915
    • Denny, M.F.1    Thacker, S.2    Mehta, H.3
  • 77
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore P.A., Belvedere O., Orr A., et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285 5425 (1999) 260-263
    • (1999) Science , vol.285 , Issue.5425 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3
  • 78
    • 0035175146 scopus 로고    scopus 로고
    • Synthesis and release of B-lymphocyte stimulator from myeloid cells
    • Nardelli B., Belvedere O., Roschke V., et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97 1 (2001) 198-204
    • (2001) Blood , vol.97 , Issue.1 , pp. 198-204
    • Nardelli, B.1    Belvedere, O.2    Roschke, V.3
  • 79
    • 17344380531 scopus 로고    scopus 로고
    • TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
    • Gross J.A., Johnston J., Mudri S., et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404 6781 (2000) 995-999
    • (2000) Nature , vol.404 , Issue.6781 , pp. 995-999
    • Gross, J.A.1    Johnston, J.2    Mudri, S.3
  • 80
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay F., Woodcock S.A., Lawton P., et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 190 11 (1999) 1697-1710
    • (1999) J Exp Med , vol.190 , Issue.11 , pp. 1697-1710
    • Mackay, F.1    Woodcock, S.A.2    Lawton, P.3
  • 81
    • 0035167632 scopus 로고    scopus 로고
    • Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus
    • Zhang J., Roschke V., Baker K.P., et al. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol 166 1 (2001) 6-10
    • (2001) J Immunol , vol.166 , Issue.1 , pp. 6-10
    • Zhang, J.1    Roschke, V.2    Baker, K.P.3
  • 82
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
    • Cheema G.S., Roschke V., Hilbert D.M., et al. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 44 6 (2001) 1313-1319
    • (2001) Arthritis Rheum , vol.44 , Issue.6 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3
  • 83
    • 23744476832 scopus 로고    scopus 로고
    • BAFF overexpression is associated with autoantibody production in autoimmune diseases
    • Pers J.O., Daridon C., Devauchelle V., et al. BAFF overexpression is associated with autoantibody production in autoimmune diseases. Ann N Y Acad Sci 1050 (2005) 34-39
    • (2005) Ann N Y Acad Sci , vol.1050 , pp. 34-39
    • Pers, J.O.1    Daridon, C.2    Devauchelle, V.3
  • 84
    • 33750526860 scopus 로고    scopus 로고
    • B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time
    • Becker-Merok A., Nikolaisen C., and Nossent H.C. B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time. Lupus 15 9 (2006) 570-576
    • (2006) Lupus , vol.15 , Issue.9 , pp. 570-576
    • Becker-Merok, A.1    Nikolaisen, C.2    Nossent, H.C.3
  • 85
    • 49649119208 scopus 로고    scopus 로고
    • Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B
    • Harigai M., Kawamoto M., Hara M., et al. Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Rheumatol 181 3 (2008) 2211-2219
    • (2008) J Rheumatol , vol.181 , Issue.3 , pp. 2211-2219
    • Harigai, M.1    Kawamoto, M.2    Hara, M.3
  • 86
    • 10744224617 scopus 로고    scopus 로고
    • B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations
    • Stohl W., Metyas S., Tan S.M., et al. B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis Rheum 48 12 (2003) 3475-3486
    • (2003) Arthritis Rheum , vol.48 , Issue.12 , pp. 3475-3486
    • Stohl, W.1    Metyas, S.2    Tan, S.M.3
  • 87
    • 49449092839 scopus 로고    scopus 로고
    • Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    • Petri M., Stohl W., Chatham W., et al. Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum 58 8 (2008) 2453-2459
    • (2008) Arthritis Rheum , vol.58 , Issue.8 , pp. 2453-2459
    • Petri, M.1    Stohl, W.2    Chatham, W.3
  • 88
    • 0028949892 scopus 로고
    • Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders
    • Stuart R.A., Littlewood A.J., Maddison P.J., et al. Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders. Clin Exp Rheumatol 13 1 (1995) 17-22
    • (1995) Clin Exp Rheumatol , vol.13 , Issue.1 , pp. 17-22
    • Stuart, R.A.1    Littlewood, A.J.2    Maddison, P.J.3
  • 89
    • 0028801050 scopus 로고
    • Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity
    • Houssiau F.A., Lefebvre C., Vanden Berghe M., et al. Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity. Lupus 4 5 (1995) 393-395
    • (1995) Lupus , vol.4 , Issue.5 , pp. 393-395
    • Houssiau, F.A.1    Lefebvre, C.2    Vanden Berghe, M.3
  • 90
    • 0036220314 scopus 로고    scopus 로고
    • Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus
    • Lard L.R., Roep B.O., Verburgh C.A., et al. Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus. Lupus 11 3 (2002) 181-185
    • (2002) Lupus , vol.11 , Issue.3 , pp. 181-185
    • Lard, L.R.1    Roep, B.O.2    Verburgh, C.A.3
  • 91
    • 0033005853 scopus 로고    scopus 로고
    • Serum IL-6, TNFalpha, p55 srTNFalpha, p75srTNFalpha, srIL-2alpha levels and disease activity in systemic lupus erythematosus
    • Davas E.M., Tsirogianni A., Kappou I., et al. Serum IL-6, TNFalpha, p55 srTNFalpha, p75srTNFalpha, srIL-2alpha levels and disease activity in systemic lupus erythematosus. Clin Rheumatol 18 1 (1999) 17-22
    • (1999) Clin Rheumatol , vol.18 , Issue.1 , pp. 17-22
    • Davas, E.M.1    Tsirogianni, A.2    Kappou, I.3
  • 92
    • 0027999047 scopus 로고
    • Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE); a long term prospective study
    • Spronk P.E., Bootsma H., Huitema M.G., et al. Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE); a long term prospective study. Clin Exp Immunol 97 3 (1994) 439-444
    • (1994) Clin Exp Immunol , vol.97 , Issue.3 , pp. 439-444
    • Spronk, P.E.1    Bootsma, H.2    Huitema, M.G.3
  • 93
    • 27344435590 scopus 로고    scopus 로고
    • Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus
    • Sjowall C., Bengtsson A.A., Sturfeldt G., et al. Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus. Arthritis Res Ther 6 (2004) R87-R94
    • (2004) Arthritis Res Ther , vol.6
    • Sjowall, C.1    Bengtsson, A.A.2    Sturfeldt, G.3
  • 94
    • 0032938545 scopus 로고    scopus 로고
    • Lupus nephritis
    • Cameron J.S. Lupus nephritis. J Am Soc Nephrol 10 2 (1999) 413-424
    • (1999) J Am Soc Nephrol , vol.10 , Issue.2 , pp. 413-424
    • Cameron, J.S.1
  • 95
    • 1242342202 scopus 로고    scopus 로고
    • Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker
    • Simon J.A., Cabiedes J., Ortiz E., et al. Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker. Rheumatology 43 2 (2004) 220-224
    • (2004) Rheumatology , vol.43 , Issue.2 , pp. 220-224
    • Simon, J.A.1    Cabiedes, J.2    Ortiz, E.3
  • 96
    • 33746729488 scopus 로고    scopus 로고
    • Diagnostic value of anti-nucleosome antibodies in the assessment of disease activity of systemic lupus erythematosus: a prospective study comparing anti-nucleosome with anti-dsDNA antibodies
    • Gutierrez-Adrianzen O.A., Koutouzov S., Mota R.M., et al. Diagnostic value of anti-nucleosome antibodies in the assessment of disease activity of systemic lupus erythematosus: a prospective study comparing anti-nucleosome with anti-dsDNA antibodies. J Rheumatol 33 8 (2006) 1538-1544
    • (2006) J Rheumatol , vol.33 , Issue.8 , pp. 1538-1544
    • Gutierrez-Adrianzen, O.A.1    Koutouzov, S.2    Mota, R.M.3
  • 97
    • 0442292073 scopus 로고    scopus 로고
    • Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus
    • Seelen M.A., Trouw L.A., and Daha M.R. Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus. Curr Opin Nephrol Hypertens 12 (2003) 619-624
    • (2003) Curr Opin Nephrol Hypertens , vol.12 , pp. 619-624
    • Seelen, M.A.1    Trouw, L.A.2    Daha, M.R.3
  • 98
    • 42049120120 scopus 로고    scopus 로고
    • Complement component c1q and anti-c1q antibodies in theory and in clinical practice
    • Potlukova E., and Kralikova P. Complement component c1q and anti-c1q antibodies in theory and in clinical practice. Scand J Immunol 67 5 (2008) 423-430
    • (2008) Scand J Immunol , vol.67 , Issue.5 , pp. 423-430
    • Potlukova, E.1    Kralikova, P.2
  • 99
    • 0027477318 scopus 로고
    • Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan C., Adams S., Stanik V., et al. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 177 5 (1993) 1367-1381
    • (1993) J Exp Med , vol.177 , Issue.5 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3
  • 100
    • 0028803299 scopus 로고
    • Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus
    • Chabre H., Amoura Z., Piette J.C., et al. Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 38 10 (1995) 1485-1491
    • (1995) Arthritis Rheum , vol.38 , Issue.10 , pp. 1485-1491
    • Chabre, H.1    Amoura, Z.2    Piette, J.C.3
  • 101
    • 0035684793 scopus 로고    scopus 로고
    • An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study
    • Ravirajan C.T., Rowse L., MacGowan J.R., et al. An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study. Rheumatology 40 12 (2001) 1405-1412
    • (2001) Rheumatology , vol.40 , Issue.12 , pp. 1405-1412
    • Ravirajan, C.T.1    Rowse, L.2    MacGowan, J.R.3
  • 102
    • 0037369380 scopus 로고    scopus 로고
    • Antinucleosome antibodies in the diagnosis of systemic lupus erythematosus
    • Cairns A.P., McMillan S.A., Crockard A.D., et al. Antinucleosome antibodies in the diagnosis of systemic lupus erythematosus. Ann Rheum Dis 62 3 (2003) 272-273
    • (2003) Ann Rheum Dis , vol.62 , Issue.3 , pp. 272-273
    • Cairns, A.P.1    McMillan, S.A.2    Crockard, A.D.3
  • 103
    • 0036193360 scopus 로고    scopus 로고
    • Anti-nucleosome antibody: significance in lupus patients lacking anti-double-stranded DNA antibody
    • Min D.J., Kim S.J., Park S.H., et al. Anti-nucleosome antibody: significance in lupus patients lacking anti-double-stranded DNA antibody. Clin Exp Rheumatol 20 1 (2002) 13-18
    • (2002) Clin Exp Rheumatol , vol.20 , Issue.1 , pp. 13-18
    • Min, D.J.1    Kim, S.J.2    Park, S.H.3
  • 104
    • 40849121009 scopus 로고    scopus 로고
    • Antinucleosome antibodies as a marker of active proliferative lupus nephritis
    • Bigler C., Lopez-Trascasa M., Potlukova E., et al. Antinucleosome antibodies as a marker of active proliferative lupus nephritis. Am J Kidney Dis 51 4 (2008) 624-629
    • (2008) Am J Kidney Dis , vol.51 , Issue.4 , pp. 624-629
    • Bigler, C.1    Lopez-Trascasa, M.2    Potlukova, E.3
  • 105
    • 0035661277 scopus 로고    scopus 로고
    • High levels of antibodies against Clq are associated with disease activity and nephritis but not with other organ manifestations in SLE patients
    • Horvath L., Czirjak L., Fekete B., et al. High levels of antibodies against Clq are associated with disease activity and nephritis but not with other organ manifestations in SLE patients. Clin Exp Rheumatol 19 6 (2001) 667-672
    • (2001) Clin Exp Rheumatol , vol.19 , Issue.6 , pp. 667-672
    • Horvath, L.1    Czirjak, L.2    Fekete, B.3
  • 106
    • 0035123526 scopus 로고    scopus 로고
    • Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis
    • Moroni G., Trendelenburg M., Papa N.D., et al. Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis. Am J Kidney Dis 37 (2001) 490-498
    • (2001) Am J Kidney Dis , vol.37 , pp. 490-498
    • Moroni, G.1    Trendelenburg, M.2    Papa, N.D.3
  • 107
    • 14144250125 scopus 로고    scopus 로고
    • Anti-C1q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus
    • Marto N., Bertolaccini M.L., Calabuig E., et al. Anti-C1q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus. Ann Rheum Dis 64 3 (2005) 444-448
    • (2005) Ann Rheum Dis , vol.64 , Issue.3 , pp. 444-448
    • Marto, N.1    Bertolaccini, M.L.2    Calabuig, E.3
  • 108
    • 0032895595 scopus 로고    scopus 로고
    • Lack of occurrence of severe lupus nephritis among anti-C1q autoantibody-negative patients
    • Trendelenburg M., Marfurt J., Gerber I., et al. Lack of occurrence of severe lupus nephritis among anti-C1q autoantibody-negative patients. Arthritis Rheum 42 (1999) 187-188
    • (1999) Arthritis Rheum , vol.42 , pp. 187-188
    • Trendelenburg, M.1    Marfurt, J.2    Gerber, I.3
  • 109
    • 33750016891 scopus 로고    scopus 로고
    • High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis
    • Trendelenburg M., Lopez-Trascasa M., Potlukova E., et al. High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis. Nephrol Dial Transplant 21 11 (2006) 3115-3121
    • (2006) Nephrol Dial Transplant , vol.21 , Issue.11 , pp. 3115-3121
    • Trendelenburg, M.1    Lopez-Trascasa, M.2    Potlukova, E.3
  • 110
    • 34250675768 scopus 로고    scopus 로고
    • New insights into central nervous system lupus: a clinical perspective
    • Hanly J.G. New insights into central nervous system lupus: a clinical perspective. Curr Rheumatol Rep 9 2 (2007) 116-124
    • (2007) Curr Rheumatol Rep , vol.9 , Issue.2 , pp. 116-124
    • Hanly, J.G.1
  • 111
    • 0006579261 scopus 로고    scopus 로고
    • Antibodies to brain
    • Wallace D.J., and Hahn B. (Eds), Williams & Wilkins, Baltimore
    • Bluestein H.G. Antibodies to brain. In: Wallace D.J., and Hahn B. (Eds). Dubois' lupus erythematosus. 5th edn. (1997), Williams & Wilkins, Baltimore 517-522
    • (1997) Dubois' lupus erythematosus. 5th edn. , pp. 517-522
    • Bluestein, H.G.1
  • 112
    • 0035173156 scopus 로고    scopus 로고
    • A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
    • DeGiorgio L.A., Konstantinov K.N., Lee S.C., et al. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 7 11 (2001) 1189-1193
    • (2001) Nat Med , vol.7 , Issue.11 , pp. 1189-1193
    • DeGiorgio, L.A.1    Konstantinov, K.N.2    Lee, S.C.3
  • 113
    • 4143110002 scopus 로고    scopus 로고
    • Cognition and immunity; antibody impairs memory
    • Kowal C., DeGiorgio L.A., Nakaoka T., et al. Cognition and immunity; antibody impairs memory. Immunity 21 2 (2004) 179-188
    • (2004) Immunity , vol.21 , Issue.2 , pp. 179-188
    • Kowal, C.1    DeGiorgio, L.A.2    Nakaoka, T.3
  • 114
    • 31444446883 scopus 로고    scopus 로고
    • Immunity and behavior: antibodies alter emotion
    • Huerta P.T., Kowal C., DeGiorgio L.A., et al. Immunity and behavior: antibodies alter emotion. Proc Natl Acad Sci U S A 103 3 (2006) 678-683
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.3 , pp. 678-683
    • Huerta, P.T.1    Kowal, C.2    DeGiorgio, L.A.3
  • 115
    • 33845893222 scopus 로고    scopus 로고
    • Human lupus autoantibodies against NMDA receptors mediate cognitive impairment
    • Kowal C., Degiorgio L.A., Lee J.Y., et al. Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci U S A 103 52 (2006) 19854-19859
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.52 , pp. 19854-19859
    • Kowal, C.1    Degiorgio, L.A.2    Lee, J.Y.3
  • 116
    • 23444443656 scopus 로고    scopus 로고
    • Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus
    • Husebye E.S., Sthoeger Z.M., Dayan M., et al. Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus. Ann Rheum Dis 64 8 (2005) 1210-1213
    • (2005) Ann Rheum Dis , vol.64 , Issue.8 , pp. 1210-1213
    • Husebye, E.S.1    Sthoeger, Z.M.2    Dayan, M.3
  • 117
    • 42449089701 scopus 로고    scopus 로고
    • Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus
    • Arinuma Y., Yanagida T., and Hirohata S. Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 58 4 (2008) 1130-1135
    • (2008) Arthritis Rheum , vol.58 , Issue.4 , pp. 1130-1135
    • Arinuma, Y.1    Yanagida, T.2    Hirohata, S.3
  • 118
    • 33747001788 scopus 로고    scopus 로고
    • Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus
    • Lapteva L., Nowak M., Yarboro C.H., et al. Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus. Arthritis Rheum 54 8 (2006) 2505-2514
    • (2006) Arthritis Rheum , vol.54 , Issue.8 , pp. 2505-2514
    • Lapteva, L.1    Nowak, M.2    Yarboro, C.H.3
  • 119
    • 33746989257 scopus 로고    scopus 로고
    • Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus
    • Harrison M.J., Ravdin L.D., and Lockshin M.D. Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus. Arthritis Rheum 54 8 (2006) 2515-2522
    • (2006) Arthritis Rheum , vol.54 , Issue.8 , pp. 2515-2522
    • Harrison, M.J.1    Ravdin, L.D.2    Lockshin, M.D.3
  • 120
    • 33746683740 scopus 로고    scopus 로고
    • Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus
    • Hanly J.G., Robichaud J., and Fisk J.D. Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus. J Rheumatol 33 8 (2006) 1553-1558
    • (2006) J Rheumatol , vol.33 , Issue.8 , pp. 1553-1558
    • Hanly, J.G.1    Robichaud, J.2    Fisk, J.D.3
  • 121
    • 17144406339 scopus 로고    scopus 로고
    • Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors
    • Omdal R., Brokstad K., Waterloo K., et al. Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors. Eur J Neurol 12 5 (2005) 392-398
    • (2005) Eur J Neurol , vol.12 , Issue.5 , pp. 392-398
    • Omdal, R.1    Brokstad, K.2    Waterloo, K.3
  • 122
    • 32444447026 scopus 로고    scopus 로고
    • Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus
    • Yoshio T., Onda K., Nara H., et al. Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 54 2 (2006) 675-678
    • (2006) Arthritis Rheum , vol.54 , Issue.2 , pp. 675-678
    • Yoshio, T.1    Onda, K.2    Nara, H.3
  • 123
    • 5044229321 scopus 로고    scopus 로고
    • The impact of systems approaches on biological problems in drug discovery
    • Hood L., and Perlmutter R.M. The impact of systems approaches on biological problems in drug discovery. Nat Biotechnol 22 10 (2004) 1215-1217
    • (2004) Nat Biotechnol , vol.22 , Issue.10 , pp. 1215-1217
    • Hood, L.1    Perlmutter, R.M.2
  • 124
    • 33845713350 scopus 로고    scopus 로고
    • Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function
    • Kyttaris V.C., Krishnan S., and Tsokos G.C. Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function. Autoimmunity 39 8 (2006) 705-709
    • (2006) Autoimmunity , vol.39 , Issue.8 , pp. 705-709
    • Kyttaris, V.C.1    Krishnan, S.2    Tsokos, G.C.3
  • 125
    • 0036718796 scopus 로고    scopus 로고
    • Clinical proteomics: translating benchside promise into bedside reality
    • Petricoin E.F., Zoon K.C., Kohn E.C., et al. Clinical proteomics: translating benchside promise into bedside reality. Nat Rev Drug Discov 1 9 (2002) 683-695
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.9 , pp. 683-695
    • Petricoin, E.F.1    Zoon, K.C.2    Kohn, E.C.3
  • 126
    • 2942754023 scopus 로고    scopus 로고
    • Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosus
    • Utz P.J. Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosus. Lupus 13 5 (2004) 304-311
    • (2004) Lupus , vol.13 , Issue.5 , pp. 304-311
    • Utz, P.J.1
  • 127
    • 33750376202 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus
    • Forabosco P., Gorman J.D., Cleveland C., et al. Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. Genes Immun 7 7 (2006) 609-614
    • (2006) Genes Immun , vol.7 , Issue.7 , pp. 609-614
    • Forabosco, P.1    Gorman, J.D.2    Cleveland, C.3
  • 128
    • 33845485330 scopus 로고    scopus 로고
    • Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes
    • Li Q.Z., Zhou J., Wandstrat A.E., et al. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol 147 1 (2007) 60-70
    • (2007) Clin Exp Immunol , vol.147 , Issue.1 , pp. 60-70
    • Li, Q.Z.1    Zhou, J.2    Wandstrat, A.E.3
  • 129
    • 46749152178 scopus 로고    scopus 로고
    • A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    • Chaussabel D., Quinn C., Shen J., et al. A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity 29 1 (2008) 150-164
    • (2008) Immunity , vol.29 , Issue.1 , pp. 150-164
    • Chaussabel, D.1    Quinn, C.2    Shen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.