Freeze-drying of tert-butyl alcohol/water cosolvent systems: Effects of formulation and process variables on residual solvents

Journal of Pharmaceutical Sciences

Volumn 87, Issue 4, 1998, Pages 491-495

  Wittaya Areekul, Sakchai ^a   Nail, Steven L ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; LIQUID NITROGEN; SOLVENT; SUCROSE; TEBOL 90; TERT BUTYL ALCOHOL; UNCLASSIFIED DRUG; WATER;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; FREEZE DRYING; GAS CHROMATOGRAPHY; TEMPERAMENT;

EID: 0031901491     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9702832     Document Type: Article

References (7)

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3. Baldi, G.; Gasco, M. R.; Pattarino, F. Statistical procedures for optimizing the freeze-drying of a model drug in tert-butyl alcohol:water mixtures. Eur. J. Pharm. Biopharm. 1994, 40, 138-41.
4. Olsen, W. P. Volatile solvents for drying and microbial kill in the final container: A proposal and a review, with emphasis on tert-butyl alcohol. Pharm. Eng. 1997, July/August, 112-117.
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