NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 26, 2009, Pages 10678-10683

  Dammermann, Werner ^a   Zhang, Bo ^b   Nebel, Merle ^a   Cordiglieri, Chiara ^c   Odoardi, Francesca ^c,d   Kirchberger, Tanja ^a   Kawakami, Naoto ^c   Dowden, James ^b   Schmid, Frederike ^a   Dornmair, Klaus ^e   Hohenegger, Martin ^f   Flügel, Alexander ^c,d,e   Guse, Andreas H ^a   Potter, Barry V L ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b University of Bath   (United Kingdom)

^c MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Antagonism; Nucleotide; Second messenger; Synthesis

Indexed keywords

3 CARBOXYL 1 OCTYLCARBAMOYLMETHYLPYRIDINIUM BROMIDE; BZ 194; CALCIUM; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; INOSITOL 1,4,5 TRISPHOSPHATE; INTERLEUKIN 2; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PYRIDINIUM DERIVATIVE; RYANODINE RECEPTOR 1; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; 3 CARBOXY 1 OCTYLCARBAMOYLMETHYLPYRIDINIUM; 3-CARBOXY-1-OCTYLCARBAMOYLMETHYLPYRIDINIUM; DRUG DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINIC ACID; NICOTINIC ACID DERIVATIVE; RYANODINE; RYANODINE RECEPTOR; TRITIUM; VITAMIN B COMPLEX;

ANIMAL CELL; ARTICLE; ASTROCYTE; AUTOIMMUNE DISEASE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SECOND MESSENGER; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ACTIVE TRANSPORT; ANIMAL; BINDING COMPETITION; CELL CULTURE; CELL NUCLEUS; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SYNTHESIS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BINDING, COMPETITIVE; CALCIUM; CALCIUM SIGNALING; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; JURKAT CELLS; NADP; NFATC TRANSCRIPTION FACTORS; NIACIN; NICOTINIC ACIDS; RATS; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; T-LYMPHOCYTES; TRITIUM; VITAMIN B COMPLEX;

EID: 67649743775     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809997106     Document Type: Article

References (47)

1. Feske S, et al. (2006) A mutation in Orai1 causes immunedeficiency by abrogating CRAC channel function. Nature 441:179-185.
2. 2+ entry. Science 312:1220-1223.
3. Yeromin AV, et al. (2006) Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443:226-229. (Pubitemid 44387612)
4. Peinelt C (2006) Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol 8:771-773.
5. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306:67-69.
6. Guse AH, et al. (1999) Regulation of calcium signaling in T lymphocytes by the second messenger cyclic ADP-ribose. Nature 398:70-73. (Pubitemid 29124469)
7. 2+-signaling. J Cell Biol 150:581-588.
8. Gasser A, Bruhn S, Guse AH (2006) Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assay. J Biol Chem 281:16906-16913. (Pubitemid 43909493)
9. 2+ signaling in T-lymphocytes. J Biol Chem 280:21394-21399.
10. 2+ signaling in T-lymphocytes. Cell Signal 16:1283-1289.
11. Lee HC, Aarhus R (1995) A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J Biol Chem 270:2152-2157.
12. 2+-signaling and cell function. Curr Mol Med 2:273-282.
13. Yamasaki M, Churchill GC, Galione A (2005) Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP). FEBS J 272:4598-4606. (Pubitemid 41366984)
14. Lee HC (2005) Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling. J Biol Chem 280:33693-33696. (Pubitemid 41443085)
15. Lee HC (2003) Calcium signaling: NAADP ascends as a new messenger. Curr Biol 13:186-188.
16. Rutter GA (2003) Calcium signalling: NAADP comes out of the shadows. Biochem J 373:3-4.
17. 2+ trigger. Sci. Signal. 1:re10.
18. 2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients. J Biol Chem 275:38687-38692.
19. Lee HC (2000) Functional visualization of the separate but interacting calcium stores sensitive to NAADP and cyclic ADP-ribose. J Cell Sci 113:4413-4420. (Pubitemid 32117901)
20. 2+ responses in clonal pancreatic beta cells. Curr Biol 13:247-251.
21. Kinnear NP, Boittin FX, Thomas JM, Galione A, Evans AM (2004) Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1. J Biol Chem 279:54319-54326. (Pubitemid 40053170)
22. 2+ from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell 111:703-708.
23. 2+ signals in pancreatic acinar and beta cells. J Biol Chem 279:7234-7240.
24. 2+ release channel from liver lysosomes of rats. J Biol Chem 282:25259-25269.
25. 2+) release channel in coronary arterial myocytes. J Cell Mol Med, 10.1111/j.1582-4934.2008.00486.x.
26. Hohenegger M, Suko J, Gscheidlinger R, Drobny H, Zidar A (2002) Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor. Biochem J 367:423-431. (Pubitemid 35216816)
27. Mojzisova A, Krizanova O, Zacikova L, Kominkova V, Ondrias K (2001) Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart. Pflugers Arch 441:674-677. (Pubitemid 32182080)
28. 2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem 278:11057-11064.
29. 2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol 163:271-282.
30. 2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci 119:226-238.
31. 2+ store in T lymphocytes. J Biol Chem 282:18864-18871.
32. Tanna B, Welch W, Ruest L, Sutko JL, Williams AJ (2006) The interaction of an impermeant cation with the sheep cardiac RyR channel alters ryanoid association. Mol Pharmacol 69:1990-1997. (Pubitemid 43894318)
33. Lee HC, Aarhus R (1997) Structural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity. J Biol Chem 272:20378-20383. (Pubitemid 27355587)
34. 2+ release. Chem Biol 13:659-665.
35. 2+-permeable pore of the calcium release channel. J Biol Chem 262:16636-16643.
36. Pessah IN, Francini AO, Scales DJ, Waterhouse AL, Casida JE (1986) Calcium-ryanodine receptor complex. Solubilization and partial characterization from skeletal muscle junctional sarcoplasmic reticulum vesicles. J Biol Chem 261:8643-8648. (Pubitemid 17205057)
37. Chu A, Díaz-Muñoz M, Hawkes MJ, Brush K, Hamilton SL (1990) Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel. Mol Pharmacol 37:735-741. (Pubitemid 20171510)
38. 2+ signaling via the T cell receptor/CD3 Complex. J Biol Chem 277:50636-50642.
39. Guse AH, Goldwich A, Weber K, Mayr GW (1995) Non-radioactive, isomer-specific inositol phosphate mass determinations: high-performance liquid chromatographymicro-metal-dye detection strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays. J Chromatogr B 672:189-198.
40. 2+ release mechanisms: Multiple pathways having multiple functions within the same cell type? Biochim Biophys Acta 1498:122-133.
41. 2+ signals and immunosuppression. Nature 383:837-840.
42. Klinger M, et al. (1999) Suramin and suramin analogs activate skeletal muscle ryanodine receptor via a calmodulin binding site. Mol Pharmacol 55:462-472. (Pubitemid 29128102)
43. Wolner I, Kassack MU, Ullmann H, Karel A, Hohenegger M (2005) Use-dependent inhibition of the skeletal muscle ryanodine receptor by the Suramin analogue NF676. Br J Pharmacol 146:525-533. (Pubitemid 41487068)
44. 2+ pools in Jurkat T-lymphocytes. Biochem J 291:447-451.
45. + T lymphocytes: Green fluorescent protein engineered, encephalitogenic T cells used to illuminate immune responses in the brain. Nature Med 5:843-847.
46. Guse AH, et al. (2005) A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells. J Biol Chem 280:15952-15959. (Pubitemid 40616718)
47. Flügel A, et al. (2001) Migratory activity and functional changes of green fluorescent effector T cells before and during experimental autoimmune encephalomyelitis. Immunity 14:547-560. (Pubitemid 32520866)