Nicotinic acid adenine dinucleotide phosphate (NAADP+) is an essential regulator of T-lymphocyte CA2+-signaling

Journal of Cell Biology

Volumn 150, Issue 3, 2000, Pages 581-588

  Berg, I ^a   Potter, B V L ^a   Mayr, G W ^a   Guse, A H ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Cyclic ADP ribose; Inositol 1,4,5 trisphosphate; Ryanodine receptor; Signal transduction; T cell activation

Indexed keywords

ADENINE DERIVATIVE; CALCIUM; CD3 ANTIGEN; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; INOSITOL 1,4,5 TRISPHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINIC ACID DERIVATIVE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADENOSINE DIPHOSPHATE RIBOSE; ANTIGENS, CD3; CALCIUM SIGNALING; CYCLIC ADP-RIBOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INOSITOL 1,4,5-TRISPHOSPHATE; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICROINJECTIONS; NADP; RECEPTORS, ANTIGEN, T-CELL; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; T-LYMPHOCYTES;

EID: 0034618134     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.3.581     Document Type: Article

References (28)

1. +
2. Calcium signaling vy cyclic ADP-ribose, NAADP, and inositol trisphosphate are involved in distinct functions in ascidian oocytes
3. Chemo-enzymatic synthesis of analogues of the second messenger candidate cyclic adenosine 5'-diphosphate ribose
4. 2+ release from brain microsomes
5. 3 and calcium-gated channels from endoplasmic reticulum of cerebellum
6. Signal transduction through the T cell receptor-CD3 complex. Evidence for heterogeneity in receptor coupling
7. 2+-signalling patterns by NAADP in pancreatic acinar cells
8. Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs
9. Pyridine nucleotide metabolite stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate
10. Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography
11. 2- from a thapsigargin-insensitive pool
12. 2+ release
13. 2--signaling in T-lymphocytes
14. ++-pools in Jurkat T-lymphocytes
15. Non-radioactive, isomer-specific inositol phosphate mass determinations: Micro metal-dye detection-HPLC strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays
16. 2--entry induced by cyclic ADP-ribose in intact T-lymphocytes
17. 2+-signaling in T-lymphocytes by the second messenger cyclic ADP-ribose
18. The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling
19. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones
20. Signaling scaffolds in immune cells
21. A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose
22. Structural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity
23. Fluorescent analogs of NAADP with calcium mobilizing activity
24. myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3,6-trisphosphoro-thioate: Partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor
25. Regulation of calcium influx across the plasma membrane of the human T-leukemic cell line, JURKAT: Dependence on a rise in cytosolic free calcium can be dissociated from formation of inositol phosphates
26. 2--releasing messengers: Are they important in the nervous system?
27. Solid-state diode laser-induced fluorescence detection in high-performance liquid chromatography
28. 2+ oscillations in pancreatic acinar cells