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Volumn 8, Issue 2, 2009, Pages 82-87

Active and passive Aβ-immunotherapy: Preclinical and clinical studies and future directions: Part II

Author keywords

[No Author keywords available]

Indexed keywords

ACC 001; AD 01; AD 02; ALUMINUM POTASSIUM SULFATE; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-42]; BAPINEUZUMAB; CAD 106; EPITOPE; GSK 933776A; HUMAN IMMUNOGLOBULIN; LY 2062430; MONOCLONAL ANTIBODY; NEUROTOXIN; PF 04360365; PF 4360365; PLACEBO; QS 21; R 1450; UNCLASSIFIED DRUG; V 950; ANTIBODY;

EID: 67649660323     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152709787847270     Document Type: Editorial
Times cited : (9)

References (28)
  • 1
    • 70349546032 scopus 로고    scopus 로고
    • www.alzforum.org. Alzheimer Research Forum, 2009.
    • (2009)
  • 2
    • 0033071176 scopus 로고    scopus 로고
    • Protein fate in neurodegenerative proteinopathies: Polyglutamine diseases join the (mis)fold
    • Paulson, H.L. Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold. Am. J. Hum. Genet., 1999, 64, 339-45.
    • (1999) Am. J. Hum. Genet , vol.64 , pp. 339-345
    • Paulson, H.L.1
  • 4
    • 38049086649 scopus 로고    scopus 로고
    • Current challenges for the successful treatment and prevention of Alzheimer's disease: Treating the pathologies of the disease to change its clinical course
    • Schenk, D. Current challenges for the successful treatment and prevention of Alzheimer's disease: treating the pathologies of the disease to change its clinical course. Alzheimers Dement., 2008, 4, S119-21.
    • (2008) Alzheimers Dement , vol.4
    • Schenk, D.1
  • 5
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J. Selkoe, D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 2002, 297, 353-6.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 8
    • 84984755327 scopus 로고    scopus 로고
    • Morgan, D.; Diamond, D.M.; Gottschall, P.E.; Ugen, K.E.; Dickey, C.; Hardy, J.; Duff, K.; Jantzen, P.; DiCarlo, G.; Wilcock, D.; Connor, K.; Hatcher, J.; Hope, C.; Gordon, M.Arendash, G.W. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 2000, 408, 982-5.
    • Morgan, D.; Diamond, D.M.; Gottschall, P.E.; Ugen, K.E.; Dickey, C.; Hardy, J.; Duff, K.; Jantzen, P.; DiCarlo, G.; Wilcock, D.; Connor, K.; Hatcher, J.; Hope, C.; Gordon, M.Arendash, G.W. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 2000, 408, 982-5.
  • 9
    • 0033835996 scopus 로고    scopus 로고
    • Bard, F.; Cannon, C.; Barbour, R.; Burke, R.L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Lieberburg, I.; Motter, R.; Nguyen, M.; Soriano, F.; Vasquez, N.; Weiss, K.; Welch, B.; Seubert, P.; Schenk, D.Yednock, T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med., 2000, 6, 916-9.
    • Bard, F.; Cannon, C.; Barbour, R.; Burke, R.L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Lieberburg, I.; Motter, R.; Nguyen, M.; Soriano, F.; Vasquez, N.; Weiss, K.; Welch, B.; Seubert, P.; Schenk, D.Yednock, T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med., 2000, 6, 916-9.
  • 10
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B.; Bales, K.R.; Cummins, D.J.; Dodart, J.C.; Paul, S.M.; Holtzman, D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2001, 98, 8850-5.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 11
    • 58149100407 scopus 로고    scopus 로고
    • The ageing immune system: Is it ever too old to become young again?
    • Dorshkind, K.; Montecino-Rodriguez, E.; Signer, R.A. The ageing immune system: is it ever too old to become young again? Nat. Rev. Immunol., 2009, 9, 57-62.
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 57-62
    • Dorshkind, K.1    Montecino-Rodriguez, E.2    Signer, R.A.3
  • 12
    • 33847343896 scopus 로고    scopus 로고
    • Immunosenescence comes of age. Symposium on Aging Research in Immunology: The Impact of Genomics
    • Pawelec, G. Immunosenescence comes of age. Symposium on Aging Research in Immunology: the Impact of Genomics. EMBO Rep., 2007, 8, 220-3.
    • (2007) EMBO Rep , vol.8 , pp. 220-223
    • Pawelec, G.1
  • 13
    • 34447636918 scopus 로고    scopus 로고
    • Phagocytosis of amyloid-beta and inflammation: Two faces of innate immunity in Alzheimer's disease
    • Fiala, M.; Cribbs, D.H.; Rosenthal, M.; Bernard, G. Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease. J. Alzheimers Dis., 2007, 11, 457-63.
    • (2007) J. Alzheimers Dis , vol.11 , pp. 457-463
    • Fiala, M.1    Cribbs, D.H.2    Rosenthal, M.3    Bernard, G.4
  • 16
    • 58649115794 scopus 로고    scopus 로고
    • Greenberg, S.M.; Vernooij, M.W.; Cordonnier, C.; Viswanathan, A.; Al-Shahi Salman, R.; Warach, S.; Launer, L.J.; Van Buchem, M.A.; Breteler, M.M. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol., 2009, 8, 165-74.
    • Greenberg, S.M.; Vernooij, M.W.; Cordonnier, C.; Viswanathan, A.; Al-Shahi Salman, R.; Warach, S.; Launer, L.J.; Van Buchem, M.A.; Breteler, M.M. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol., 2009, 8, 165-74.
  • 17
    • 41149149333 scopus 로고    scopus 로고
    • The role of the immune system in clearance of abeta from the brain
    • Boche, D.; Nicoll, J.A. The role of the immune system in clearance of abeta from the brain. Brain Pathol., 2008, 18, 267-78.
    • (2008) Brain Pathol , vol.18 , pp. 267-278
    • Boche, D.1    Nicoll, J.A.2
  • 18
    • 59049104731 scopus 로고    scopus 로고
    • Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy
    • Hawkes, C.A.; McLaurin, J. Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy. Proc. Natl. Acad. Sci. USA, 2009, 106, 1261-6.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 1261-1266
    • Hawkes, C.A.1    McLaurin, J.2
  • 19
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll, J.A.; Wilkinson, D.; Holmes, C.; Steart, P.; Markham, H.; Weller, R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med., 2003, 1, 448-52.
    • (2003) Nat. Med , vol.1 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 21
    • 20944448555 scopus 로고    scopus 로고
    • Gilman, S.; Koller, M.; Black, R.S.; Jenkins, L.; Griffith, S.G.; Fox, N.C.; Eisner, L.; Kirby, L.; Rovira, M.B.; Forette, F.Orgogozo, J.M. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology, 2005, 64, 1553-62.
    • Gilman, S.; Koller, M.; Black, R.S.; Jenkins, L.; Griffith, S.G.; Fox, N.C.; Eisner, L.; Kirby, L.; Rovira, M.B.; Forette, F.Orgogozo, J.M. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology, 2005, 64, 1553-62.
  • 22
    • 40449086748 scopus 로고    scopus 로고
    • Progress in the active immunotherapeutic approach to Alzheimer's disease: Clinical investigations into AN1792-associated meningoencephalitis
    • Pride, M.; Seubert, P.; Grundman, M.; Hagen, M.; Eldridge, J.; Black, R.S. Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis. Neurodegener. Dis., 2008, 5, 194-6.
    • (2008) Neurodegener. Dis , vol.5 , pp. 194-196
    • Pride, M.1    Seubert, P.2    Grundman, M.3    Hagen, M.4    Eldridge, J.5    Black, R.S.6
  • 23
    • 58549089731 scopus 로고    scopus 로고
    • Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives
    • Trouche, S.G.; Asuni, A.; Rouland, S.; Wisniewski, T.; Frangione, B.; Verdier, J.M.; Sigurdsson, E.M.; Mestre-Frances, N. Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine, 2009, 27, 957-64.
    • (2009) Vaccine , vol.27 , pp. 957-964
    • Trouche, S.G.1    Asuni, A.2    Rouland, S.3    Wisniewski, T.4    Frangione, B.5    Verdier, J.M.6    Sigurdsson, E.M.7    Mestre-Frances, N.8
  • 24
    • 45749103230 scopus 로고    scopus 로고
    • The coming of age of virus-like particle vaccines
    • Jennings, G.T.; Bachmann, M.F. The coming of age of virus-like particle vaccines. Biol. Chem., 2008, 389, 521-36.
    • (2008) Biol. Chem , vol.389 , pp. 521-536
    • Jennings, G.T.1    Bachmann, M.F.2
  • 25
    • 67650409845 scopus 로고    scopus 로고
    • Safety, tolerability and immunogenicity of the Ab immunotherapeutic vaccine CAD 106 in a first-in-man study in Alzheimer patients
    • Abstract S2-04-06
    • Winblad, B. Safety, tolerability and immunogenicity of the Ab immunotherapeutic vaccine CAD 106 in a first-in-man study in Alzheimer patients. International Conference on Alzheimer's Disease (ICAD), 2008, Abstract S2-04-06.
    • (2008) International Conference on Alzheimer's Disease (ICAD)
    • Winblad, B.1
  • 26
    • 67650428377 scopus 로고    scopus 로고
    • Clinical trials of bapineuzumab a beta-amyloid-targeted immunotherapy in patients with mild-to-moderate Alzheimer's disease
    • Abstract O3-04-05
    • Grundman, M.A.B.R. Clinical trials of bapineuzumab a beta-amyloid-targeted immunotherapy in patients with mild-to-moderate Alzheimer's disease. Int. Conference Alzheimer's Dis., (ICAD), 2008, Abstract O3-04-05.
    • (2008) Int. Conference Alzheimer's Dis., (ICAD)
    • Grundman, M.A.B.R.1
  • 28
    • 65249091605 scopus 로고    scopus 로고
    • Safety, tolerability and biomarker effects of an Abeta monoclonal antibody administered to patients with Alzheimer's disease
    • Abstract P
    • Siemers, E.R. Safety, tolerability and biomarker effects of an Abeta monoclonal antibody administered to patients with Alzheimer's disease. Int. Conference Alzheimer's Dis. (ICAD) Chicago, 2008, Abstract P4-346.
    • (2008) Int. Conference Alzheimer's Dis. (ICAD) Chicago , pp. 4-346
    • Siemers, E.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.