Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 14, 2009, Pages 3756-3759

  Lawrence, Harshani R ^a   Li, Zhenyu ^a   Richard Yip, M L ^a   Sung, Shen Shu ^a   Lawrence, Nicholas J ^a,b   McLaughlin, Mark L ^a,b,c   McManus, Gregory J ^c   Zaworotko, Michael J ^c   Sebti, Saïd M ^a,b   Chen, Jiandong ^a,b   Guida, Wayne C ^a,b,c  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Alphascreen ; Anticancer; Mdm2 p53; Protein protein interaction; Virtual screening

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; HYDRAZONE DERIVATIVE; KETONE; METHANOL; NSC 333003; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPUTER MODEL; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOLECULAR DOCKING; POLYMERIZATION; PROTEIN PROTEIN INTERACTION; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ANALYSIS;

ANIMALS; BENZOTHIAZOLES; CELL LINE, TUMOR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDRAZINES; MICE; MOLECULAR CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS C-MDM2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67649646649     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.124     Document Type: Article

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