Delay of adequate empiric antibiotic therapy is associated with increased mortality among solid-organ transplant patients

American Journal of Transplantation

Volumn 9, Issue 7, 2009, Pages 1657-1665

  Hamandi, B ^a,b   Holbrook, A M ^a,c,d   Humar, A ^e   Brunton, J ^a   Papadimitropoulos, E A ^a   Wong, G G ^a,b   Thabane, L ^c,d,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c CENTRE FOR EVALUATION OF MEDICINES   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

^f MCMASTER UNIVERSITY   (Canada)

Author keywords

Antibiotics; Infection; Logistic analysis; Organ transplantation; Retrospective study

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; CARBAPENEM; COTRIMOXAZOLE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ANTIBODY; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; THYMOCYTE ANTIBODY;

ABDOMINAL INFECTION; ADULT; ANTIBIOTIC THERAPY; APACHE; ARTICLE; BACTEREMIA; BACTERIUM CULTURE; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; ENTEROCOCCUS; ESCHERICHIA COLI; FEMALE; GRAFT REJECTION; GRAM NEGATIVE INFECTION; HOSPITAL INFECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION; KLEBSIELLA; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORTALITY; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; STATISTICAL ANALYSIS; THERAPY DELAY; TREATMENT DURATION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ADULT; ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIAL INFECTIONS; COHORT STUDIES; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; ORGAN TRANSPLANTATION; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 67649644199     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02664.x     Document Type: Article

References (44)

1. Wagener MM, Yu VL. Bacteremia in transplant recipients: A prospective study of demographics, etiologic agents, risk factors, and outcomes. Am J Infect Control 1992 20 : 239 247.
2. Alangaden GJ, Thyagarajan R, Gruber SA et al. Infectious complications after kidney transplantation: Current epidemiology and associated risk factors. Clin Transplant 2006 20 : 401 409. (Pubitemid 43983815)
3. Fischer SA. Infections complicating solid organ transplantation. Surg Clin North Am 2006 86 : 1127 1145, v-vi. (Pubitemid 44311154)
4. Grimaldi A, Barletta A, Rascente M et al. Infectious complications in the renal transplant recipient. Transplant Proc 2005 37 : 2502 2503. (Pubitemid 41354651)
5. Kusne S, Dummer JS, Singh N et al. Infections after liver transplantation. An analysis of 101 consecutive cases. Medicine (Baltimore) 1988 67 : 132 143. (Pubitemid 18106367)
6. Miemois-Foley J, Paunio M, Lyytikainen O, Salmela K. Bacteremia among kidney transplant recipients: A case-control study of risk factors and short-term outcomes. Scand J Infect Dis 2000 32 : 69 73. (Pubitemid 30102959)
7. Patel R, Paya CV. Infections in solid-organ transplant recipients. Clin Microbiol Rev 1997 10 : 86 124. (Pubitemid 27042833)
8. Husain S, Chan KM, Palmer SM et al. Bacteremia in lung transplant recipients in the current era. Am J Transplant 2006 6 : 3000 3007. (Pubitemid 44777931)
9. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000 118 : 146 155. (Pubitemid 30485502)
10. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients. Chest 1999 115 : 462 474. (Pubitemid 29083057)
11. Luna CM, Vujacich P, Niederman MS et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997 111 : 676 685. (Pubitemid 27132946)
12. Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 1997 156 : 196 200. (Pubitemid 27293188)
13. Leibovici L, Shraga I, Drucker M, Konigsberger H, Samra Z, Pitlik SD. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998 244 : 379 386. (Pubitemid 28513125)
14. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002 122 : 262 268. (Pubitemid 34754172)
15. Luna CM, Aruj P, Niederman MS et al. Appropriateness and delay to initiate therapy in ventilator-associated pneumonia. Eur Respir J 2006 27 : 158 164. (Pubitemid 43092680)
16. Lodise TP, McKinnon PS, Swiderski L, Rybak MJ. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis 2003 36 : 1418 1423. (Pubitemid 36702876)
17. Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 2004 164 : 637 644. (Pubitemid 38392978)
18. Garner J, Hughes JM, Horan TC, Mori TG, Arvis WR. CDC definitions for nosocomial infections. In : Olmsted R, ed. APIC Infection Control and Applied Epidemiology: Principles and Practice, St. Louis, CO : Mosby, 1996 : A1 A20.
19. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S17, 2002.
20. NNIS System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004 32 : 470 485.
21. Gilbert DN, Moellering R Jr., Sande M. The Sanford Guide to Antimicrobial Therapy 2006. Hyde Park, VT : Antimicrobial Therapy Inc., 2006.
22. Hosmer D, Lemeshow S. Applied Logistic Regression. 2nd Ed. Toronto : Wiley, 2000.
23. Babyak MA. What you see may not be what you get: A brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 2004 66 : 411 421. (Pubitemid 38668414)
24. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996 49 : 1373 1379. (Pubitemid 27028925)
25. Canadian Organ Replacement Register C. e-Statistics on Organ Transplants, Waiting Lists and Donors; Table 1A. Transplants by Organ and Donor Type, Canada and Provinces, Summary Statistics, January 1 to December 31, 2003, 2004.
26. Micek ST, Lloyd AE, Ritchie DJ, Reichley RM, Fraser VJ, Kollef MH. Pseudomonas aeruginosa bloodstream infection: Importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother 2005 49 : 1306 1311. (Pubitemid 40463352)
27. Rello J, Ausina V, Ricart M, Castella J, Prats G. Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia. Chest 1993 104 : 1230 1235. (Pubitemid 23306084)
28. Kollef MH, Ward S, Sherman G et al. Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices. Crit Care Med 2000 28 : 3456 3464. (Pubitemid 30792367)
29. Vanderkooi OG, Low DE, Green K, Powis JE, McGeer A. Predicting antimicrobial resistance in invasive pneumococcal infections. Clin Infect Dis 2005 40 : 1288 1297. (Pubitemid 40570238)
30. Goldmann DA, Weinstein RA, Wenzel RP et al. Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals. A challenge to hospital leadership. JAMA 1996 275 : 234 240. (Pubitemid 26028565)
31. Singh N. Impact of current transplantation practices on the changing epidemiology of infections in transplant recipients. Lancet Infect Dis 2003 3 : 156 161. (Pubitemid 36278125)
32. Rubin RH, Schaffner A, Speich R. Introduction to the Immunocompromised Host Society consensus conference on epidemiology, prevention, diagnosis, and management of infections in solid-organ transplant patients. Clin Infect Dis 2001 33 (Suppl 1 S1 S4.
33. Torre-Cisneros J, Herrero C, Canas E, Reguera JM, De La MM, Gomez-Bravo MA. High mortality related with Staphylococcus aureus bacteremia after liver transplantation. Eur J Clin Microbiol Infect Dis 2002 21 : 385 388. (Pubitemid 34810675)
34. Sitges-Serra A, Lopez MJ, Girvent M, Almirall S, Sancho JJ. Postoperative enterococcal infection after treatment of complicated intra-abdominal sepsis. Br J Surg 2002 89 : 361 367. (Pubitemid 34227039)
35. Barie PS, Christou NV, Dellinger EP, Rout WR, Stone HH, Waymack JP. Pathogenicity of the enterococcus in surgical infections. Ann Surg 1990 212 : 155 159. (Pubitemid 20241040)
36. Trouillet JL, Chastre J, Vuagnat A et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998 157 : 531 539. (Pubitemid 28090546)
37. Kollef MH, Kollef KE. Antibiotic utilization and outcomes for patients with clinically suspected ventilator-associated pneumonia and negative quantitative BAL culture results. Chest 2005 128 : 2706 2713. (Pubitemid 41507631)
38. Rello J, Ollendorf DA, Oster G et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002 122 : 2115 2121. (Pubitemid 36051151)
39. Cosgrove SE, Carmeli Y. The impact of antimicrobial resistance on health and economic outcomes. Clin Infect Dis 2003 36 : 1433 1437. (Pubitemid 36702878)
40. Chamot E, Boffi EA, Rohner P, Van Delden C. Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother 2003 47 : 2756 2764. (Pubitemid 37040244)
41. Dellit TH, Owens RC, McGowan JJ et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis: Off Pub Infect Dis Soc Am 2007 44 : 159 177. (Pubitemid 46084814)
42. Shlaes DM, Gerding DN, John JF, Jr. et al. Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: Guidelines for the prevention of antimicrobial resistance in hospitals. Clin Infect Dis 1997 25 : 584 599. (Pubitemid 127774277)
43. Rello J, Sa-Borges M, Correa H, Leal SR, Baraibar J. Variations in etiology of ventilator-associated pneumonia across four treatment sites: Implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 1999 160 : 608 613. (Pubitemid 29380680)
44. Namias N, Samiian L, Nino D et al. Incidence and susceptibility of pathogenic bacteria vary between intensive care units within a single hospital: Implications for empiric antibiotic strategies. J Trauma 2000 49 : 638 645.