Insulin hyposecretion in nondiabetic, tacrolimus-treated renal transplant recipients more than 6 months posttransplantation

Transplantation

Volumn 87, Issue 12, 2009, Pages 1870-1876

  Ravindran, Vinod K ^a   Moore, Richard H ^a   Dunseath, Gareth ^b   Luzio, Steve D ^b   Owens, David R ^b   Baboolal, Keshwar ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b LLANDOUGH HOSPITAL   (United Kingdom)

Author keywords

Insulin secretion; Renal transplantation; Tacrolimus

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTRAL INSULIN; PREDNISOLONE; TACROLIMUS;

ADULT; AGED; ARTICLE; BONE MARROW SUPPRESSION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIABETES MELLITUS; FEMALE; GASTROINTESTINAL DISEASE; GLOMERULUS FILTRATION RATE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; KIDNEY CELL; KIDNEY FUNCTION; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADULT; AGED; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; GLUCOSE TOLERANCE TEST; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; INSULIN; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; TACROLIMUS; TIME FACTORS; WAIST-HIP RATIO;

EID: 67649610585     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181a767b3     Document Type: Article

References (37)

1. Kasiske BL, Snyder J, Matas A, et al. The impact of transplantation on survival with kidney failure. Clin Transpl 2000; 135.
2. Tutone VK, Mark PB, Revanur V, et al. Random blood glucose measurements and survival in nondiabetic renal transplant recipients. Transplant Proc 2004; 36: 3006.
3. Kasiske BL, Snyder JJ, Gilbertson D, et al. Diabetes mellitus after kidney transplantation in the United States. Am J Transplant 2003; 3: 178.
4. Hjelmesaeth J, Hartmann A, Kofstad J, et al. Glucose intolerance after renal transplantation depends upon prednisolone dose and recipient age. Transplantation 1997; 64: 979.
5. Knoll GA, Bell RC. Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: Meta-analysis of randomised trials. BMJ 1999; 318: 1104.
6. Pirsch JD, Miller J, Deierhoi MH, et al. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. Transplantation 1997; 63: 977.
7. Mayer AD, Dmitrewski J, Squifflet JP, et al. Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: A report of the European Tacrolimus Multicenter Renal Study Group. Transplantation 1997; 64: 436.
8. NamJH,MunJI, Kim SI, et al. Beta-cell dysfunction rather than insulin resistance is the main contributing factor for the development of postrenal transplantation diabetes mellitus. Transplantation 2001; 71: 1417.
9. Ekstrand AV, Eriksson JG, Gronhagen-Riska C, et al. Insulin resistance and insulin deficiency in the pathogenesis of posttransplantation diabetes in man. Transplantation 1992; 53: 563.
10. Midtvedt K, Hartmann A, Hjelmesaeth J, et al. Insulin resistance is a common denominator of post-transplant diabetes mellitus and impaired glucose tolerance in renal transplant recipients. Nephrol Dial Transplant 1998; 13: 427.
11. Hjelmesaeth J, Hagen M, Hartmann A, et al. The impact of impaired insulin release and insulin resistance on glucose intolerance after renal transplantation. Clin Transplant 2002; 16: 389.
12. Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003; 46: 3.
13. Lawrence MC, Bhatt HS, Watterson JM, et al. Regulation of insulin gene transcription by a calcium-responsive pathway involving calcineurin and nuclear factor of activated T cells. Mol Endocrinol 2001; 15: 1758.
14. Hirano Y, Fujihira S, Ohara K, et al. Morphological and functional changes of islets of Langerhans in FK506-treated rats. Transplantation 1992; 53: 889.
15. Dufer M, Krippeit-Drews P, Lembert N, et al. Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol Pharmacol 2001; 60: 873.
16. +-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. J Biol Chem 2002; 277: 24232.
17. Oetjen E, Baun D, Beimesche S, et al. Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice. Mol Pharmacol 2003; 63: 1289.
18. Teuscher AU, Seaquist ER, Robertson RP. Diminished insulin secretory reserve in diabetic pancreas transplant and nondiabetic kidney transplant recipients. Diabetes 1994; 43: 593.
19. Alvestrand A. Carbohydrate and insulin metabolism in renal failure. Kidney Int Suppl 1997; 62: S48.
20. Davidson J, Wilkinson A, Dantal J, et al. New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003. Transplantation 2003; 75 (10 suppl): SS3.
21. Owens DR, Luzio SD, Coates PA. Insulin secretion and sensitivity in newly diagnosed NIDDM Caucasians in the UK. Diabet Med 1996; 13(9suppl 6): S19.
22. Welch S, Gebhart SS, Bergman RN, et al. Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 1990; 71: 1508.
23. Mosteller RD. Simplified calculation of body-surface area.NEngl J Med 1987; 317: 1098.
24. Roubenoff R, Drew H, Moyer M, et al. Oral cimetidine improves the accuracy and precision of creatinine clearance in lupus nephritis. Ann Intern Med 1990; 113: 501.
25. Brochner-Mortensen J, Rodbro P. Optimum time of blood sampling for determination of GFR by single-injection [51Cr]EDTA plasma clearance. Scand J Clin Lab Invest 1976; 36: 795.
26. Mehring GH, Coates PA, Brunel PC, et al. Insulin sensitivity in type 2 diabetes: Univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified intravenous glucose tolerance test (FSIGT). Comput Methods Programs Biomed 2002; 68: 161.
27. Bergman RN, Ider YZ, Bowden CR, et al. Quantitative estimation of insulin sensitivity. Am J Physiol 1979; 236: E667.
28. Laaksonen DE, Lakka HM, Niskanen LK, et al. Metabolic syndrome and development of diabetes mellitus: Application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 2002; 156: 1070.
29. Greenspan LC, Gitelman SE, Leung MA, et al. Increased incidence in post-transplant diabetes mellitus in children: A case-control analysis. Pediatr Nephrol 2002; 17: 1.
30. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539.
31. van Duijnhoven EM, Christiaans MH, Boots JM, et al. Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. J Am Soc Nephrol 2002; 13: 213.
32. Godsland IF, Jeffs JA, Johnston DG. Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 2004; 47: 1157.
33. PorteDJr, Kahn SE. beta-cell dysfunction and failure in type 2 diabetes: Potential mechanisms. Diabetes 2001; 50(suppl 1): S160.
34. Bergman RN, Ader M, Huecking K, et al. Accurate assessment of betacell function: The hyperbolic correction. Diabetes 2002; 51(suppl 1): S212.
35. Bonadonna RC, Stumvoll M, Fritsche A, et al. Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: Studies with a minimal model to assess beta-cell function. Diabetes 2003; 52: 470.
36. Alvestrand A, Mujagic M, Wajngot A, et al. Glucose intolerance in uremic patients: The relative contributions of impaired beta-cell function and insulin resistance. Clin Nephrol 1989; 31: 175.
37. Tamura K, Fujimura T, Tsutsumi T, et al. Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein- 12 in pancreatic beta-cell. Transplantation 1995; 59: 1606.