Freezing step controls the mannitol phase composition heterogeneity

Chemical Engineering Research and Design

Volumn 87, Issue 8, 2009, Pages 1017-1027

  Nakagawa, Kyuya ^a   Murakami, Wataru ^a   Andrieu, Julien ^b   Vessot, Séverine ^b  

^a UNIVERSITY OF HYOGO   (Japan)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Crystal growth; Freeze drying; Freezing model; Ice; Mannitol; Polymorph

Indexed keywords

COOLING RATES; CRYSTALLINE FORM; CRYSTALLINE STRUCTURE; D-MANNITOL; FREEZE-DRIED FORMULATIONS; FREEZE-DRYING; FREEZING CONDITIONS; HIGHER TEMPERATURES; ICE CRYSTALS; MANNITOL; NUCLEATION TEMPERATURE; POLYMORPH; SLOW COOLING; STABLE FORM; STEP CONTROL; TEMPERATURE PROFILES; XRD ANALYSIS;

COOLING; CRYSTAL GROWTH; CRYSTALLINE MATERIALS; CRYSTALLIZATION; DEWATERING; GRAIN BOUNDARIES; ICE; LOW TEMPERATURE DRYING; NUCLEATION; POLYMORPHISM; QUALITY ASSURANCE; QUALITY CONTROL; QUALITY FUNCTION DEPLOYMENT; TOTAL QUALITY MANAGEMENT;

FREEZING;

EID: 67649534714     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2009.01.008     Document Type: Article

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