Expression of protease-activated receptor-2 (PAR-2) in patients with nasopharyngeal carcinoma: Correlation with clinicopathological features and prognosis

Pathology Research and Practice

Volumn 205, Issue 8, 2009, Pages 542-550

  Li, Zhi ^a   Bian, Li Juan ^a   Li, Yang ^a   Liang, Ying Jie ^a   Liang, Hui Zhen ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Angiogenesis; Latent membrane protein 1 (LMP 1); Matrix metalloproteinases 9 (MMP9); Nasopharyngeal carcinoma (NPC); Protease activated receptor 2 (PAR 2)

Indexed keywords

GELATINASE B; LATENT MEMBRANE PROTEIN 1; PROTEINASE ACTIVATED RECEPTOR 2;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CELL LABELING; CORRELATION ANALYSIS; ENDOTHELIUM CELL; EPSTEIN BARR VIRUS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CHINA; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; RECEPTOR, PAR-2; RIBOSOMAL PROTEINS; RNA-BINDING PROTEINS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 67649523127     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.01.015     Document Type: Article

References (38)

1. Fandi A., Altun M., Azli N., Armand J.P., and Cvitkovic E. Nasopharyngeal cancer: epidemiology, staging, and treatment. Semin. Oncol. 21 (1994) 382-397
2. Darmoul D., Marie J.C., Devaud H., Gratio V., and Laburthe M. Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2. Br. J. Cancer 85 (2001) 772-779
3. Fujimoto D., Hirono Y., Goi T., Katayama K., Hirose K., and Yamaguchi A. Expression of protease activated receptor-2 (PAR-2) in gastric cancer. J. Surg. Oncol. 93 (2006) 139-144
4. Mayer E.A., and Collins S.M. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology 122 (2002) 2032-2048
5. Deryugina E.I., and Quigley J.P. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 25 (2006) 9-34
6. Chang E.T., and Adami H.O. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol. Biomarkers Prev. 15 (2006) 1765-1777
7. Mule F., Baffi M.C., and Cerra M.C. Dual effect mediated by protease-activated receptors on the mechanical activity of rat colon. Br. J. Pharmacol. 136 (2002) 367-374
8. Hjortoe G.M., Petersen L.C., Albrektsen T., Sorensen B.B., Norby P.L., Mandal S.K., Pendurthi U.R., and Rao L.V. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood 103 (2004) 3029-3037
9. Takeshita H., Yoshizaki T., Miller W.E., Sato H., Furukawa M., Pagano J.S., and Raab-Traub N. Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. J. Virol. 73 (1999) 5548-5555
10. Vliagoftis H., Schwingshackl A., Milne C.D., Duszyk M., Hollenberg M.D., Wallace J.L., Befus A.D., and Moqbel R. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J. Allergy Clin. Immunol. 106 (2000) 537-545
11. Zheng H., Takahashi H., Murai Y., Cui Z., Nomoto K., Niwa H., Tsuneyama K., and Takano Y. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. Anticancer Res. 26 (2006) 3579-3583
12. Jahan I., Fujimoto J., Alam S.M., Sato E., Sakaguchi H., and Tamaya T. Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers. Oncol. Rep. 17 (2007) 345-350
13. Belperio J.A., Keane M.P., Arenberg D.A., Addison C.L., Ehlert J.E., Burdick M.D., and Strieter R.M. CXC chemokines in angiogenesis. J. Leukoc. Biol. 68 (2000) 1-8
14. Rubio L., Burgos J.S., Morera C., and Vera-Sempere F.J. Morphometric study of tumor angiogenesis as a new prognostic factor in nasopharyngeal carcinoma patients. Pathol. Oncol. Res. 6 (2000) 210-216
15. Rubio L., Burgos J.S., Lopez-Guerrero J.A., Morera C., and Vera-Sempere F.J. Expression of p53 protein and tumor angiogenesis as prognostic factors in nasopharyngeal carcinoma patients. Pathol. Res. Pract. 198 (2002) 97-102
16. Presta M., Dell'Era P., Mitola S., Moroni E., Ronca R., and Rusnati M. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 16 (2005) 159-178
17. Hollenberg M.D., and Compton S.J. International union of pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol. Rev. 54 (2002) 203-217
18. D'Andrea M.R., Derian C.K., Santulli R.J., and Andrade-Gordon P. Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am. J. Pathol. 158 (2001) 2031-2041
19. Vergnolle N. Modulation of visceral pain and inflammation by protease-activated receptors. Br. J. Pharmacol. 141 (2004) 1264-1274
20. Ikeda O., Egami H., Ishiko T., Ishikawa S., Kamohara H., Hidaka H., Takahashi M., and Ogawa M. Signal of proteinase-activated receptor-2 contributes to highly malignant potential of human pancreatic cancer by up-regulation of interleukin-8 release. Int. J. Oncol. 28 (2006) 939-946
21. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
22. Nyberg P., Moilanen M., Paju A., Sarin A., Stenman U.H., Sorsa T., and Salo T. MMP-9 activation by tumor trypsin-2 enhances in vivo invasion of human tongue carcinoma cells. J. Dent. Res. 81 (2002) 831-835
23. Foote R.L., Weidner N., Harris J., Hammond E., Lewis J.E., Vuong T., Ang K.K., and Fu K.K. Evaluation of tumor angiogenesis measured with microvessel density (MVD) as a prognostic indicator in nasopharyngeal carcinoma: results of RTOG 9505. Int. J. Radiat. Oncol. Biol. Phys. 61 (2005) 745-753
24. Curran S., and Murray G.I. Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis. Eur. J. Cancer 36 (2000) 1621-1630
25. Miyata S., Koshikawa N., Yasumitsu H., and Miyazaki K. Trypsin stimulates integrin alpha(5)beta(1)- dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2. J. Biol. Chem. 275 (2000) 4592-4598
26. Murono S., Inoue H., Tanabe T., Joab I., Yoshizaki T., Furukawa M., and Pagano J.S. Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. Proc. Natl. Acad. Sci. USA 98 (2001) 6905-6910
27. Bohm S.K., McConalogue K., Kong W., and Bunnett N.W. Proteinase-activated receptors: new functions for old enzymes. News Physiol. Sci. 13 (1998) 231-240
28. Wilson S.R., Gallagher S., Warpeha K., and Hawthorne S.J. Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors. Prostate 60 (2004) 168-174
29. Horikawa T., Yoshizaki T., Sheen T.S., Lee S.Y., and Furukawa M. Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer 89 (2000) 715-723
30. Li T., and He S. Induction of IL-6 release from human T cells by PAR-1 and PAR-2 agonists. Immunol. Cell Biol. 84 (2006) 461-466
31. Yoshizaki T., Horikawa T., Qing-Chun R., Wakisaka N., Takeshita H., Sheen T.S., Lee S.Y., Sato H., and Furukawa M. Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma. Clin. Cancer Res. 7 (2001) 1946-1951
32. Yoshizaki T. Promotion of metastasis in nasopharyngeal carcinoma by Epstein-Barr virus latent membrane protein-1. Histol. Histopathol. 17 (2002) 845-850
33. Kim T.D., Song K.S., Li G., Choi H., Park H.D., Lim K., Hwang B.D., and Yoon W.H. Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. BMC Cancer 6 (2006) 211
34. Shi W., Pataki I., MacMillan C., Pintilie M., Payne D., O'Sullivan B., Cummings B.J., Warde P., and Liu F.F. Molecular pathology parameters in human nasopharyngeal carcinoma. Cancer 94 (2002) 1997-2006
35. Cho W.C. Nasopharyngeal carcinoma: molecular biomarker discovery and progress. Mol. Cancer 6 (2007) 1
36. Shi X., Gangadharan B., Brass L.F., Ruf W., and Mueller B.M. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol. Cancer. Res. 2 (2004) 395-402
37. Liu Y., and Mueller B.M. Protease-activated receptor-2 regulates vascular endothelial growth factor expression in MDA-MB-231 cells via MAPK pathways. Biochem. Biophys. Res. Commun. 344 (2006) 1263-1270
38. Li Z., Ren Y., Wu Q.C., Lin S.X., Liang Y.J., and Liang H.Z. Macrophage migration inhibitory factor enhances neoplastic cell invasion by inducing the expression of matrix metalloproteinase 9 and interleukin-8 in nasopharyngeal carcinoma cell lines. Chin. Med. J. (Engl.) 117 (2004) 107-114