BMP-7 functions as a novel hormone to facilitate liver regeneration

FASEB Journal

Volumn 21, Issue 1, 2007, Pages 256-264

  Sugimoto, Hikaru ^a   Yang, Changqing ^a   LeBleu, Valerie S ^a   Soubasakos, Mary A ^a   Giraldo, Mauricio ^a   Zeisberg, Michael ^a   Kalluri, Raghu ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Hepatocytes; Transforming growth factor

Indexed keywords

ACTIVIN LIKE KINASE 3; ENZYME; OSTEOGENIC PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; HOMEOSTASIS; LIVER FUNCTION; LIVER REGENERATION; LIVER RESECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; HEPATECTOMY; HUMANS; LIVER FUNCTION TESTS; LIVER REGENERATION; MALE; MICE; ORGAN SIZE; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33846025410     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6837com     Document Type: Article

References (26)

1. Kingsley, D. M. (1994) The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133-146
2. Ozkaynak, E., Rueger, D. C., Drier, E. A., Corbett, C., Ridge, R. J., Sampath, T. K., and Oppermann, H. (1990) OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J. 9, 2085-2093
3. Wozney, J. M. (1998) The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult. Eur J. Oral Sci. 106 Suppl. 1, 160-166
4. Hruska, K. A., Guo, G., Wozniak, M., Martin, D., Miller, S., Liapis, H., Loveday, K., Klahr, S., Sampath, T. K., and Morrissey, J. (2000) Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am. J. Physiol. Renal Physiol. 279, F130-F143
5. Davies, M. R., Lund, R. J., Mathew, S., and Hruska, K. A. (2005) Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J. Am. Soc. Nephrol. 16, 917-928
6. Zaret, K. S. (2002) Regulatory phases of early liver development: paradigms of organogenesis. Nat. Rev. Genet. 3, 499-512
7. Hogan, B. L. (1996) Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6, 432-438
8. Vukicevic, S., Latin, V., Chen, P., Batorsky, R., Reddi, A. H., and Sampath, T. K. (1994) Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: high affinity binding to basement membranes. Biochem. Biophys. Res. Commun. 198, 693-700
9. Taub, R. (2004) Liver regeneration: from myth to mechanism. Nat. Rev. Mol. Cell. Biol. 5, 836-847
10. Michalopoulos, G. K., and DeFrances, M. C. (1997) Liver regeneration. Science 276, 60-66
11. Rabes, H. M., Wirsching, R., Tuczek, H. V., and Iseler, G. (1976) Analysis of cell cycle compartments of hepatocytes after partial hepatecomy. Cell Tissue Kinet. 9, 517-532
12. Zeisberg, M., Kramer, K., Sindhi, N., Sarkar, P., Upton, M., and Kalluri, R. (2006) De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Mol. Cell Biochem. 283, 181-189
13. Fausto, N. (2001) Liver regeneration: from laboratory to clinic. Liver Transpl. 7, 835-844
14. Gill, R. Q., and Sterling, R. K. (2001) Acute liver failure. J. Clin. Gastroenterol. 33, 191-198
15. Kalluri, R., and Zeisberg, M. (2003) Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7. Histol. Histopathol. 18, 217-224
16. Thorgeirsson, S. S. (1996) Hepatic stem cells in liver regeneration. FASEB J. 10, 1249-1256
17. Ozkaynak, E., Schnegelsberg, P. N., and Oppermann, H. (1991) Murine osteogenic protein (OP-1): high levels of mRNA in kidney. Biochem. Biophys. Res. Commun. 179, 116-123
18. Luo, G., Hofmann, C., Bronckers, A. L., Sohocki, M., Bradley, A., and Karsenty, G. (1995) BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9, 2808-2820
19. Wrana, J., and Pawson, T. (1997) Signal transduction. Mad about SMADs. Nature 388, 28-29
20. Davies, M. R., Lund, R. J., and Hruska, K. A. (2003) BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J. Am. Soc. Nephrol. 14, 1559-1567
21. Higgins, and Anderson (1931) Experimental pathology of the liver. I. Restoration of the liver ofthe white rat following partial surgical removal. Arch. Pathol. 12, 186-202
22. Kaibori, M., Inoue, T., Oda, M., Naka, D., Kawaguchi, T., Kitamura, N., Miyazawa, K., Kwon, A. H., Kamiyama, Y., and Okumura, T. (2002) Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. Biochem. Biophys. Res. Commun. 290, 475-481
23. Zeisberg, M., Bonner, G., Maeshima, Y., Colorado, P., Muller, G. A., Strutz, F., and Kalluri, R. (2001) Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am. J. Pathol. 159, 1313-1321
24. Yang, C., Zeisberg, M., Mosterman, B., Sudhakar, A., Yerramalla, U., Holthaus, K., Xu, L., Eng, F., Afdhal, N., and Kalluri, R. (2003) Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology. 124, 147-159
25. Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J. C., Maeshima, Y., Yang, C., Hynes, R. O., Werb, Z., Sudhakar, A., and Kalluri, R. (2003) Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 3, 589-601
26. Okuno, Y., Huettner, C. S., Radomska, H. S., Petkova, V., Iwasaki, H., Akashi, K., and Tenen, D. G. (2002) Distal elements are critical for human CD34 expression in vivo. Blood 100, 4420-4426