Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3

International Journal of Oncology

Volumn 34, Issue 5, 2009, Pages 1467-1473

  Kim, Byeong Mo ^a   Won, Juyoon ^a   Maeng, Kyung Ah ^a   Han, Young Soo ^a   Yun, Yeon Sook ^a   Hong, Sung Hee ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Caspase 3; Caspase 8; COX 2 inhibitor; Nimesulide; Radiation

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NIMESULIDE; PROTEIN BID; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SENSITIVITY; FEMALE; GENE ACTIVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RADIATION DOSE; RADIOSENSITIVITY; TUMOR REGRESSION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CYCLOOXYGENASE 2 INHIBITORS; DRUG SYNERGISM; ENZYME ACTIVATION; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; SUBSTRATE SPECIFICITY; SULFONAMIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 67649446829     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000276     Document Type: Article

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