Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas

Cytogenetics and Cell Genetics

Volumn 94, Issue 1-2, 2001, Pages 1-8

  Loeper, S ^a   Romeike, B F M ^a   Heckmann, N ^a   Jung, V ^a   Henn, W ^a   Feiden, W ^a   Zang, K D ^a   Urbschat, Steffi ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EOSIN; HEMATOXYLIN; PARAFFIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER TISSUE; CELL CLONING; CELL VIABILITY; CHROMOSOME 10; CHROMOSOME 12; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME ABERRATION; CHROMOSOME NUMBER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; KARYOTYPE; MALE; MITOSIS RATE; MOLECULAR CLONING; MONOSOMY; PRIORITY JOURNAL; STRESS; TRISOMY; TUMOR CELL;

EID: 0034759748     PISSN: 03010171     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048773     Document Type: Article

References (22)

1. Fluorescence in situ hybridization study of chromosomes 7, 10, X and Y in primary and secondary glioblastomas
2. Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations
3. Molecular analysis of microdissected de novo glioblastoma and paired astrocytic tumors
4. Study on aneuploidy and p53 mutations in astrocytomas
5. Use of fluorescence in situ hybridization to detect loss of chromosome 10 in astrocytomas
6. Twelve amplified and expressed genes localized in a single domain in glioma
7. Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas
8. Polysomy 7 is correlated with overexpression of the erbB oncogene in human glioblastoma cell lines
9. In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors
10. Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area specific CGH on microdissected tumor cells
11. Gliobastomas
12. Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors
13. Allelic deletion analysis of MMAC/PTEN and DMBT1 loci in gliomas: Relationship to prognostic significance
14. A two color technique for chromosome in situ hybridization in tissue sections
15. Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression
16. Chromosomal composition of a series of 22 human low-grade gliomas
17. Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses
18. Early proliferation enhancement by monosomy 10 and intratu-mor heterogeneity in malignant human gliomas as revealed by smear preparations from biopsies
19. Genetic heterogeneity in human astrocytomas: Spatial distribution of p16 and p53 deletions in biopsies
20. Karyotypes in 90 human gliomas
21. p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma
22. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas