Creatine

Sports Nutrition: Fats and Proteins

Volumn , Issue , 2007, Pages 165-186

  Kreider, Richard B ^a  

^a BAYLOR UNIVERSITY   (United States)

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EID: 67649425928     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (120)

1. Chanutin, A., The fate of creatine when administered to man. J Biol Chem, 67: 29-34, 1926.
2. Hultman, E., J. Bergstrom, L. Spreit, and K. Soderlund, Energy metabolism and fatigue, in Biochemistry of Exercise VII, A. Taylor, P.D. Gollnick, and H. Green, Eds. Human Kinetics Publishers, Champaign, IL, 1990, pp. 73-92.
3. Balsom, P.D., K. Soderlund, and B. Ekblom, Creatine in humans with special reference to creatine supplementation. Sports Med, 18: 268-280, 1994.
4. Greenhaff, P., The nutritional biochemistry of creatine. J Nutr Biochem, 11: 610-618, 1997.
5. Greenhaff, P.L., Muscle creatine loading in humans: procedures and functional and metabolic effects, in 6th Internationl Conference on Guanidino Compounds in Biology and Medicine. Cincinatti, OH, 2001.
6. Greenhaff, P., A. Casey, and A.L. Green, Creatine supplementation revisited: an update. Insider, 4: 1-2, 1996.
7. Harris, R.C., K. Soderlund, and E. Hultman, Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Colch), 83: 367-374, 1992.
8. Paddon-Jones, D., E. Borsheim, and R.R. Wolfe, Potential ergogenic effects of arginine and creatine supplementation. J Nutr, 134: 2888S-28894S, 2004.
9. Hultman, E., K. Soderlund, J.A. Timmons, G. Cederblad, and P.L. Greenhaff, Muscle creatine loading in men. J Appl Physiol, 81: 232-237, 1996.
10. Burke, D.G., T. Smith-Palmer, L.E. Holt, B. Head, and P.D. Chilibeck, The effect of 7 days of creatine supplementation on 24-hour urinary creatine excretion. J Strength Cond Res, 15: 59-62, 2001.
11. Williams, M.H. and J.D. Branch, Creatine supplementation and exercise performance: an update. J Am Coll Nutr, 17: 216-234, 1998.
12. Williams, M.H., R. Kreider, and J.D. Branch, Creatine: The Power Supplement. Human Kinetics Publishers, Champaign, IL, 1999, p. 252.
13. Burke, D.G., PD. Chilibeck, G. Parise, D.G. Candow, D. Mahoney, and M. Tarnopolsky, Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc, 35: 1946-1955, 2003.
14. DeGrauw, T.J., K.C. Cecil, G.S. Salomons, S.J.M. Van Dooren, N.M. Verhoeven, W. S. Ball, and C. Gadobs, The clinical syndrome of creatine transporter deficiency, in 6th Internationl Conference on Guanidino Compounds in Biology and Medicine. Cincinatti, OH, 2001 (abstract).
15. Stockler, S. and F. Hanefeld, Guanidinoacetate methyltransferase deficiency: a newly recognized inborn error of creatine biosynthesis. Wiener Klinische Wochenschrift, 109: 86-88, 1997.
16. Kreider, R.B., B.C. Leutholtz, and M. Greenwood, Creatine, in Nutritional Ergogenic Aids, I. Wolinsky and J. Driskell, Eds. CRC Press, Boca Raton, FL, 2004, pp. 81-104.
17. Steenge, G.R., E.J. Simpson, and P.L. Greenhaff, Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. J Appl Physiol, 89: 1165-1171, 2000.
18. Green, A.L., E. Hultman, I.A. Macdonald, D.A. Sewell, and P.L. Greenhaff, Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol, 271 (Pt 1): E821-E826, 1996.
19. Willoughby, D.S. and J. Rosene, Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc, 33: 1674-1681, 2001.
20. Willoughby, D.S. and J.M. Rosene, Effects of oral creatine and resistance training on myogenic regulatory factor expression. Med Sci Sports Exerc, 35: 923-929, 2003.
21. Greenhaff, P.L., A. Casey, A.H. Short, R. Harris, K. Soderlund, and E. Hultman, Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci (Colch), 84: 565-571, 1993.
22. Greenhaff, P.L., K. Bodin, K. Soderlund, and E. Hultman, Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol, 266 (Pt 1): E725-E730, 1994.
23. Greenwood, M., R.B. Kreider, C. Rasmussen, A.L. Almada, and C.P. Earnest, D-Pinitol augments whole body creatine retention in man. J Exerc Physiol, 4: 41-47, 2001 (online).
24. Kreider, R.B., D.S. Willoughby, M. Greenwood, G. Parise, E. Payne, and M.A. Tarnopolsky, Effects of serum creatine supplementation on muscle creatine content. J Exerc Physiol, 6: 24-33, 2003 (online).
25. Vandenberghe, K., M. Goris, P. Van Hecke, M. Van Leemputte, L. Vangerven, and P. Hespel, Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol, 83: 2055-2063, 1997.
26. Candow, D.G., P.D. Chilibeck, K.E. Chad, M.J. Chrusch, K.S. Davison, and D.G. Burke, Effect of ceasing creatine supplementation while maintaining resistance training in older men. J Aging Phys Act, 12: 219-231, 2004.
27. Kreider, R., M. Greenwood, C. Melton, C. Rasmussen, E. Cantler, P Milner, and A. Almada, Long-term creatine supplementation during training/competition does not increase perceptions of fatigue or adversely affect health status. Med Sci Sport Exerc, 34: S146, 2002.
28. Kreider, R.B., Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem, 244: 89-94, 2003.
29. Wallimann, T., M. Dolder, D. Neumann, and U. Schlattner, Compartmentation, structure, and function of creatine kinases: a rationale for creatine action, in 6th International Conference on Guanidino Compounds in Biology and Medicine. Cincinatti, OH, 2001 (abstract).
30. Bessman, S. and F. Savabi, The role of phosphocreatine energy shuttle in exercise and muscle hypertrophy, in Creatine and Creatine Phosphate: Scientific and Clinical Perspectives, M.A. Conway and J.F. Clark, Eds. Academic Press, San Diego, CA, 1988, pp. 185-198.
31. Wallimann, T., M. Dolder, U. Schlattner, M. Eder, T. Hornemann, E. O'Gorman, A. Ruck, and D. Brdiczka, Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology. Biofactors, 8: 229-234, 1998.
32. Clark, J.F., M.L. Field, and R. Ventura-Clapier, An introduction to the cellular creatine kinase system in contractile tissue, in Creatine and Creatine Phosphate: Scientific and Clinical Perspectives, M.A. Conway and J.F. Clark, Eds. Academic Press, San Diego, CA, 996, pp. 51-64.
33. Clark, J.F., Creatine and phosphocreatine: a review of their use in exercise and sport. J Athl Train, 32: 45-50, 1997.
34. Ma, T.M., D.L. Friedman, and R. Roberts, Creatine phosphate shuttle pathway in tissues with dynamic energy demand, in Creatine and Creatine Phosphate: Scientific and Clinical Perspectives, M.A. Conway and J.F. Clark, Eds. Academic Press, San Diego, CA, 1996, pp. 17-32.
35. van Deursen, J., A. Heerschap, F. Oerlemans, W. Ruitenbeek, P. Jap, H. ter Laak, and B. Weiringa, Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell, 74: 621-631, 1993.
36. Askenasy, N. and A.P. Koretsky, Differential effects of creatine kinase isoenzymes and substrates on regeneration in livers of transgenic mice. Am J Physiol, 273 (Pt 1): C741-C746, 1997.
37. Wyss, M. and A. Schulze, Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease? Neuroscience, 112: 243-260, 2002.
38. Tarnopolsky, M.A., A. Parshad, B. Walzel, U. Schlattner, and T. Wallimann, Creatine transporter and mitochondrial creatine kinase protein content in myopathies. Muscle Nerve, 24: 682-688, 2001.
39. Hespel, P., B.O. Eijnde, W. Derave, and E.A. Richter, Creatine supplementation: exploring the role of the creatine kinase/phosphocreatine system in human muscle. Can J Appl Physiol, 26 (Suppl): S79-S102, 2001.
40. Felber, S., D. Skladal, M. Wyss, C. Kremser, A. Koller, and W. Sperl, Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study. Neurol Res, 22: 145-150, 2000.
41. Matthews, R.T., L. Yang, B.G. Jenkins, R.J. Ferrante, B.R. Rosen, R. Kaddurah-Daouk, and M.F. Beal, Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci, 18: 156-163, 1998.
42. Newsholme, E. and I. Beis, Old and new ideas on the roles of phosphagens and the kinases, in Creatine and Creatine Phosphate: Scientific and Clinical Perspectives, M.A. Conway and J.F. Clark, Eds. Academic Press, San Diego, CA, 1996, pp. 3-15.
43. Blei, M.L., K.E. Conley, and M.J. Kushmerick, Separate measures of ATP utilization and recovery in human skeletal muscle. J Physiol, 465: 203-222, 1993.
44. Radda, G.K., Control of energy metabolism during energy metabolism. Diabetes, 45: S88-S92, 1996.
45. Ferrante, R.J., O.A. Andreassen, B.G. Jenkins, A. Dedeoglu, S. Kuemmerle, J.K. Kubilus, R. Kaddurah-Daouk, S.M. Hersch, and M.F. Beal, Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci, 20: 4389-4397, 2000.
46. Dechent, P., P.J. Pouwels, B. Wilken, F. Hanefeld, and J. Frahm, Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol, 277 (Pt 2): R698-R704, 1999.
47. Hausmann, O.N., K. Fouad, T. Wallimann, and M.E. Schwab, Protective effects of oral creatine supplementation on spinal cord injury in rats. Spinal Cord, 40: 449-456, 2002.
48. Nelson, A.G., D.A. Arnall, J. Kokkonen, R. Day, and J. Evans, Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc, 33: 1096-1100, 2001.
49. van Loon, L.J., R. Murphy, A.M. Oosterlaar, D. Cameron-Smith, M. Hargreaves, A.J. Wagenmakers, and R. Snow, Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. Clin Sci (Lond), 106: 99-106, 2004.
50. Op't Eijnde, B., E.A. Richter, J.C. Henquin, B. Kiens, and P Hespel, Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle. Acta Physiol Scand, 171: 169-76, 2001.
51. Kehnder, M., J. Rico-Sanz, G. Kuhne, M. Dambach, R. Buchli, and U. Boutellier, Muscle phosphocreatine and glycogen concentrations in humans after creatine and glucose polymer supplementation measured noninvasively by 31P and 13C-MRS. Med Sci Sports Exerc, 30: S264, 1998.
52. Volek, J.S., N.D. Duncan, S.A. Mazzetti, R.S. Staron, M. Putukian, A.L. Gomez, D.R. Pearson, W.J. Fink, and W.J. Kraemer, Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc, 31: 1147-1156, 1999.
53. Stone, M.H., K. Sanborn, L.L. Smith, H.S. O'Bryant, T. Hoke, A.C. Utter, R.L. Johnson, R. Boros, J. Hruby, K.C. Pierce, M.E. Stone, and B. Garner, Effects of inseason (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr, 9: 146-165, 1999.
54. Kreider, R.B., M. Ferreira, M. Wilson, P. Grindstaff, S. Plisk, J. Reinardy, E. Cantler, and A.L. Almada, Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc, 30: 73-82, 1998.
55. Earnest, C.P, P. Snell, R. Rodriguez, A. Almada, and T.L. Mitchell, The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand, 153: 207-209, 1995.
56. Volek, J.S., W.J. Kraemer, J.A. Bush, M. Boetes, T. Incledon, K.L. Clark, and J.M. Lynch, Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc, 97: 765-770, 1997.
57. Tarnopolsky, M.A. and D.P. MacLennan, Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab, 10: 452-463, 2000.
58. Wiroth, J.B., S. Bermon, S. Andrei, E. Dalloz, X. Hebuterne, and C. Dolisi, Effects of oral creatine supplementation on maximal pedalling performance in older adults. Eur J Appl Physiol, 84: 533-539, 2001.
59. Skare, O.C., Skadberg, and A.R. Wisnes, Creatine supplementation improves sprint performance in male sprinters. Scand J Med Sci Sports, 11: 96-102, 2001.
60. Mujika, I., S. Padilla, J. Ibanez, M. Izquierdo, and E. Gorostiaga, Creatine supplementation and sprint performance in soccer players. Med Sci Sports Exerc, 32: 518-525, 2000.
61. Ostojic, S.M., Creatine supplementation in young soccer players. Int J Sport Nutr Exerc Metab, 14: 95-103, 2004.
62. Theodorou, A.S., C.B. Cooke, R.F. King, C. Hood, T. Denison, B.G. Wainwright, and K. Havenetidis, The effect of longer-term creatine supplementation on elite swimming performance after an acute creatine loading. J Sports Sci, 17: 853-859, 1999.
63. Mero, A.A., K.L. Keskinen, M.T. Malvela, and J.M. Sallinen, Combined creatine and sodium bicarbonate supplementation enhances interval swimming. J Strength Cond Res, 18: 306-310, 2004.
64. Preen, D., B. Dawson, C. Goodman, S. Lawrence, J. Beilby, and S. Ching, Effect of creatine loading on long-term sprint exercise performance and metabolism. Med Sci Sports Exerc, 33: 814-821, 2001.
65. Noonan, D., K. Berg, R.W. Latin, J.C. Wagner, and K. Reimers, Effects of varying dosages of oral creatine relative to fat free body mass on strength and body composition. J Strength Cond Res, 12: 104-108, 1998.
66. Kirksey, K.B., M.H. Stone, B.J. Warren, R.L. Johnson, M. Stone, G. Haff, F.E. Williams, and C. Proulx, The effects of 6 weeks of creatine monohydrate supplementation on performance measures and body composition in collegiate track and field athletes. J Strength Cond Res, 13: 148-156, 1999.
67. Jones, A.M., T. Atter, and K.P. Georg, Oral creatine supplementation improves multiple sprint performance in elite ice-hockey players. J Sports Med Phys Fitness, 39: 189-196, 1999.
68. Jowko, E., P Ostaszewski, M. Jank, J. Sacharuk, A. Zieniewicz, J. Wilczak, and S. Nissen, Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition, 17: 558-566, 2001.
69. Sipila, I., J. Rapola, O. Simell, and A. Vannas, Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N Engl J Med, 304: 867-870, 1981.
70. Vannas-Sulonen, K., I. Sipila, A. Vannas, O. Simell, and J. Rapola, Gyrate atrophy of the choroid and retina. A five-year follow-up of creatine supplementation. Ophthalmology, 92: 1719-1727, 1985.
71. Heinanen, K., K. Nanto-Salonen, M. Komu, M. Erkintalo, A. Alanen, O.J. Heinonen, K. Pulkki, E. Nikoskelainen, I. Sipila, and O. Simell, Creatine corrects muscle 31P spectrum in gyrate atrophy with hyperornithinaemia. Eur J Clin Invest, 29: 1060-1065, 1999.
72. Nanto-Salonen, K., M. Komu, N. Lundbom, K. Heinanen, A. Alanen, I. Sipila, and O. Simell, Reduced brain creatine in gyrate atrophy of the choroid and retina with hyperornithinemia. Neurology, 53: 303-307, 1999.
73. Ensenauer, R., T. Thiel, K.O. Schwab, U. Tacke, S. Stockler-Ipsiroglu, A. Schulze, J. Hennig, and W. Lehnert, Guanidinoacetate methyltransferase deficiency: differences of creatine uptake in human brain and muscle. Mol Genet Metab, 82: 208-213. 2004.
74. Schulze, A., F. Ebinger, D. Rating, and E. Mayatepek, Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. Mol Genet Metab, 74: 413-419, 2001.
75. Ganesan, V., A. Johnson, A. Connelly, S. Eckhardt, and R.A. Surtees, Guanidinoacetate methyltransferase deficiency: new clinical features. Pediatr Neurol, 17: 155-157, 1997.
76. Zhu, S., M. Li, B.E. Figueroa, A. Liu, I.G. Stavrovskaya, P. Pasinelli, M.F. Beal, R.H. Brown, Jr., B.S. Kristal, R.J. Ferrante, and R.M. Friedlander, Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. J Neurosci, 24: 5909-5912, 2004.
77. Brustovetsky, N., T. Brustovetsky, and J.M. Dubinsky, On the mechanisms of neuroprotection by creatine and phosphocreatine. J Neurochem, 76: 425-434, 2001.
78. Sullivan, P.G., J.D. Geiger, M.P. Mattson, and S.W. Scheff, Dietary supplement creatine protects against traumatic brain injury. Ann Neurol, 48: 723-729, 2000.
79. Jacobs, P.L., E.T. Mahoney, K.A. Cohn, L.F. Sheradsky, and B.A. Green, Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil, 83: 19-23, 2002.
80. Tarnopolsky, M.A., Potential use of creatine monohydrate in muscular dystrophy and neurometabolic disorders, in 6th Internationl Conference on Guanidino Compounds in Biology and Medicine. Cincinnati, OH, 2001 (abstract).
81. Tarnopolsky, M.A. and G. Parise, Direct measurement of high-energy phosphate compounds in patients with neuromuscular disease. Muscle Nerve, 22: 1228-1233, 1999.
82. Zange, J., C. Kornblum, K. Muller, S. Kurtscheid, H. Heck, R. Schroder, T. Grehl, and M. Vorgerd, Creatine supplementation results in elevated phosphocreatine/adenosine triphosphate (ATP) ratios in the calf muscle of athletes but not in patients with myopathies. Ann Neurol, 52: 126, 2002; discussion, 1206-1207.
83. Koumis, T., J.P Nathan, J.M. Rosenberg, and L.A. Cicero, Strategies for the prevention and treatment of statin-induced myopathy: is there a role for ubiquinone supplementation? Am J Health Syst Pharm, 61: 515-519, 2004.
84. Borchert, A., E. Wilichowski, and F. Hanefeld, Supplementation with creatine monohydrate in children with mitochondrial encephalomyopathies. Muscle Nerve, 22: 1299-1300, 1999.
85. Tarnopolsky, M.A., B.D. Roy, and J.R. MacDonald, A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve, 20: 1502-1509, 1997.
86. Andreassen, O.A., A. Dedeoglu, R.J. Ferrante, B.G. Jenkins, K.L. Ferrante, M. Thomas, A. Friedlich, S.E. Browne, G. Schilling, D.R. Borchelt, S.M. Hersch, C.A. Ross, and M.F. Beal, Creatine increases survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis, 83: 479-491, 2001.
87. Verbessem, P., J. Lemiere, B.O. Eijnde, S. Swinnen, L. Vanhees, M. Van Leemputte, P. Hespel, and R. Dom, Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial. Neurology, 61: 925-930, 2003.
88. Andreassen, O.A., B.G. Jenkins, A. Dedeoglu, K.L. Ferrante, M.B. Bogdanov, R. Kaddurah-Daouk, and M.F. Beal, Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. J Neurochem, 77: 383-390, 2001.
89. Tarnopolsky, M.A., Potential benefits of creatine monohydrate supplementation in the elderly. Curr Opin Clin Nutr Metab Care, 3: 497-502, 2000.
90. Drory, V.E. and D. Gross, No effect of creatine on respiratory distress in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord, 3: 43-46, 2002.
91. Mazzini, L., C. Balzarini, R. Colombo, G. Mora, I. Pastore, R. De Ambrogio, and M. Caligari, Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results. J Neurol Sci, 191: 139-144, 2001.
92. Willer, B., G. Stucki, H. Hoppeler, P. Bruhlmann, and S. Krahenbuhl, Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis. Rheumatology (Oxford), 39: 293-298, 2000.
93. Op't Eijnde, B., B. Urso, E.A. Richter, PL. Greenhaff, and P. Hespel, Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes, 50: 18-23, 2001.
94. Earnest, C.P., A. Almada, and T.L. Mitchell, High-performance capillary electrophoresis-pure creatine monohydrate reduced blood lipids in men and women. Clin Sci, 91: 113-118, 1996.
95. Brosnan, J.T., R.L. Jacobs, L.M. Stead, S. Ratnam, and M.E. Brosnan, Regulation of homocysteine metabolism: effects of insulin, glucagon and creatine. FASEB J, 15(4): A395, 2001.
96. Steenge, G.R., P. Verhoef, and P.L. Greenhaff, The effect of creatine and resistance training on plasma homocysteine concentration in healthy volunteers. Arch Intern Med, 161: 1455-1456, 2001.
97. McCarty, M.F., Supplemental creatine may decrease serum homocysteine and abolish the homocysteine 'gender gap' by suppressing endogenous creatine synthesis. Med Hypotheses, 56: 5-7, 2001.
98. Taes, Y.E., J.R. Delanghe, A.S. De Vriese, R. Rombaut, J. Van Camp, and N.H. Lameire, Creatine supplementation decreases homocysteine in an animal model of uremia. Kidney Int, 64: 1331-1337, 2003.
99. Greenwood, M., R.B. Kreider, C. Melton, C. Rasmussen, S. Lancaster, E. Cantler, P. Milnor, and A. Almada, Creatine supplementation during college football training does not increase the incidence of cramping or injury. Mol Cell Biochem, 244: 83-88, 2003.
100. Greenwood, M., R.B. Kreider, L. Greenwood, and A. Byars, Cramping and injury incidence in collegiate football players are reduced by creatine supplementation. J Athl Train, 38: 216-219, 2003.
101. Greenwood, M., J. Farris, R. Kreider, L. Greenwood, and A. Byars, Creatine supplementation patterns and perceived effects in select division I collegiate athletes. Clin J Sport Med, 10: 191-194, 2000.
102. Greenwood, M., R. Kreider, L. Greenwood, and A. Byars, Creatine supplementation does not increase the incidence of injury or cramping in college baseball players. J Exerc Physiol, 6: 16-22, 2003 (online).
103. Ortega Gallo, P.A., F. Dimeo, J. Batista, F. Bazan, L. Betchakian, C. Garcia Cambon, and J. Griffa, Creatine supplementation in soccer players, effects in body composition and incidence of sport-related injuries. Med Sci Sports Exerc, 32: S134, 2000.
104. Volek, J.S., N.A. Ratamess, M.R. Rubin, A.L. Gomez, D.N. French, M.M. McGuigan, T.P. Scheett, M.J. Sharman, K. Hakkinen, and W.J. Kraemer, The effects of creatine supplementation on muscular performance and body composition responses to shortterm resistance training overreaching. Eur J Appl Physiol, 91: 628-637, 2004.
105. Kreider, R., C. Rasmussen, C. Melton, M. Greenwood, T. Stroud, J. Ransom, E. Cantler, P. Milnor, and A.L. Almada, Long-term creatine supplementation does not adversely affect clinical markers of health. Med Sci Sports Exerc, 32: S134, 2000.
106. Schroeder, C., J. Potteiger, J. Randall, D. Jacobsen, L. Magee, S. Benedict, and M. Hulver, The effects of creatine dietary supplementation on anterior compartment pressure in the lower leg during rest and following exercise. Clin J Sport Med, 11: 87-95, 2001.
107. Carper, M.J., J.A. Potteiger, J.C. Randall, D.J. Jacobsen, M.W. Hulver, and J.P. Thyfault, Lower leg anterior compartment pressure response prior to, during, and following chronic creatine supplementation. Med Sci Sports Exerc, 33: S207, 2001.
108. Hile, A.M., J.M. Anderson, K.A. Fiala, J.H. Stevenson, D.J. Casa, and C.M. Maresh, Creatine supplementation and anterior compartment pressure during exercise in the heat in dehydrated men. J Athl Train, 41: 30-35, 2006.
109. Watson, G., D.J. Casa, K.A. Fiala, A. Hile, M.W. Roti, J.C. Healey, L.E. Armstrong, and C.M. Maresh, Creatine use and exercise heat tolerance in dehydrated men. J Athl Train, 41: 18-29, 2006.
110. Yoshizumi, W.M. and C. Tsourounis, Effects of creatine supplementation on renal function. J Herb Pharmcother, 4: 1-7, 2004.
111. Kreider, R.B., C. Melton, C.J. Rasmussen, M. Greenwood, S. Lancaster, E.C. Cantler, P. Milnor, and A.L. Almada, Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Mol Cell Biochem, 244: 95-104, 2003.
112. Schilling, B.K., M.H. Stone, A. Utter, J.T. Kearney, M. Johnson, R. Coglianese, L. Smith, H.S. O'Bryant, A.C. Fry, M. Starks, R. Keith, and M.E. Stone, Creatine supplementation and health variables: a retrospective study. Med Sci Sports Exerc, 33: 183-188, 2001.
113. Earnest, C.P, A. Almada, and T.L. Mitchell, Influence of chronic creatine supplementation on hepatorenal function. FASEB J, 10: A790, 1996.
114. Poortmans, J.R., H. Auquier, V. Renaut, A. Durussel, M. Saugy, and G.R. Brisson, Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol, 76: 566-567, 1997.
115. Poortmans, J.R. and M. Francaux, Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc, 31: 1108-1110, 1999.
116. Robinson, T.M., D.A. Sewell, A. Casey, G. Steenge, and P.L. Greenhaff, Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br J Sports Med, 34: 284-288, 2000.
117. Kilduff, L.P., E. Georgiades, N. James, R.H. Minnion, M. Mitchell, D. Kingsmore, M. Hadjicharlambous, and Y.P. Pitsiladis, The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. Int J Sport Nutr Exerc Metab, 14: 443-460, 2004.
118. Volek, J.S., S.A. Mazzetti, W.B. Farquhar, B.R. Barnes, A.L. Gomez, and W.J. Kraemer, Physiological responses to short-term exercise in the heat after creatine loading. Med Sci Sports Exerc, 33: 1101-1108, 2001.
119. Tyler, T.F., S.J. Nicholas, E.B. Hershman, B.W. Glace, M.J. Mullaney, and M.P. McHugh, The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, doubleblind trial. Am J Sports Med, 32: 383-388, 2004.
120. Hespel, P., B. Op't Eijnde, M. Van Leemputte, B. Urso, P.L. Greenhaff, V. Labarque, S. Dymarkowski, P. Van Hecke, and E.A. Richter, Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J Physiol, 536 (Pt 2): 625-633, 2001.