Effects of oral creatine and resistance training on myogenic regulatory factor expression

Medicine and Science in Sports and Exercise

Volumn 35, Issue 6, 2003, Pages 923-929

  Willoughby, Darryn S ^a   Rosene, John M ^b  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

DNA binding protein; Gene expression; Transcription factor; Translation

Indexed keywords

CREATINE; CREATINE KINASE; DNA BINDING PROTEIN; MESSENGER RNA; MYOD PROTEIN; MYOGENIC FACTOR; MYOGENIC FACTOR 5; MYOGENIC REGULATORY FACTOR 4; MYOGENIN; MYOSIN HEAVY CHAIN; PLACEBO; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA BINDING; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; KNEE FUNCTION; MALE; MUSCLE BIOPSY; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; CREATINE; CREATINE KINASE; DOUBLE-BLIND METHOD; GENE EXPRESSION REGULATION; HUMANS; MALE; MUSCLE, SKELETAL; MYOGENIC REGULATORY FACTORS; PLACEBOS; RNA, MESSENGER; WEIGHT LIFTING;

EID: 0037777863     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000069746.05241.F0     Document Type: Article

References (25)

1. ASKENADY, N., and A. KORETSKY. Differential effects of creatine kinase isoenzymes and substrates on regeneration in livers of transgenic mice. Am. J. Physiol. 273:C741-C746, 1997.
2. BALSOM, P., K. SODERLUND, B. SJODIN, and B. EKBLOM. Creatine in humans with special reference to creatine supplementation. Sports Med. 18:268-280, 1994.
3. CARLSEN, H., and K. GUNDERSEN. Helix-loop-helix transcription factors in electrically active and inactive skeletal muscles. Muscle Nerve 23:1374-1380, 2000.
4. CHAKRABORTY, T., and E. OLSON. Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF-4. Mol. Cell Biol. 11:6103-6108, 1991.
5. CAMPOS, G., T. LUECKE, H. WENDELN, et al. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur. J. Appl. Physiol. 88:50-60, 2002.
6. +-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. J. Biol. Chem. 268:8418-8421, 1993.
7. HAKKINEN, K., R. NEWTON, S. GORDON, et al. Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and older men. J. Gerontol. A Biol. Sci. Med. Sci. 53:B415-B423, 1998.
8. HARDY, S., Y. KONG, and S. KONIECZNY. Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. Mol. Cell Biol. 13:5943-5956, 1993.
9. HARRIS, R., K. SODERLUND, and E. HULTMAN. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. 83:367-374, 1992.
10. HELLER, H., and E. BENGAL. TFIID (TBP) stabilizes the binding of MyoD to its DNA site at the promoter and MyoD facilitates the association of TFIIB with the preinitiation complex. Nucl. Acids Res. 26:2112-2119, 1998.
11. HESPEL, P., B. OP'T EIJNDE, M. VAN LEEMPUTTE, et al. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J. Physiol. 536:625-633, 2001.
12. HUGHES, S., K. KOISHI, M. RUDNICKI, and A. MAGGS. MyoD protein is differentially accumulated in fast and slow skeletal muscle fibres and required for normal fibre type balance in rodents. Mech. Dev. 61:151-163, 1997.
13. INGWALL, J. Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle. Circ. Res. 38:1115-1123, 1976.
14. INGWALL, J., M. MORALES, and F. STOCKDALE. Creatine and the control of myosin synthesis in differentiating skeletal muscle. Proc. Natl. Acad. Sci. USA 69:2250-2253, 1972.
15. INGWALL, J., C. WEINER, M. MORALES, E. DAVIS, and F. STOCKDALE. Specificity of creatine in the control of muscle protein synthesis. J. Cell Biol. 63:145-151, 1974.
16. LOWE, D., T. LUND, and S. ALWAYS. Hypertrophy-stimulated myogenic regulatory factor mRNA increases are attenuated in fast muscle of aged quails. Am. J. Physiol. 275:C155-C162, 1998.
17. STARON, R., F. HAGERMAN, R. HIKIDA, et al. Fiber type composition of the vastus lateralis muscle of young men and women. J. Histchem. Cytochem. 48:623-629, 2000.
18. VAN DEURSEN, J., W. RUITENBEEK, A. HEERSCHAP, P. JAP, H. TER LAAK, and B. WIERINGA. Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression. Proc. Natl. Acad. Sci. USA 91:9091-9095, 1994.
19. VOLEK, J., N. DUNCAN, S. MAZZETTI, et al. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med. Sci. Sports Exerc. 31:1147-1156, 1999.
20. VOYTIK, S., M. PRIZYBORSKI, S. BADYLAK, and S. KONTECZNY. Differential expression of muscle regulatory genes in normal and denervated adult rat hindlimb muscle. Dev. Dyn. 198:214-224, 1993.
21. WALTERS, E., N. STRICKLAND, and P. LOUGHNA. MRF-4 exhibits fiber type- and muscle-specific pattern of expression in postnatal rat muscle. Am. J. Physiol. 278:R1381-R1384, 2000.
22. WALZEL, B., O. SPEER, E. BOEHM, et al. New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle. Am. J. Physiol. 283:E390-E401, 2002.
23. WELLE, S., K. BHATT, and C. THORNTON. Stimulation of myofibrillar synthesis by exercise is mediated by more efficient translation of mRNA. J. Appl. Physiol. 86:1220-1225, 1999.
24. WILLOUGHBY, D., and M. NELSON. Myosin heavy chain mRNA expression after a single session of heavy resistance exercise. Med. Sci. Sports Exerc. 34:1262-1269, 2002.
25. WILLOUGHBY, D., and J. ROSENE. Effects of oral creatine and resistance training on myosin heavy chain expression. Med. Sci. Sports Exerc. 33:1674-1681, 2001.