Reduced pH induces an inactive non-native conformation of the monomeric bothropstoxin-I (Lys49-PLA2)

Toxicon

Volumn 54, Issue 3, 2009, Pages 373-378

  de Oliveira, Arthur H C ^a   Ferreira, Tatiana L ^b   Ward, Richard J ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Verdartis Desenvolvimento Biotecnologico Ltda ME   (Brazil)

Author keywords

Membrane permeabilization; Molten globule; Phospholipase A2

Indexed keywords

8 ANILINO 1 NAPHTHALENESULFONIC ACID; BOTHROPSTOXIN 1; LIPOSOME; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; BOTHROPS JARARACUSSU; CONTROLLED STUDY; ENZYME CONFORMATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LYSOSOME MEMBRANE; MEMBRANE BINDING; MEMBRANE DAMAGE; PH MEASUREMENT; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; SNAKE; STRUCTURE ACTIVITY RELATION; ULTRACENTRIFUGATION;

CROTALID VENOMS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; ULTRACENTRIFUGATION;

BOTHROPS JARARACUSSU;

EID: 67649414197     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.04.022     Document Type: Article

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