Synthesis of highly functionalized proline derivatives via a one-pot Michael/aldol addition-cyclization approach

Synlett

Volumn , Issue 7, 2009, Pages 1136-1140

  Kazmaier, Uli ^a   Schmidt, Christian ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Aldol reaction; Amino acids; Chelates; Cyclization; Michael addition; One pot reaction

Indexed keywords

ALDEHYDE; ALPHA BETA UNSATURATED ESTER; CHELATE; CHELATED ENOLATE DERIVATIVE; ESTER DERIVATIVE; PROLINE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYCLIZATION; MICHAEL ADDITION; ONE POT SYNTHESIS; STEREOCHEMISTRY; SYNTHESIS;

EID: 67649388100     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0028-1088150     Document Type: Article

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43. Unfortunately the aldol products obtained with aromatic aldehydes could not be analyzed by GC; NMR has to be used in this case. Therefore, we were not able to determine exact ratios, but the NMR spectra indicated that the isomers were formed in comparable amounts.