Transmission of light to the aging human retina: Possible implications for age related macular degeneration

Experimental Eye Research

Volumn 79, Issue 6, 2004, Pages 753-759

  Dillon, James ^a   Zheng, Lei ^a   Merriam, John C ^a   Gaillard, Elizabeth R ^b  

^a Columbia Univ 630 W 168th St N ^*  (United States)

^b NORTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

ARMD; human lens; light damage; lipofuscin proprietary interest: none; spectral sensitivity

Indexed keywords

3 HYDROXYKYNURENINE; LIPOFUSCIN;

AGING; BLUE LIGHT; CATARACT EXTRACTION; CONFERENCE PAPER; CONTROLLED STUDY; EYE; HUMAN; HUMAN TISSUE; LENS; LENS IMPLANT; LIGHT; LIGHT ABSORPTION; PRIORITY JOURNAL; RETINA DISEASE; RETINA MACULA AGE RELATED DEGENERATION; SPECTROPHOTOMETRY;

AGED; AGED, 80 AND OVER; AGING; FIBER OPTICS; HUMANS; LENS, CRYSTALLINE; LIPOFUSCIN; MACULAR DEGENERATION; MIDDLE AGED; RETINA; SCATTERING, RADIATION; SPECTROPHOTOMETRY;

EID: 11844269325     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2004.06.025     Document Type: Conference Paper

References (18)

1. E.A. Boettner, and J.R. Wolter Transmission of the ocular media Invest. Ophthalmol. 1 1962 776 783
2. M. Delmelle An investigation of retinal as a source of singlet oxygen Photochem. Photobiol. 27 1978 721 734
3. F.C. DeLori, C.K. Dorey, G. Staurenghi, O. Arend, D.G. Goger, and J.J. Weiter In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics Invest. Ophthalmol. Vis. Sci. 36 1995 718 728
4. J. Dillon, R.H. Wang, and S. Atherton Photochemical and photo-physical studies on human lens constituents Photochem. Photobiol. 52 1990 849 854
5. J. Dillon, L. Zheng, J.C. Merriam, and E.R. Gaillard Transmission spectra of light to the mammalian retina Photochem. Photobiol. 71 2000 225 229
6. L.A. Ervin, J. Dillon, and E.R. Gaillard Photochemically modified a-crystallin: a model system for aging in the primate lens Photochem. Photobiol. 73 2001 685 691
7. E.R. Gaillard, S.J. Atherton, G. Eldred, and J. Dillon Photophysical studies on human retinal lipofuscin Photochem. Photobiol. 61 1995 448 453
8. E.R. Gaillard, L. Zheng, J.C. Merriam, and J. Dillon Age related changes in the absorption characteristics of the primate lens Invest. Ophthalmol. Vis. Sci. 41 2000 1454 1459
9. J.D. Gottsch, S. Pou, L.A. Bynow, and G.M. Rosent Hematogenous photosensitization Invest. Ophthalmol. Vis. Sci. 31 1990 1674 1682
10. R.K. Gurrey, W.T. Ham, and H.A. Mueller Light toxicity in the posterior segment T.D. Duane Clinical Ophthalmology 1985 Harper and Rowe Philadelphia 1 17
11. B.S. Hawkins, A. Bird, R. Klein, and S. West Epidemiology of age-related macular degeneration Mol. Vis. 5 1999 26
12. C.A. Parish, M. Hashimoto, K. Nakanishi, J. Dillon, and J. Sparrow Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium Proc. Natl. Acad. Sci. 95 1998 14609 14613
13. A. Pollack, A. Marcovich, A. Bukelman, and M. Oliver Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation Ophthalmology 103 1996 1546 1553
14. L. Ragauskaite, R. Heckathorn, and E.R. Gaillard Environmental effects on the photochemistry of A2-E, a component of human retinal lipofuscin Photochem. Photobiol. 74 2001 483 488
15. K. Reszka, G. Eldred, R.H. Wang, C. Chignell, and J. Dillon The photochemistry of human retinal lipofuscin as studied by EPR Photochem. Photobiol. 62 1995 1005 1008
16. N. Sakai, J. Decatur, K. Nakanishi, and G.E. Eldred Ocular age pigment A2-E an unprecedented pyridinium bis-retinoid J. Am. Chem. Soc. 118 1996 1559 1560
17. H.R. Taylor, B. Munoz, S. West, N.M. Besslar, S.B. Besslar, and F.S. Rosenthal Visible light and risk of age-related macular degeneration Trans. Am. Ophthalmol. Soc. 88 1990 163 173
18. J. Wassel, S. Davies, W. Bardsley, and B. Boulton The photoreactivity of the retinal age pigment lipofuscin J. Biol. Chem. 274 1999 23828 23832