2(±)-7,8,3′,4′,5′-pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells

Toxicology in Vitro

Volumn 23, Issue 5, 2009, Pages 874-879

  Ma, Enlong ^a   Li, Yanchun ^a   Zhang, Weige ^a   Wang, Xiaolong ^a   Tai, Wenjiao ^a   Li, Te ^a   Zhang, Liang ^a   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Death receptor; Flavan; G2 M arrest; Mitochondria

Indexed keywords

2 7,8,3',4',5' PENTAMETHOXYFLAVAN; CASPASE 3; CASPASE 8; CASPASE 9; CELL CYCLE PROTEIN; CYCLIN A; CYTOCHROME C; DEATH RECEPTOR; FLAVONOID; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; THREONINE; UNCLASSIFIED DRUG; 2 5,6,7,8,4' PENTAMETHOXYFLAVANONE; 2-5,6,7,8,4'-PENTAMETHOXYFLAVANONE; ANTINEOPLASTIC AGENT; CASPASE; FLAVANONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HL 60; CONTROLLED STUDY; DATA ANALYSIS; DNA FRAGMENTATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RACEMIC MIXTURE; CELL DIVISION; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL DIVISION; CELL PROLIFERATION; DNA FRAGMENTATION; FLAVANONES; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HL-60 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHORYLATION; RECEPTORS, DEATH DOMAIN;

EID: 67649311422     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.05.001     Document Type: Article

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