The paradox of viable sup45 STOP mutations: A necessary equilibrium between translational readthrough, activity and stability of the protein

Molecular Genetics and Genomics

Volumn 282, Issue 1, 2009, Pages 83-96

  Kiktev, Denis ^a   Moskalenko, Svetlana ^a   Murina, Olga ^a   Baudin Baillieu, Agnès ^b   Rousset, Jean Pierre ^b   Zhouravleva, Galina ^a  

^a ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

PSI + ; ERF1; Nonsense; Protein stability; PTC; Sup45; Translation termination

Indexed keywords

MESSENGER RNA; PROTEIN; PROTEIN SUP45; UNCLASSIFIED DRUG; FUNGAL DNA; FUNGAL RNA; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SUP45 PROTEIN, S CEREVISIAE; TRANSLATION TERMINATION FACTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE; MUTANT; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; RNA STABILITY; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; SUP45 GENE; FUNGAL GENE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; STOP CODON;

BASE SEQUENCE; CODON, NONSENSE; DNA, FUNGAL; ESCHERICHIA COLI; GENES, FUNGAL; MUTAGENESIS, SITE-DIRECTED; PEPTIDE TERMINATION FACTORS; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; RNA STABILITY; RNA, FUNGAL; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 67649226102     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-009-0447-5     Document Type: Article

References (49)

1. H Beier M Grimm 2001 Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs Nucleic Acids Res 29 4767 4782
2. A Belle A Tanay L Bitincka R Shamir EK O'Shea 2006 Quantification of protein half-lives in the budding yeast proteome Proc Natl Acad Sci USA 103 13004 13009
3. G Bertram HA Bell DW Ritchie G Fullerton I Stansfield 2000 Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition RNA 6 1236 1247
4. G Bertram S Innes O Minella J Richardson I Stansfield 2001 Endless possibilities: translation termination and stop codon recognition Microbiology 147 255 269
5. L Bidou G Stahl I Hatin O Namy JP Rousset PJ Farabaugh 2000 Nonsense-mediated decay mutants do not affect programmed-1 frameshifting RNA 6 952 961
6. JD Boeke F LaCroute GR Fink 1984 A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance Mol Genet Genomics 197 345 346
7. B Bonetti L Fu J Moon DM Bedwell 1995 The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae J Mol Biol 251 334 345
8. ME Bradley S Bagriantsev N Vishveshwara SW Liebman 2003 Guanidine reduces stop codon read-through caused by missense mutations in SUP35 or SUP45 Yeast 20 625 632
9. S Chabelskaya D Kiktev S Inge-Vechtomov M Philippe G Zhouravleva 2004 Nonsense mutations in the essential gene SUP35 of Saccharomyces cerevisiae are non-lethal Mol Genet Genomics 272 297 307
10. Chabelskaya S, Gryzina V, Moskalenko S, Le Goff C, Zhouravleva G (2007) Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae. BMC Mol Biol. doi: 10.1186/1471-2199-8-71
11. C Chauvin S Salhi C LeGoff W Viranaicken D Diop O Jean-Jean 2005 Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation Mol Cell Biol 25 5801 5811
12. YO Chernoff 2001 Mutation processes at the protein level: is Lamarck back? Mutat Res 488 39 64
13. +] Science 268 880 884
14. +] propagation Mol Cell Biol 22 3301 3315
15. AG Cridge LL Major AA Mahagaonkar ES Poole LA Isaksson WP Tate 2006 Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms Nucleic Acids Res 34 1959 1973
16. IL Derkatch YO Chernoff VV Kushnirov SG Inge-Vechtomov SW Liebman 1996 Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae Genetics 144 1375 1386
17. M Du X Liu EM Welch S Hirawat SW Peltz DM Bedwell 2008 PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model Proc Natl Acad Sci USA 105 2064 2069
18. L Eurwilaichitr FM Graves I Stansfield MF Tuite 1999 The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae Mol Microbiol 32 485 496
19. RD Gietz RH Schiestl AR Willems RA Woods 1995 Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure Yeast 11 355 360
20. S Inge-Vechtomov G Zhouravleva M Philippe 2003 Eukaryotic release factors (eRFs) history Biol Cell 95 195 209
21. H Inoue H Nojima H Okayama 1990 High efficiency transformation of Escherichia coli with plasmids Gene 96 23 28
22. K Ito K Ebihara Y Nakamura 1998 The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast RNA 4 958 972
23. DA Kiktev SG Inge-Vechtomov GA Zhouravleva 2007 Prion-dependent lethality of sup45 mutants in Saccharomyces cerevisiae Prion 1-2 136 143
24. L Kisselev M Ehrenberg L Frolova 2003 Termination of translation: interplay of mRNA, rRNAs and release factors? EMBO J 22 175 182
25. P Leeds SW Peltz A Jacobson MR Culbertson 1991 The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon Genes Dev 5 2303 2314
26. JP Lin M Aker KC Sitney RK Mortimer 1986 First position wobble in codon-anticodon pairing: amber suppression by a yeast glutamine tRNA Gene 49 383 388
27. Lowry R (2000) t-Test for the significance of the differences between the means of two independent samples: the Mann-Whitney test. In: Concepts and applications of inferential statistics. Vassar College, New York. http://faculty.vassar.edu/lowry/webtext.html
28. M Manuvakhova K Keeling DM Bedwell 2000 Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system RNA 6 1044 1055
29. Moskalenko SE, Chabelskaya SV, Inge-Vechtomov SG, Philippe M, Zhouravleva GA (2003) Viable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiae. BMC Mol Biol. doi: 10.1186/1471-2199-4-2
30. O Namy I Hatin JP Rousset 2001 Impact of the six nucleotides downstream of the stop codon on translation termination EMBO Rep 2 787 793
31. O Namy G Duchateau-Nguyen JP Rousset 2002 Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae Mol Microbiol 43 641 652
32. GP Newnam RD Wegrzyn SL Lindquist YO Chernoff 1999 Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing Mol Cell Biol 19 1325 1333
33. ES Poole CM Brown WP Tate 1995 The identity of the base following the stop codon determines the efficiency of in vivo translational termination in Escherichia coli EMBO J 14 151 158
34. GA Pure GW Robinson L Naumovski EC Friedberg 1985 Partial suppression of an ochre mutation in Saccharomyces cerevisiae by multicopy plasmids containing a normal yeast tRNAGln gene J Mol Biol 183 31 42
35. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning, a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor
36. Sherman F, Fink GR, Hicks JB (1986) Laboratory course manual for methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor
37. G Stahl L Bidou JP Rousset M Cassan 1995 Versatile vectors to study recoding: conservation of rules between yeast and mammalian cells Nucleic Acids Res 23 1557 1560
38. I Stansfield KM Jones VV Kushnirov AR Dagkesamanskaya AI Poznyakovski SV Paushkin CR Nierras BS Cox MD Ter Avanesyan MF Tuite 1995 The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae EMBO J 14 4365 4373
39. Stansfield I, Eurwilaichitr L, Akhmaloka, Tuite MF (1996) Depletion in the levels of the release factor eRF1 causes a reduction in the efficiency of translation termination in yeast. Mol Microbiol 20:1135-1143
40. WP Tate ES Poole JA Horsfield SA Mannering CM Brown JG Moffat ME Dalphin KK McCaughan LL Major DN Wilson 1995 Translational termination efficiency in both bacteria and mammals is regulated by the base following the stop codon Biochem Cell Biol 73 1095 1103
41. IA Valouev VN Urakov NV Kochneva-Pervukhova VN Smirnov MD Ter Avanesyan 2004 Translation termination factors function outside of translation: yeast eRF1 interacts with myosin light chain, Mlc1p, to effect cytokinesis Mol Microbiol 53 687 696
42. WA Weiss EC Friedberg 1986 Normal yeast tRNA(CAGGln) can suppress amber codons and is encoded by an essential gene J Mol Biol 192 725 735
43. WA Weiss I Edelman MR Culbertson EC Friedberg 1987 Physiological levels of normal tRNA(CAGGln) can effect partial suppression of amber mutations in the yeast Saccharomyces cerevisiae Proc Natl Acad Sci USA 84 8031 8034
44. I Williams J Richardson A Starkey I Stansfield 2004 Genome-wide prediction of stop codon readthrough during translation in the yeast Saccharomyces cerevisiae Nucleic Acids Res 32 6605 6616
45. K Zerfass H Beier 1992 Pseudouridine in the anticodon G psi A of plant cytoplasmic tRNA(Tyr) is required for UAG and UAA suppression in the TMV-specific context Nucleic Acids Res 20 5911 5918
46. +], a prion-like form of release factor eRF3 EMBO J 18 1182 1191
47. G Zhouravleva L Frolova X Le Goff R Le Guellec S Inge-Vechtomov L Kisselev M Philippe 1995 Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3 EMBO J 14 4065 4072
48. GA Zhouravleva SE Moskalenko SV Shabel'skaia M Philippe SG Inge-Vechtomov 2006 Increased tRNA concentration in yeast containing mutant termination translation factors eRF1 and eRF3 Mol Biol (Mosk) 40 724 730
49. G Zhouravleva S Moskalenko O Murina S Inge-Vechtomov 2007 Viable nonsense mutants for the SUP45 gene in the yeast Saccharomyces cerevisiae are lethal at increased temperature Genetika 43 1363 1371