Nonsense mutations in the essential gene SUP35 of Saccharomyces cerevisiae are non-lethal

Molecular Genetics and Genomics

Volumn 272, Issue 3, 2004, Pages 297-307

  Chabelskaya, S ^a,b   Kiktev, D ^a   Inge Vechtomov, S ^a   Philippe, M ^b   Zhouravleva, G ^a,b  

^a ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITÉ DE RENNES 1   (France)

Author keywords

eRF3; Readthrough; Release factor; Translation termination; Yeast

Indexed keywords

MESSENGER RNA; TRANSFER RNA; TRANSLATION TERMINATION FACTOR;

ARTICLE; AUXOTROPHIC MUTANT; BACTERIAL GENE; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEADY STATE; YEAST;

BASE SEQUENCE; BLOTTING, NORTHERN; CODON, NONSENSE; DNA PRIMERS; GENES, ESSENTIAL; GENES, FUNGAL; GENES, LETHAL; PRIONS; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 8644225583     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-004-1053-1     Document Type: Article

References (41)

1. Beier H, Grimm M (2001) Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Nucleic Acids Res 29:4767-4782
2. Bertram G, Innes S, Minella O, Richardson J, Stansfield I (2001) Endless possibilities: translation termination and stop codon recognition. Microbiology 147:255-269
3. Boeck R, Lapeyre B, Brown CE, Sachs AB (1998) Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant. Mol Cell Biol 18:5062-5072
4. Boeke JD, Lacroute F, Fink GR (1984) A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197:345-346
5. Bonetti B, Fu L, Moon J, Bedwell DM (1995) The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae. J Mol Biol 251:334-345
6. Bradley ME, Bagriantsev S, Vishveshwara N, Liebman SW (2003) Guanidine reduces stop codon read-through caused by missense mutations in SUP35 or SUP45. Yeast 20:625-632
7. Cai T, Reilly TR, Cerio M, Schmitt ME (1999) Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation. Mol Cell Biol 19:7857-7869
8. Carr-Schmid A, Durko N, Cavallius J, Merrick WC, Kinzy TG (1999) Mutations in a GTP-binding motif of eukaryotic elongation factor IA reduce both translational fidelity and the requirement for nucleotide exchange. J Biol Chem 274:30297-30302
9. Chernoff YO (2001) Mutation processes at the protein level: is Lamarck back? Mutat Res 488:39-64
10. Cosson B, Couturier A, Chabelskaya S, Kiktev D, Inge-Vechtomov S, Philippe M, Zhouravleva G (2002) Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation. Mol Cell Biol 22:3301-3315
11. Eurwilaichitr L, Graves FM, Stansfield I, Tuite MF (1999) The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae. Mol Microbiol 32:485-496
12. Fearon K, McClendon V, Bonetti B, Bedwell DM (1994) Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family. J Biol Chem 269:17802-17808
13. Gietz D, St Jean A, Woods RA, Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20:1425
14. Harrell L, Melcher U, Atkins JF (2002) Predominance of six different hexanucleotide recoding signals 3′ of read-through stop codons. Nucleic Acids Res 30:2011-2017
15. Inge-Vechtomov S, Zhouravleva G, Philippe M (2003) Eukaryotic release factors (eRFs) history. Biol Cell 95:195-209
16. Ito-Harashima S, Hartzog PE, Sinha H, McCusker JH (2002) The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency. Genetics 161:1395-1410
17. Kisselev L, Ehrenberg M, Frolova L (2003) Termination of translation: interplay of mRNA, rRNAs and release factors? EMBO J 22:175-182
18. Kokoska RJ, Stefanovic L, Buermeyer AB, Liskay RM, Petes TD (1999) A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences. Genetics 151:511-519
19. Kong C, Ito K, Walsh MA, Wada M, Liu Y, Kumar S, Barford D, Nakamura Y, Song H (2004) Crystal structure and functional analysis of the eukaryotic Class II release factor eRF3 from S. pombe. Mol Cell 14:233-245
20. Kopczynski JB, Raff AC, Bonner JJ (1992) Translational readthrough at nonsense mutations in the HSF1 gene of Saccharomyces cerevisiae. Mol Gen Genet 234:369-378
21. Liu JJ, Sondheimer N, Lindquist SL (2002) Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]. Proc Natl Acad Sci USA 99 Suppl 4:16446-16453
22. Moskalenko SE, Chabelskaya SV, Inge-Vechtomov SG, Philippe M, Zhouravleva GA (2003) Viable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiae. BMC Mol Biol 4:2
23. Percudani R, Pavesi A, Ottonello S (1997) Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae. J Mol Biol 268:322-330
24. Pure GA, Robinson GW, Naumovski L, Friedberg EC (1985) Partial suppression of an ochre mutation in Saccharomyces cerevisiae by multicopy plasmids containing a normal yeast tRNAGln gene. J Mol Biol 183:31-42
25. Riles L, Olson MV (1988) Nonsense mutations in essential genes of Saccharomyces cerevisiae. Genetics 118:601-607
26. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual (2nd edn). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Serio TR, Lindquist SL (1999) [PSI+]: an epigenetic modulator of translation termination efficiency. Annu Rev Cell Dev Biol 15:661-703
28. Sherman F, Fink GR, Hicks JB (1986) Laboratory course manual for methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor
29. Song JM, Liebman SW (1985) Interaction of UAG suppressors and omnipotent suppressors in Saccharomyces cerevisiae. J Bacteriol 161:778-780
30. Stansfield I, Jones KM, Kushnirov VV, Dagkesamanskaya AR, Poznyakovski AI, Paushkin SV, Nierras CR, Cox BS, Ter-Avanesyan MD, Tuite MF (1995) The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae. EMBO J 14:4365-4373
31. Stansfield I, Eurwilaichitr L, Akhmaloka, Tuite MF (1996) Depletion in the levels of the release factor eRF1 causes a reduction in the efficiency of translation termination in yeast. Mol Microbiol 20:1135-1143
32. Ter-Avanesyan MD, Kushnirov VV, Dagkesamanskaya AR, Didichenko SA, Chernoff YO, Inge-Vechtomov SG, Smirnov VN (1993) Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein. Mol Microbiol 7:683-692
33. Tork S, Hatin I, Roussel JP, Fabret C (2004) The major 5′ determinant in stop codon read-through involves two adjacent adenines. Nucleic Acids Res 32:415-421
34. Valouev IA, Kushnirov VV, Ter-Avanesyan MD (2002) Yeast polypeptide chain release factors eRF1 and eRF3 are involved in cytoskeleton organization and cell cycle regulation. Cell Motil Cytoskeleton 52:161-173
35. Volkov KV, Aksenova AY, Soom MJ, Osipov KV, Svitin AV, Kurischko C, Shkundina IS, Ter-Avanesyan MD, Inge-Vechtomov SG, Mironova LN (2002) Novel non-Mendelian determinant involved in the control of translation accuracy in Saccharomyces cerevisiae. Genetics 160:25-36
36. Wang W, Czaplinski K, Rao Y, Peltz SW (2001) The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts. EMBO J 20:880-890
37. Weiss WA, Friedberg EC (1986) Normal yeast tRNA(CAGGln) can suppress amber codons and is encoded by an essential gene. J Mol Biol 192:725-735
38. Weiss WA, Edelman I, Culbertson MR, Friedberg EC (1987) Physiological levels of normal tRNA(CAGGln) can effect partial suppression of amber mutations in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 84:8031-8034
39. Woods A, Sherwin T, Sasse R, MacRae TH, Baines AJ, Gull K (1989) Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies. J Cell Sci 93:491-500
40. Zhou P, Derkatch IL, Uptain SM, Patino MM, Lindquist S, Liebman SW (1999) The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3. EMBO J 18:1182-1191
41. Zhouravleva G, Frolova L, Le Goff X, Le Guellec R, Inge-Vechtomov S, Kisselev L, Philippe M (1995) Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3. EMBO J 14:4065-4072