Lipophilicity studies on pyrrolyl-acetic acid derivatives. Experimental versus predicted logP values in relationship with aldose reductase inhibitory activity

QSAR and Combinatorial Science

Volumn 28, Issue 5, 2009, Pages 551-560

  Chrysanthakopoulos, Marios ^a   Koletsou, Antigoni ^a   Nicolaou, Ioannis ^b   Demopoulos, Vassilis J ^b   Tsantili Kakoulidou, Anna ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Aldose reductase inhibitory activity; Distribution coefficients; logP prediction algorithms; Partitioning experiments; Pyrrolyl acetic acid derivatives

Indexed keywords

BIOACTIVITY; FORECASTING; HYDROGEN BONDS; NEURAL NETWORKS; PH;

ACID DERIVATIVE; ALDOSE REDUCTASE; ALDOSE REDUCTASE INHIBITORY ACTIVITY; DISTRIBUTION COEFFICIENT; INHIBITORY ACTIVITY; LOGP PREDICTION ALGORITHM; PARTITIONING EXPERIMENT; PREDICTION ALGORITHMS; PYRROLYL; PYRROLYL-ACETIC ACID DERIVATIVE;

ACETIC ACID;

ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; OCTANOL; PYRROLYL ACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANALYTICAL ERROR; ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOLOGICAL ACTIVITY; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG STRUCTURE; ELECTRICAL PARAMETERS; ENZYME INHIBITION; HYDROGEN BOND; LIPOPHILICITY; PREDICTION; PRIORITY JOURNAL; RELIABILITY;

EID: 67649222529     PISSN: 1611020X     EISSN: 16110218     Source Type: Journal    
DOI: 10.1002/qsar.200860138     Document Type: Article

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