Biomarkers of induced active and passive smoking damage

International Journal of Environmental Research and Public Health

Volumn 6, Issue 3, 2009, Pages 874-888

  Lodovici, Maura ^a   Bigagli, Elisabetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Biomarkers; Cancer risk; Carcinogenic dna adducts; Genetic polymorphisms; Tobacco smoking

Indexed keywords

BIOLOGICAL MARKER;

BLADDER CANCER; CANCER PATIENT; COLON CANCER; DISEASE ASSOCIATION; DNA ADDUCT; ESOPHAGUS CANCER; GENETIC SUSCEPTIBILITY; HUMAN; KIDNEY CANCER; LARYNX CANCER; LEUKOCYTE; LIVER CANCER; LUNG CANCER; LUNG LAVAGE; MOUTH CANCER; MYELOID LEUKEMIA; NOSE CANCER; OROPHARYNX CANCER; PANCREAS CANCER; PASSIVE SMOKING; REVIEW; SMOKING; STOMACH CANCER; UTERINE CERVIX CANCER;

NICOTIANA TABACUM;

EID: 67649211303     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph6030874     Document Type: Review

References (71)

1. Bettcher, D.W.; Sanda, L.S. Clinical cancer control and prevention. Eliminating tobacco-induced cancers: a worldwide challenge. Ann. Oncol. 2008, 19, 230-233.
2. Hecht, S.S. Progress and challenges in selected areas of tobacco carcinogenesis. Chem. Res. Toxicol. 2008, 21, 160-171.
3. Taioli, E. Gene-environment interaction in tobacco-related cancers. Carcinogenesis 2008, 29, 1467-1474.
4. Jemal, A.; Thun, M.J.; Ries, L.A.; Howe, H.L.; Weir, H.K.; Center, M.M.; Ward, E.; Wu, X.C.; Eheman, C.; Anderson, R.; Ajani, U.A.; Kohler, B.; Edwards, B.K. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. J. Natl. Cancer Ins. 2008, 100, 1672-1694.
5. Ambrose, J.A.; Barua, R.S. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J. Am. Coll. Cardiol. 2004, 43, 1731-1737.
6. IDEM. The health consequences of involuntary smoking: a report of the Surgeon General. Publication N. DHHS (CDC) 87-(8398). Government Printing Office: Washington DC, USA, 1986.
7. National Research Council. Committee on passive smoking. National Academy Press: Washington DC, USA, 1986.
8. California Environmental Protection Agency. Health effects of exposure to environmental tobacco smoke. Final Draft. California Environmental Protection Agency, 1997.
9. IARC (International Agency for Research on Cancer): Tobacco smoking and involuntary smoking. ARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Available at http://monographs.iarc.fr/ENG/Monographs/vol83/volume83.pdf (Accessed 20 February 2009).
10. Lodovici, M.; Akpan, V.; Evangelisti, C.; Dolara, P. Sidestream tobacco smoke as the main predictor of exposure to polycyclic aromatic hydrocarbons. J. Appl. Toxicol. 2004, 24, 277-281.
11. Besaratinia, A.; Pfeifer, G.P. Second-hand smoke and human lung cancer. Lancet Oncol. 2008, 9, 657-666.
12. Biological markers in environmental health research. Committee on Biological Markers of the National Research Council. Environ. Health Perspect. 1987, 74, 3-9.
13. Wogan, G.N. Molecular epidemiology in cancer risk assessment and prevention: recent progress and avenues for future research. Environ. Health Perspec. 1992, 98, 167-178.
14. Groopman, J.D.; Kensler, T.W.; Links, J.M. Molecular epidemiology and human risk monitoring. Toxicol. Lett. 1995, 82-83, 763-769.
15. 32P- postlabelling assay. Mutat Res. 1997, 378, 1-12.
16. Wild, C.P.; Pisani, P. Carcinogen DNA and protein adducts as biomarkers of human exposure in environmental cancer epidemiology. Cancer Detect. Prev. 1998, 22, 273-283.
17. Poirier, M.C.; Santella, R.M.; Weston, A. Carcinogen macromolecular adducts and their measurement. Carcinogenesis 2000, 21, 353-359.
18. Phillips, D.H.; Hewer, A.; Martin, C.N.; Garner, R.C.; King, M.M. Correlation of DNA adduct levels in human lung with cigarette smoking. Nature 1988, 336, 790-792.
19. Talaska, G.; Schamer, M.; Skipper, P.; Tannenbaum, S.; Caporaso, N.; Unruh, L.; Kadlubar, F.F.; Bartsch, H.; Malaveille, C.; Vineis, P. Detection of carcinogen-DNA adducts in exfoliated urothelial cells of cigarette smokers: association with smoking, hemoglobin adducts, and urinary mutagenicity. Cancer Epidemiol. Biomarkers Prev. 1991, 1, 61-66.
20. Alexandrov, K.; Rojas, M.; Geneste, O.; Castegnaro, M.; Camus, A.M.; Petruzzelli, S.; Giuntini, C.; Bartsch, H. An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity. Cancer Res. 1992, 52, 6248-6253.
21. Simons, A.M.; Múgica, van Herckenrode C.; Rodriguez, J.A.; Maitland, N.; Anderson, M.; Phillips, D.H.; Coleman, D.V. Demonstration of smoking-related DNA damage in cervical epithelium and correlation with human papillomavirus type 16, using exfoliated cervical cells. Br. J. Cancer 1995, 71, 246-249.
22. Andreassen, A.; Kure, E.H.; Nielsen, P.S.; Autrup, H.; Haugen, A. Comparative synchronous fluorescence spectrophotometry and 32P-postlabeling analysis of PAH-DNA adducts in human lung and the relationship to TP53 mutations. Mutat. Res. 1996, 368, 275-282.
23. Wang, M.; Abbruzzese, J.L.; Friess, H.; Hittelman, W.N.; Evans, D.B.; Abbruzzese, M.C.; Chiao, P.; Li, D. DNA adducts in human pancreatic tissues and their potential role in carcinogenesis Cancer Res. 1998, 58, 38-41.
24. Lodovici, M.; Akpan, V.; Giovannini, L.; Migliani, F.; Dolara, P. Benzo[a]pyrene diol-epoxide DNA adducts and levels of polycyclic aromatic hydrocarbons in autoptic samples from human lungs. Chem. Biol. Interact. 1998, 116, 199-212.
25. Asami, S.; Manabe, H.; Miyake, J.; Tsurudome, Y.; Hirano, T.; Yamaguchi, R.; Itoh, H.; Kasai, H. Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis 1997, 18, 1763-1766.
26. Savela, K.K.; Hemminki, K. DNA adducts in lymphocytes and granulocytes of smokers and nonsmokers detected by the 32P-postlabelling assay. Carcinogenesis 1991, 12, 503-508.
27. Tang, D.; Phillips, D.H.; Stampfer, M.; Mooney, L.A.; Hsu, Y.; Cho, S.; Tsai, W.Y.; Ma, J.; Cole, K.J.; Shé, M.N.; Perera, F.P. Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. Cancer Res. 2001, 61, 6708-6712.
28. Wiencke, J.K.; Kelsey, K.T.; Varkonyi, A.; Semey, K.; Wain, J.C.; Mark, E.; Christiani, D.C. Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung. Cancer Res. 1995, 55, 4910-4914.
29. Van Schooten, F.J.; Hillebrand, M.J.; van Leeuwen, F.E.; van Zandwijk, N.; Jansen, H.M.; den Engelse, L.; Kriek, E. Polycyclic aromatic hydrocarbon--DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung. Carcinogenesis 1992, 13, 987-993.
30. 32P-postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures. Mutat. Res. 1997, 375, 65-75.
31. Yang, K.; Airoldi, L.; Pastorelli, R.; Restano, J.; Guanci, M.; Hemminki, K. Aromatic DNA adducts in lymphocytes of humans working at high and low traffic density areas. Chem. Biol. Interact. 1996, 101, 127-136.
32. Lodovici M.; Akpan V.; Casalini C.; Nencini L.; Pinzauti M.; Marcoccia M.; Dolara P. Benzo(a)pyrene diol-epoxide-DNA adduct levels and aryl hydrocarbon hydroxylase (AHH) in human white blood cells from smokers and non-smokers. Biomarkers 1999, 4, 272-280.
33. Lodovici, M.; Casalini, C.; Cariaggi, R.; Michelucci, L.; Dolara, P. Levels of 8- hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes. Free Radic. Biol. Med. 2000, 28, 13-17.
34. Howard, D.J.; Ota, R.B.; Briggs, L.A.; Hampton, M.; Pritsos, C.A. Oxidative stress induced by environmental tobacco smoke in the workplace is mitigated by antioxidant supplementation Cancer Epidemiol. Biomarkers Prev. 1998, 7, 981-988.
35. Lodovici, M.; Caldini, S.; Luceri, C.; Bambi, F.; Boddi, V.; Dolara, P. Active and passive smoking and lifestyle determinants of 8-oxo-7,8-dihydro-2'- deoxyguanosine levels in human leukocyte DNA. Cancer Epidemiol. Biomarkers Prev. 2005, 14, 2975-2977.
36. Izzotti, A.; Rossi, G.A.; Bagnasco, M.; De Flora, S. Benzo[a]pyrene diolepoxide-DNA adducts in alveolar macrophages of smokers. Carcinogenesis 1991, 12, 1281-1285.
37. Sherman, M.P.; Aeberhard, E.E.; Wong, V.Z.; Simmons, M.S.; Roth, M.D.; Tashkin, D.P. Effects of smoking marijuana, tobacco or cocaina alone or in combination on DNA damage in human alveolar macrophages. Life Sci. 1995, 56, 2201-2207.
38. Godschalk, R.W.; Maas, L.M.; Van Zandwijk, N.; van 't Veer, L.J.; Breedijk, A.; Borm, P.J.; Verhaert, J.; Kleinjans, J.C.; van Schooten, F.J. Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers, Carcinogenesis 1998, 19, 819-825.
39. Piipari, R.; Savela, K.; Nurminen, T.; Hukkanen, J.; Raunio, H.; Hakkola, J.; Mantyla, T.; Beaune, P.; Edwards, R.J.; Boobis, A.R.; Anttila, S. Expression of CYP1A1, CYP1B1 and CYP3A and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers. Int. J. Cancer 2000, 86, 610-616.
40. Butkiewicz, D.; Cole, K.J.; Phillips, D.H.; Harris, C.C.; Chorazy, M. GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels. Eur. J. Cancer Prev. 1999, 8, 315-323.
41. Lewis, S.J.; Cherry, N.M.; Niven, R.M.; Barber, P.V.; Povey, A.C. Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells. Mutat. Res. 2004, 559, 11-18.
42. Peluso, M.; Neri, M.; Margarino, G.; Mereu, C.; Munnia, A.; Ceppi, M.; Buratti, M.; Felletti, R.; Stea, F.; Quaglia, R.; Puntoni, R.; Taioli, E.; Garte, S.; Bonassi, S. Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms. Carcinogenesis 2004, 25, 2459-2465.
43. Teixeira, J.P.; Gaspar, J.; Martinho, G.; Silva, S.; Rodrigues, S.; Mayan, O.; Martin, E.; Farmer, P.B.; Rueff, J. Aromatic DNA adduct levels in coke oven workers: correlation with polymorphisms in genes GSTP1, GSTM1, GSTT1 and CYP1A1. Mutat. Res. 2002, 517, 147-155.
44. Godschalk, R.W.; Dallinga, J.W.; Wikman, H.; Risch, A.; Kleinjans, J.C.; Bartsch, H.; van Schooten, F.J. Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2. Pharmacogenetics 2001, 11, 389-398.
45. Lodovici, M.; Luceri, C.; Guglielmi, F.; Bacci, C.; Akpan, V.; Fonnesu, M.L.; Boddi, V.; Dolara, P. Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. Cancer Epidemiol. Biomarkers Prev. 2004, 13, 1342-1348.
46. Van Schooten, F.J.; Boots A.W.; Knaapen A.M.; Godschalk R.W.; Maas L.M.; Borm P.J.; Drent M.; Jacobs J.A. Myeloperoxidase (MPO) -463G-A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers. Cancer Epidemiol. Biomarkers Prev. 2004, 13, 828-833.
47. Ketelslegers, H.B.; Gottschalk, R.W.; Knaapen, A.M.; van Schooten, F.J.; Vlietinck, R.F.; Kleinjans, J.C.; van Delft, J.H. Interindividual variations in DNA adduct levels assessed by analysis of multiple genetic polymorphisms in smokers. Cancer Epidemiol. Biomarkers Prev. 2006, 15, 624-629.
48. Mollerup, S.; Berge, G.; Baera, R.; Skaug, V.; Hewer, A.; Phillips, D.H.; Stangeland, L.; Haugen, A. Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts. Int. J. Cancer 2006, 119, 741-744.
49. Perera, F.P.; Poirier, M.C.; Yuspa, S.H.; Nakayama, J.; Jaretzki, A.; Curnen, M.M.; Knowles, D.M.; Weinstein, I.B. A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene-DNA adducts in animal and human tissues by immunoassays. Carcinogenesis 1982, 3,1405-1410.
50. Rothman, N.; Shields, P.G.; Poirier, M.C.; Harrington, A.M.; Ford, D.P.; Strickland, P.T. The impact of glutathione s-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-DNA adduct levels in humans. Mol. Carcinog. 1995, 14, 63-68.
51. Marshall, C.J.; Vousden, K.H.; Phillips, D.H. Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide. Nature 1984, 310, 586-589.
52. Vousden, K.; Bos, J.L.; Marshall, C.J.; Phillips, D.H. Mutations activating human c-Ha-ras1 protooncogene (HRAS) induced by chemical carcinogens and depurination. Proc. Natl. Acad. Sci. 1986, 83, 1222-1226.
53. Hemminki, K.; Koskinen, M.; Rajaniemi, H.; Zhao, C. Dna adducts, mutations, and cancer 2000. Regul. Toxicol. Pharmacol. 2000, 32, 264-275.
54. Vineis, P.; Perera, F. DNA adducts as markers of exposure to carcinogens and risk of cancer. Int. J. Cancer 2000, 88, 325-328.
55. Veglia, F.; Matullo, G.; Vineis, P. Bulky DNA adducts and risk of cancer: a meta-analysis Cancer Epidemiol. Biomarkers Prev. 2003, 12, 157-160.
56. Phillips, D.H. DNA adducts as markers of exposure and risk. Mutat. Res. 2005, 577, 284-292.
57. Tang, D.; Santella, R.M.; Blackwood, A.M.; Young, T.L.; Mayer, J.; Jaretzki, A.; Grantham, S.; Tsai, W.Y.; Perera, F.P. A molecular epidemiological case-control study of lung cancer. Cancer Epidemiol. Biomark Prev. 1995, 4, 341-346.
58. Hou, S.M.; Yang, K.; Nyberg, F.; Hemminki, K.; Pershagen, G.; Lambert, B. Hprt mutant frequency and aromatic DNA adduct level in nonsmoking and smoking lung cancer patients and population controls. Carcinogenesis 1999, 20, 437-444.
59. Vulimiri, S.V.; Wu, X.; Baer-Dubowska, W.; Andrade, M.D.; Detry, M.; Spitz, M.R.; DiGiovanni, J. Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo-2' deoxyguanosine in lymphocyte DNA from a case-control study of lung cancer involving minority populations. Mol. Carcinog. 2000, 27, 34-46.
60. Cheng, Y.W.; Chen, C.Y.; Lin, P.; Huang, K.H.; Lin, T.S.; Wu, M.H.; Lee, H. DNA adduct level in lung tissue may act as a risk biomarker of lung cancer. Eur. J. Cancer 2000, 36, 1381-1388.
61. Popp, W.; Schell, C.; Kraus, R.; Vahrenholz, C.; Wolf, R.; Radtke, J.; Bierwirth, K.; Norpoth, K. DNA strand breakage and DNA adducts in lymphocytes of oral cancer patients. Carcinogenesis 1993, 14, 2251-2256.
62. Peluso, M.; Airoldi, L.; Magagnotti, C.; Fiorini, L.; Munnia, A.; Hautefeuille, A.; Malaveille, C.; Vineis, P. White blood cell DNA adducts and fruit and vegetable consumption in bladder cancer. Carcinogenesis 2000, 21, 183-187.
63. Rothman K. Modern Epidemiology. Little Brown & Co: Boston, MA, USA, 1986.
64. Benhamou, S.; Laplanche, A.; Guillonneau, B.; Mejean, A.; Desgrandchamps, F.; Schrameck, C.; Degieux, V.; Perin, F. DNA adducts in normal bladder tissue and bladder cancer risk. Mutagenesis 2003, 18, 445-448.
65. Peluso, M.; Munnia, A.; Hoek, G.; Krzyzanowski, M.; Veglia, F.; Airoldi, L.; Autrup, H.; Dunning, A.; Garte, S.; Hainaut, P.; Malaveille, C.; Gormally, E.; Matullo, G.; Overvad, K.; Raaschou-Nielsen, O.; Clavel-Chapelon, F.; Linseisen, J.; Boeing, H.; Trichopoulou, A.; Trichopoulos, D.; Kaladidi, A.; Palli, D.; Krogh, V.; Tumino, R.; Panico, S.; Bueno-De-Mesquita, H.B.; Peeters, P.H.; Kumle, M.; Gonzalez, C.A.; Martinez, C.; Dorronsoro, M.; Barricarte, A.; Navarro, C.; Quiros, J.R.; Berglund, G.; Janzon, L.; Jarvholm, B.; Day, N.E.; Key, T.J.; Saracci, R.; Kaaks, R.; Riboli, E.; Vineis, P. DNA adducts and lung cancer risk: a prospective study. Cancer Res. 2005, 65, 8042-8048.
66. Bak, H.; Autrup, H.; Thomsen, B.L.; Tjonneland, A.; Overvad, K.; Vogel, U.; Raaschou-Nielsen, O.; Loft, S. Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study. Int. J. Cancer 2006, 118, 1618-1622.
67. Schwartz, A.G.; Prysak, G.M.; Bock, C.H.; Cote, M.L. The molecular epidemiology of lung cancer. Carcinogenesis 2007, 28, 507-518.
68. Ryberg, D.; Skaug, V.; Hewer, A.; Phillips, D.H.; Harries, L.W.; Wolf, C.R.; Ogreid, D.; Ulvik, A.; Vu, P.; Haugen, A. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis 1997, 18, 1285-1289.
69. Rojas, M.; Alexandrov, K.; Cascorbi, I.; Brockmöller, J.; Likhachev, A.; Pozharisski, K.; Bouvier, G.; Auburtin, G.; Mayer, L.; Kopp-Schneider, A.; Roots, I.; Bartsch, H. High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp- GSTM1*0/*0 genotypes. Pharmacogenetics 1998, 8, 109-118.
70. Schoket, B.; Phillips, D.H.; Kostic, S.; Vincze, I. Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients. Carcinogenesis 1998, 19, 841-846.
71. Li, D.; Firozi, P.F.; Zhang, W.; Shen, J.; DiGiovanni, J.; Lau, S.; Evans, D.; Friess, H.; Hassan, M.; Abbruzzese, J.L. DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer. Mutat. Res. 2002, 513, 37-48.