Placenta-derived fetal specific mRNA is more readily detectable in maternal plasma than in whole blood

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Heung, Macy M S ^a,b   Jin, Shengnan ^a,b   Tsui, Nancy B Y ^a,b   Ding, Chunming ^b   Leung, Tak Y ^b   Lau, Tze K ^b   Chiu, Rossa W K ^a,b   Lo, Y M Dennis ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 8; MEMBRANE PROTEIN; MESSENGER RNA; METASTIN; MYELOPEROXIDASE; NEUTROPHIL COLLAGENASE; OLFACTOMEDIN 4; OROSOMUCOID; PLACENTA LACTOGEN; PLACENTA PROTEIN; PLACENTA PROTEIN 1; PLACENTA PROTEIN 4; UNCLASSIFIED DRUG; KISS1 PROTEIN, HUMAN; PLAC1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOTYPE; HUMAN; INTERMETHOD COMPARISON; MATERNAL BLOOD; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROARRAY ANALYSIS; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PLACENTA; PREGNANCY; PUERPERIUM; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; THIRD TRIMESTER PREGNANCY; UPREGULATION; BLOOD; FEMALE; FETUS; METABOLISM; MOTHER; PRENATAL DIAGNOSIS;

FEMALE; FETUS; GENE EXPRESSION PROFILING; GENOTYPE; HUMANS; MOTHERS; PLACENTA; PLACENTAL LACTOGEN; PREGNANCY; PREGNANCY PROTEINS; PRENATAL DIAGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 67649206343     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005858     Document Type: Article

References (44)

1. Wright CF, Burton H (2009) The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis. Hum Reprod Update 15: 139-151.
2. Chiu RWK, Chan KCA, Gao Y, Lau VYM, Zheng W, et al. (2008) Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A 105: 20458-20463.
3. Lun FMF, Tsui NBY, Chan KCA, Leung TY, Lau TK, et al. (2008) Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma. Proc Natl Acad Sci U S A 105: 19920-19925.
4. Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, et al. (1997) Presence of fetal DNA in maternal plasma and serum. Lancet 350: 485-487.
5. Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu RWK, et al. (2003) mRNA of placental origin is readily detectable in maternal plasma. Proc Natl Acad Sci U S A 100: 4748-4753.
6. Tsui NBY, Chim SSC, Chiu RWK, Lau TK, Ng EKO, et al. (2004) Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling. J Med Genet 41: 461-467.
7. Farina A, Chan CWM, Chiu RWK, Tsui NBY, Carinci P, et al. (2004) Circulating corticotropin-releasing hormone mRNA in maternal plasma: relationship with gestational age and severity of preeclampsia. Clin Chem 50: 1851-1854.
8. Ng EKO, Leung TN, Tsui NBY, Lau TK, Panesar NS, et al. (2003) The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia. Clin Chem 49: 727-731.
9. Lo YMD, Tsui NBY, Chiu RWK, Lau TK, Leung TN, et al. (2007) Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat Med 13: 218-223.
10. Concu M, Banzola I, Farina A, Sekizawa A, Rizzo N, et al. (2005) Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery. Fetal Diagn Ther 20: 27-30.
11. Farina A, Rizzo N, Concu M, Banzola I, Sekizawa A, et al. (2005) Lower maternal PLAC1 mRNA in pregnancies complicated with vaginal bleeding (threatened abortion <20 weeks) and a surviving fetus. Clin Chem 51: 224-227.
12. Okazaki S, Sekizawa A, Purwosunu Y, Iwasaki M, Farina A, et al. (2006) Measurement of mRNA of trophoblast-specific genes in cellular and plasma components of maternal blood. J Med Genet 43: e47.
13. Maron JL, Johnson KL, Slonim D, Lai CQ, Ramoni M, et al. (2007) Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood. J Clin Invest 117: 3007-3019.
14. Banzola I, Rusterholz C, Zannoni L, Rizzo N, Zhong XY, et al. (2008) PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21. Prenat Diagn 28: 1262-1267.
15. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, et al. (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A 101: 6062-6067.
16. Chiu RWK, Poon LLM, Lau TK, Leung TN, Wong EMC, et al. (2001) Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma. Clin Chem 47: 1607-1613.
17. Affymetrix (2003) Globin reduction protocol: a method for processing whole blood RNA samples for improved array results. Affymetrix Technical Note. pp 1-9.
18. Bianchi DW (1999) Fetal cells in the maternal circulation: feasibility for prenatal diagnosis. Br J Haematol 105: 574-583.
19. Krabchi K, Gros-Louis F, Yan J, Bronsard M, Masse J, et al. (2001) Quantification of all fetal nucleated cells in maternal blood between the 18th and 22nd weeks of pregnancy using molecular cytogenetic techniques. Clin Genet 60: 145-150.
20. Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210.
21. Brown ES (1963) Foetal erythrocytes in the maternal circulation. Br Med J 1: 1000-1001.
22. Mavrou A, Kouvidi E, Antsaklis A, Souka A, Kitsiou Tzeli S, et al. (2007) Identification of nucleated red blood cells in maternal circulation: a second step in screening for fetal aneuploidies and pregnancy complications. Prenat Diagn 27: 150-153.
23. Bianchi DW, Simpson JL, Jackson LG, Elias S, Holzgreve W, et al. (2002) Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data. National Institute of Child Health and Development Fetal Cell Isolation Study. Prenat Diagn 22: 609-615.
24. Halicka HD, Bedner E, Darzynkiewicz Z (2000) Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp Cell Res 260: 248-256.
25. Go AT, Visser A, Mulders MA, Blankenstein MA, van Vugt JM, et al. (2007) 44 single-nucleotide polymorphisms expressed by placental RNA: assessment for use in noninvasive prenatal diagnosis of trisomy 21. Clin Chem 53: 2223-2224.
26. Kimoto Y (1998) A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. Mol Gen Genet 258: 233-239.
27. Ko Y, Grunewald E, Totzke G, Klinz M, Fronhoffs S, et al. (2000) High percentage of false-positive results of cytokeratin 19 RT-PCR in blood: a model for the analysis of illegitimate gene expression. Oncology 59: 81-88.
28. Gala JL, Heusterspreute M, Loric S, Hanon F, Tombal B, et al. (1998) Expression of prostate-specific antigen and prostate-specific membrane antigen transcripts in blood cells: implications for the detection of hematogenous prostate cells and standardization. Clin Chem 44: 472-481.
29. Germain SJ, Sacks GP, Soorana SR, Sargent IL, Redman CW (2007) Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles. J Immunol 178: 5949-5956.
30. Sacks GP, Studena K, Sargent K, Redman CW (1998) Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol 179: 80-86.
31. Schneider JJ, Unholzer A, Schaller M, Schafer-Korting M, Korting HC (2005) Human defensins. J Mol Med 83: 587-595.
32. Zhao L, Xu S, Fjaertoft G, Pauksen K, Hakansson L, et al. (2004) An enzyme-linked immunosorbent assay for human carcinoembryonic antigen-related cell adhesion molecule 8, a biological marker of granulocyte activities in vivo. J Immunol Methods 293: 207-214.
33. Koshida S, Kobayashi D, Moriai R, Tsuji N, Watanabe N (2007) Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci 98: 315-320.
34. Adley BP, Smith ND, Nayar R, Yang XJ (2006) Birt-Hogg-Dube syndrome: clinicopathologic findings and genetic alterations. Arch Pathol Lab Med 130: 1865-1870.
35. Fournier T, Medjoubi NN, Porquet D (2000) Alpha-1-acid glycoprotein. Biochim Biophys Acta 1482: 157-171.
36. Thomas T (1993) Distribution of alpha 2-macroglobulin and alpha 1-acid glycoprotein mRNA shows regional specialization in rat decidua. Placenta 14: 417-428.
37. Hanemaaijer R, Sorsa T, Konttinen YT, Ding Y, Sutinen M, et al. (1997) Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem 272: 31504-31509.
38. Prikk K, Maisi P, Pirila E, Sepper R, Salo T, et al. (2001) In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. J Pathol 194: 232-238.
39. Nien JK, Yoon BH, Espinoza J, Kusanovic JP, Erez O, et al. (2006) A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery. Am J Obstet Gynecol 195: 1025-1030.
40. Arechavaleta-Velasco F, Marciano D, Diaz-Cueto L, Parry S (2004) Matrix metalloproteinase-8 is expressed in human chorion during labor. Am J Obstet Gynecol 190: 843-850.
41. Klebanoff SJ (1999) Myeloperoxidase. Proc Assoc Am Physicians 111: 383-389.
42. Kindzelskii AL, Clark AJ, Espinoza J, Maeda N, Aratani Y, et al. (2006) Myeloperoxidase accumulates at the neutrophil surface and enhances cell metabolism and oxidant release during pregnancy. Eur J Immunol 36: 1619-1628.
43. Pitkin RM, Witte DL (1979) Platelet and leukocyte counts in pregnancy. Jama 242: 2696-2698.
44. Kuhnert M, Strohmeier R, Stegmuller M, Halberstadt E (1998) Changes in lymphocyte subsets during normal pregnancy. Eur J Obstet Gynecol Reprod Biol 76: 147-151.