P16INK4A is a strong biomarker for cervical intraepithelial neoplasia and invasive cervical carcinoma: A reappraisal

Reproductive Sciences

Volumn 16, Issue 7, 2009, Pages 685-693

  Haidopoulos, Dimitrios ^a   Partsinevelos, George A ^a,b   Vlachos, George D ^a   Rodolakis, Alexandros ^a   Markaki, Sonia ^a   Voulgaris, Zannis ^a   Diakomanolis, Emmanuel ^a   Antsaklis, Aris ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NONE   (Greece)

Author keywords

Bcl 2; Cervical cancer; HPV; P16INK4A; P53

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN BCL 2; PROTEIN P53; VIRUS DNA;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER PATIENT; CANCER SCREENING; COLPOSCOPY; CONTROLLED STUDY; DNA FINGERPRINTING; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; PAPANICOLAOU TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; VIRUS STRAIN; WART VIRUS;

ADULT; AGED; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM INVASIVENESS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 67649204817     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719109334259     Document Type: Article

References (36)

1. Sano T., Oyama T., Kashiwabara K., Fukuda T., Nakajima T. Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int. 1998 ; 48 (8). 580-585. (Pubitemid 28399627)
2. Klaes R., Benner A., Friedrich T., et al. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2002 ; 26 (11). 1389-1399. (Pubitemid 35239415)
3. Katsumata M., Siegel RM, Louie DC, et al. Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc Natl Acad Sci U S A. 1992 ; 89 (23). 11376-11380.
4. Tjalma W., Weyler J., Goovaerts G., De Pooter C., Van Marck E., van Dam P. Prognostic value of bcl-2 expression in patients with operable carcinoma of the uterine cervix. J Clin Pathol. 1997 ; 50 (1). 33-36. (Pubitemid 27060202)
5. Crawford RA, Caldwell C., Iles RK, Lowe D., Shepherd JH, Chard T. Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. Br J Cancer. 1998 ; 78 (2). 210-214. (Pubitemid 28302258)
6. Spitkovsky D., Aengeneyndt F., Braspenning J., von Knebel Doeberitz M. p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene. Oncogene. 1996 ; 13 (5). 1027-1035. (Pubitemid 26329089)
7. Scheffner M. Ubiquitin, E6-AP, and their role in p53 inactivation. Pharmacol Ther. 1998 ; 78 (3). 129-139. (Pubitemid 28255145)
8. Zheng PS, Li SR, Iwasaka T., Song J., Cui MH, Sugimori H. Simultaneous detection by concensus multiplex PCR of high and low-risk and other types of human papilloma virus in clinical samples. Gynecol Oncol. 1995 ; 58 (2). 179-183.
9. Bernard HU, Chan SY, Manos MM, et al. Identification and assesment of known and novel human papillomavirus by polymerase chain reaction amplification, restriction fragment length polymorphism nucleotide sequence, and phylogenetic algorithms. J Infect Dis. 1994 ; 170 (5). 1077-1085.
10. Vernon SD, Unger ER, Williams S. Comparison of human papillomavirus detection and typing by cycle sequencing, line blotting, and hybrid capture. J Clin Microbiol. 2000 ; 38 (2). 651-655. (Pubitemid 30082658)
11. DeMay RM Failure of the Pap smear. In: The art & science of 3 cytopathology, Philip Rogers (Ed), Chicago: American Society for Clinical Pathology Press (ASCP Press) ; 1996: 141-147.
12. de Vet HC, Knipschild PG, Schouten HJ, et al. Interobserver variation in histopathological grading of cervical dysplasia. J Clin Epidemiol. 1990 ; 43 (12). 1395-1398.
13. Robertson AJ, Anderson JM, Beck JS, et al. Observer variability in histopathological reporting of cervical biopsy specimens. J Clin Pathol. 1989 ; 42 (3). 231-238. (Pubitemid 19077263)
14. Dehn D., Torkko KC, Shroyer KR Human papillomavirus testing and molecular markers of cervical dysplasia and carcinoma. Cancer. 2007 ; 111 (1). 1-14. (Pubitemid 46281079)
15. Klaes R., Friedrich T., Spitkovsky D., et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001 ; 92 (2). 276-284. (Pubitemid 32225381)
16. Murphy N., Ring M., Killalea AG, et al. p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears. J Clin Pathol. 2003 ; 56 (1). 56-63. (Pubitemid 36132476)
17. Volgareva G., Zavalishina L., Andreeva Y., et al. Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells. BMC Cancer. 2004 ; 4: 58.
18. Guo M., Hu L., Baliga M., He Z., Hughson MD The predictive value of p16(INK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2004 ; 122 (6). 894-901. (Pubitemid 39577357)
19. Hu L., Guo M., He Z., Thornton J., McDaniel LS, Hughson MD Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol. 2005 ; 18 (2). 267-273. (Pubitemid 40188635)
20. Qiao X., Bhuiya TA, Spitzer M. Differentiating high-grade cervical intraepithelial lesion from atrophy in postmenopausal women using Ki-67, cyclin E, and p16 immunohistochemical analysis. J Low Genit Tract Dis. 2005 ; 9 (2). 100-107. (Pubitemid 40464079)
21. Lin ZH, Shen XH, Jin Z., et al. Human papillomavirus genotyping by oligonucleotide microarray and p16 expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in Korean women. Pathol Int. 2005 ; 55 (8). 491-496. (Pubitemid 41097850)
22. Lambert AP, Anschau F., Schmitt VM p16INK4A expression in cervical premalignant and malignant lesions. Exp Mol Pathol. 2006 ; 80 (2). 192-196. (Pubitemid 43295540)
23. Queiroz C., Silva TC, Alves VA, et al. p16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathol Res Pract. 2006 ; 202 (2). 77-83. (Pubitemid 43125707)
24. Benevolo M., Mottolese M., Marandino F., et al. Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol. 2006 ; 19 (3). 384-391. (Pubitemid 43276992)
25. Ishikawa M., Fujii T., Saito M., et al. Overexpression of p16 INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer. 2006 ; 16 (1). 347-353.
26. Eleut?©rio J. Jr, Giraldo PC, Gon?§alves AK, et al. Prognostic markers of high-grade squamous intraepithelial lesions: the role of p16INK4a and high-risk human papillomavirus. Acta Obstet Gynecol Scand. 2007 ; 86 (1). 94-98. (Pubitemid 46009533)
27. Guedes AC, Brenna SM, Coelho SA, Martinez EZ, Syrj?Currency signnen KJ, Zeferino LC p16(INK4a) Expression does not predict the outcome of cervical intraepithelial neoplasia grade 2. Int J Gynecol Cancer. 2007 ; 17 (5). 1099-1103. (Pubitemid 47414816)
28. Focchi GR, Silva ID, Nogueira-de-Souza NC, Dobo C., Oshima CT, Stavale JN Immunohistochemical expression of p16(INK4A) in normal uterine cervix, nonneoplastic epithelial lesions, and low-grade squamous intraepithelial lesions. J Low Genit Tract Dis. 2007 ; 11 (2). 98-104. (Pubitemid 46597703)
29. Bahnassy AA, Zekri AR, Saleh M., Lotayef M., Moneir M., Shawki O. The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma. BMC Clin Pathol. 2007 ; 7: 4.
30. Yildiz IZ, Usub?1/4t?1/4n A., Firat P., Ayhan A., K?1/4?§?1/4kali T. Efficiency of immunohistochemical p16 expression and HPV typing in cervical squamous intraepithelial lesion grading and review of the p16 literature. Pathol Res Pract. 2007 ; 203 (6). 445-449. (Pubitemid 46860176)
31. Monsonego J., Pollini G., Evrard MJ, et al. p16(INK4a) immunocytochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear. Acta Cytol. 2007 ; 51 (5). 755-766. (Pubitemid 47443610)
32. Liu H., Shi J., Wilkerson M., Huang Y., et al. Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections. Cancer. 2007 ; 111 (2). 74-82. (Pubitemid 46648405)
33. Feng W., Xiao J., Zhang Z., et al. Senescence and apoptosis in carcinogenesis of cervical squamous carcinoma. Mod Pathol. 2007 ; 20 (9). 961-966. (Pubitemid 47267824)
34. El-Ghobashy AA, Shaaban AM, Innes J., Prime W., Herrington CS Differential expression of cyclin-dependent kinase inhibitors and apoptosis-related proteins in endocervical lesions. Eur J Cancer. 2007 ; 43 (13). 2011-2018. (Pubitemid 47284870)
35. Milde-Langosch K., Albrecht K., Joram S., Schlechte H., Giessing M., Loning T. Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva. Int J Cancer. 1995 ; 63 (5). 639-645.
36. Avall-Lundqvist EH, Silfeverswand C., Aspenblad U., Nilsson BR, Auer GU The impact of tumor angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival in squamous cervical carcinoma. Eur J Cancer. 1997 ; 33 (11). 1799-1804. (Pubitemid 28129207)