p6INK4a Expression does not predict the outcome of cervical intraepithelial neoplasia grade 2

International Journal of Gynecological Cancer

Volumn 17, Issue 5, 2007, Pages 1099-1103

  Guedes, A C ^a   Brenna, S M F ^a,e   Coelho, S A S ^b   Martinez, E Z ^b   Syrjanen K J ^c   Zeferino, L C ^d  

^a HOSPITAL MATERNIDADE LEONOR MENDES DE BARROS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF CAMPINAS   (Brazil)

^e NONE   (Brazil)

Author keywords

Cervical intraepithelial neoplasia; CIN2; Natural history; p16 INK4a; Regression

Indexed keywords

PROTEIN P16INK4A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SQUAMOUS CELL; TISSUE SECTION; TUMOR REGRESSION; UNIVARIATE ANALYSIS; UTERINE CERVIX CARCINOMA IN SITU; VIRUS INFECTION; WART VIRUS; ADOLESCENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; MIDDLE AGED; PATHOLOGY; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; UTERINE CERVIX TUMOR;

ADOLESCENT; ADULT; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM REGRESSION, SPONTANEOUS; NEOPLASM STAGING; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 34548664379     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2007.00899.x     Document Type: Article

References (28)

1. Östör AG. Natural history of cervical intraepithelial neoplasia: the critical review. Int J Gynecol Pathol 1993 12 : 186 92.
2. Nasiell K, Nasiell M, Vaclavinkova V. Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 1983 61 : 609 14.
3. Syrjänen K, Syrjänen S. Papillomavirus infections in human pathology. Chichester, UK : J. Wiley & Sons 2000 : 615.
4. Syrjänen KJ. Immunohistochemistry in assessment of molecular pathogenesis of cervical carcinogenesis. Eur J Gynaecol Oncol 2005 26 : 5 19.
5. INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer 2006 16 : 347 53.
6. INK4a expression is related to grade of CIN and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome. Int J Gynecol Pathol 2004 23 : 354 65.
7. Walker P, Dexeus S, De Palo G et al. International terminology of colposcopy: an updated report from the International Federation for Cervical Pathology and Colposcopy. Obstet Gynecol 2003 101 : 175 7.
8. Galvin GA, Jones HW, TeLinde RW. The significance of basal-cell hyperactivity in cervical biopsies. Am J Obstet Gynecol 1955 70 : 808 21.
9. Lambert B, Woodruff JD. Spinal cell atypia of the cervix. A clinicopathological study. Cancer 1963 16 : 1141 50.
10. Nieburgs HE. The significance of tissue cell changes preceding uterine cervix carcinoma. Cancer 1963 16 : 141 59.
11. Patten SF. Dysplasia of the uterine cervix. In : Lewis GC Jr., Wentz WB, Jaffe RM, eds. New concepts in gynecological oncology. Philadelphia, PA : FA Davis 1966 : 33 44.
12. Srivannaboon S, Bhamarapravati N. Prevalence and outcome of dysplasia of cervix in self-selected population of Thailand. J Med Assoc Thai 1974 57 : 351 6.
13. Macgregor JE, Teper S. Uterine cervical cytology and young women. Lancet 1978 13 : 1029 31 YS, Reagan JW, Richart RM. Definition of precursors. Gynecol Oncol 1981 12 : 220 31.
14. DeBrux J, Orth G, Croissant O, Cochard B, Ionesco M. Condylomatous lesions of the uterine cervix: their course in 2466 patients. Bull Cancer 1983 70 : 410 22.
15. Bibbo M, Dytch HE, Alenghat E, Bartels PH, Wied GL. DNA ploidy profiles as prognostic indicators in CIN lesions. Am J Clin Pathol 1989 92 : 261 5.
16. Weaver MG, Abdul-Karim FW, Dale G, Sorensen K, Huang YT. Outcome in mild and moderate cervical dysplasias related to the presence of specific human papillomavirus types. Mod Pathol 1990 3 : 679 83.
17. Kataja V, Syrjänen S, Mäntyjärvi R, Yliskoski M, Saarikoski S, Syrjänen K. Prognostic factors in cervical human papillomavirus infections. Sex Transm Dis 1992 19 : 154 60.
18. ink4a and hybrid capture 2 human papillomavirus testing for high-grade cervical intraephitelial neoplasia. Am J Clin Pathol 2004 122 : 894 901.
19. Pientong C, Ekalaksananan T, Kongyingyoes B et al. Immunocytochemical staining of p16INK4a protein from conventional Pap test and its association with human papillomavirus infection. Diagn Cytopathol 2004 31 : 235 42.
20. Bose S, Evans H, Lantzy L, Scharre K, Youssef E. p16(INK4a) is a surrogate biomarker for a subset of human papilloma virus-associated dysplasias of the uterine cervix as determined on the Pap smear. Diagn Cytopathol 2005 32 : 21 4.
21. Moore GD, Lear SC, Wills-Frank LA, Martin AW, Snyder JW, Helm, CW. Differential expression of cdk inhibitors p16, p21cip1, p27kip and cyclin E in cervical cytological smears prepared by the ThinPrep method. Diagn Cythopatol 2005 32 : 82 7.
22. Syrjanen S, Shabalova IP, Petrovichev N et al. Human papillomavirus testing and conventional Pap smear cytology as optional screening tools of women at different risk for cervical câncer in countries of former Soviet Union. J Lower Genital Tract Dis 2002 6 : 97 110.
23. Costa S, Simenoe PD, Venturoli S et al. Factors predicting human papillomavirus (HPV) clearence in cervical intraepithelial neoplasia (CIN) lesions treated by conization. Gynecol Oncol 2003 90 : 358 65.
24. Nagai Y, Maehama T, Asato T, Kanazawa K. Persistence of human papillomavirus infection after therapeutic conization for CIN3: is it alarm for disease recurrence. Gynecol Oncol 2000 79 : 294 99.
25. Nobbenhuis MAE, Meijer CJLM, van den Brule AJC et al. Addition of high-risk HPV testing improves the current guidelines on follow up after treatment for cervical intraephitelial neoplasia. Brit J Cancer 2001 84 : 796 801.
26. Paraskevaidis E, Koliopuolos G, Alamanos Y, Malamoumitsi V, Lolis ED, Kitchener HC. Human papillomavirus testing in the prediction of the outcome of treatment for cervical intraephitelial neoplasia. Obstet Gynecol 2001 98 : 833 6.
27. Wang SS, Trunk M, Schiffman M et al. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 2004 13 : 1355 60.
28. Tripathi A, Banerjee S, Roy A, Roychowdhury S, Panda CK. Alterations of the p16 gene in uterine cervical carcinoma from Indian patients. Int J Gynecol Cancer 2003 13 : 472 9.