Senescence and apoptosis in carcinogenesis of cervical squamous carcinoma

Modern Pathology

Volumn 20, Issue 9, 2007, Pages 961-966

  Feng, Wei ^a   Xiao, Jianguo ^a   Zhang, Zhihong ^b   Rosen, Daniel G ^b   Brown, Robert E ^a   Liu, Jinsong ^b   Duan, Xiuzhen ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Apoptosis; Carcinogenesis; Carcinoma; Cervical squamous; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2B; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P14ARF; PROTEIN P16INK4A; PROTEIN P53;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SQUAMOUS CELL CARCINOMA; STAINING; TISSUE MICROARRAY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CONIZATION; UTERINE CERVIX DYSPLASIA;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; NEOPLASM STAGING; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

EID: 34547955181     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800927     Document Type: Article

References (25)

1. Collado M, Gil J, Efeyan A, et al. Tumour biology: senescence in premalignant tumours. Nature 2005;436:642.
2. Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature 2005;436:636-637.
3. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004;432:307-315.
4. Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
5. Kim YT, Zhao M. Aberrant cell cycle regulation in cervical carcinoma. Yonsei Med J 2005;46:597-613.
6. Tsuda H, Hashiguchi Y, Nishimura S, et al. Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm. Gynecol Oncol 2003;91:476-485.
7. Michaloglou C, Vredeveld LC, Soengas MS, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005;436:720-724.
8. Stott FJ, Bates S, James MC, et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998;17:5001-5014.
9. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 1997;3:614-620.
10. Hockenbery D, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-336.
11. Hockenbery DM. The bcl-2 oncogene and apoptosis. Semin Immunol 1992;4:413-420.
12. Agoff SN, Lin P, Morihara J, et al. p16(INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 2003;16:665-673.
13. Cameron RI, Maxwell P, Jenkins D, et al. Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia. Histopathology 2002;41:313-321.
14. Graflund M, Sorbe B, Karlsson M. Immunohistochemical expression of p53, bcl-2, and p21(WAF1/CIP1) in early cervical carcinoma: correlation with clinical outcome. Int J Gynecol Cancer 2002;12:290-298.
15. Graflund M, Sorbe B, Sigurdardottir S, et al. Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: correlation with clinical outcome. Oncol Rep 2004;12:169-176.
16. Guimaraes MC, Goncalves MA, Soares CP, et al. Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. J Histochem Cytochem 2005;53:509-516.
17. Munakata S, Watanabe O, Ohashi K, et al. Expression of Fas ligand and bcl-2 in cervical carcinoma and their prognostic significance. Am J Clin Pathol 2005;123:879-885.
18. Zhang Z, Rosen DG, Yao JL, et al. Expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 increases during prostate cancer progression. Mod Pathol 2006;19:1339-1343.
19. Jin M, Piao Z, Kim NG, et al. p16 is a major inactivation target in hepatocellular carcinoma. Cancer 2000;89:60-68.
20. Kanao H, Enomoto T, Ueda Y, et al. Correlation between p14(ARF)/p16(INK4A) expression and HPV infection in uterine cervical cancer. Cancer Lett 2004;213:31-37.
21. Sano T, Oyama T, Kashiwabara K, et al. Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int 1998;48:580-585.
22. Sano T, Masuda N, Oyama T, et al. Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. Pathol Int 2002;52:375-383.
23. van Slooten HJ, van d V, van d V, et al. Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity. Br J Cancer 1998;77:789-796.
24. Ryan JJ, Prochownik E, Gottlieb CA, et al. c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 1994;91:5878-5882.
25. Troncone G, Martinez JC, Palombini L, et al. Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. J Clin Pathol 1998;51:754-760.