Inhibitory effect of ghrelin on nicotine-induced VCAM-1 expression in human umbilical vein endothelial cells

Journal of Cardiovascular Pharmacology

Volumn 53, Issue 3, 2009, Pages 241-245

  Hu, Cui Zhu ^a   Cao, Yan Li ^a   Huo, Hai Yang ^a   Zhao, Wei Hua ^a   Hu, Jian ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Adhesion molecules; Atherosclerosis; Endothelial cells; Ghrelin; Smoking

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GHRELIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINE; PROTEIN KINASE C; RECOMBINANT GHRELIN; RECOMBINANT HORMONE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE ACTIVATION; HORMONE ACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TIME; UMBILICAL VEIN; ATHEROSCLEROSIS; BIOSYNTHESIS; CELL LINE; CYTOLOGY; ENZYMOLOGY; METABOLISM; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ATHEROSCLEROSIS; BLOTTING, WESTERN; CELL LINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GHRELIN; HUMANS; NF-KAPPA B; NICOTINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 67649203652     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31819c74dc     Document Type: Article

References (30)

1. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature. 1999;402:656-660. (Pubitemid 129516334)
2. Kojima M, Hosoda H, Matsuo H, et al. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab. 2001;12:118-122. (Pubitemid 33714199)
3. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86:5992.
4. Broglio F, Gottero C, Benso A, et al. Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans. J Clin Endocrinol Metab. 2003;88:4268-4272. (Pubitemid 37153730)
5. Dornonville de la Cour C, Lindström E, Norlén P, et al. Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul Pept. 2004;120:23-32. (Pubitemid 38726188)
6. Kleinz MJ, Maguire JJ, Skepper JN, et al. Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man. Cardiovasc Res. 2006;69:227-235.
7. Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab. 2002;87:2988. (Pubitemid 34655375)
8. Nagaya N, Kojima M, Uematsu M, et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1483-R1487. (Pubitemid 32436103)
9. Pemberton CJ, Tokola H, Bagi Z, et al. Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion. Am J Physiol Heart Circ Physiol. 2004;287:H1522-H1529. (Pubitemid 39313255)
10. Pöykkö SM, Kellokoski E, Hörkkö S, et al. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes. 2003;52:2546-2553. (Pubitemid 37210544)
11. Dixit VD, Schaffer EM, Pyle RS, et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest. 2004;114:57-66.
12. Li WG, Gavrila D, Liu X, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 2004;109:2221-2226. (Pubitemid 38625400)
13. Cucina A, Sapienza P, Corvino V, et al. Nicotine-induced smooth muscle cell proliferation is mediated through bFGF and TGF-beta 1. Surgery. 2000;127:316-322. (Pubitemid 30140630)
14. Haussig S, Schubert A, Mohr FW, et al. Sub-chronic nicotine exposure induces intercellular communication failure and differential downregulation of connexins in cultured human endothelial cells. Atherosclerosis. 2008;196:210-218.
15. Ueno H, Pradhan S, Schlessel D, et al. Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1. Cardiovasc Toxicol. 2006;6:39-50. (Pubitemid 44127951)
16. Kokkinos A, Tentolouris N, Kyriakaki E, et al. Differentiation in the short- and long-term effects of smoking on plasma total ghrelin concentrations between male nonsmokers and habitual smokers. Metabolism. 2007;56:523-527. (Pubitemid 46427850)
17. Hanyu M, Kume N, Ikeda T, et al. VCAM-1 expression precedes macrophage infiltration into subendothelium of vein grafts interposed into carotid arteries in hypercholesterolemic rabbits: a potential role in vein graft atherosclerosis. Atherosclerosis. 2001;158:313-319. (Pubitemid 32913640)
18. O'Brien KD, McDonald TO, Chait A, et al. Neovascular expression of E-selectin, intercellular adhesion molecule-1 and vascular adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation. 1996;93:672-682. (Pubitemid 26052452)
19. Dansky HM, Barlow CB, Lominska C, et al. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol. 2001;21:1662-1667. (Pubitemid 34215588)
20. Skilton MR, Nakhla S, Sieveking DP, et al. Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells. Clin Exp Pharmacol Physiol. 2005;32:839-844. (Pubitemid 43906527)
21. Min JK, Kim YM, Kim SW, et al. TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells. J Immunol. 2005;175:531-540.
22. Kawanami D, Maemura K, Takeda N, et al. C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells. Atherosclerosis. 2006;185:39-46. (Pubitemid 43117549)
23. Zhao D, Zhan Y, Zeng H, et al. Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. J Cell Biochem. 2006;97:1317-1327.
24. Nanzer AM, Khalaf S, Mozid AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004;151:233-240. (Pubitemid 39207019)
25. Madonna R, Massaro M, Pandolfi A, et al. The prominent role of p38 mitogen-activated protein kinase in insulin-mediated enhancement of VCAM-1 expression in endothelial cells. Int J Immunopathol Pharmacol. 2007;20:539-555. (Pubitemid 47531057)
26. Vega-Ostertag ME, Ferrara DE, Romay-Penabad Z, et al. Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation. J Thromb Haemost. 2007;5:1828-1834. (Pubitemid 47288938)
27. Waseem T, Duxbury M, Ito H, et al. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery. 2008;143:334-342.
28. Ma W, Lim W, Gee K, et al. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J Biol Chem. 2001;276:13664-13674. (Pubitemid 37391738)
29. Wu R, DongW, Zhou M, et al. Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1. Cardiovasc Res. 2005;68:318-326. (Pubitemid 41428428)
30. Rossi F, Castelli A, Bianco MJ, et al. Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation. Peptides. 2008;29:2046-2051.