Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures

Journal of Molecular and Cellular Cardiology

Volumn 47, Issue 2, 2009, Pages 335-345

  Formigli, Lucia ^a   Francini, Fabio ^a   Nistri, Silvia ^a   Margheri, Martina ^a   Luciani, Giorgia ^a   Naro, Fabio ^b   Silvertown, Josh D ^c   Orlandini, Sandra Zecchi ^a   Meacci, Elisabetta ^a   Bani, Daniele ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

C2C12 myoblasts; Cardiomyocytes; Gap junctions; Myocardial differentiation; Relaxin

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CALCIUM ION; CONNEXIN 43; POTASSIUM CHANNEL; RELAXIN; SODIUM ION; STEM CELL FACTOR; TROPONIN T;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM SIGNALING; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL ORGANELLE; CELL REGENERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; GAP JUNCTION; GENE OVEREXPRESSION; HEART CELL CULTURE; IMMUNOPHENOTYPING; IN VITRO STUDY; MOUSE; MYOBLAST; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN SECRETION; SODIUM CURRENT; WILD TYPE;

ANIMALS; ANIMALS, NEWBORN; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; COCULTURE TECHNIQUES; CONNEXIN 43; ELECTROPHYSIOLOGICAL PHENOMENA; IMMUNOPHENOTYPING; ION CHANNEL GATING; MICE; MYOBLASTS, SKELETAL; MYOCYTES, CARDIAC; RELAXIN; TIME FACTORS;

MURINAE;

EID: 67649134912     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.05.008     Document Type: Article

References (44)

1. Jaber W.A., and Holmes Jr. D.R. Outcome and quality of care of patients who have acute myocardial infarction. Med. Clin. North Am. 91 (2007) 751-768
2. Rubart M., and Field L.J. Cardiac regeneration: repopulating the heart. Annu. Rev. Physiol. 68 (2006) 29-49
3. Vacanti C.A. The history of tissue engineering. J. Cell. Mol. Med. 10 (2006) 569-576
4. Caplice N.M. The future of cell therapy for acute myocardial infarction. Nat. Clin. Pract. Cardiovasc. Med. 3 Suppl. 1 (2006) S129-S132
5. Dowell J.D., Rubart M., Pasumarthi K.B.S., Soonpaa M.H., and Field L.J. Myocyte and myogenic stem cell transplantation in the heart. Cardiovasc. Res. 58 (2003) 336-350
6. Menasché P. Skeletal myoblasts and cardiac repair. J. Mol. Cell. Cardiol. 45 (2008) 545-553
7. Formigli L., Francini F., Tani A., Squecco R., Nosi D., Polidori L., et al. Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell-cell contacts and relaxin treatment. Am. J. Physiol. (Cell Physiol.) 288 (2005) C795-C804
8. Formigli L., Perna A.M., Meacci E., Cinci L., Margheri M., Nistri S., et al. Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodeling. J. Cell. Mol. Med. 11 (2007) 1087-1110
9. Bonacchi M., Nistri S., Nanni C., Gelsomino S., Pini A., Cinci L., et al. Functional and histopathological improvement of the post-infarcted rat heart upon myoblast cell grafting and relaxin therapy. J. Cell. Mol. Med. (2008) Sep 15. [Electronic publication ahead of print]
10. Müller P., Beltrami A.P., Cesselli D., Pfeiffer P., Kazakov A., and Böhm M. Myocardial regeneration by endogenous adult progenitor cells. J. Mol. Cell. Cardiol. 39 (2005) 377-387
11. Torella D., Ellison G.M., Méndez-Ferrer S., Ibanez B., and Nadal-Ginard B. Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration. Nat. Clin. Pract. Cardiovasc. Med. 3 Suppl. 1 (2006) S8-S13
12. Bearzi C., Rota M., Hosoda T., Tillmanns J., Nascimbene A., De Angelis A., et al. Human cardiac stem cells. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 14068-14073
13. Rota M., Hosoda T., De Angelis A., Arcarese M.L., Esposito G., Rizzi R., et al. The young mouse heart is composed of myocytes heterogeneous in age and function. Circ. Res. 101 (2007) 387-399
14. Popescu L.M., Gherghiceanu M., Manole C.G., and Pellegrini Faussone M.S. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J. Cell. Mol. Med. (2009) 13 Electronic publication ahead of print
15. Urbanek K., Cesselli D., Rota M., Nascimbene A., De Angelis A., Hosoda T., et al. Stem cell niches in the adult mouse heart. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9226-9231
16. Scobioala S., Klocke R., Kuhlmann M., Tian W., Hasib L., Milting H., et al. Up-regulation of nestin in the infarcted myocardium potentially indicates differentiation of resident cardiac stem cells into various lineages including cardiomyocytes. FASEB J. 22 (2008) 1021-1031
17. Braun T., and Martire A. Cardiac stem cells: paradigm shift or broken promise? A view from developmental biology. Trends Biotechnol. 25 (2007) 441-447
18. Limana F., Germani A., Zacheo A., Kajstura J., Di Carlo A., Borsellino G., et al. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ. Res. 97 (2005) e73-83
19. Mazhari R., and Hare J.M. Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche. Nat. Clin. Pract. Cardiovasc. Med. 4 (2007) S21-S26
20. Dschietzig T., Richter C., Bartsch C., Laule M., Armbruster F.P., Baumann G., et al. The pregnancy hormone relaxin is a player in human heart failure. FASEB J. 15 (2001) 2187-2195
21. Hsu S.Y., Nakabayashi K., Nishi S., Kumagai J., Kudo M., Sherwood O.D., et al. Activation of orphan receptors by the hormone relaxin. Science 295 (2002) 671-674
22. Bani D., and Bigazzi M. Clinical aspects and therapeutic perspectives of relaxin. Curr. Med. Chem-Immunol,. Endocr. Metab. Agents 5 (2005) 403-410
23. Samuel C.S., Du X.J., Bathgate R.A.D., and Summers R.J. 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharm. Ther. 112 (2006) 529-552
24. Bani Sacchi T., Bigazzi M., Bani D., Mannaioni P.F., and Masini E. Relaxin-induced increased coronary flow through stimulation of nitric oxide production. Br. J. Pharmacol. 116 (1995) 1589-1594
25. Samuel C.S., Unemori E.N., Mookerjee I., Bathgate R.A., Layfield S.L., Mak J., et al. Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145 (2003) 4125-4133
26. Perna A.M., Masini E., Nistri S., Briganti V., Chiappini L., Stefano P., et al. Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model. FASEB J. 19 (2005) 1525-1527
27. Teerlink J.R., Metra M., Felker G.M., Panikowski P., Voors A.A., Weatherley B.D., et al. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet 373 (2009) 1429-1439
28. Collesi C., Zentilin L., Sinagra G., and Giacca M. Notch1 signaling stimulates proliferation of immature cardiomyocytes. J. Cell Biol. 183 (2008) 117-128
29. Sreejit P., Kumar S., and Verma R.S. An improved protocol for primary culture of cardiomyocytes from neonatal mice. In Vitro Cell. Dev. Biol., Anim. 44 (2008) 45-50
30. Silvertown J.D., Ng J., Sato T., Summerlee A.J., and Medin J.A. H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. Int. J. Cancer 118 (2006) 62-73
31. Koyanagi M., Brandes R.P., Haendeler J., Zeiher A.M., and Dimmeler S. Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes?. Circ. Res. 96 (2005) 1039-1041
32. Benvenuti S., Saccardi R., Luciani P., Urbani S., Deledda C., Cellai I., et al. Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. Exp. Cell Res. 312 (2006) 2592-2604
33. Rustom A., Saffrich R., Markovic I., Walther P., and Gerdes H.H. Nanotubular highways for intercellular organelle transport. Science 303 (2004) 1007-1010
34. Gerdes H.H., Bukoreshtliev N.V., and Barroso J.F. Tunneling nanotubes: a new route for the exchange of components between animal cells. FEBS Lett. 581 (2007) 2194-2201
35. Crescioli C., Squecco R., Cosmi L., Sottili M., Gelmini S., Borgogni E., et al. Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs. Exp. Cell Res. 314 (2008) 1337-1350
36. Plotnikov E.Y., Khryapenkova T.G., Vasileva A.K., Marey M.V., Galkina S.I., Isaev N.K., et al. Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in coculture. J. Cell. Mol. Med. 12 (2008) 1622-1631
37. Muller-Borer B.J., Cascio W.E., Esch G.L., Kim H.S., Coleman W.B., Grisham J.W., et al. Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 3877-3882
38. Moorman A.F., and Lamers W.H. Development of the conduction system of the vertebrate heart. In: Harvey R.P., and Rosenthal N. (Eds). Heart Development (1999), Academic Press, San Diego 195-207
39. Sedmera D., Pexieder T., Vuillemin M., Thompson R.P., and Anderson R.H. Developmental patterning of the myocardium. Anat. Rec. 258 (2000) 319-337
40. Mummery C., Ward-van Oostwaard D., Doevendans P., Spijker R., van den Brink S., Hassink R., et al. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 107 (2003) 2733-2740
41. Boni A., Urbanek K., Nascimbene A., Hosoda T., Zheng H., Delucchi F., et al. Notch1 regulates the fate of cardiac progenitor cells. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 15529-15534
42. Kostin S., and Popescu L.M. A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLC). J. Cell. Mol. Med. (2009) Jan 27. [Electronic publication ahead of print]
43. Fahrenbach J.P., Mejia-Alvarez R., and Banach K. The relevance of non-excitable cells for cardiac pacemaker function. J. Physiol. 585 (2007) 565-578
44. Weissman I.L., Anderson D.J., and Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17 (2001) 387-403