Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas-an image cytometric DNA ploidy analysis of 307 cases with histogenetic implications

Virchows Archiv

Volumn 454, Issue 6, 2009, Pages 677-683

  Pradhan, Manohar ^a   Davidson, Ben ^a,c   Tropé, Claes Göran ^a,c   Danielsen, Håvard Emil ^a,b   Abeler, Vera Maria ^a   Risberg, Björn ^a,d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

DNA ploidy; Gross genomic alteration; Histogenesis; Image cytometry; Ovary; S phase fraction; Serous adenocarcinoma; Serous borderline tumor

Indexed keywords

ADULT; AGED; ANEUPLOIDY; ARTICLE; COMPARATIVE STUDY; CYSTADENOCARCINOMA; DIPLOIDY; DNA DETERMINATION; FEMALE; GENOMICS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE CYTOMETRY; MAJOR CLINICAL STUDY; OVARIAN SEROUS BORDERLINE TUMOR; OVARY ADENOCARCINOMA; OVARY TUMOR; PLOIDY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEUPLOIDY; CELL NUCLEUS; COHORT STUDIES; CYSTADENOCARCINOMA, SEROUS; DNA, NEOPLASM; FEMALE; HUMANS; IMAGE CYTOMETRY; MIDDLE AGED; OVARIAN NEOPLASMS; PRECANCEROUS CONDITIONS; RETROSPECTIVE STUDIES; S PHASE; YOUNG ADULT;

EID: 67649111135     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-009-0778-y     Document Type: Article

References (29)

1. Lee KR, Tavassoli FA, Prat J et al (2003) Tumors of the ovary and peritoneum. In: Tavassoli FA, Devilee P (eds) World Health Organization classification of tumours: pathology and genetics. Tumours of the breast and female genital organs. IARC, Lyon, pp 117-124
2. CL Trimble C Kosary EL Trimble 2002 Long-term survival and patterns of care in women with ovarian tumors of low malignant potential Gynecol Oncol 86 34 37 (Pubitemid 34757048)
3. AP Heintz F Odicino P Maisonneuve 2003 Carcinoma of the ovary Int J Gynaecol Obstet 83 Suppl 1 135 166 (Pubitemid 39658498)
4. GD Aletti MM Gallenberg WA Cliby 2007 Current management strategies for ovarian cancer Mayo Clin Proc 82 751 770 (Pubitemid 46878099)
5. RJ Kurman S IEM 2008 Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications Int J Gynecol Pathol 27 151 160
6. S Hauptmann C Denkert I Koch 2002 Genetic alterations in epithelial ovarian tumors analyzed by comparative genomic hybridization Hum Pathol 33 632 641 (Pubitemid 34827545)
7. I Meinhold-Heerlein D Bauerschlag F Hilpert 2005 Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential Oncogene 24 1053 1065 (Pubitemid 40313882)
8. MG Tibiletti B Bernasconi M Taborelli 2003 Genetic and cytogenetic observations among different types of ovarian tumors are compatible with a progression model underlying ovarian tumorigenesis Cancer Genet Cytogenet 146 145 153 (Pubitemid 37211313)
9. GB Kristensen W Kildal VM Abeler 2003 Large-scale genomic instability predicts long-term outcome for women with invasive stage I ovarian cancer Ann Oncol 14 1494 1500 (Pubitemid 37304603)
10. NG Wolf FW Abdul-Karim C Farver 1999 Analysis of ovarian borderline tumors using fluorescence in situ hybridization Genes Chromosomes Cancer 25 307 315
11. H Blegen N Einhorn K Sjövall 2000 Prognostic significance of cell cycle proteins and genomic instability in borderline, early and advanced stage ovarian carcinoma Int J Gynecol Cancer 10 477 487 (Pubitemid 32066631)
12. MK Dodson LC Hartmann WA Cliby 1993 Comparison of loss of heterozygosity patterns in invasive low-grade and high-grade epithelial ovarian carcinomas Cancer Res 53 4456 4460 (Pubitemid 23304361)
13. J Hu V Khanna MM Jones U Surti 2002 Genomic imbalances in ovarian borderline and mucinous tumors Cancer Genet Cytogenet 139 18 23 (Pubitemid 36120401)
14. T Pejovic CS Iosif F Mitelman 1996 Karyotypic characteristics of borderline malignant tumors of the ovary: trisomy 12, trisomy 7, and r(1) as nonrandom features Cancer Genet Cytogenet 92 95 98 (Pubitemid 26427670)
15. J Kaern CG Tropé GB Kristensen 1993 DNA ploidy; the most important prognostic factor in patients with borderline tumors of the ovary Int J Gynecol Cancer 3 349 358 (Pubitemid 23336312)
16. MB Verbruggen PJ van Diest JP Baak 2009 The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: a prospective study Int J Gynecol Pathol 28 35 40
17. K Erhardt G Auer E Björkholm 1984 Prognostic significance of nuclear DNA content in serous ovarian tumors Cancer Res 44 2198 2202 (Pubitemid 14145751)
18. M Dietel H Arps A Rohlff 1986 Nuclear DNA content of borderline tumors of the ovary: correlation with histology and significance for prognosis Virchows Arch 409 829 836 (Pubitemid 16044950)
19. BC Padberg H Arps U Franke 1992 DNA cytophotometry and prognosis in ovarian tumors of borderline malignancy. A clinicomorphologic study of 80 cases Cancer 69 2510 2514
20. M deNictolis R Montironi S Tommasoni 1992 Serous borderline tumors of the ovary-a clinicopathological, immunohistochemical, and quantitative study of 44 cases Cancer 70 152 160
21. PJ Klemi H Joensuu P Kilholma 1988 Clinical significance of nuclear DNA content in serous ovarian tumors Cancer 62 2005 2010 (Pubitemid 18261828)
22. D Demirel R Laucirica A Fishman 1996 Ovarian tumors of low malignant potential. Correlation of DNA index and S-phase fraction with histopathologic grade and clinical outcome Cancer 77 1494 1500
23. JD Seidman HJ Norris JL Griffin 1993 DNA flow cytometric analysis of serous ovarian tumors of low malignant potential Cancer 71 3947 3951 (Pubitemid 23172975)
24. MS Fležar I But R Kavalar 2003 Flow and image cytometric DNA ploidy, including 5c exceeding cells, of serous borderline malignant ovarian tumors. Correlation with clinicopathologic characteristics Anal Quant Cytol Histol 25 139 145 (Pubitemid 36702640)
25. JA Scheuler JB Trimbos MVD Burg 1996 DNA index reflects biological behavior of ovarian carcinoma stage I-IIa Gynecol Oncol 63 59 66 (Pubitemid 26234546)
26. C-H Lai S Hseuh T-C Chang 1996 The role of DNA flow cytometry in borderline malignant ovarian tumors Cancer 78 794 802 (Pubitemid 26268610)
27. L Österberg M Åkeson K Levan 2006 Genetic alterations of serous borderline tumors of the ovary compared to stage I serous ovarian carcinomas Cancer Genet Cytogenet 167 103 108 (Pubitemid 43841753)
28. P Duesberg C Rausch D Rasnick 1998 Genetic instability of cancer cells is proportional to their degree of aneuploidy Proc Natl Acad Sci U S A 95 13692 13697 (Pubitemid 28523034)
29. A Fabarius R Hehlmann PH Duesberg 2003 Instability of chromosome structure in cancer cells increase exponentially with degree of aneuploidy Cancer Genet Cytogenet 143 59 72 (Pubitemid 36549008)