The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: A prospective study

International Journal of Gynecological Pathology

Volumn 28, Issue 1, 2009, Pages 35-40

  Verbruggen, Marjolijn B ^a   Van Diest, Paul J ^b   Baak, Jan P ^c   Broeckaert, Mark A M ^a   Kenemans, Peter ^a   Verheijen, René H M ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c STAVANGER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Borderline ovarian tumor; Cytometry; Mitotic activity index (MAI); Morphometry; Prognostic factors; Volume percentage of epithelium (VPE)

Indexed keywords

ADULT; AGED; ARTICLE; BORDERLINE OVARIAN TUMOR; CANCER STAGING; CANCER SURVIVAL; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOMETRY; DIAGNOSTIC VALUE; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MITOSIS RATE; MORPHOMETRICS; OVARY TUMOR; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; TUMOR VOLUME; DISEASE FREE SURVIVAL; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; ONSET AGE; PATHOLOGY;

DNA;

ADULT; AGE OF ONSET; AGED; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MIDDLE AGED; OVARIAN NEOPLASMS; PLOIDIES; PROGNOSIS;

EID: 61449522286     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31818131ff     Document Type: Article

References (32)

1. Taylor HC Jr. Malignant and semimalignant tumors of the ovary. Surg Gynecol Obstet 1929;48:204-230
2. Serov SF, Scully RE, Sobin LH. Histological Typing of Ovarian Tumors, Number 91. Geneva, Switzerland: WHO; 1973:37-41.
3. Burger CW, Prinssen HM, Baak JP, et al. The management of borderline epithelial tumors of the ovary. Int J Gynecol Cancer 2000;10:181-197
4. Trimble CL, Kosary C, Trimble EL. Long-term survival and patterns of care in women with ovarian tumors of low malignant potential. Gynecol Oncol 2002;86:34-37 (Pubitemid 34757048)
5. Gardner GJ, Birrer MJ. Ovarian tumors of low malignant potential: can molecular biology solve this enigma? J Natl Cancer Inst 2001;93:1122-1123
6. Hart WR, Norris HJ. Borderline and malignant mucinous tumors of the ovary. Histologic criteria and clinical behavior. Cancer 1973;31:1031-1045
7. Baak JP, Blanco AA, Kurver PH, et al. Quantitation of borderline and malignant mucinous ovarian tumours. Histopathology 1981;5:353-360 (Pubitemid 11012846)
8. Baak JP, Fox H, Langley FA, et al. The prognostic value of morphometry in ovarian epithelial tumors of borderline malignancy. Int J Gynecol Pathol 1985;4:186-191 (Pubitemid 16214522)
9. Baak JP, Chan KK, Stolk JG, et al. Prognostic factors in borderline and invasive ovarian tumors of the common epithelial type. Pathol Res Pract 1987;182:755-774
10. Kaern J, Trope CG, Kristensen GB, et al. DNA ploidy; the most important prognostic factor in patients with borderline tumors of the ovary. Int J Gynecol Cancer 1993;3:349-358 (Pubitemid 23336312)
11. Padberg BC, Stegner HE, von Sengbusch S, et al. DNA-cytophotometry and immunocytochemistry in ovarian tumours of borderline malignancy and related peritoneal lesions. Virchows Arch A Pathol Anat Histopathol 1992;421: 497-503.
12. Padberg BC, Arps H, Franke U, et al. DNA cytophotometry and prognosis in ovarian tumors of borderline malignancy. A clinicomorphologic study of 80 cases. Cancer 1992;69: 2510-2514
13. Casey AC, Bell DA, Lage JM, et al. Epithelial ovarian tumors of borderline malignancy: long-term follow-up. Gynecol Oncol 1993;50:316-322 (Pubitemid 23299726)
14. Trope C, Kaern J. Management of borderline tumors of the ovary: state of the art. Semin Oncol 1998;25:372-380 (Pubitemid 28272612)
15. Trope CG, Kristensen G, Makar A. Surgery for borderline tumor of the ovary. Semin Surg Oncol 2000;19:69-75.
16. Bergers E, Baak JP, van Diest PJ, et al. Prognostic value of DNA ploidy using flow cytometry in 1301 breast cancer patients: results of the prospective Multicenter Morphometric Mammary Carcinoma Project. Mod Pathol 1997;10: 762-768 (Pubitemid 27374845)
17. Acs G. Serous and mucinous borderline (low malignant potential) tumors of the ovary. Am J Clin Pathol 2005; 123(suppl):S13-57.
18. Winter WE III, Kucera PR, Rodgers W, et al. Surgical staging in patients with ovarian tumors of low malignant potential. Obstet Gynecol 2002;100:671-676 (Pubitemid 35300021)
19. Brinkhuis M, Baak JP, Meijer GA, et al. Value of quantitative pathological variables as prognostic factors in advanced ovarian carcinoma. J Clin Pathol 1996;49:142-148 (Pubitemid 26064921)
20. De Nictolis M, Montironi R, Tommasoni S, et al. Serous borderline tumors of the ovary. A clinicopathologic, immunohistochemical, and quantitative study of 44 cases. Cancer 1992; 70:152-160
21. Baak JP, van Diest PJ. Borderline ovarian tumors. Am J Surg Pathol 1998;22:904-907
22. Sherman ME, Mink PJ, Curtis R, et al. Survival among women with borderline ovarian tumors and ovarian carcinoma: a population-based analysis. Cancer 2004;100:1045-1052 (Pubitemid 38222865)
23. Sieben NL, Roemen GM, Oosting J, et al. Clonal analysis favours a monoclonal origin for serous borderline tumours with peritoneal implants. J Pathol 2006;210:405-411 (Pubitemid 44830600)
24. Gilks CB, Alkushi A, Yue JJ, et al. Advanced-stage serous borderline tumors of the ovary: a clinicopathological study of 49 cases. Int J Gynecol Pathol 2003;22:29-36. (Pubitemid 36014273)
25. Burks RT, Sherman ME, Kurman RJ. Micropapillary serous carcinoma of the ovary. A distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol 1996;20: 1319-1330
26. Seidman JD, Kurman RJ. Subclassification of serous borderline tumors of the ovary into benign and malignant types. A clinicopathologic study of 65 advanced stage cases. Am J Surg Pathol 1996;20:1331-1345
27. Seidman JD, Kurman RJ. Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. Hum Pathol 2000;31:539-557
28. Eichhorn JH, Bell DA, Young RH, et al. Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. Am J Surg Pathol 1999;23:397-409.
29. Prat J, De Nictolis M. Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion. Am J Surg Pathol 2002;26:1111-1128 (Pubitemid 34969181)
30. Slomovitz BM, Caputo TA, Gretz HF III, et al. A comparative analysis of 57 serous borderline tumors with and without a noninvasive micropapillary component. Am J Surg Pathol 2002;26:592-600.
31. Shih I, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004;164:1511-1518 (Pubitemid 38529752)
32. Sieben NL, Macropoulos P, Roemen GM, et al. In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 2004;202:336-340