Carbachol increases contractions and intracellular Ca++ transients in guinea pig ventricular myocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 1, 1998, Pages 66-74

  Protas, Lev ^a,b   Shen, Jian Bing ^a   Pappano, Achilles J ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR; OTENZEPAD; PIRENZEPINE; RECEPTOR SUBTYPE; RYANODINE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; DRUG ANTAGONISM; EXCITATION CONTRACTION COUPLING; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; CALCIUM; CALCIUM CHANNELS; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; MALE; MUSCARINIC AGONISTS; MYOCARDIAL CONTRACTION; PROTEIN KINASE C; TEMPERATURE;

EID: 0031886262     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM and Sheu S-S (1994) Autonomic modulation of action potential and tension in guinea pig papillary muscles. Eur J Pharmacol 271:309-317.
2. Du XY, Schoemaker RG, Bos E and Saxena PR (1995) Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium. Eur J Pharmacol 284:119-127.
3. Endoh M and Blinks JR (1984) Effects of endogenous neurotransmitters on calcium transients in mammalian atrial muscle, in Neuronal and Extraneuronal Events in Autonomie Pharmacology (Fleming WW, Graefe KH, Langer SZ and Weiner N eds) pp 221-230, Raven Press, New York.
4. Fukuda K, Kubo T, Akiba I, Maeda A, Mishina M and Numa S (1987) Molecular distinction between muscarinic acetylcholine receptor subtypes. Nature 327:623-625.
5. 1 muscarinic receptors increase calcium current and phosphoinositide turnover in guinea-pig ventricular cardiocytes. J Physiol (Lond) 471:41-60.
6. Gibbons WR and Zygmunt AC (1992) Excitation-contraction coupling in heart, in The Heart and Cardiovascular System (Fozzard HA, Haber E, Jennings RB, Katz AM and Morgan HE eds) pp1249-1279, Raven Press, New York.
7. Gilmour RF Jr and Zipes DP (1985) Positive inotropic effect of acetylcholine in canine cardiac Purkinje fibers. Am J Physiol 249: H735-H740.
8. 2+ exchanger in the rate-dependent increase in contraction in guinea-pig ventricular myocytes. J Physiol (Lond) 482:555-566.
9. Iacono G and Vassalle M (1989) Acetylcholine increases intracellular sodium activity in sheep cardiac Purkinje fibers. Am J Physiol 256:H1407-H1416.
10. Inui J, Brodde O-E and Schümann HJ (1982) Influence of acetylcholine on the positive inotropic effect evoked by α-or β-adrenoceptor stimulation in the rabbit heart. Naunyn-Schmiedeberg's Arch Pharmacol 320:152-159.
11. +-ion activity and force of contraction. Pflügers Arch 403:266-272.
12. Korth M and Kühlkamp V (1987) Muscarinic receptors mediate negative and positive inotropic effects in mammalian ventricular myocardium: Differentiation by agonists. Br J Pharmacol 90:81-90.
13. 2+ concentration in rat ventricular myocytes. Circ Res 62:1080-1087.
14. Leblanc N and Hume JR (1990) Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science 248:372-376.
15. Lee H-C, Smith N, Mohabir R and Clusin WT (1987) Cytosolic calcium transients from the beating mammalian heart. Proc Natl Acad Sci USA 84:7793-7797.
16. Levi AJ, Spitzer KW, Kohmoto O and Bridge JHB (1994) Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am J Physiol 266:H1422-H1433.
17. Matsumoto K and Pappano AJ (1989) Sodium-dependent membrane current induced by carbachol in single guinea-pig ventricular myocytes. J Physiol (Lond) 415:487-502.
18. Matsumoto K and Pappano AJ (1991) Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors. Mol Pharmacol 39:359-363.
19. McDonald TF, Pelzer S, Trautwein W and Pelzer DJ (1994) Regulation and modulation of calcium channels in cardiac, skeletal and smooth muscle cells. Physiol Rev 74:365-507.
20. McMorn SO, Harrison SM, Zang WJ, Yu X-J and Boyett MR (1993) A direct negative inotropic effect of acetylcholine on rat ventricular myocytes. Am J Physiol 265: H1393-H1400.
21. Nosek TM, Williams MF, Ziegler ST and Godt RE (1986) Inositol trisphosphate enhances calcium release in skinned cardiac and skeletal muscle. Am J Physiol 250:C807-C811.
22. Pappano AJ (1991) Vagal stimulation of the heartbeat: Muscarinic receptor hypothesis. J Cardiovasc Electrophysiol 2:262-273.
23. Pappano AJ (1995) Modulation of the Heartbeat by the Vagus Nerve, in Cardiac Electrophysiology: From Cell to Bedside (Zipes DP and Jalife J eds) 2nd ed, pp 411-422, W. B. Saunders Co., Philadelphia.
24. Pappano AJ and Mubagwa K (1992) Actions of muscarinic agents and adenosine on the heart, in The Heart and Cardiovascular System (Fozzard HA, Haber E, Jennings RB, Katz AM and Morgan HE eds) pp 1765-1776, Raven Press, New York.
25. Protas LL (1990) Muscarinic receptors mediating the positive inotropic effect of carbachol in embryonic chick ventricle have a low affinity for pirenzepine. Eur J Pharmacol 175:215-218.
26. Protas LL (1992) Positive and negative inotropic effects of carbachol on the embryonic chick atrium. Experientia 48:1007-1009.
27. 2+ transients and contractions in ventricular myocytes (Abstract). Biophys J 72:A233.
28. Prystowsky EN and Zipes DP (1985) Observations on postvagal tachycardia in humans, in Cardiac Electrophysiology and Arrhythmias (Zipes DP and Jalife J eds) pp 177-179, Grune and Stratton, Inc., New York.
29. 2+ in intact cardiac myocytes. Circ Res 74:970-978.
30. 1 muscarinic acetylcholine receptors in rat ventricular myocytes. Circ Res 79:86-93.
31. Shepherd N, Vornanen M and Isenberg GZ (1990) Force measurements from voltageclamped guinea pig ventricular myocytes. Am J Physiol 258:H452-H459.
32. 2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes. J Physiol (Land) 489:1-17.
33. ++-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes. J Pharmacol Exp Ther 266: 919-925.
34. 1-adrenoceptors: An overview. Pharmacol Rev 45:147-175.
35. 2+ in permeabilized atrial muscle. Am J Physiol 258: H1745-H1752.
36. Vornanen M, Shepherd N and Isenberg G (1994) Tension-voltage relations of single myocytes reflect Ca release triggered by Na/Ca exchange at 35° but not at 23°C. Am J Physiol 267:C623-C632.
37. 2+ exchange in activation of excitation-contraction coupling in rat ventricular myocytes. J Physiol (Lond) 493:529-542.
38. Webb WW and Pappano AJ (1995) Muscarinic agonist-induced positive inotropic response in chick atria. Life Sci 57:2365-2376.
39. + activity, action potential, and twitch tension in guinea-pig cardiac ventricular papillary muscles. Jpn J Physiol 46:225-230.