Quantification of polyethylene glycol esters of methotrexate and determination of their partition coefficients by validated HPLC methods

Iranian Journal of Pharmaceutical Research

Volumn 8, Issue 1, 2009, Pages 27-31

  Yousefi, Gholamhossein ^a   Foroutan, Seyed Mohsen ^a   Zarghi, Afshin ^b   Shafaati, Alireza ^b  

^a SHAHID BEHESHTI UNIVERSITY   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

HPLC; Methotrexate; Partition coefficient; Pegylation; Polymer conjugation; Validation

Indexed keywords

1,2,4 TRICHLOROBENZENE; 2 NAPHTHOL; 3,4 DICHLOROANILINE; BENZOPHENONE; BIPHENYL; BROMOBENZENE; BUFFER; CHLOROBENZENE; MACROGOL; MACROGOL 35000; MACROGOL 5000; MACROGOL 750; MACROGOL DERIVATIVE; METHANOL; METHOTREXATE; NAPHTHALENE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IONIZATION; LIPOPHILICITY; MOLECULAR WEIGHT; PARTITION COEFFICIENT; RETENTION TIME; TIME; ULTRAVIOLET RADIATION;

EID: 67649086117     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Greenwald RB. PEG drugs: an overview. J. Control. Rel. (2001) 74: 159-171
2. Pliska V, Testa B and van de Waterbeemd H. Lipophilicity in drug action and toxicology. Wiley, New York (1996)
3. Camenisch G, Folkers G and van de Waterbeemd H. Review of theoretical passive drug absorption models: historical background, recent developments and limitations. Pharm. Acta Helv. (1996) 71: 309-314
4. Lipinski CA, Lombardo F, Dominy BW and Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. (1997) 23: 23-25
5. Crivori P, Cruciani G, Carrupt PA and Testa B. Predicting blood-brain barrier permeation from three dimensional molecular structure. J. Med. Chem. (2000) 43: 2204-16
6. Valko K. Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution. J. Chromatogr. A (2004) 1037: 299-310
7. Gocan S, Cimpan G and Comer J. Lipophilicity measurements by liquid chromatography. Adv. Chromatogr. (2006) 44: 79-176
8. Liu X, Tanaka H, Yamauchi A, Testa B and Chuman H. Determination of lipophilicity by reversed-phase high-performance liquid chromatography. Influence of 1-octanol in the mobile phase. J. Chromatogr. A (2005) 1091: 51-59
9. Balogh GT, Szanto Z, Forrai E, Gyorffy W and Lopata A. Use of reversed-phase liquid chromatography for determining the lipophilicity of α-aryl-N-cyclopropylnitrones. J. Pharm. Biomed. Anal. (2005) 39: 1057-1062
10. Darrouzain F, Dallet P, Dubost JP, Ismaili L, Pehourcq F, Bannwarth B, Matoga M and Guillaume YC. Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases. J. Pharm. Biomed. Anal. (2006) 41: 228-232
11. Cimpan G, Hadaruga M and Miclaus V. Lipophilicity characterization by reversed-phase liquid chromatography of some furan derivatives. J. Chromatogr. A (2000) 869: 49-55
12. Welerowicz T and Buszewski B. The effect of stationary phase on lipophilicity determination of beta-blockers using reverse-phase chromatographic systems. Biomed. Chromatogr. (2005) 19: 725-736
13. Mrkvickova Z, Kovarýkova P, Balýkova S and Klimes J. Determination of lipophilicity of novel potential antituberculotic agents using HPLC on monolithic stationary phase and theoretical calculations. J. Pharm. Biomed. Anal. (2008). in press
14. Griffin S, Grant Wyllie S and Markham J. Determination of octanol-water partition coefficient for terpenoids using reversed-phase high-performance liquid chromatography. J. Chromatogr. A (1999) 864: 221-228