-
2
-
-
22144481007
-
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma
-
Yasui H., Hideshima T., Hamasaki M., et al. SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma. Blood 106 (2005) 706-712
-
(2005)
Blood
, vol.106
, pp. 706-712
-
-
Yasui, H.1
Hideshima, T.2
Hamasaki, M.3
-
3
-
-
33751193178
-
Multiple myeloma bone disease: pathophysiology of osteoblast inhibition
-
Giuliani N., Rizzoli V., and Roodman G. Multiple myeloma bone disease: pathophysiology of osteoblast inhibition. Blood 108 (2006) 3992-3996
-
(2006)
Blood
, vol.108
, pp. 3992-3996
-
-
Giuliani, N.1
Rizzoli, V.2
Roodman, G.3
-
4
-
-
1542330894
-
Pathogenesis of myeloma bone disease
-
Goodman G.D. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis 32 (2004) 290-292
-
(2004)
Blood Cells Mol Dis
, vol.32
, pp. 290-292
-
-
Goodman, G.D.1
-
5
-
-
18144451007
-
New insights in myeloma-induced osteolysis
-
Barille-Nion S., and Bataille R. New insights in myeloma-induced osteolysis. Leuk Lymphoma 44 (2003) 1463-1467
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1463-1467
-
-
Barille-Nion, S.1
Bataille, R.2
-
6
-
-
4143082697
-
New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand (RANKL)
-
Giuliani N., Colla S., and Rizzoli V. New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand (RANKL). Exp Hematol 32 (2004) 685-691
-
(2004)
Exp Hematol
, vol.32
, pp. 685-691
-
-
Giuliani, N.1
Colla, S.2
Rizzoli, V.3
-
7
-
-
1542330894
-
Pathogenesis of myeloma bone disease
-
Roodman G.D. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis 32 (2004) 290-292
-
(2004)
Blood Cells Mol Dis
, vol.32
, pp. 290-292
-
-
Roodman, G.D.1
-
8
-
-
29244465497
-
Myeloma bone disease
-
Sezer O. Myeloma bone disease. Hematology 10 (2005) 19-24
-
(2005)
Hematology
, vol.10
, pp. 19-24
-
-
Sezer, O.1
-
9
-
-
9044219839
-
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group
-
Berenson J.R., Lichtenstein A., Porter L., et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 334 (1996) 488-493
-
(1996)
N Engl J Med
, vol.334
, pp. 488-493
-
-
Berenson, J.R.1
Lichtenstein, A.2
Porter, L.3
-
10
-
-
0034993316
-
Zoledronic acid in cancer patients with bone metastases: results of phase I and II trials
-
Berenson J.R. Zoledronic acid in cancer patients with bone metastases: results of phase I and II trials. Semin Oncol 28 (2001) 25-34
-
(2001)
Semin Oncol
, vol.28
, pp. 25-34
-
-
Berenson, J.R.1
-
11
-
-
0025783336
-
Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma
-
Bataille R., Chappard D., Marcelli C., et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 88 (1991) 62-66
-
(1991)
J Clin Invest
, vol.88
, pp. 62-66
-
-
Bataille, R.1
Chappard, D.2
Marcelli, C.3
-
12
-
-
0026690115
-
Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption
-
Taube T., Beneton M.N., McCloskey E.V., et al. Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. Eur J Haematol 49 (1992) 192-198
-
(1992)
Eur J Haematol
, vol.49
, pp. 192-198
-
-
Taube, T.1
Beneton, M.N.2
McCloskey, E.V.3
-
13
-
-
33847397091
-
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
-
Yaccoby S., Ling W., Zhan F., et al. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109 (2007) 2106-2111
-
(2007)
Blood
, vol.109
, pp. 2106-2111
-
-
Yaccoby, S.1
Ling, W.2
Zhan, F.3
-
14
-
-
0037108435
-
Osteoprotegerin is bound internalized and degraded by multiple myeloma cells
-
Standal T., Seidel C., Hjertner O., et al. Osteoprotegerin is bound internalized and degraded by multiple myeloma cells. Blood 100 (2002) 3002-3007
-
(2002)
Blood
, vol.100
, pp. 3002-3007
-
-
Standal, T.1
Seidel, C.2
Hjertner, O.3
-
15
-
-
0035943676
-
Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3
-
Lihua W., Xiaoyi Y., Kelly M., et al. Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. J Biol Chem 276 (2001) 31839-31844
-
(2001)
J Biol Chem
, vol.276
, pp. 31839-31844
-
-
Lihua, W.1
Xiaoyi, Y.2
Kelly, M.3
-
16
-
-
0021717406
-
Relative contributions of aging and estrogen deficiency to postmenopausal bone loss
-
Richelson L.S., Wahner H.W., Melton L.J., et al. Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl J Med 311 (1984) 1273-1275
-
(1984)
N Engl J Med
, vol.311
, pp. 1273-1275
-
-
Richelson, L.S.1
Wahner, H.W.2
Melton, L.J.3
-
17
-
-
0027465435
-
Preventive effects of transdermal 17-β estradiol on osteoporotic changes after surgical menopause: a two-year placebo-controlled trial
-
Field C.S., Ory S.J., Wahner H.W., et al. Preventive effects of transdermal 17-β estradiol on osteoporotic changes after surgical menopause: a two-year placebo-controlled trial. Am J Obstet Gynecol 168 (1993) 114-121
-
(1993)
Am J Obstet Gynecol
, vol.168
, pp. 114-121
-
-
Field, C.S.1
Ory, S.J.2
Wahner, H.W.3
-
18
-
-
0027746012
-
Use of low-dosage 17-β-estradiol for the prevention of osteoporosis
-
Ettinger B. Use of low-dosage 17-β-estradiol for the prevention of osteoporosis. Clin Ther 15 (1993) 950-956
-
(1993)
Clin Ther
, vol.15
, pp. 950-956
-
-
Ettinger, B.1
-
19
-
-
0024121473
-
Enhanced osteoblast proliferation and collagen gene expression by estradiol
-
Ernst M., Schmid Ch., and Froesch E.R. Enhanced osteoblast proliferation and collagen gene expression by estradiol. PNAS 85 (1988) 2307-2310
-
(1988)
PNAS
, vol.85
, pp. 2307-2310
-
-
Ernst, M.1
Schmid, Ch.2
Froesch, E.R.3
-
20
-
-
0016353218
-
Separation of parathyroid hormone and calcitonin-sensitive cells from non-responsive bone cells
-
Wong G., and Cohn D.V. Separation of parathyroid hormone and calcitonin-sensitive cells from non-responsive bone cells. Nature 252 (1974) 713-715
-
(1974)
Nature
, vol.252
, pp. 713-715
-
-
Wong, G.1
Cohn, D.V.2
-
21
-
-
18744387365
-
A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2
-
Saito Y., Yoshizawa T., Takizawa F., et al. A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J Cell Sci 115 (2002) 4191-4200
-
(2002)
J Cell Sci
, vol.115
, pp. 4191-4200
-
-
Saito, Y.1
Yoshizawa, T.2
Takizawa, F.3
-
22
-
-
0142182080
-
Receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis
-
Grimaud E., Soubigou L., Couillaud S., et al. Receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am J Pathol 163 (2003) 2021
-
(2003)
Am J Pathol
, vol.163
, pp. 2021
-
-
Grimaud, E.1
Soubigou, L.2
Couillaud, S.3
-
23
-
-
0024786736
-
Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease
-
Bataille R., Chappard D., Marcelli C., et al. Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease. J Clin Oncol 7 (1989) 1909-1914
-
(1989)
J Clin Oncol
, vol.7
, pp. 1909-1914
-
-
Bataille, R.1
Chappard, D.2
Marcelli, C.3
-
24
-
-
0025678591
-
Osteoblast stimulation in multiple myeloma lacking lytic bone lesions
-
Bataille R., Chappard D., Marcelli C., et al. Osteoblast stimulation in multiple myeloma lacking lytic bone lesions. Br J Haematol 76 (1990) 484-487
-
(1990)
Br J Haematol
, vol.76
, pp. 484-487
-
-
Bataille, R.1
Chappard, D.2
Marcelli, C.3
-
25
-
-
0032930729
-
Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice
-
Hjorth-Hansen H., Seifert M.F., Borset M., et al. Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice. J Bone Miner Res 14 (1999) 256-263
-
(1999)
J Bone Miner Res
, vol.14
, pp. 256-263
-
-
Hjorth-Hansen, H.1
Seifert, M.F.2
Borset, M.3
-
26
-
-
0026558465
-
Myeloma affects both the growth and function of human osteoblast-like cells
-
Evans C.E., Ward C., Rathour L., et al. Myeloma affects both the growth and function of human osteoblast-like cells. Clin Exp Metastasis 10 (1992) 33-38
-
(1992)
Clin Exp Metastasis
, vol.10
, pp. 33-38
-
-
Evans, C.E.1
Ward, C.2
Rathour, L.3
-
27
-
-
0038345395
-
Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease
-
Silvestris F., Cafforio P., Tucci M., et al. Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease. Br J Haematol 122 (2003) 39-52
-
(2003)
Br J Haematol
, vol.122
, pp. 39-52
-
-
Silvestris, F.1
Cafforio, P.2
Tucci, M.3
-
28
-
-
33646270891
-
A role of TRAIL in killing osteoblasts by myeloma cells
-
Tinhofer I., Biedermann R., Krismer M., et al. A role of TRAIL in killing osteoblasts by myeloma cells. FASEB J 20 (2006) 759-761
-
(2006)
FASEB J
, vol.20
, pp. 759-761
-
-
Tinhofer, I.1
Biedermann, R.2
Krismer, M.3
-
29
-
-
33751193178
-
Multiple myeloma bone disease: pathophysiology of osteoblast inhibition
-
Giuliani N., Rizzoli V., and Roodman G.D. Multiple myeloma bone disease: pathophysiology of osteoblast inhibition. Blood 108 (2006) 3992-3996
-
(2006)
Blood
, vol.108
, pp. 3992-3996
-
-
Giuliani, N.1
Rizzoli, V.2
Roodman, G.D.3
-
30
-
-
0037114636
-
Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease
-
Giuliani N., Colla S., Sala R., et al. Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood 100 (2002) 4615-4621
-
(2002)
Blood
, vol.100
, pp. 4615-4621
-
-
Giuliani, N.1
Colla, S.2
Sala, R.3
-
31
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
Lacey D.L., Timms E., Tan H.L., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
-
(1998)
Cell
, vol.93
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.L.3
-
32
-
-
0035895083
-
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
-
Giuliani N., Bataille R., Mancini C., et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 98 (2001) 3527-3533
-
(2001)
Blood
, vol.98
, pp. 3527-3533
-
-
Giuliani, N.1
Bataille, R.2
Mancini, C.3
-
33
-
-
0043245842
-
Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index
-
Terpos E., Szydlo R., Apperley J.F., et al. Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 102 (2003) 1064-1069
-
(2003)
Blood
, vol.102
, pp. 1064-1069
-
-
Terpos, E.1
Szydlo, R.2
Apperley, J.F.3
-
34
-
-
0035949510
-
Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
-
Pearse R.N., Sordillo E.M., Yaccoby S., et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 98 (2001) 11581-11586
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11581-11586
-
-
Pearse, R.N.1
Sordillo, E.M.2
Yaccoby, S.3
-
35
-
-
0037439916
-
Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
-
Vanderkerken K., De Leenheer E., Shipman C., et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res 63 (2003) 287-289
-
(2003)
Cancer Res
, vol.63
, pp. 287-289
-
-
Vanderkerken, K.1
De Leenheer, E.2
Shipman, C.3
-
36
-
-
0036181668
-
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
-
Yaccoby S., Pearse R.N., Johnson C.L., et al. Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 116 (2002) 278-290
-
(2002)
Br J Haematol
, vol.116
, pp. 278-290
-
-
Yaccoby, S.1
Pearse, R.N.2
Johnson, C.L.3
-
37
-
-
0035866796
-
Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy
-
Oyajobi B.O., Anderson D.M., Traianedes K., et al. Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. Cancer Res 61 (2001) 2572-2578
-
(2001)
Cancer Res
, vol.61
, pp. 2572-2578
-
-
Oyajobi, B.O.1
Anderson, D.M.2
Traianedes, K.3
-
38
-
-
37349060697
-
Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade
-
Chen J.R., Shankar K., Nagarajan S., et al. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J Pharmacol Exp Ther 324 (2008) 50-59
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 50-59
-
-
Chen, J.R.1
Shankar, K.2
Nagarajan, S.3
-
39
-
-
0035937747
-
Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kB ligand (RANKL)-induced JNK activation
-
Sunil Srivastava, Gianluca Toraldo M., Neale Weitzmann, et al. Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kB ligand (RANKL)-induced JNK activation. J Biol Chem 276 (2001) 8836-8840
-
(2001)
J Biol Chem
, vol.276
, pp. 8836-8840
-
-
Sunil Srivastava1
Gianluca Toraldo, M.2
Neale Weitzmann3
-
40
-
-
0032170090
-
Anti-estrogens induce apoptosis of multiple myeloma cells
-
Treon S.P., Teoh G., Urashima M., et al. Anti-estrogens induce apoptosis of multiple myeloma cells. Blood 92 (1998) 1749-1757
-
(1998)
Blood
, vol.92
, pp. 1749-1757
-
-
Treon, S.P.1
Teoh, G.2
Urashima, M.3
|