Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin

Biopolymers

Volumn 92, Issue 3, 2009, Pages 194-200

  Liu, Yinan ^a   Carroll, Jacob R ^a   Holt, Lindsey A ^a   McMahon, James ^b   Giomarelli, Barbara ^b   Ghirlanda, Giovanna ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antiviral protein; Cyanovirin; HIV; Lectin; Multivalency

Indexed keywords

ANTIVIRAL PROTEIN; CYANOVIRIN; HIV; LECTIN; MULTIVALENCY;

BINDING ENERGY; CARBOHYDRATES; DIMERS;

BINDING SITES;

CYANOVIRIN N; DIMER; GLYCOPROTEIN GP 120; MUTANT PROTEIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOCYTE CULTURE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; WILD TYPE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DIMERIZATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; THERMODYNAMICS;

CYANOBACTERIA;

ANTI-HIV AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELLS, CULTURED; CIRCULAR DICHROISM; DIMERIZATION; HIV ENVELOPE PROTEIN GP120; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; THERMODYNAMICS;

EID: 67549112686     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21173     Document Type: Article

References (36)

1. Balzarini, J. Nat Rev Microbiol 2007, 5, 583-597.
2. Ziolkowska, N. E.; Wlodawer, A. Acta Biochim Polym 2006, 53, 617-626.
3. Barrientos, L. G.; Gronenborn, A. M. Mini Rev Med Chem 2005, 5, 21-31.
4. Balzarini, J. Antiviral Res 2006, 71, 237-247.
5. Scanlan, C. N.; Offer, J.; Zitzmann, N.; Dwek, R. A. Nature 2007, 446, 1038-1045.
6. Fromme, R.; Katiliene, Z.; Giomarelli, B.; Bogani, F.; Mahon, J. M.; Mori, T.; Fromme, P.; Ghirlanda, G. Biochemistry 2007, 46, 9199-9207.
7. Bewley, C. A. Structure (Camb) 2001, 9, 931-940.
8. Bewley, C. A.; Gustafson, K. R.; Boyd, M. R.; Covell, D. G.; Bax, A.; Clore, G. M.; Gronenborn, A. M. Nat Struct Biol 1998, 5, 571-578.
9. Bolmstedt, A. J.; O'Keefe, B. R.; Shenoy, S. R.; McMahon, J. B.; Boyd, M. R. Mol Pharmacol 2001, 59, 949-954.
10. Boyd, M. R.; Gustafson, K. R.; McMahon, J. B.; Shoemaker, R. H.; O'Keefe, B. R.; Mori, T.; Gulakowski, R. J.; Wu, L.; Rivera, M. I.; Laurencot, C. M.; Currens, M. J.; Cardellina, J. H., II; Buckheit, R. W., Jr.; Nara, P. L.; Pannell, L. K.; Sowder, R. C., II; Henderson, L. E. Antimicrob Agents Chemother 1997, 41, 1521-1530.
11. Esser, M. T.; Mori, T.; Mondor, I.; Sattentau, Q. J.; Dey, B.; Berger, E. A.; Boyd, M. R.; Lifson, J. D. J Virol 1999, 73, 4360-4371.
12. Tsai, C. C.; Emau, P.; Jiang, Y.; Agy, M. B.; Shattock, R. J.; Schmidt, A.; Morton, W. R.; Gustafson, K. R.; Boyd, M. R. AIDS Res Hum Retroviruses 2004, 20, 11-18.
13. Yang, F.; Bewley, C. A.; Louis, J. M.; Gustafson, K. R.; Boyd, M. R.; Gronenborn, A. M.; Clore, G. M.; Wlodawer, A. J Mol Biol 1999, 288, 403-412.
14. Botos, I.; O'Keefe, B. R.; Shenoy, S. R.; Cartner, L. K.; Ratner, D. M.; Seeberger, P. H.; Boyd, M. R.; Wlodawer, A. J Biol Chem 2002, 277, 34336-34342.
15. Fromme, R.; Katiliene, Z.; Fromme, P.; Ghirlanda, G. Protein Sci 2008, 17, 939-944.
16. Kelley, B. S.; Chang, L. C.; Bewley, C. A. J Am Chem Soc 2002, 124, 3210-3211.
17. Botos, I.; Mori, T.; Cartner, L. K.; Boyd, M. R.; Wlodawer, A. Biochem Biophys Res Commun 2002, 294, 184-190.
18. Han, Z.; Xiong, C.; Mori, T.; Boyd, M. R. Biochem Biophys Res Commun 2002, 292, 1036-1043.
19. Barrientos, L. G.; Lasala, F.; Delgado, R.; Sanchez, A.; Gronenborn, A. M. Structure (Camb) 2004, 12, 1799-1807.
20. Barrientos, L. G.; Louis, J. M.; Botos, I.; Mori, T.; Han, Z.; O'Keefe, B. R.; Boyd, M. R.; Wlodawer, A.; Gronenborn, A. M. Structure 2002, 10, 673-686.
21. Blixt, O.; Head, S.; Mondala, T.; Scanlan, C.; Huflejt, M. E.; Alvarez, R.; Bryan, M. C.; Fazio, F.; Calarese, D.; Stevens, J.; Razi, N.; Stevens, D. J.; Skehel, J. J.; van Die, I.; Burton, D. R.; Wilson, I. A.; Cummings, R.; Bovin, N.; Wong, C. H.; Paulson, J. C. Proc Natl Acad Sci USA 2004, 101, 17033-17038.
22. Manimala, J. C.; Roach, T. A.; Li, Z.; Gildersleeve, J. C. Angew Chem Int Ed Engl 2006, 45, 3607-3610.
23. Mori, T.; Boyd, M. R. Antimicrob Agents Chemother 2001, 45, 664-672.
24. Chang, L. C.; Bewley, C. A. J Mol Biol 2002, 318, 1-8.
25. Barrientos, L. G.; Matei, E.; Lasala, F.; Delgado, R.; Gronenborn, A. M. Protein Eng Des Sel 2006, 19, 525-535.
26. Mori, T.; Barrientos, L. G.; Han, Z.; Gronenborn, A. M.; Turpin, J. A.; Boyd, M. R. Protein Expr Purif 2002, 26, 42-49.
27. Barrientos, L. G.; Louis, J. M.; Hung, J.; Smith, T. H.; O'Keefe, B. R.; Gardella, R. S.; Mori, T.; Boyd, M. R.; Gronenborn, A. M. Proteins 2002, 46, 153-160.
28. Nussbaum, O.; Broder, C. C.; Berger, E. A. J Virol 1994, 68, 5411-5422.
29. Ziolkowska, N. E.; O'Keefe, B. R.; Mori, T.; Zhu, C.; Giomarelli, B.; Vojdani, F.; Palmer, K. E.; McMahon, J. B.; Wlodawer, A. Structure 2006, 14, 1127-1135.
30. Mori, T.; O'Keefe, B. R.; Sowder, R. C., II; Bringans, S.; Gardella, R.; Berg, S.; Cochran, P.; Turpin, J. A.; Buckheit, R. W., Jr.; McMahon, J. B.; Boyd, M. R. J Biol Chem 2005, 280, 9345-9353.
31. Chiba, H.; Inokoshi, J.; Okamoto, M.; Asanuma, S.; Matsuzaki, K.; Iwama, M.; Mizumoto, K.; Tanaka, H.; Oheda, M.; Fujita, K.; Nakashima, H.; Shinose, M.; Takahashi, Y.; Omura, S. Biochem Biophys Res Co 2001, 282, 595-601.
32. Chiba, H.; Inokoshi, J.; Nakashima, H.; Omura, S.; Tanaka, H. Biochem Bioph Res Co 2004, 316, 203-210.
33. Williams, D. C., Jr.; Lee, J. Y.; Cai, M.; Bewley, C. A.; Clore, G. M. J Biol Chem 2005, 280, 29269-29276.
34. Balzarini, J. Antivir Chem Chemother 2007, 18, 1-11.
35. Sacchettini, J. C.; Baum, L. G.; Brewer, C. F. Biochemistry 2001, 40, 3009-3015.
36. Gulakowski, R. J.; McMahon, J. B.; Staley, P. G.; Moran, R. A.; Boyd, M. R. J Virol Methods 1991, 33, 87-100.