Preparation and in vitro evaluation of sustained-release matrix tablets of flutamide using synthetic and naturally occurring polymers

Iranian Journal of Pharmaceutical Research

Volumn 7, Issue 4, 2008, Pages 247-257

  Emami, Jaber ^a   Tajeddin, Mona ^a   Ahmadi, Fatemeh ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Drug release; Flutamide; Hydrophilic polymers; Kienetic studies; Matrix tablets; Sustained release

Indexed keywords

CARBOXYMETHYLCELLULOSE; EUDRAGIT; EUDRAGIT RS; FLUTAMIDE; GUAR GUM; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; XANTHAN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; IN VITRO STUDY; MATRIX TABLET; PHYSICAL CHEMISTRY; SUSTAINED RELEASE FORMULATION; TABLET COMPRESSION; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET MATRIX; TABLET THICKNESS;

EID: 67549105664     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Posti J, Katila K and Kostiainen T. Dissolution rate limited bioavailability of flutamide, and in vitro-in vivo correlation. Eur. J. Pharm. Biopharm. (2000) 49: 35-39
2. Sweetman SC. (ed.) Martindale, Complete Drug Reference. 34th ed. Pharmaceutical Press, London (2005) 556-557
3. Tzanavaras PD and Themelis DG. Automated determination of flutamide by a validated flowinjection method: Application to dissolution studies of pharmaceutical tablets. J. Pharm. Biomed. Anal. (2007) 43: 1820-1824
4. Asade RH, Prizont L, Muino JP and Tessler J. Steady-state hydroxyflutamide plasma levels after the administration of two dosage forms of flutamide. Cancer Chemother. Pharmacol. (1991) 27: 401-405
5. Lamas MC, Bregni C, Frias M and Velazquez R. Hydrogel microspheres for flutamide obtained by multiple emulsions. STP Pharma. Sciences (1998) 8: 375-378
6. Lamas C, Frias M, Bregni C and Velazquez R. Microspheres obtained by multiple emulsions. Boll. Chim. Farm. (1998) 137: 357-361
7. Bravo SA, Lamas MC and Salamon CJ. In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. J. Pharm. Pharmaceut. Sci. (2002) 5: 213-219
8. Reddy KR, Mutalik S and Reddy S. Once-daily sustainedrelease matrix tablets of nicorandil: formulation and in vitro evaluation. AAPS PharmSciTech. (2003) 4: article no. 61
9. Arthur HK. Handbook of Pharmaceutical Excipients. 3rd ed. American Pharmaceutical Association, London (2000) 271, 297, 463-464
10. Gennaro A. (ed.) Remington: The Science and Practice of Pharmacy. 21th ed. Mack Publishing Company, Easton (2006) 917
11. Woolfson D. (ed.) British Pharmacopoeia. The Stationery Office, London (2007) 916
12. Williams RL. (ed.) The United States Pharmacopoeia. 29th ed. United States Pharmacopeial Convention Inc., Rockville (2006) 958-959
13. Banakar UV. Pharmaceutical Dissolution Testing. Marcel Dekker. Inc., New York (1992) 191-192
14. Ei-Arini SK and Leuenberger H. Modelling of drug release from polymer matrices: Effect of drug loading. Int. J. Pharm. (1995) 121: 141-148
15. 2 factorial design. Drug Dev. Ind. Pharm. (2002) 28: 77-87
16. Costa P. An alternative method to the evaluation of similarity factor in dissolution testing. Int. J. Pharm. (2001) 220: 77-83
17. Costa P and Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. (2001) 13: 123-133
18. Abrahamsson B, Alpsten M, Bake B, Larsson A and Sjogren J. In vitro and in vivo erosion of two different hydrophilic gel matrix tablets. Eur. J. Pharm. Biopharm. (1998) 46: 69-75
19. Chien YW. Fundamentals of rate-controlled drug Chien YW (ed.) Novel Drug Delivery Systems. Marcel Dekker Inc., New York (1992) 43-137
20. Al Taani BM and Tashtoush BM. Effect of microenvironment pH of swellable and erodable buffered matrices on the release characteristics of diclofenac sodium. AAPS PharmSciTech (2003) 4(3): article no. 43
21. Heng PWS, Chan LW, Easterbrook MG and Li X. Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets. J. Control. Rel. (2001) 76: 39-49
22. Colombo P. Swelling-controlled release in hydrogel matrices for oral route. Adv. Drug Del. Rev. (1993) 11: 37-57
23. Takka S, Rajbhandari S and Sakr A. Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. Eur. J. Pharm. Biopharm. (2001) 52: 75-82
24. Vazquez MJ, Gomez-Amoza JL, Martinez-Pacheco R, Souto C and Concheiro A. Relationships between drug dissolution profile and gelling agent viscosity in tablets prepared with Hydroxypropylmethylcellulose (HPMC) and sodium Carboxymethylcellulose (NaCMC) mixtures. Drug Dev. Ind. Pharm. (1995) 21: 1859-1874
25. Gohel MC and Panchal MK. Formulation optimization of diltiazem HCl matrix tablets containing modified guar gum using a central composite design. Pharm. Pharmacol. Commun. (1999) 5: 331-338
26. Sankalia JM, Sankalia MG and Mashru RC. Drug release and swelling kinetics of directly compressed glipizide sustained-release matrices: Establishment of level A IVIVC. J. Control. Rel. (2008) In Press.
27. Talukdar MM, Michoel A, Rombaut P and Kinget R. Comparative study on xanthan gum and hydroxypropylmethyl cellulose as matrices for controlled-release drug delivery I. Compaction and in vitro drug release behaviour. Int. J. Pharm. (1996) 129: 233-241
28. Talukdar MM and Kinget R. Comparative study on xanthan gum and hydroxypropylmethyl cellulose as matrices for controlled-release drug delivery. II. Drug diffusion in hydrated matrices. Int. J. Pharm. (1997) 151: 99-107
29. Khullar P, Khar RK and Agarwal SP. Evaluation of guar gum in the preparation of sustained-release matrix tablets. Drug Dev. Ind. Pharm. (1998) 24: 1095-1099
30. Krishnaiah YSR, Karthikeyan RS and Satyanarayana V. A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate. Int. J. Pharm. (2002) 241: 353-366
31. Sanchez-Lafuente C, Teresa Faucci M, Fernandez-Arévalo M, Alvarez-Fuentes J, Rabasco AM and Mura P. Development of sustained release matrix tablets of didanosine containing methacrylic and ethylcellulose polymers. Int. J. Pharm. (2002) 234: 213-221
32. Ceballos A, Cirri M, Maestrelli F, Corti G and Mura P. Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets. Il Farmaco (2005) 60: 913-918
33. Kuksal A, Tiwary AK, Jain NK and Jain S. Formulation and in vitro, in vivo evaluation of extended- release matrix tablet of zidovudine: influence of combination of hydrophilic and hydrophobic matrix formers. AAPS PharmSciTech (2006) 7(1): article no. 1